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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP-13 and JNK pathway
In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP-13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.PMID:37710409 | DOI:10.1111/jcmm.17954
Source: J Cell Mol Med - September 15, 2023 Category: Molecular Biology Authors: Hsin-Yu Ho Mu-Kuan Chen Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Source Type: research
ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer
CONCLUSION: ARHGAP21 downregulation can significantly promote the migration and metastatic ability of NSCLC possibly as a result of WNT signaling pathway activation, which reduces the ubiquitination of β-catenin by affecting the expressions of APC, GSK3β, and Axin.PMID:37712268 | PMC:PMC10505574 | DOI:10.12122/j.issn.1673-4254.2023.08.08
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Xie L Liu J Fang X Zhong J Lin F Chen Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
Role of the tripartite motif (TRIM) family in female genital neoplasms
Pathol Res Pract. 2023 Sep 9;250:154811. doi: 10.1016/j.prp.2023.154811. Online ahead of print.ABSTRACTThe tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital neoplasms, to provide a better understanding of its role in the development and progression of such diseases, and emphasize its potential as targeted cancer therapy. Overall, ...
Source: Pathology, Research and Practice - September 15, 2023 Category: Pathology Authors: Tianyu Liu Jian Chen Jinjie Wu Qiqiao Du Junxiu Liu Silu Tan Yuwen Pan Shuzhong Yao Source Type: research
ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer
CONCLUSION: ARHGAP21 downregulation can significantly promote the migration and metastatic ability of NSCLC possibly as a result of WNT signaling pathway activation, which reduces the ubiquitination of β-catenin by affecting the expressions of APC, GSK3β, and Axin.PMID:37712268 | PMC:PMC10505574 | DOI:10.12122/j.issn.1673-4254.2023.08.08
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Xie L Liu J Fang X Zhong J Lin F Chen Source Type: research
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future
We present a fundamental analysis of the actual understanding of molecular mechanisms along with regulatory networks associated with ferroptosis, expected physiological functions in growth concealment, ferroptosis-associated differentially expressed genes, treatment targeting potential, and recent advances in the development of therapeutic strategies in this review.PMID:37711099 | DOI:10.2174/1566524023666230913105735
Source: Current Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research
ARHGAP21 inhibits epithelial-mesenchymal transition by inactivating the WNT signaling pathway in non-small cell lung cancer
CONCLUSION: ARHGAP21 downregulation can significantly promote the migration and metastatic ability of NSCLC possibly as a result of WNT signaling pathway activation, which reduces the ubiquitination of β-catenin by affecting the expressions of APC, GSK3β, and Axin.PMID:37712268 | DOI:10.12122/j.issn.1673-4254.2023.08.08
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Z Xie L Liu J Fang X Zhong J Lin F Chen Source Type: research
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis
CONCLUSION: Chronic exposure to DLM, even at small doses, can cause damage to the colon tissue, which cannot be ignored. The production and use of pesticides such as DLM should be strictly regulated during agricultural production.PMID:37714033 | DOI:10.1016/j.ecoenv.2023.115475
Source: Ecotoxicology and Environmental Safety - September 15, 2023 Category: Environmental Health Authors: Rulan Ma Tuanhe Sun Xueni Wang Kaijie Ren Tianhao Min Xin Xie Dangdang Wang Kang Li Yong Zhang Kun Zhu Caijing Mo Chengxue Dang Yong Yang Hao Zhang Source Type: research
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP-13 and JNK pathway
In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP-13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.PMID:37710409 | DOI:10.1111/jcmm.17954
Source: J Cell Mol Med - September 15, 2023 Category: Molecular Biology Authors: Hsin-Yu Ho Mu-Kuan Chen Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Source Type: research
Resveratrol Inhibits Hepatocellular Carcinoma Progression Through Regulating Exosome Secretion
CONCLUSION: Resveratrol inhibits hepatocellular carcinoma progression by regulating exosome secretion and contents.PMID:37711128 | DOI:10.2174/0929867331666230914090053
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Kun Tong Pingfeng Wang Ying Li Yaoyao Tong Xuejie Li Shirong Yan Pei Hu Source Type: research
Metaplastic Breast Carcinoma: Clinicopathologic Features and Recurrence Score Results From a Population-based Database
CONCLUSIONS: All molecular subtypes of MBC had a poorer prognosis compared with IDC, NOS. The different molecular subtypes of MBC did not affect the BCSD. HR-positive MBC patients had a significantly higher high-risk RS than IDC, NOS patients.PMID:37705411 | DOI:10.1097/COC.0000000000001041
Source: Clinical Breast Cancer - September 14, 2023 Category: Cancer & Oncology Authors: Valarie McMurtry Allison S Cleary Ana L Ruano Lesley Lomo H Evin Gulbahce Source Type: research
Integration and deconvolution methodology deciphering prognosis-related signatures in lung adenocarcinoma
CONCLUSIONS: The constructed risk prediction model in this study offers clinicians a valuable tool for tailoring treatment strategies of LUAD and provides a comprehensive interpretation on the biological activities of PRGs in LUAD.PMID:37710052 | DOI:10.1007/s00432-023-05403-9
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Ming Yi Jiaying Shi Xiaolan Tan Xinyue Zhang Dachang Tao Yuan Yang Yunqiang Liu Source Type: research
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Cancer Metastasis Rev. 2023 Sep 14. doi: 10.1007/s10555-023-10138-7. Online ahead of print.ABSTRACTResistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially the genetic mutation behind the therapeutic resistance. However, non-mutational mechanisms, such as epigenetic modifications, and TME alteration, which is mainly driven by cancer cell plasticity, are also involved in therapeutic resistance. The concept of plasticity mainly relies on the conversion of non-cancer stem cells (CSCs) to CSCs or epithelial-to-mesenchymal transition via d...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Priya Mondal Syed Musthapa Meeran Source Type: research
