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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Tumor-derived exosomes RNA expression profiling identifies the prognosis, immune characteristics, and treatment in HR+/HER2-breast cancer
Aging (Albany NY). 2023 Aug 29;15. doi: 10.18632/aging.204986. Online ahead of print.ABSTRACTExosomes play crucial roles in intercellular communication and are involved in the onset and progression of various types of cancers, including breast cancer. However, the RNA composition of breast cancer-derived exosomes has not been comprehensively explored. We conducted microarray assays on exosomes isolated from breast cancer and healthy breast epithelial cells from three patients with hormone receptor (HR) +/ human epidermal growth factor receptor (HER2) - breast cancer and identified 817 differentially expressed genes (DEGs)....
Source: Aging - August 30, 2023 Category: Biomedical Science Authors: Qi Zhou Jing Wang Haiping Zhang Lu Sun Jingjing Liu Lingchao Meng Jingwu Li Source Type: research
Loss of EGF receptor polarity enables homeostatic imbalance in epithelial cell models
Mol Biol Cell. 2023 Aug 30:mbcE23040133. doi: 10.1091/mbc.E23-04-0133. Online ahead of print.ABSTRACTThe polarized distribution of membrane proteins into apical and basolateral domains provides the basis for specialized functions of epithelial tissues. The EGF receptor (EGFR) plays important roles in embryonic development, adult epithelial tissue homeostasis, and growth and survival of many carcinomas. Typically targeted to basolateral domains, there is also considerable evidence of EGFR sorting plasticity but very limited knowledge regarding domain-specific EGFR substrates. Here we have investigated effects of selective E...
Source: Mol Biol Cell - August 30, 2023 Category: Molecular Biology Authors: Cathleen R Carlin Syntyche Ngalula Source Type: research
Osimertinib resistance prognostic gene signature: STRIP2 is associated with immune infiltration and tumor progression in lung adenocarcinoma
CONCLUSION: We developed a reliable prognostic model based on DEGs associated with osimertinib resistance and screened for biomarker that can predict the immune response in LUAD patients, which may help in the selection of treatment regimens after osimertinib resistance.PMID:37648810 | DOI:10.1007/s00432-023-05294-w
Source: Clinical Lung Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Guixing Zhang Huiting Guan Yi-Le Ning Kainan Yao Hao Tang Gulizeba Muhetaer Hang Li Jihong Zhou Source Type: research
Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing
CONCLUSION: Our study provides a comprehensive landscape of selenium metabolism levels and diverse regulatory patterns in different cancers, deepening the understanding of selenium's roles in tumorigenesis and immunity.PMID:37648807 | DOI:10.1007/s00432-023-05333-6
Source: Clinical Colorectal Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Xiaorui Fu Yiqi Deng Heng Xu Yang Shu Hai-Ning Chen Source Type: research
Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy
CONCLUSIONS: Overall, this study provided a new insight into the role of circRNAs in the mechanism of DDP-resistance in ovarian cancer. Hsa_circRNA_0000585 may be promising therapeutic targets for the enhancement of the sensitivity of ovarian cancer cells to cisplatin-mediated chemotherapy.PMID:37643536 | DOI:10.1016/j.bbrc.2023.08.048
Source: Biochemical and Biophysical Research communications - August 29, 2023 Category: Biochemistry Authors: Pei Du Xueyuan Xu Ying Wang Source Type: research
Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer
CONCLUSION: Our encouraging results show that EpCAM-binding DARPins are a promising class of targeting moieties for pan-carcinoma targeting, providing clear tumor delineation at 24 h post-injection. The work described provides the preclinical foundation for DARPin-based bimodal NIRF/PA imaging of cancer.PMID:37642704 | DOI:10.1007/s00259-023-06407-w
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Ruben D Houvast Nada Badr Taryn March Lysanne D A N de Muynck Vincent Q Sier Timo Schomann Shadhvi Bhairosingh Victor M Baart Judith A H M Peeters Gerard J P van Westen Andreas Pl ückthun Jacobus Burggraaf Peter J K Kuppen Alexander L Vahrmeijer Cornelis Source Type: research
Regulation of Epithelial-Mesenchymal Transition by Cyrtopodion Scabrum: An in vitro Study against Colorectal Cancer Cells
CONCLUSION: The results suggest that C. scabrum extract (CsE) may induce its anti-cancer activity through the inhibition of cancer cell growth and the EMT process. CCE, as a valuable natural source, could be also suggested, to be used as an alternative/complementary medicine for the treatment of cancer, in clinical trials.PMID:37642063 | DOI:10.31557/APJCP.2023.24.8.2765
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Fatemeh Khademi Atefeh Seghatoleslam Amin Ramezani Zohreh Mostafavipour Hadi Ghasemi Source Type: research
Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy
CONCLUSIONS: Overall, this study provided a new insight into the role of circRNAs in the mechanism of DDP-resistance in ovarian cancer. Hsa_circRNA_0000585 may be promising therapeutic targets for the enhancement of the sensitivity of ovarian cancer cells to cisplatin-mediated chemotherapy.PMID:37643536 | DOI:10.1016/j.bbrc.2023.08.048
Source: Biochemical and Biophysical Research communications - August 29, 2023 Category: Biochemistry Authors: Pei Du Xueyuan Xu Ying Wang Source Type: research
A Polyherbal Formulation Habb-e-Ustukhuddus Induces Apoptosis and Inhibits Cell Migration in Lung and Breast Cancer Cells without Any Toxicity in Mice
CONCLUSION: Together, these results demonstrated the anticancer potential HU, without any apparent toxicity in mice, and thus HU could be further explored for its clinical utility in cancer control.PMID:37642058 | DOI:10.31557/APJCP.2023.24.8.2713
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Reenu Punia Mansoor Ali Yasmeen Shamsi Rana P Singh Source Type: research
Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer
CONCLUSION: Our encouraging results show that EpCAM-binding DARPins are a promising class of targeting moieties for pan-carcinoma targeting, providing clear tumor delineation at 24 h post-injection. The work described provides the preclinical foundation for DARPin-based bimodal NIRF/PA imaging of cancer.PMID:37642704 | DOI:10.1007/s00259-023-06407-w
Source: Molecular Medicine - August 29, 2023 Category: Molecular Biology Authors: Ruben D Houvast Nada Badr Taryn March Lysanne D A N de Muynck Vincent Q Sier Timo Schomann Shadhvi Bhairosingh Victor M Baart Judith A H M Peeters Gerard J P van Westen Andreas Pl ückthun Jacobus Burggraaf Peter J K Kuppen Alexander L Vahrmeijer Cornelis Source Type: research
Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors
CONCLUSIONS: Our work identified a unique tumorigenic microenvironment of the interface zone and allowed for deeper insights into the tumor microenvironment of breast cancer that will serve as a helpful resource for advancing breast cancer diagnosis and therapy.PMID:37644609 | DOI:10.1186/s13058-023-01703-7
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Wei Yang Meiyu Xu Shuoqi Xu Qingxian Guan Shuaiming Geng Juanhong Wang Wei Wei Hongwei Xu Ying Liu Yong Meng Ming-Qing Gao Source Type: research
Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy
CONCLUSIONS: Overall, this study provided a new insight into the role of circRNAs in the mechanism of DDP-resistance in ovarian cancer. Hsa_circRNA_0000585 may be promising therapeutic targets for the enhancement of the sensitivity of ovarian cancer cells to cisplatin-mediated chemotherapy.PMID:37643536 | DOI:10.1016/j.bbrc.2023.08.048
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Pei Du Xueyuan Xu Ying Wang Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Molecular Biology Reports - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
Homologous Recombination Deficiency Testing to Inform Patient Decisions About Niraparib Maintenance Therapy for High-Grade Serous or Endometrioid Epithelial Ovarian Cancer: A Health Technology Assessment
CONCLUSIONS: In patients with newly diagnosed (advanced) or recurrent high-grade serous or endometrioid ovarian cancer, niraparib maintenance therapy improved progression-free survival compared with no maintenance therapy in tumours with HRD or HRP (GRADE: High). Because we identified no studies on the clinical utility of HRD testing, we cannot comment on how it would affect patient decisions and clinical outcomes.Over a 5-year time horizon, HRD testing for people with BRCA wild type could save $4,509 per person and lead to a loss of 0.116 QALY. The findings of our economic analyses are dependent on assumptions about the u...
Source: Ontario Health Technology Assessment Series - August 28, 2023 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research
