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Cancer: Epithelial Cancer
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Total 20002 results found since Jan 2013.
Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis
Dev Cell. 2023 Aug 25:S1534-5807(23)00407-0. doi: 10.1016/j.devcel.2023.08.011. Online ahead of print.ABSTRACTChronic colonic injury and inflammation pose high risks for field cancerization, wherein injury-associated mutations promote stem cell fitness and gradual clonal expansion. However, the long-term stability of some colitis-associated mutational fields could suggest alternate origins. Here, studies of acute murine colitis reveal a punctuated mechanism of massive, neutral clonal expansion during normal wound healing. Through three-dimensional (3D) imaging, quantitative fate mapping, and single-cell transcriptomics, we...
Source: Developmental Cell - August 31, 2023 Category: Cytology Authors: Cambrian Y Liu Nandini Girish Marie L Gomez Martin Kalski Jessica K Bernard Benjamin D Simons D Brent Polk Source Type: research
Acetyl-cinobufagin suppresses triple-negative breast cancer progression by inhibiting the STAT3 pathway
CONCLUSIONS: The findings of this study support the potential clinical use of acetyl-cinobufagin as a STAT3 inhibitor in TNBC adjuvant therapy.PMID:37651362 | DOI:10.18632/aging.204967
Source: Aging - August 31, 2023 Category: Biomedical Science Authors: Yufeng Qi Haodong Wu Tianru Zhu Zitian Liu Conghui Liu Congzhi Yan Zhixuan Wu Yiying Xu Ying Bai Lehe Yang Dezhi Cheng Xiaohua Zhang Haiyang Zhao Chengguang Zhao Xuanxuan Dai Source Type: research
Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
Endocrinology. 2023 Aug 31:bqad133. doi: 10.1210/endocr/bqad133. Online ahead of print.ABSTRACTNuclear receptor 4A1 (NR4A1) plays an important role in endometriosis progression; levels of NR4A1 in endometriotic lesions are higher than in normal endometrium, and substituted bis-indole analogs (NR4A1) antagonists suppress endometriosis progression in mice with endometriosis. In addition, flavonoids kaempferol and quercetin are natural products that directly bind NR4A1 and significantly repress the intrinsic NR4A1-dependent transcriptional activity in human endometriotic epithelial and stromal cells and Ishikawa endometrial c...
Source: Endocrinology - August 31, 2023 Category: Endocrinology Authors: Lei Zhang Kumaravel Mohankumar Gregory Martin Fuada Mariyam Yuri Park Sang Jun Han Stephen Safe Source Type: research
Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis
Dev Cell. 2023 Aug 25:S1534-5807(23)00407-0. doi: 10.1016/j.devcel.2023.08.011. Online ahead of print.ABSTRACTChronic colonic injury and inflammation pose high risks for field cancerization, wherein injury-associated mutations promote stem cell fitness and gradual clonal expansion. However, the long-term stability of some colitis-associated mutational fields could suggest alternate origins. Here, studies of acute murine colitis reveal a punctuated mechanism of massive, neutral clonal expansion during normal wound healing. Through three-dimensional (3D) imaging, quantitative fate mapping, and single-cell transcriptomics, we...
Source: Developmental Cell - August 31, 2023 Category: Cytology Authors: Cambrian Y Liu Nandini Girish Marie L Gomez Martin Kalski Jessica K Bernard Benjamin D Simons D Brent Polk Source Type: research
Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice
Endocrinology. 2023 Aug 31:bqad133. doi: 10.1210/endocr/bqad133. Online ahead of print.ABSTRACTNuclear receptor 4A1 (NR4A1) plays an important role in endometriosis progression; levels of NR4A1 in endometriotic lesions are higher than in normal endometrium, and substituted bis-indole analogs (NR4A1) antagonists suppress endometriosis progression in mice with endometriosis. In addition, flavonoids kaempferol and quercetin are natural products that directly bind NR4A1 and significantly repress the intrinsic NR4A1-dependent transcriptional activity in human endometriotic epithelial and stromal cells and Ishikawa endometrial c...
Source: Endocrinology - August 31, 2023 Category: Endocrinology Authors: Lei Zhang Kumaravel Mohankumar Gregory Martin Fuada Mariyam Yuri Park Sang Jun Han Stephen Safe Source Type: research
Osimertinib resistance prognostic gene signature: STRIP2 is associated with immune infiltration and tumor progression in lung adenocarcinoma
CONCLUSION: We developed a reliable prognostic model based on DEGs associated with osimertinib resistance and screened for biomarker that can predict the immune response in LUAD patients, which may help in the selection of treatment regimens after osimertinib resistance.PMID:37648810 | DOI:10.1007/s00432-023-05294-w
Source: Clinical Lung Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Guixing Zhang Huiting Guan Yi-Le Ning Kainan Yao Hao Tang Gulizeba Muhetaer Hang Li Jihong Zhou Source Type: research
Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing
CONCLUSION: Our study provides a comprehensive landscape of selenium metabolism levels and diverse regulatory patterns in different cancers, deepening the understanding of selenium's roles in tumorigenesis and immunity.PMID:37648807 | DOI:10.1007/s00432-023-05333-6
Source: Clinical Colorectal Cancer - August 30, 2023 Category: Cancer & Oncology Authors: Xiaorui Fu Yiqi Deng Heng Xu Yang Shu Hai-Ning Chen Source Type: research
Tumor-derived exosomes RNA expression profiling identifies the prognosis, immune characteristics, and treatment in HR+/HER2-breast cancer
Aging (Albany NY). 2023 Aug 29;15. doi: 10.18632/aging.204986. Online ahead of print.ABSTRACTExosomes play crucial roles in intercellular communication and are involved in the onset and progression of various types of cancers, including breast cancer. However, the RNA composition of breast cancer-derived exosomes has not been comprehensively explored. We conducted microarray assays on exosomes isolated from breast cancer and healthy breast epithelial cells from three patients with hormone receptor (HR) +/ human epidermal growth factor receptor (HER2) - breast cancer and identified 817 differentially expressed genes (DEGs)....
Source: Aging - August 30, 2023 Category: Biomedical Science Authors: Qi Zhou Jing Wang Haiping Zhang Lu Sun Jingjing Liu Lingchao Meng Jingwu Li Source Type: research
Hypoxia-inducible-factors differentially contribute to clinical disease and the control of viral replication during RSV infection
This study aimed to characterize the disease modulating properties and antiviral potential of anti-HIF-1α (PX478) and anti-HIF-2α (PT2385) in RSV-infected BALB/c mice. We found inhibition of HIF-1α to worsen clinical disease parameters, while simultaneously improving airway function. Additionally, anti-HIF-1α results in significantly reduced viral titer at early and peak time points of RSV replication, followed by a loss in viral clearance when given every day, but not every-other-day. In contrast, inhibition of HIF-2α was associated with improved clinical parameters, with no changes in airway function, and ameliorati...
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Dorothea R Morris Yue Qu Yava L Jones-Hall Teodora Ivanciuc Tianshuang Liu Roberto P Garofalo Antonella Casola Source Type: research
Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells
DISCUSSION: PKCε mediates relevant actions in the neuronal and glial compartment of the PNS. In particular, we posit a novel function for PKCε in the transformation of SCs, assuming a role in the mechanisms controlling SCs' fate and plasticity.PMID:37645595 | PMC:PMC10461112 | DOI:10.3389/fncel.2023.1237479
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Tasnim Mohamed Alessandra Colciago Marina Montagnani Marelli Roberta Manuela Moretti Valerio Magnaghi Source Type: research
