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Specialty: Drugs & Pharmacology
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Translated article Consensus recommendations on the preventive treatment of migraine
CONCLUSIONS: The high degree of consensus indicates that the opinion of neurologists and hospital pharmacists on the role of anti-Calcitonin Gene-related Peptide monoclonal antibodies in the preventive treatment of migraine is very similar and allows identifying those controversies that still exist, to improve the care and follow-up of patients with migraine.PMID:37730507 | DOI:10.1016/j.farma.2023.07.002
Source: Farmacia Hospitalaria - September 20, 2023 Category: Drugs & Pharmacology Authors: Miguel Ángel Calleja-Hernández Ángel Luis Guerrero-Peral Pablo Irimia-Sieira Ic íar Martínez-López Sonia Santos-Lasaosa Maite Sarobe-Carricas Jos é María Serra López-Matencio Jos é Miguel Láinez-Andrés Source Type: research
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone
Arch Pharm Res. 2023 Sep 20. doi: 10.1007/s12272-023-01462-1. Online ahead of print.ABSTRACTTolperisone, a muscle relaxant used for post-stroke spasticity, is metabolized to its main metabolite by CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2. We investigated the effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on tolperisone pharmacokinetics. A 150 mg oral dose of tolperisone was given to 184 healthy Korean subjects and plasma concentrations of tolperisone were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A 3.14-fold significant increase in AUC0-∞ was observed in ...
Source: Archives of Pharmacal Research - September 20, 2023 Category: Drugs & Pharmacology Authors: Ji-Young Byeon Chang-Keun Cho Pureum Kang Se-Hyung Kim Choon-Gon Jang Seok-Yong Lee Yun Jeong Lee Source Type: research
Nucleic Acid Nanomaterials: Biostability and Applications
Curr Drug Metab. 2023;24(5):314. doi: 10.2174/138920022405230824141125.NO ABSTRACTPMID:37728080 | DOI:10.2174/138920022405230824141125
Source: Current Drug Metabolism - September 20, 2023 Category: Drugs & Pharmacology Authors: Shaojingya Gao YunFeng Lin Source Type: research
Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research
The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Biomed Pharmacother. 2023 Sep 18;167:115511. doi: 10.1016/j.biopha.2023.115511. Online ahead of print.ABSTRACTCorydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jia-Hua Feng Kang Chen Si-Yu Shen Yun-Feng Luo Xi-Hong Liu Xin Chen Wei Gao Yu-Ru Tong Source Type: research
Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc ía-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart ínez-Alarcón V íctor López-López Antonio R íos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram írez Pablo Pelegr Source Type: research
Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions
Biomed Pharmacother. 2023 Sep 18;167:115538. doi: 10.1016/j.biopha.2023.115538. Online ahead of print.ABSTRACTTripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin-proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biologi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jie Zhang Yuting Zhou Jiao Feng Xuanfu Xu Jianye Wu Chuanyong Guo Source Type: research
Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease
Biomed Pharmacother. 2023 Sep 18;167:115469. doi: 10.1016/j.biopha.2023.115469. Online ahead of print.ABSTRACTExtracellular matrix (ECM) is an active player in cardiovascular calcification (CVC), a major public health issue with an unmet need for effective therapies. Lysyl oxidase (LOX) conditions ECM biomechanical properties; thus, we hypothesized that LOX might impact on mineral deposition in calcific aortic valve disease (CAVD) and atherosclerosis. LOX was upregulated in calcified valves from two cohorts of CAVD patients. Strong LOX immunostaining was detected surrounding calcified foci in calcified human valves and ath...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Carme Ballester-Servera Judith Alonso Laia Ca ñes Paula V ázquez-Sufuentes L ídia Puertas-Umbert Amaya Fern ández-Celis Manel Taur ón Antonio Rodr íguez-Sinovas Natalia L ópez-Andrés Cristina Rodr íguez Jos é Martínez-González Source Type: research
Acetylation in pathogenesis: Revealing emerging mechanisms and therapeutic prospects
Biomed Pharmacother. 2023 Sep 18;167:115519. doi: 10.1016/j.biopha.2023.115519. Online ahead of print.ABSTRACTProtein acetylation modifications play a central and pivotal role in a myriad of biological processes, spanning cellular metabolism, proliferation, differentiation, apoptosis, and beyond, by effectively reshaping protein structure and function. The metabolic state of cells is intricately connected to epigenetic modifications, which in turn influence chromatin status and gene expression patterns. Notably, pathological alterations in protein acetylation modifications are frequently observed in diseases such as metabo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Nan Jiang Wenyong Li Shuanglin Jiang Ming Xie Ran Liu Source Type: research
Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice
CONCLUSIONS: Overall, our results characterize a new versatile neurotoxic animal model of ALS that may be useful for the identification of new druggable targets to develop innovative therapeutic strategies for this disease.PMID:37729728 | DOI:10.1016/j.biopha.2023.115503
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Serenella Anzilotti Valeria Valente Paola Brancaccio Cristina Franco Antonella Casamassa Giovanna Lombardi Alessandra Palazzi Andrea Conte Simona Paladino Lorella Maria Teresa Canzoniero Lucio Annunziato Giovanna Maria Pierantoni Giuseppe Pignataro Source Type: research
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
In this study, we found that TUC339 was lower in the research group than in the control group and it was negatively correlated with IL-6, IL-8 and TNF-α. Prognosis TUC339 was lower in patients with recurrent OA than in those without recurrence, and ROC analysis manifested that TUC339 had a better predictive value for recurrence of OA. Phenotypic identification revealed elevated expression of CD29 and CD44 in BMSCs and TSG101, CD63 and CD81 in BMSCs-exosome (BMSCs-exo), with a stem cell versus exosome phenotype. Finally, animal experiments improved significantly in joint injury in the BMSCs-exo and TUC339-overexpression ve...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xun Shen Jian Qin Zijian Wei Feng Liu Source Type: research
Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors
Biomed Pharmacother. 2023 Sep 18;167:115534. doi: 10.1016/j.biopha.2023.115534. Online ahead of print.ABSTRACTThe analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1 agonists on pain are not well studied. Here, we used a mouse model to show that the administration of the sigma-1 agonists dextromethorphan (a widely used antitussive drug), PRE-084 (a standard sigma-1 ligand), and pridopidine (a selective drug being investigated in clinical trials for the treatment of neurodegenerative diseases) enhances PGE2-induced mechanical hyperalgesia. Superficial plantar incision induced transient weight...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: M Carmen Ruiz-Cantero Miguel Á Huerta Miguel Á Tejada Miriam Santos-Caballero Eduardo Fern ández-Segura Francisco J Ca ñizares Jos é M Entrena Jos é M Baeyens Enrique J Cobos Source Type: research
Impact of ferroptosis on preeclampsia: A review
Biomed Pharmacother. 2023 Sep 18;167:115466. doi: 10.1016/j.biopha.2023.115466. Online ahead of print.ABSTRACTPreeclampsia (PE) is usually associated with the accumulation of reactive oxygen species (ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid peroxidation-induced iron-dependent cell death distinct from traditional apoptosis, necroptosis, and pyroptosis and most likely contributes considerable to PE pathogenesis. At approximately 10-12 weeks of gestation, trophoblasts create an environment rich in oxygen and iron. In patients with PE, ferroptosis-related genes such as HIF1 an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Yuping Shan Chengcheng Guan Jingli Wang Weihong Qi Aiping Chen Shiguo Liu Source Type: research
Heterogeneous vasomotor responses in segments from G öttingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study
In conclusion, the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways are different and the phenotypes are similar to sporadic human findings.PMID:37730143 | DOI:10.1016/j.vph.2023.107231
Source: Vascular Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Anette Sams Kristian Agmund Haanes Anja Holm Spyridoula Kazantzi Lars Friis Mikkelsen Lars Edvinsson Susan Brain Majid Sheykhzade Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
