High-mobility group box 1 overexpression predicts a poor prognosis and promotes EMT in gastric cancer by activating TLR4/NF- κB signaling

Conclusion HMGB1 is highly expressed in GC tissues and is associated with a poorer prognosis in patients with GC. HMGB1 activates the TLR4/NF-κB signaling pathway to promote EMT progression in GC cell lines. HMGB1 may be a critical molecule in prognosis prediction and a therapeutic target for patients with GC.PMID:37666221 | DOI:10.1159/000533927
Source: Oncology - Category: Cancer & Oncology Authors: Source Type: research