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Regulating Tumorigenicity and Cancer Metastasis through TRKA Signaling
Curr Cancer Drug Targets. 2023 Sep 4. doi: 10.2174/1568009623666230904150957. Online ahead of print.ABSTRACTTropomyosin receptor kinase (TRK) A, TRKA, is a specific binding receptor of nerve growth factor (NGF), which plays an essential role in the occurrence and progression of human cancers. TRKA overexpression has been proven to be a powerful carcinogenic driver and has been verified in many tumors. The TRKA receptor kinase domain is over-activated in an NGF-dependent manner, accompanied by activation of downstream signal pathways, such as RAS-MAPK, PI3K-AKT, JAK2-STAT3 pathway, PLC γ pathway, and Hippo pathway, which p...
Source: Current Cancer Drug Targets - September 6, 2023 Category: Cancer & Oncology Authors: Yichao Fan Boya Zhang Xinhui Du Bangmin Wang Qiang Yan Liangyu Guo Weitao Yao Source Type: research
Intratumoral metabolic heterogeneity of colorectal cancer
Am J Physiol Cell Physiol. 2023 Sep 4. doi: 10.1152/ajpcell.00139.2021. Online ahead of print.ABSTRACTAlthough the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic charact...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Yoshinobu Hirose Kohei Taniguchi Source Type: research
High-mobility group box 1 overexpression predicts a poor prognosis and promotes EMT in gastric cancer by activating TLR4/NF- κB signaling
Conclusion HMGB1 is highly expressed in GC tissues and is associated with a poorer prognosis in patients with GC. HMGB1 activates the TLR4/NF-κB signaling pathway to promote EMT progression in GC cell lines. HMGB1 may be a critical molecule in prognosis prediction and a therapeutic target for patients with GC.PMID:37666221 | DOI:10.1159/000533927
Source: Oncology - September 4, 2023 Category: Cancer & Oncology Authors: Jichun Ma Mingxu Da Source Type: research
Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway
In this study, we aimed to explore the potential anti-cancer effect of Polygonatum sibiricum polysaccharide (PSP) on the tumor immune microenvironment in liver cancer cells. HepG2 and Hep3B cells were pretreated in the absence or the presence of PSP (20, 50, 100 µg/mL) for a period of 24 h. Subsequently, dendritic cells (DCs) were co-cultured with HepG2 and Hep3B cell supernatant to investigate the effect of PSP on the tumor microenvironment. The results showed that PSP dose-dependently inhibited proliferation and promoted apoptosis of HepG2 and Hep3B cells. Meanwhile, PSP dose-dependently inhibited migration, invasion, a...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yunke Xu Yong Guo Changyou Lu Linlin Yu Chao Fang Chuntao Li Source Type: research
Influence of lymphadenectomy on survival and recurrence in patients with early-stage epithelial ovarian cancer: a meta-analysis
CONCLUSIONS: Patients with eEOC can benefit from lymphadenectomy, with improved survival outcomes (OS and PFS) and a lower recurrence rate.PMID:37667358 | DOI:10.1186/s12905-023-02615-6
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Chenchen Yang Ting Zhang Aifeng Gong Can Shi Source Type: research
High-mobility group box 1 overexpression predicts a poor prognosis and promotes EMT in gastric cancer by activating TLR4/NF- κB signaling
Conclusion HMGB1 is highly expressed in GC tissues and is associated with a poorer prognosis in patients with GC. HMGB1 activates the TLR4/NF-κB signaling pathway to promote EMT progression in GC cell lines. HMGB1 may be a critical molecule in prognosis prediction and a therapeutic target for patients with GC.PMID:37666221 | DOI:10.1159/000533927
Source: Oncology - September 4, 2023 Category: Cancer & Oncology Authors: Jichun Ma Mingxu Da Source Type: research
Intratumoral metabolic heterogeneity of colorectal cancer
Am J Physiol Cell Physiol. 2023 Sep 4. doi: 10.1152/ajpcell.00139.2021. Online ahead of print.ABSTRACTAlthough the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic charact...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Yoshinobu Hirose Kohei Taniguchi Source Type: research
miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers
Cell Signal. 2023 Sep 2:110881. doi: 10.1016/j.cellsig.2023.110881. Online ahead of print.ABSTRACTThe metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells....
Source: Cellular Signalling - September 4, 2023 Category: Cytology Authors: Ameer S Sahib Amjid Fawzi Rahman S Zabibah Nisar Ahmad Koka Shaymaa Abdulhameed Khudair Faris Anad Muhammad Doaa A Hamad Source Type: research
LncRNA-LINC00472 suppresses the malignant progression of non-small cell lung cancer via modulation of the miRNA-1275/Homeobox A2 axis
CONCLUSIONS: The LINC00472 functioned as a competing endogenous RNA to modulate HOXA2 level by sponging miR-1275 in NSCLC. Simultaneously, the LINC00472/miR-1275/HOXA2 axis may be a possible therapeutic target and biomarker for NSCLC.PMID:37665081 | DOI:10.17219/acem/168431
Source: Clinical Lung Cancer - September 4, 2023 Category: Cancer & Oncology Authors: Meichen Jiang Xiangli Ye Dongliang Shi Qili Lin Feijian Huang Yong Li Source Type: research
miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers
Cell Signal. 2023 Sep 2:110881. doi: 10.1016/j.cellsig.2023.110881. Online ahead of print.ABSTRACTThe metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells....
Source: Cellular Signalling - September 4, 2023 Category: Cytology Authors: Ameer S Sahib Amjid Fawzi Rahman S Zabibah Nisar Ahmad Koka Shaymaa Abdulhameed Khudair Faris Anad Muhammad Doaa A Hamad Source Type: research
Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer
CONCLUSIONS: A high expression level of MAZ in thyroid cancer tissues was associated with a poor prognosis of patients. MAZ could affect the progression of thyroid cancer by inducing the EMT process.PMID:37664917 | DOI:10.31083/j.fbl2808162
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Chuanjun Zheng Hongmei Wu Shidong Zhang Run Tian Hu Long Huixia Zhang Xuefeng Guo Di Li Shengkui Tan Xiaonian Zhu Source Type: research
Intratumoral metabolic heterogeneity of colorectal cancer
Am J Physiol Cell Physiol. 2023 Sep 4. doi: 10.1152/ajpcell.00139.2021. Online ahead of print.ABSTRACTAlthough the metabolic phenotype within tumors is known to differ significantly from that of the surrounding normal tissue, the importance of this heterogeneity is just becoming widely recognized. Colorectal cancer (CRC) is often classified as the Warburg phenotype, a metabolic type in which the glycolytic system is predominant over oxidative phosphorylation (OXPHOS) in mitochondria for energy production. However, this dichotomy (glycolysis vs OXPHOS) may be too simplistic and not accurately represent the metabolic charact...
Source: American Journal of Physiology. Cell Physiology - September 4, 2023 Category: Cytology Authors: Yoshinobu Hirose Kohei Taniguchi Source Type: research
Reverse engineering morphogenesis through Bayesian optimization of physics-based models
bioRxiv. 2023 Aug 22:2023.08.21.553928. doi: 10.1101/2023.08.21.553928. Preprint.ABSTRACTMorphogenetic programs direct the cell signaling and nonlinear mechanical interactions between multiple cell types and tissue layers to define organ shape and size. A key challenge for systems and synthetic biology is determining optimal combinations of intra- and inter-cellular interactions to predict an organ's shape, size, and function. Physics-based mechanistic models that define the subcellular force distribution facilitate this, but it is extremely challenging to calibrate parameters in these models from data. To solve this inver...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Nilay Kumar Alexander Dowling Jeremiah Zartman Source Type: research
Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway
In this study, we aimed to explore the potential anti-cancer effect of Polygonatum sibiricum polysaccharide (PSP) on the tumor immune microenvironment in liver cancer cells. HepG2 and Hep3B cells were pretreated in the absence or the presence of PSP (20, 50, 100 µg/mL) for a period of 24 h. Subsequently, dendritic cells (DCs) were co-cultured with HepG2 and Hep3B cell supernatant to investigate the effect of PSP on the tumor microenvironment. The results showed that PSP dose-dependently inhibited proliferation and promoted apoptosis of HepG2 and Hep3B cells. Meanwhile, PSP dose-dependently inhibited migration, invasion, a...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yunke Xu Yong Guo Changyou Lu Linlin Yu Chao Fang Chuntao Li Source Type: research
