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Total 46 results found since Jan 2013.

PKCα regulates TMEM16A-mediated Cl- secretion in human biliary cells.
In conclusion, our studies demonstrate that PKCα is coupled to ATP-stimulated TMEM16A activation in BECs. Targeting this ATP-Ca(2+)-PKCα signaling pathway may represent a therapeutic strategy to increase biliary secretion and promote bile formation. PMID: 26542395 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - November 5, 2015 Category: Gastroenterology Authors: Dutta AK, Khimji AK, Liu S, Karamysheva Z, Fujita A, Kresge C, Rockey DC, Feranchak AP Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-{beta} Research Communication
Chronic fibroproliferative diseases account for approximately 45% of all deaths in the developed world. In the kidney, glomerulosclerosis is the underlying pathology in approximately half of patients with renal failure receiving dialysis. Mesangial cell expression of the LIM protein hydrogen peroxide-induced clone-5 (Hic-5) is important in its pathogenesis. Hic-5 expression increases following mesangial cell attachment to collagen I, associated with increased collagen I expression and increased susceptibility to apoptosis both in vitro and in experimental glomerulosclerosis. TGF-β has an established role in many fibro...
Source: FASEB Journal - December 1, 2015 Category: Biology Authors: Hornigold, N., Mooney, A. Tags: Research Communication Source Type: research

PKC{alpha} regulates TMEM16A-mediated Cl- secretion in human biliary cells
In conclusion, our studies demonstrate that PKCα is coupled to ATP-stimulated TMEM16A activation in BECs. Targeting this ATP-Ca2+-PKCα signaling pathway may represent a therapeutic strategy to increase biliary secretion and promote bile formation.
Source: AJP: Gastrointestinal and Liver Physiology - January 1, 2016 Category: Gastroenterology Authors: Dutta, A. K., Khimji, A.-K., Liu, S., Karamysheva, Z., Fujita, A., Kresge, C., Rockey, D. C., Feranchak, A. P. Tags: LIVER AND BILIARY TRACT PHYSIOLOGY/PATHOPHYSIOLOGY Source Type: research

Monocarboxylate Transporter ‐1 Mediates the Protective Effects of Neutral‐pH Bicarbonate/Lactate‐Buffered Peritoneal Dialysis Fluid on Cell Viability and Apoptosis
Abstract We investigated the effects of bicarbonate/lactate‐buffered peritoneal dialysis fluid (B/L‐PDF) and lactate‐buffered PDF (L‐PDF) on cell viability and apoptosis, focusing on monocarboxylate transporters (MCTs). MCT‐1 transports lactate into cells. Cell viability and apoptosis of human peritoneal mesothelial cells (HPMCs) were examined by water‐soluble tetrazolium salt‐1 and TUNEL assays, respectively. The relative number of viable HPMCs was significantly decreased by L‐PDF at 48 h (8.8 ± 0.4%) compared with cells cultured in M199, but not by B/L‐PDF (66.7 ± 1.1%). Apoptosis was marked...
Source: Therapeutic Apheresis and Dialysis - December 11, 2016 Category: Hematology Authors: Akihiro Kuma, Masahito Tamura, Nana Ishimatsu, Yoshikazu Harada, Hiroto Izumi, Tetsu Miyamoto, Yumi Furuno, Yoko Nakano, Ryota Serino, Yutaka Otsuji Tags: Original Article Source Type: research

DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells
In conclusion, and in agreement with the other studies (Ford et al., 2007; Koh et al., 2015; Toy et al., 2015; Takai et al., 2018), our data suggest that during the acquisition of mesenchymal features, the level of full-length DDR1 expression should be considered, in addition to the other markers, as an important biomarker in the prognosis of aggressive breast carcinomas. As summarized in Figure 9, the regulation of cell proliferation and apoptosis by the collagen/DDR1 axis involves a differential activation of DDR1 signaling pathway and thus BIK expression. In the case of the basal-like bre...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Elevated expression of HDAC6 in clinical peritoneal dialysis patients and its pathogenic role on peritoneal angiogenesis.
In this study, we analyzed the expression of HDAC6 in the peritoneum from patients with non-PD and PD-related peritonitis and dialysis effluent from stable PD patients. Our study revealed that HDAC6 expressed highly in the peritoneum with peritonitis and co-stained with α-smooth muscle actin (α-SMA), a biomarker of the myofibroblast. And the level of HDAC6 in the dialysate increased with time and positively correlated with transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), and negatively with cancer antigen 125 (CA125). In vitro, blockading HDAC6 with a selective...
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Tubular ischemia and toxicity
Conclusions: EPC-derived EVs protect the kidney from ischemic AKI by delivering mRNAs coding for factor H, DAF and CD59 to injured tubular epithelial and endothelial cells. These results confirmed previous data on the relevance of complement inhibition after kidney IRI and suggest the potential use of EPC-derived EVs as therapeutic option to avoid delayed graft function after kidney transplantation.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Cantaluppi, V., Medica, D., Figliolini, F., Gatti, S., Bruno, S., Quercia, A. D., Dellepiane, S., Biancone, L., Tetta, C., Camussi, G., Zhou, L., Dai, X., Feng, M., Huang, X., Fu, P., Lan, H. Y., de Ramon, L., Ripoll, E., Luzardo, L., Merino, A., Bolanos, Tags: Abstracts Source Type: research

Experimental acute kidney injury
Conclusions: WNT10A expression may promote fibrotic progression and kidney dysfunction in AIN. Blockade of WNT10A expression may be a feasible therapeutic strategy against kidney fibrosis.
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Kuma, A., Yamada, S., Miyamoto, T., Serino, R., Tamura, M., Otsuji, Y., Kohno, K., Cho, W. Y., Kim, M.-G., Jo, S.-K., Kim, H. K., Jado, J. C., Humanes, B., Lopez-Parra, V., Camano, S., Lara, J. M., Cercenado, E., Tejedor, A., Lazaro, A., Jansen, M., Caste Tags: Sunday, June 1st, 2014: Posters Source Type: research

AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by smurf2 and deubiquitinating enzyme USP4
Conclusions: These data implied that Akt mediated MMT in PD via Smurf2 modulation/and or Smad7 degradation while conceivably maintaining the TβRI stability, most likely by the USP4.
Source: BMC Cell Biology - March 6, 2015 Category: Cytology Authors: Li XiaoXiang PengFuyou LiuChengyuan TangChun HuXiaoxuan XuMing WangYing LuoShikun YangPanai SongPing XiaoYashpal KanwarLin Sun Source Type: research

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS.
Abstract It has been suggested that continuous exposure of peritoneal mesothelial cells (PMCs) to high glucose-containing peritoneal dialysis (PD) solutions may result in peritoneal inflammatory injury and impairment of local peritoneal host defence. Here, we investigated the effect of glucose-based PD solutions on mitochondrial reactive oxygen species (ROS) and nod-like receptor 3 (NLRP3) inflammasome activation in human PMCs (HPMCs). Exposure of HPMCs to high glucose-based PD solutions resulted in ROS production, which can trigger NLRP3 activation, leading to IL-1β secretion. Additionally, resveratrol (RSV) tre...
Source: Experimental Cell Research - January 26, 2016 Category: Cytology Authors: Wu J, Li X, Zhu G, Zhang Y, He M, Zhang J Tags: Exp Cell Res Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells
Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in  HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin or regulatory-as...
Source: American Journal of Nephrology - November 13, 2018 Category: Neurology Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.
Abstract Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Liu J, Zhu W, Jiang CM, Feng Y, Xia YY, Zhang QY, Xu PF, Zhang M Tags: Am J Nephrol Source Type: research

Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy
This study aimed to investigate the protective effect of DMAMCL against PD-related PF and the mechanisms involved. In this study, we found that DMAMCL significantly decreased PD-induced extracellular matrix (ECM) deposition in a mouse model of PD, and that delayed DMAMCL administration halted the progression of PF in an established PD model. In addition, rapamycin administration induced autophagy and significantly ameliorated PF. The protective effect of DMAMCL against PF was weakened when co-administered with DMAMCL and 3-methyladenine. Inducing autophagy by rapamycin decreased transforming growth factor- β1–induced EC...
Source: Journal of Molecular Medicine - March 10, 2019 Category: Molecular Biology Source Type: research

Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy.
This study aimed to investigate the protective effect of DMAMCL against PD-related PF and the mechanisms involved. In this study, we found that DMAMCL significantly decreased PD-induced extracellular matrix (ECM) deposition in a mouse model of PD, and that delayed DMAMCL administration halted the progression of PF in an established PD model. In addition, rapamycin administration induced autophagy and significantly ameliorated PF. The protective effect of DMAMCL against PF was weakened when co-administered with DMAMCL and 3-methyladenine. Inducing autophagy by rapamycin decreased transforming growth factor-β1-induced ECM a...
Source: Molecular Medicine - March 10, 2019 Category: Molecular Biology Authors: Li S, Peng F, Gong W, Wu J, Wang Y, Xu Z, Liu W, Li H, Yin B, Zhang Y, Chen S, Luo C, Li P, Chen Y, Huang Q, Zhou W, Long H Tags: J Mol Med (Berl) Source Type: research

Activation of RAS contributes to peritoneal fibrosis via dysregulation of low-density lipoprotein receptor.
In conclusion, increased intracellular RAS activity impaired lipid homeostasis and induced ECM accumulation in HPMCs by disrupting the LDLr pathway, which contributed to PF. PMID: 33427062 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - January 11, 2021 Category: Urology & Nephrology Authors: Liu J, Feng Y, Li N, Shao QY, Zhang Q, Sun C, Xu P, Jiang CM Tags: Am J Physiol Renal Physiol Source Type: research