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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
Acta Pharm. 2023 Sep 14;73(3):475-488. doi: 10.2478/acph-2023-0021. Print 2023 Sep 1.ABSTRACTIn women, ovarian cancer is a common gynecological cancer associated with poor prognosis, reoccurrence and chemoresistance. Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. Thus, we investigated the impact of scoulerine on ovarian cancer cells (OVCAR3). Cell viability was assessed by MTT assay, migration was determined by Boyden Chamber assay, while the invasion was monitored by Boyden Chamber assay using the matrigel. The stemness properties of OVCAR3 cells were observed by tumorsp...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Fang Wang Yang Zhang Rui Pang Shaohong Shi Ran Wang Source Type: research
An early neoplasia index (ENI10), based on molecular identity of CD10 cells and associated stemness biomarkers, is a predictor of patient outcome in many cancers
Cancer Res Commun. 2023 Sep 14. doi: 10.1158/2767-9764.CRC-23-0196. Online ahead of print.ABSTRACTAn accurate estimate of patient survival at diagnosis is critical to plan efficient therapeutic options. A simple and multi-application tool is needed to move forward the precision medicine era. Taking advantage of the broad and high CD10 expression in stem and cancers cells, we evaluated the molecular identity of aggressive cancer cells. We used epithelial primary cells and developed a breast cancer stem cells-based progressive model. The superiority of the early-transformed isolated molecular index was evaluated by large-sca...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Boris Guyot Flora Cl ément Youenn Drouet Xenia Schmidt Sylvain Lefort Emmanuel Delay Isabelle Treilleux Jean-Philippe Foy Sandrine Jeanpierre Emilie Thomas Janice Kielbassa Laurie Tonon Helen He Zhu Pierre Saintigny Wei-Qiang Gao Arnaud de la Fouchardier Source Type: research
Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
Acta Pharm. 2023 Sep 14;73(3):475-488. doi: 10.2478/acph-2023-0021. Print 2023 Sep 1.ABSTRACTIn women, ovarian cancer is a common gynecological cancer associated with poor prognosis, reoccurrence and chemoresistance. Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. Thus, we investigated the impact of scoulerine on ovarian cancer cells (OVCAR3). Cell viability was assessed by MTT assay, migration was determined by Boyden Chamber assay, while the invasion was monitored by Boyden Chamber assay using the matrigel. The stemness properties of OVCAR3 cells were observed by tumorsp...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Fang Wang Yang Zhang Rui Pang Shaohong Shi Ran Wang Source Type: research
Integration and deconvolution methodology deciphering prognosis-related signatures in lung adenocarcinoma
CONCLUSIONS: The constructed risk prediction model in this study offers clinicians a valuable tool for tailoring treatment strategies of LUAD and provides a comprehensive interpretation on the biological activities of PRGs in LUAD.PMID:37710052 | DOI:10.1007/s00432-023-05403-9
Source: Clinical Lung Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Ming Yi Jiaying Shi Xiaolan Tan Xinyue Zhang Dachang Tao Yuan Yang Yunqiang Liu Source Type: research
Metaplastic Breast Carcinoma: Clinicopathologic Features and Recurrence Score Results From a Population-based Database
CONCLUSIONS: All molecular subtypes of MBC had a poorer prognosis compared with IDC, NOS. The different molecular subtypes of MBC did not affect the BCSD. HR-positive MBC patients had a significantly higher high-risk RS than IDC, NOS patients.PMID:37705411 | DOI:10.1097/COC.0000000000001041
Source: Clinical Genitourinary Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Valarie McMurtry Allison S Cleary Ana L Ruano Lesley Lomo H Evin Gulbahce Source Type: research
Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
Acta Pharm. 2023 Sep 14;73(3):475-488. doi: 10.2478/acph-2023-0021. Print 2023 Sep 1.ABSTRACTIn women, ovarian cancer is a common gynecological cancer associated with poor prognosis, reoccurrence and chemoresistance. Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. Thus, we investigated the impact of scoulerine on ovarian cancer cells (OVCAR3). Cell viability was assessed by MTT assay, migration was determined by Boyden Chamber assay, while the invasion was monitored by Boyden Chamber assay using the matrigel. The stemness properties of OVCAR3 cells were observed by tumorsp...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Fang Wang Yang Zhang Rui Pang Shaohong Shi Ran Wang Source Type: research
Metaplastic Breast Carcinoma: Clinicopathologic Features and Recurrence Score Results From a Population-based Database
CONCLUSIONS: All molecular subtypes of MBC had a poorer prognosis compared with IDC, NOS. The different molecular subtypes of MBC did not affect the BCSD. HR-positive MBC patients had a significantly higher high-risk RS than IDC, NOS patients.PMID:37705411 | DOI:10.1097/COC.0000000000001041
Source: Clinical Breast Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Valarie McMurtry Allison S Cleary Ana L Ruano Lesley Lomo H Evin Gulbahce Source Type: research
Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis
Acta Pharm. 2023 Sep 14;73(3):475-488. doi: 10.2478/acph-2023-0021. Print 2023 Sep 1.ABSTRACTIn women, ovarian cancer is a common gynecological cancer associated with poor prognosis, reoccurrence and chemoresistance. Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. Thus, we investigated the impact of scoulerine on ovarian cancer cells (OVCAR3). Cell viability was assessed by MTT assay, migration was determined by Boyden Chamber assay, while the invasion was monitored by Boyden Chamber assay using the matrigel. The stemness properties of OVCAR3 cells were observed by tumorsp...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Fang Wang Yang Zhang Rui Pang Shaohong Shi Ran Wang Source Type: research
Impact of Sodium Thiosulfate on Prevention of Nephrotoxicities in HIPEC: An Ancillary Evaluation of Cisplatin-Induced Toxicities in Ovarian Cancer
CONCLUSIONS: ST significantly reduces acute renal toxicity associated with HIPEC with cisplatin in ovarian cancer patients. As nephrotoxicity is high in HIPEC with cisplatin, nephroprotective agents should be considered.PMID:37710139 | DOI:10.1245/s10434-023-14216-6
Source: Ann Oncol - September 14, 2023 Category: Cancer & Oncology Authors: Rosemary N Senguttuvan Nicole Lugo Santiago Ernest S Han Byrne Lee Stephen Lee Wei-Chien Lin Mehdi Kebria Amy Hakim Jeff F Lin Mark T Wakabayashi Nora Ruel Raechelle Tinsley Melissa Eng Daphne B Stewart Edward W Wang Benjamin I Paz Xiwei Wu Hyejin Cho Win Source Type: research
A novel synthesized prodrug of gemcitabine based on oxygen-free radical sensitivity inhibited the growth of lung cancer cells
J Biomed Res. 2023 Sep 28:1-12. doi: 10.7555/JBR.37.20230022. Online ahead of print.ABSTRACTIn the present study, we introduced the H 2O 2-sensitive thiazolidinone moiety at the 4th amino group of gemcitabine (GEM) to synthesize a new target compound named GEM-ZZQ, and then we confirmed its chemical structure by nuclear magnetic resonance spectroscopy. We further confirmed that GEM-ZZQ had a good chemical stability in different pH solutions in vitro and that it could be activated by H 2O 2 to release GEM. Pharmacodynamic studies revealed that the growth inhibition of human normal epithelial cells was weaker by GEM-ZZQ than...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Xinlu Chai Yuting Meng Wei Ge Juan Wang Fei Li Xue Jun Wang Xuerong Wang Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer
CONCLUSION: The current findings suggest an oncogenic role for STEAP4 in GC, with significantly high levels being associated with poor prognosis. Investigation of the GC tumor microenvironment suggests the potential function of STEAP4 is connected with the infiltration of diverse immune cells, which may contribute to the regulation of the tumor microenvironment. In conclusion, STEAP4 may serve as a potential therapeutic target for GC to improve the immune infiltration, as well as serve as a prognostic biomarker for judging the prognosis and immune infiltration status of GC.PMID:37700807 | PMC:PMC10494559 | DOI:10.5306/wjco.v14.i8.297
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Ze-Xuan Fang Yan-Yu Hou Zheng Wu Bing-Xuan Wu Yu Deng Hua-Tao Wu Jing Liu Source Type: research
Head and neck cancer treatment in the era of molecular medicine
Adv Cancer Res. 2023;160:205-252. doi: 10.1016/bs.acr.2023.03.004. Epub 2023 Apr 12.ABSTRACTHead and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized b...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Subramanya Pandruvada Remi Kessler Ann Thai Source Type: research
