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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway
In this study, we aimed to explore the potential anti-cancer effect of Polygonatum sibiricum polysaccharide (PSP) on the tumor immune microenvironment in liver cancer cells. HepG2 and Hep3B cells were pretreated in the absence or the presence of PSP (20, 50, 100 µg/mL) for a period of 24 h. Subsequently, dendritic cells (DCs) were co-cultured with HepG2 and Hep3B cell supernatant to investigate the effect of PSP on the tumor microenvironment. The results showed that PSP dose-dependently inhibited proliferation and promoted apoptosis of HepG2 and Hep3B cells. Meanwhile, PSP dose-dependently inhibited migration, invasion, a...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yunke Xu Yong Guo Changyou Lu Linlin Yu Chao Fang Chuntao Li Source Type: research
Intratumoral metabolic heterogeneity of colorectal cancer
Am J Physiol Cell Physiol. 2023 Sep 4. doi: 10.1152/ajpcell.00139.2021. Online ahead of print.ABSTRACTAlthough the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic charact...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Yoshinobu Hirose Kohei Taniguchi Source Type: research
miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers
Cell Signal. 2023 Sep 2:110881. doi: 10.1016/j.cellsig.2023.110881. Online ahead of print.ABSTRACTThe metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells....
Source: Cellular Signalling - September 4, 2023 Category: Cytology Authors: Ameer S Sahib Amjid Fawzi Rahman S Zabibah Nisar Ahmad Koka Shaymaa Abdulhameed Khudair Faris Anad Muhammad Doaa A Hamad Source Type: research
Intratumoral metabolic heterogeneity of colorectal cancer
Am J Physiol Cell Physiol. 2023 Sep 4. doi: 10.1152/ajpcell.00139.2021. Online ahead of print.ABSTRACTAlthough the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic charact...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Yoshinobu Hirose Kohei Taniguchi Source Type: research
Fascin in migration and metastasis of breast cancer cells - A review
Adv Med Sci. 2023 Sep 1;68(2):290-297. doi: 10.1016/j.advms.2023.08.003. Online ahead of print.ABSTRACTCancer cell migration and metastasis are the biggest problems in the treatment of cancer patients. The most aggressive breast cancer (BC) is the triple-negative type. Therefore, effective therapeutic targets that limit cell migration are sought. One such target may be fascin, as its overexpression is characteristic to triple-negative breast cancer. The high level of fascin enables the formation of protrusion and thus promotes the invasion of cancer cells. Fascin also shows co-localization or functional relationships with ...
Source: Advances in Medical Sciences - September 3, 2023 Category: Biomedical Science Authors: Magdalena Izdebska Wioletta Zieli ńska Adrian Krajewski Alina Grzanka Source Type: research
Steric hindrance and charge influence on the cytotoxic activity and protein binding properties of diruthenium complexes
Int J Biol Macromol. 2023 Sep 1:126666. doi: 10.1016/j.ijbiomac.2023.126666. Online ahead of print.ABSTRACTPaddlewheel diruthenium complexes are being used as metal-based drugs. It has been proposed that their charge and steric properties determine their selectivity towards proteins. Here, we explore these parameters using the first water-soluble diruthenium complex bearing two formamidinate ligands, [Ru2Cl(DPhF)2(O2CCH3)2], and two derivatives, [Ru2Cl(DPhF)(O2CCH3)3] and K2[Ru2(DPhF)(CO3)3] (DPhF- = N,N'-diphenylformamidinate), with one formamidinate. Their protein binding properties have been assessed employing hen egg w...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Aar ón Terán Giarita Ferraro Paola Imbimbo Ana E S ánchez-Peláez Daria Maria Monti Santiago Herrero Antonello Merlino Source Type: research
Fascin in migration and metastasis of breast cancer cells - A review
Adv Med Sci. 2023 Sep 1;68(2):290-297. doi: 10.1016/j.advms.2023.08.003. Online ahead of print.ABSTRACTCancer cell migration and metastasis are the biggest problems in the treatment of cancer patients. The most aggressive breast cancer (BC) is the triple-negative type. Therefore, effective therapeutic targets that limit cell migration are sought. One such target may be fascin, as its overexpression is characteristic to triple-negative breast cancer. The high level of fascin enables the formation of protrusion and thus promotes the invasion of cancer cells. Fascin also shows co-localization or functional relationships with ...
Source: Advances in Medical Sciences - September 3, 2023 Category: Biomedical Science Authors: Magdalena Izdebska Wioletta Zieli ńska Adrian Krajewski Alina Grzanka Source Type: research
