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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets
This study reports an analytical approach to the largest multi-parameter immunoprofiling study of clinical trial samples to date. We analysed 12,592 tissue microarray (TMA) spots from 3,545 colorectal cancers sourced from more than 240 institutions in two clinical trials (QUASAR 2 and SCOT) stained for CD4, CD8, CD20, CD68, FoxP3, pan-cytokeratin, and DAPI by mIF. TMA slides were multi-spectrally imaged and analysed by cell-based and pixel-based marker analysis. We developed an adaptive thresholding method to account for inter- and intra-slide intensity variation in TMA analysis. Applying this method effectively ameliorate...
Source: Clinical Colorectal Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Anja L Frei Anthony McGuigan Ritik Rak Sinha Mark A Glaire Faiz Jabbar Luciana Gneo Tijana Tomasevic Andrea Harkin Tim J Iveson Mark Saunders Karin Oein Noori Maka Francesco Pezella Leticia Campo Jennifer Hay Joanne Edwards Owen J Sansom Caroline Kelly Ia Source Type: research
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis
Biochem Pharmacol. 2023 Sep 9:115797. doi: 10.1016/j.bcp.2023.115797. Online ahead of print.ABSTRACTBoth aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a wide range of environmental and dietary carcinogens. The data accumulated over the last two decades suggest that both of these transcriptional regulators play a much wider role in the maintenance of gut homeostasis, and that both transcription factors may affect processes linked with intestinal tumorigenesis. Intestinal epithelium is continuously...
Source: Biochemical Pharmacology - September 11, 2023 Category: Drugs & Pharmacology Authors: Gerardo V ázquez-Gómez Ji ří Petráš Zden ěk Dvořák Jan Vondr áček Source Type: research
Comprehensive profiling of enhancer RNA in stage II/III colorectal cancer defines two prognostic subtypes with implications for immunotherapy
CONCLUSION: Our study unravels the molecular heterogeneity of stage II/III CRC at the eRNA level and highlights the potential applications of the novel eRNA-based subtyping system in predicting prognosis and guiding immunotherapy.PMID:37697139 | DOI:10.1007/s12094-023-03319-x
Source: Clinical Colorectal Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Xiaoyun Bu Shuang Liu Zhiqing Zhang Jie Wu Shuguang Pan Yingbin Hu Source Type: research
Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions
Environ Sci Pollut Res Int. 2023 Sep 11. doi: 10.1007/s11356-023-29768-z. Online ahead of print.ABSTRACTEndocrine disruptors (ED) are compounds dispersed in the environment that modify hormone biosynthesis, affecting hormone-dependent organs such as the prostate. Studies have only focused on evaluating the effects of ED alone or in small groups and short intervals and have not adequately portrayed human exposure. Therefore, we characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. Pregnant females of the Sprague-Dawley strain were randomly distributed into two exper...
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Thaina Cavalleri Sousa Let ícia Pereira de Souza Maria Luiza Silva Ricardo Andreia Yuri Yoshigae Karianne Delalibera Hinokuma Ana Beatriz Ratto Gorzoni Ariana Musa de Aquino Wellerson Rodrigo Scarano Anthony C ésar de Sousa Castillho Maria Eduarda Almei Source Type: research
Effects of Dichloromethane and N-Butanol Fractions of < em > Nigella sativa < /em > on ACHN and GP-293 Cell Line Morphology, Viability, and Apoptosis
CONCLUSION: Our findings demonstrated that these two fractions of N. sativa induce inhibitory effects on the ACHN cell line morphology and viability. These effects were lower than those induced by the total extract. In addition, the two fractions caused more marked effects in the renal cancer cell line compared with the GP-293 cell line.PMID:37694244 | PMC:PMC10492620 | DOI:10.4103/abr.abr_394_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Samira Shahraki Sara Hosseinian Elham Shahraki Mehdi Kheirandish Abolfazl Khajavirad Source Type: research
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis
Biochem Pharmacol. 2023 Sep 9:115797. doi: 10.1016/j.bcp.2023.115797. Online ahead of print.ABSTRACTBoth aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a wide range of environmental and dietary carcinogens. The data accumulated over the last two decades suggest that both of these transcriptional regulators play a much wider role in the maintenance of gut homeostasis, and that both transcription factors may affect processes linked with intestinal tumorigenesis. Intestinal epithelium is continuously...
Source: Biochemical Pharmacology - September 11, 2023 Category: Drugs & Pharmacology Authors: Gerardo V ázquez-Gómez Ji ří Petráš Zden ěk Dvořák Jan Vondr áček Source Type: research
Role of LRRN4 in promoting malignant behavior in a p53- and Rb-defective human fallopian tube epithelial cell line
This study explored the role of leucine-rich repeat neuronal 4 (LRRN4) in ovarian carcinogenesis using the p53- and Rb-defective human fallopian tube epithelial cell line FE25. We evaluated the expression of LRRN4 in FE25 cells with and without LRRN4 knockdown by short hairpin RNA (shRNA) and studied its effects on cell proliferation, cell cycle, migration, invasion, chemotherapeutic sensitivity, apoptosis, and xenograft formation. The results showed that FE25 shRNA-LRRN4 cells exhibited more aggressive malignant behaviors than FE25 cells, including faster proliferation and increased cell distribution in the G2/M phase, Ak...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Yu-Hsun Chang Kun-Chi Wu Kai-Hung Wang Dah-Ching Ding Source Type: research
Yulangsan polysaccharide inhibits epithelial-mesenchymal transition and invasion in NSCLC by attenuating the TGF- β1/ERK signaling pathway
Am J Cancer Res. 2023 Aug 15;13(8):3401-3416. eCollection 2023.ABSTRACTActive polysaccharides have unique advantages in inhibiting cancer cell proliferation, invasion and metastasis and inducing apoptosis. Yulangsan polysaccharide (YLSPS) is derived from the root of Millettia pulchra var. laxior (Dunn) Z. Wei. Previous studies revealed that YLSPS exhibits bioactivities such as antibacterial, antidepressive, antitumor, hepatoprotective and immunomodulating activities. However, the anticancer effects of YLSPS on lung cancer have not yet been studied, and its mechanism of action remains unclear. The present study investigated...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Feifeng Lan Menghua Chen Xiaowei Xie Yanyan Mo Fengti Chen Renbin Huang Wenqi Liu Source Type: research
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis
Biochem Pharmacol. 2023 Sep 9:115797. doi: 10.1016/j.bcp.2023.115797. Online ahead of print.ABSTRACTBoth aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) belong among key regulators of xenobiotic metabolism in the intestinal tissue. AhR in particular is activated by a wide range of environmental and dietary carcinogens. The data accumulated over the last two decades suggest that both of these transcriptional regulators play a much wider role in the maintenance of gut homeostasis, and that both transcription factors may affect processes linked with intestinal tumorigenesis. Intestinal epithelium is continuously...
Source: Biochemical Pharmacology - September 11, 2023 Category: Drugs & Pharmacology Authors: Gerardo V ázquez-Gómez Ji ří Petráš Zden ěk Dvořák Jan Vondr áček Source Type: research
Cordycepin improves sensitivity to temozolomide in glioblastoma cells by down-regulating MYC
CONCLUSION: Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.PMID:37695389 | DOI:10.1007/s00432-023-05347-0
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Shi-Xing Zheng Jing Chen Bing-Bo Zhuang Qiang Zhang Song-Sheng Shi Guo-Liang Zhang Source Type: research
Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/ β-catenin signaling pathway
CONCLUSIONS: Matrine can reverse EMT, alleviate intrahepatic inflammation, and counteract immune depletion by inhibiting the Wnt-1/β-catenin signaling pathway in HCC.PMID:37692966 | PMC:PMC10492086
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jianfei Shi Hua Zhang Guangjie Han Jinfeng Wang Xin Han Man Zhao Xiaoling Duan Lili Mi Ning Li Xiaolei Yin Cuizhen Li Fei Yin Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma.PMID:37685545 | DOI:10.3390/jcm12175477
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Marlena Brzozowa-Zasada Adam Piecuch Marek Michalski Katarzyna St ęplewska Natalia Matysiak Marek Kucharzewski Source Type: research
