Filtered By:
Cancer: Epithelial Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 20002 results found since Jan 2013.
Characterization of histone chaperone MCM2 as a key regulator in arsenic-induced depletion of H3.3 at genomic loci
Toxicol Appl Pharmacol. 2023 Sep 19:116697. doi: 10.1016/j.taap.2023.116697. Online ahead of print.ABSTRACTArsenic exposure is associated with an increased risk of many cancers, and epigenetic mechanisms play a crucial role in arsenic-mediated carcinogenesis. Our previous studies have shown that arsenic exposure induces polyadenylation of H3.1 mRNA and inhibits the deposition of H3.3 at critical gene regulatory elements. However, the precise underling mechanisms are not yet understood. To characterize the factors governing arsenic-induced inhibition of H3.3 assembly through H3.1 mRNA polyadenylation, we utilized mass spect...
Source: Toxicology and Applied Pharmacology - September 21, 2023 Category: Toxicology Authors: Peipei Wu Su-Jiun Lin Danqi Chen Chunyuan Jin Source Type: research
Chromatin accessibility landscape of human triple-negative breast cancer cell lines reveals variation by patient donor ancestry
Cancer Res Commun. 2023 Sep 21. doi: 10.1158/2767-9764.CRC-23-0236. Online ahead of print.ABSTRACTAfrican American (AA) women have an excessive risk of developing triple-negative breast cancer (TNBC). We employed ATAC-sequencing to characterize differences in chromatin accessibility between 9 commonly used TNBC cell lines derived from patients of European and African ancestry. Principal component and chromosome mapping analyses of accessibility peaks with the most variance revealed separation of chromatin profiles by patient group. Motif enrichment and footprinting analyses of disparate open chromatin regions revealed diff...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Alexandra R Harris Gatikrushna Panigrahi Huaitian Liu Vishal N Koparde Maeve Bailey-Whyte Tiffany H Dorsey Clayton C Yates Stefan Ambs Source Type: research
EDIL3 as an angiogenic target of immune exclusion following checkpoint blockade
Cancer Immunol Res. 2023 Sep 20. doi: 10.1158/2326-6066.CIR-23-0171. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) has become the standard of care for several solid tumors. Multiple combinatorial approaches have been studied to improve therapeutic efficacy. The combination of anti-angiogenesis agents and ICB has demonstrated efficacy in several cancers. To improve the mechanistic understanding of synergies with these treatment modalities, we performed serologic screens of human protein array using sera from long-term responding patients treated with ipilimumab and bevacizumab. We discovered a high-titer an...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Saba Tabasum Dinesh Thapa Anita Giobbie-Hurder Jason L Weirather Marco Campisi Pieter J Schol Xiaoyu Li Jingjing Li Charles H Yoon Michael P Manos David A Barbie F Stephen Hodi Source Type: research
Ovarian cancer in the older patient: where are we now? What to do next?
Ther Adv Med Oncol. 2023 Sep 16;15:17588359231192397. doi: 10.1177/17588359231192397. eCollection 2023.ABSTRACTIn recent years, major advances have been made toward the individualization of epithelial ovarian cancer care, leading to an overall improvement of patient outcomes. However, real-life data indicate that the oldest populations do not benefit from this, due to aspects related to cancer (more aggressive histopathological features), treatment (i.e. frequently suboptimal), and the host (increased toxicities in patients with lower physiological reserve). A specific risk-benefit perspective should therefore be taken whe...
Source: Adv Data - September 19, 2023 Category: Epidemiology Authors: Fr édérique Rousseau Florence Ranchon Christophe Bardin Naoual Bakrin Vincent Lavou é Leila Bengrine-Lefevre Claire Falandry Source Type: research
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00640-8. doi: 10.1016/j.freeradbiomed.2023.09.016. Online ahead of print.ABSTRACTIn the tumor microenvironment (TME), communication between cancer cells and tumor-associated macrophages (TAMs) through secreted extracellular proteins promotes cancer progression. Here, we observed that co-culturing cancer cells (4T1) and macrophage cells (Raw264.7) significantly enhanced superoxide production in both cell types. Using MALDI-TOF, we identified PKM2 as a highly secreted protein by Raw264.7 cells and bone marrow-derived monocytes. The extracellular recombinant PKM2 protein not only...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Amir Hamza Jung Yoon Cho Kim Cuong Cap Abu Jubayer Hossain Jae-Gyu Kim Jae-Bong Park Source Type: research
Exploring tumor-normal cross-talk with TranNet: Role of the environment in tumor progression
PLoS Comput Biol. 2023 Sep 18;19(9):e1011472. doi: 10.1371/journal.pcbi.1011472. Online ahead of print.ABSTRACTThere is a growing awareness that tumor-adjacent normal tissues used as control samples in cancer studies do not represent fully healthy tissues. Instead, they are intermediates between healthy tissues and tumors. The factors that contribute to the deviation of such control samples from healthy state include exposure to the tumor-promoting factors, tumor-related immune response, and other aspects of tumor microenvironment. Characterizing the relation between gene expression of tumor-adjacent control samples and tu...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Bayarbaatar Amgalan Chi-Ping Day Teresa M Przytycka Source Type: research
Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer
Front Med. 2023 Sep 18. doi: 10.1007/s11684-023-1008-8. Online ahead of print.ABSTRACTAltered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human cancer. However, knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely limited. Here, by taking advantage of in situ Hi-C, RNA-sequencing, and chromatin immunoprecipitation sequencing (ChIP-seq), we investigated structural reorganization and functional changes in chromosomal compartments, topologically associated domains (TADs), and CCCTC binding factor (CTCF)-mediated l...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Guoqiang Li Peng Pu Mengqiao Pan Xiaoling Weng Shimei Qiu Yiming Li Sk Jahir Abbas Lu Zou Ke Liu Zheng Wang Ziyu Shao Lin Jiang Wenguang Wu Yun Liu Rong Shao Fatao Liu Yingbin Liu Source Type: research
Prognostic significance of TM4SF1 and DDR1 expression in epithelial ovarian cancer
Oncol Lett. 2023 Aug 30;26(4):448. doi: 10.3892/ol.2023.14035. eCollection 2023 Oct.ABSTRACTTransmembrane 4 L6 family member 1 (TM4SF1) and discoidin domain receptor 1 (DDR1) are expressed in numerous types of cancer, but their expression in epithelial ovarian cancer and the association between their expression and patient prognosis are unclear. The present study aimed to explore the expression of TM4SF1 and DDR1 and their relationship with prognosis in epithelial ovarian cancer. Firstly, the Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) platforms were used to compare the expression levels of TM4SF1 a...
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Zhijiong Huang Hongyu Yao Zhijun Yang Source Type: research
NKX3.1 Expression Contributes to Epithelial-Mesenchymal Transition of Prostate Cancer Cells
ACS Omega. 2023 Sep 1;8(36):32580-32592. doi: 10.1021/acsomega.3c03127. eCollection 2023 Sep 12.ABSTRACTStudies demonstrate that inflammation synergizes with high-grade aggressive prostate tumor development and ultimately metastatic spread, in which a lot of work has been done in recent years. However, the clear mechanism of inflammation inciting prostate cancer remains largely uncharacterized. Our previous study has shown that the conditioned media (CM)-mediated LNCaP cell migration is partially correlated with the loss of expression of the tumor suppressor NKX3.1. Here, we continue to investigate the inflammation-mediate...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Iroda Saydullaeva Bilge Debelec Butuner Kemal Sami Korkmaz Source Type: research
Machine learning developed a programmed cell death signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma
CONCLUSION: Our study developed a novel CDS for LUAD. The CDS served as an indicator for predicting the prognosis and immunotherapy benefits of LAUD patients.PMID:37722290 | DOI:10.1016/j.tranon.2023.101784
Source: Translational Oncology - September 18, 2023 Category: Cancer & Oncology Authors: Dongxiao Ding Liangbin Wang Yunqiang Zhang Ke Shi Yaxing Shen Source Type: research
Prognostic significance of TM4SF1 and DDR1 expression in epithelial ovarian cancer
Oncol Lett. 2023 Aug 30;26(4):448. doi: 10.3892/ol.2023.14035. eCollection 2023 Oct.ABSTRACTTransmembrane 4 L6 family member 1 (TM4SF1) and discoidin domain receptor 1 (DDR1) are expressed in numerous types of cancer, but their expression in epithelial ovarian cancer and the association between their expression and patient prognosis are unclear. The present study aimed to explore the expression of TM4SF1 and DDR1 and their relationship with prognosis in epithelial ovarian cancer. Firstly, the Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) platforms were used to compare the expression levels of TM4SF1 a...
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Zhijiong Huang Hongyu Yao Zhijun Yang Source Type: research
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00640-8. doi: 10.1016/j.freeradbiomed.2023.09.016. Online ahead of print.ABSTRACTIn the tumor microenvironment (TME), communication between cancer cells and tumor-associated macrophages (TAMs) through secreted extracellular proteins promotes cancer progression. Here, we observed that co-culturing cancer cells (4T1) and macrophage cells (Raw264.7) significantly enhanced superoxide production in both cell types. Using MALDI-TOF, we identified PKM2 as a highly secreted protein by Raw264.7 cells and bone marrow-derived monocytes. The extracellular recombinant PKM2 protein not only...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Amir Hamza Jung Yoon Cho Kim Cuong Cap Abu Jubayer Hossain Jae-Gyu Kim Jae-Bong Park Source Type: research
Machine learning developed a programmed cell death signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma
CONCLUSION: Our study developed a novel CDS for LUAD. The CDS served as an indicator for predicting the prognosis and immunotherapy benefits of LAUD patients.PMID:37722290 | DOI:10.1016/j.tranon.2023.101784
Source: Translational Oncology - September 18, 2023 Category: Cancer & Oncology Authors: Dongxiao Ding Liangbin Wang Yunqiang Zhang Ke Shi Yaxing Shen Source Type: research
