Filtered By:
Specialty: Pathology

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 681 results found since Jan 2013.

Hyperthermia inhibited the migration of tongue squamous cell carcinoma through TWIST2
ConclusionsThis demonstrated that hyperthermia might decrease the migration of Tca8113 and Cal‐27 cells by reducing TWIST2 expression. Altogether, these findings suggest an as yet undescribed link between TWIST2 and hyperthermia in TSCC.
Source: Journal of Oral Pathology and Medicine - July 22, 2014 Category: Pathology Authors: Ya‐ling Tang, Jian Jiang, Jeffrey Liu, Min Zheng, Yong‐wen He, Wei Chen, Yun‐long Fan, Qian‐ming Chen, Chu‐hang Liao, Xin‐hua Liang Tags: Original Article Source Type: research

CXCR4 antagonist inhibits perineural invasion of adenoid cystic carcinoma
Conclusions CXCR4 is associated with perineural invasion in ACC. AMD3100, which can effectively diminish perineural invasion of ACC, may have an adjuvant role in the management of ACC.
Source: Journal of Clinical Pathology - October 16, 2014 Category: Pathology Authors: Jeong, W.-J., Choi, I. J., Park, M.-W., An, S.-Y., Jeon, E.-H., Paik, J. H., Sung, M.-W., Ahn, S.-H. Tags: Immunology (including allergy) Original article Source Type: research

YM155 induces apoptosis through downregulation of specificity protein 1 and myeloid cell leukemia‐1 in human oral cancer cell lines
ConclusionsWe demonstrated the novel mechanism that YM155 causes apoptosis of human oral cancer cell lines through downregulation of Sp1 and Mcl‐1. Therefore, it may be a potential anticancer drug candidate for the treatment of oral cancer.
Source: Journal of Oral Pathology and Medicine - December 5, 2014 Category: Pathology Authors: Khadka Sachita, Hyun‐Ju Yu, Jun‐Won Yun, Jeong‐Sang Lee, Sung‐Dae Cho Tags: Original Article Source Type: research

Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in Glioma
This study showed that high CCT8 protein expression might be related to poor outcome of glioma, and that CCT8 regulates the proliferation and invasion of glioblastomas.
Source: Pathology Research and Practice - May 19, 2015 Category: Pathology Source Type: research

α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells.
Abstract Cigarette smoking is the most important risk factor in the development of human lung cancer. Nicotine, the major component in tobacco, not only contributes to carcinogenesis but also promotes tumor metastasis. By binding to nicotinic acetylcholine receptors (nAChRs), nicotine induces the proliferation and migration of non-small cell lung cancer. Recently studies have indicated that α5-nAChR is highly associated with lung cancer risk and nicotine dependence. Nevertheless, it is unclear whether nicotine promotes the migration and invasion through activation of α5-nAChR in lung cancer. In the present study...
Source: Experimental and Toxicologic Pathology - July 20, 2015 Category: Pathology Authors: Sun H, Ma X Tags: Exp Toxicol Pathol Source Type: research

Anticancer activity of Ashwagandha against human head and neck cancer cell lines
ConclusionsThese suggest that MEAG and WA may be potential natural materials for the treatment of HNSCC.
Source: Journal of Oral Pathology and Medicine - August 1, 2015 Category: Pathology Authors: Haeng‐Eun Lee, Ji‐Ae Shin, Joseph H. Jeong, Jae‐Gyu Jeon, Min‐Ho Lee, Sung‐Dae Cho Tags: Original Article Source Type: research

Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis.
Abstract Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies that target proteins at the neuromuscular junction, primarily the acetylcholine receptor (AChR) and the muscle-specific kinase. Because downstream of kinase 7 (Dok-7) is essential for the full activation of muscle-specific kinase and consequently for dense clustering of AChRs, we hypothesized that reduced levels of Dok-7 increase the susceptibility to passive transfer MG. To test this hypothesis, Dok-7 expression was reduced by transfecting shRNA-coding plasmids into the tibialis anterior muscle of adult rats by in vivo electropor...
Source: The American Journal of Pathology - September 25, 2016 Category: Pathology Authors: Gomez AM, Stevens JA, Mané-Damas M, Molenaar P, Duimel H, Verheyen F, Cossins J, Beeson D, De Baets MH, Losen M, Martinez-Martinez P Tags: Am J Pathol Source Type: research

Long noncoding RNA MALAT1 affects the efficacy of radiotherapy for esophageal squamous cell carcinoma by regulating Cks1 expression
ConclusionMALAT1 acted as one positive regulator of the radioresistance of ESCC, at least partly due to its promotion on Cks1 expression. Furthermore, MALAT1‐targeted therapies showed great potential in enhancing the radiotherapeutic effect on ESCC.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - December 8, 2016 Category: Pathology Authors: Zhijun Li, Yang Zhou, Bo Tu, Yu Bu, Aqiu Liu, Conghua Xie Tags: Original Article Source Type: research

Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis.
Abstract Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that arises from the surface of the pleura and is associated with a history of asbestos exposure. The tumor is characterized by a strong local invasiveness and a poor response to any single modality therapy. Therefore clinical outcome of patients with MPM is poor and median survival time of untreated patients with MPM is 7 months from initial diagnosis. The Wilms Tumor Protein 1 (WT1) is a transcription factor which is highly expressed by MPM and is involved in cellular development and survival. We evaluated the role of WT1 in two human MP...
Source: Pathology Oncology Research - January 3, 2017 Category: Pathology Authors: Plönes T, Fischer M, Höhne K, Sato H, Müller-Quernheim J, Zissel G Tags: Pathol Oncol Res Source Type: research

High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Abstract The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubules and up-regulated in the diabetic state. Previously, we reported its transcriptional and translation regulation by high glucose (HG), osmolytes, and fatty acids. However, its epigenetic regulation is unknown. Bisulfite sequencing revealed that both human and mouse MIOX promoters, enriched with CpG sites, are hypomethylated and unmethylated under HG ambience and hyperglycemic states associated with increased MIOX expression. Eletrophoretic mobility shift assays revealed increased binding of unmethylated oligos with nucleopro...
Source: The American Journal of Pathology - February 12, 2017 Category: Pathology Authors: Sharma I, Dutta RK, Singh NK, Kanwar YS Tags: Am J Pathol Source Type: research

Hypoxia ‐Inducible Factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2
ABSTRACT Osteogenic‐angiogenic coupling is promoted by the Hypoxia‐Inducible Factor 1‐alpha (HIF‐1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralisation and treat pathological osteolysis. However, HIF also enhances the bone resorbing activity of mature osteoclasts. It is therefore essential to determine the full effect(s) of HIF on both the formation and bone‐resorbing function of osteoclasts in order to understand how they might respond to such a strategy. Expression of HIF‐1α mRNA and protein increased during osteoclast differentiation fr...
Source: The Journal of Pathology - April 18, 2017 Category: Pathology Authors: Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles Tags: Original Paper Source Type: research

An in vitro study of the long non ‐coding RNA TUG1 in tongue squamous cell carcinoma
ConclusionThe lncRNA TUG1 may represent a potential oncogene in TSCC.This article is protected by copyright. All rights reserved.
Source: Journal of Oral Pathology and Medicine - May 1, 2017 Category: Pathology Authors: Zhi ‐qiang Li, Rui Zou, Ke‐Xiong Ouyang, Wei‐Jian Ai Tags: Original Article Source Type: research

An in  vitro study of the long non‐coding RNA TUG1 in tongue squamous cell carcinoma
ConclusionThe lncRNA TUG1 may represent a potential oncogene in TSCC.
Source: Journal of Oral Pathology and Medicine - July 16, 2017 Category: Pathology Authors: Zhi ‐qiang Li, Rui Zou, Ke‐Xiong Ouyang, Wei‐Jian Ai Tags: ORIGINAL ARTICLE Source Type: research

Apolipoprotein E promotes invasion in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, due to the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (WPOI 5) versus a less invasive (WPOI 3) pattern of invasion, we identified a total of 97 genes that were overexpressed at least 1.5-fold in the more invasive tumor subtype. The most functionally relevant genes were assessed using in vitro invasion assays with an OSCC cell line (UM-SCC-1). Individual siRNA knockdown of 15 of these 45 genes resulted in significant reductions in tumor cell invasion compared to a non-targeting siRNA control.
Source: American Journal of Pathology - July 24, 2017 Category: Pathology Authors: Sangeeta K. Jayakar, Olivier Loudig, Margaret Brandwein-Gensler, Ryung S. Kim, Thomas J. Ow, Berrin Ustun, Thomas M. Harris, Michael B. Prystowsky, Geoffrey Childs, Jeffrey E. Segall, Thomas J. Belbin Tags: Regular Article Source Type: research

Apolipoprotein E promotes invasion in oral squamous cell carcinoma.
Abstract Oral squamous cell carcinoma (OSCC) patients generally have a poor prognosis, due to the invasive nature of these tumors. In comparing transcription profiles between OSCC tumors with a more invasive (WPOI 5) versus a less invasive (WPOI 3) pattern of invasion, we identified a total of 97 genes that were overexpressed at least 1.5-fold in the more invasive tumor subtype. The most functionally relevant genes were assessed using in vitro invasion assays with an OSCC cell line (UM-SCC-1). Individual siRNA knockdown of 15 of these 45 genes resulted in significant reductions in tumor cell invasion compared to a...
Source: Am J Pathol - July 24, 2017 Category: Pathology Authors: Jayakar SK, Loudig O, Brandwein-Gensler M, Kim RS, Ow TJ, Ustun B, Harris TM, Prystowsky MB, Childs G, Segall JE, Belbin TJ Tags: Am J Pathol Source Type: research