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Total 681 results found since Jan 2013.

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer.
CONCLUSION: Silence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration. The siRNA-mediated TRIM66 silencing could block the occurrence of EMT. TRIM66 could be a promising novel target for future NSCLC treatments. PMID: 29929749 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - June 18, 2018 Category: Pathology Authors: Dai HY, Ma Y, Da Z, Hou XM Tags: Pathol Res Pract Source Type: research

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer
ConclusionSilence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration. The siRNA-mediated TRIM66 silencing could block the occurrence of EMT. TRIM66 could be a promising novel target for future NSCLC treatments.
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research

The down-regulation of SNCG inhibits the proliferation and invasiveness of human bladder cancer cell line 5637 and suppresses the expression of MMP-2/9.
In conclusion, the proliferation and invasiveness of bladder cancer cells can be decreased by specifically interfering with the SNCG expression. And SNCG siRNA deserves further study as a novel target for biomedical therapy in bladder cancer. PMID: 32782717 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - August 13, 2020 Category: Pathology Authors: Chen Z, Zhang F, Zhang S, Ma L Tags: Int J Clin Exp Pathol Source Type: research

Derlin-1 Is Overexpressed in Non-Small Cell Lung Cancer and Promotes Cancer Cell Invasion via EGFR-ERK-Mediated Up-Regulation of MMP-2 and MMP-9.
Abstract Previous studies indicated a role of Derlin-1 in human cancers; however, its expression pattern in non-small cell lung cancer (NSCLC) and the molecular mechanism of Derlin-1 on cancer progression have not been characterized. In the present study, Derlin-1 expression was examined in lung cancer cell lines and human tissues. Derlin-1 overexpression correlated with pTNM stage, lymph node metastasis, and poor overall survival. siRNA knockdown of Derlin-1 impaired anchorage-dependent and anchorage-independent cell growth and invasion in A549 and H1299 cell lines, and its overexpression promoted proliferation a...
Source: The American Journal of Pathology - January 7, 2013 Category: Pathology Authors: Dong QZ, Wang Y, Tang ZP, Fu L, Li QC, Wang ED, Wang EH Tags: Am J Pathol Source Type: research

Hepatopoietin Cn reduces ethanol‐induced hepatoxicity via sphingosine kinase 1 and sphingosine 1‐phosphate receptors
This study demonstrated that HPPCn attenuated oxidative injury and fibrosis induced by ethanol feeding and that the SphK1/S1P/S1PRs signalling pathway contributes to the protective effect of HPPCn on hepatocyte apoptosis and HSC activation. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Source: The Journal of Pathology - July 9, 2013 Category: Pathology Authors: Yang Liu, Saiyan Saiyan, Tong‐Yi Men, Hui‐Ying Gao, Chuan Wen, Yong Liu, Xu Zhou, Chu‐Tse Wu, Li‐Sheng Wang, Chun‐Ping Cui Tags: Original Paper Source Type: research

Caspase 3 Silencing Inhibits Biomechanical Overload-Induced Intervertebral Disk Degeneration.
Abstract Intervertebral disk (IVD) degeneration causes debilitating low back pain in much of the worldwide population. No efficient treatment exists because of an unclear pathogenesis. One characteristic event early in such degeneration is the apoptosis of nucleus pulposus (NP) cells embedded in IVDs. Excessive biomechanical loading may also be a major etiology of IVD degeneration. The present study used in vitro and in vivo models of compressive loading to elucidate the underlying mechanism of IVD degeneration. In addition, we investigated whether the inhibition of apoptosis is a potential clinical therapeutic ...
Source: The American Journal of Pathology - January 2, 2014 Category: Pathology Authors: Yamada K, Sudo H, Iwasaki K, Sasaki N, Higashi H, Kameda Y, Ito M, Takahata M, Abumi K, Minami A, Iwasaki N Tags: Am J Pathol Source Type: research

TPX2 Overexpression in Medullary Thyroid Carcinoma Mediates TT Cell Proliferation.
Abstract TPX2 (targeting protein for xenopus kinesin-like protein 2), a microtubule-associated protein, plays an important role in the formation of the mitotic spindle. Abnormal expression of TPX2 in various types of malignant tumors has been reported, but less is known for medullary thyroid cancer (MTC). We investigated the expression of TPX2 in human MTC tissues and its potential use as a therapeutic target. Immunohistochemical analysis of TPX2 expression was performed for 32 cases of MTC and 8 cases of normal thyroid. TPX2 expression was found to be significantly higher in MTC compared to normal thyroid tissues...
Source: Pathology Oncology Research - February 1, 2014 Category: Pathology Authors: Yang X, Liu G, Xiao H, Yu F, Xiang X, Lu Y, Li W, Liu X, Li S, Shi Y Tags: Pathol Oncol Res Source Type: research

A rational study for identification of highly effective siRNAs against hepatitis B virus.
In this study, we demonstrate that an assembly of results generated from different siRNA designing programs could provide clusters of predicting sites that aided selection of potent siRNAs. Based on the clusters, three siRNA target sites were selected on a conserved RNA region of hepatitis B virus (HBV), known as HBV post-transcriptional regulatory element (HBV PRE) at nucleotide positions 1317-1337, 1357-1377 and 1644-1664. All three chosen siRNAs driven by H1 promoter were highly effective and could drastically decrease expression of HBV transcripts (core, surface and X) and surface protein without induction of interfero...
Source: Experimental and Molecular Pathology - June 19, 2014 Category: Pathology Authors: Thongthae N, Payungporn S, Poovorawan Y, T-Thienprasert NP Tags: Exp Mol Pathol Source Type: research

MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4
Background: Overexpression of microRNA-182 (miR-182) is found in various human cancers, including non-small cell lung cancer (NSCLC). Our aim is to investigate the association of miR-182 expression with the sensitivity of NSCLC to cisplatin. Methods: TaqMan RT-PCR or Western blot assay was performed to detect the expression of mature miR-182 and programmed cell death 4 (PDCD4) protein. miR-182 and (or) PDCD4 depleted cell lines were generated using miR-182 inhibitor and (or) siRNA. The viabilities of treated cells were analyzed using MTT assay. Results: The expression level of miR-182 in A549 cell line was significantly hi...
Source: Diagnostic Pathology - July 10, 2014 Category: Pathology Authors: Fang-ling NingFeng WangMian-li LiZe-shun YuYan-zhang HaoShao-shui Chen Source Type: research

Macrophage‐mediated nanoparticle delivery to the periodontal lesions in established murine model via Pg‐LPS induction
We established a murine periodontitis model by local injection of lipopolysaccharide of Porphyromonas gingivalis (Pg‐LPS) into the gingival sulcus of mandibular left incisor four times with 48‐h interval. The histological examination of the periodontal tissues demonstrated that significant loss of periodontal bone and ligaments was observed in the lesion side with abundant inflammatory cell infiltration. Two days after the last injection, Cy5‐labelled siRNA/chitosan particles were injected intraperitoneally (ip). The chitosan/siRNA particles were taken up by peritoneal macrophages, which subsequently migrated to the ...
Source: Journal of Oral Pathology and Medicine - September 25, 2014 Category: Pathology Authors: Zhiwei Ma, Frederik Dagnæs‐Hansen, Henrik Løvschall, Wen Song, Gitte K. Nielsen, Chuanxu Yang, Qintao Wang, Jørgen Kjems, Shan Gao Tags: Original Article Source Type: research

Effects of microRNA-183 on epithelial-mesenchymal transition, proliferation, migration, invasion and apoptosis in human pancreatic cancer SW1900 cells by targeting MTA1.
CONCLUSION: Our study supported that miR-183 could repress EMT and invasion of human PC cells through inhibition of MTA1 expression. PMID: 28506766 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - May 12, 2017 Category: Pathology Authors: Lin X, Song H, Xiao J, Pan B, Chen H, Jin X, Yu H Tags: Exp Mol Pathol Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases by immunohistochemistry. In contrast to weak or no staining of KIFC1 in non-neoplastic mucosa, ESCC tissue showed stronger, more extensive KIFC1 staining. In total, 95 (72%) of 132 ESCC cases were positive for...
Source: Pathology, Research and Practice - September 12, 2017 Category: Pathology Authors: Imai T, Oue N, Yamamoto Y, Asai R, Uraoka N, Sentani K, Yoshida K, Yasui W Tags: Pathol Res Pract Source Type: research

YAP1 Is Involved in Tumorigenic Properties of Prostate Cancer Cells.
In this study, YAP1 expression was upregulated in the whole cell lysates and cytoplasmic/nuclear extracts of AR negative (PC3) compared to AR positive (LNCaP) prostate cancer cell lines and primary prostate epithelial cells (PrePEC). pYAP1 expression elevated in LNCaP compared to PC3 and PrePEC in whole cell lysates and cytoplasmic extracts. The treatment of LNCaP and PC3 with YAP1-targeting siRNA oligonucleotides (YAP1 siRNA) significantly reduced their proliferation in vitro. Furthermore, treatment with YAP1 siRNA diminished the clonogenicity, anchorage-independent growth on soft agar, migration and invasion of PC3 cells...
Source: Pathology Oncology Research - March 10, 2019 Category: Pathology Authors: Collak FK, Demir U, Sagir F Tags: Pathol Oncol Res Source Type: research