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Total 681 results found since Jan 2013.

Inhibitory effect of siRNA-Annexin A7 on growth, migration, and invasion in BGC823 cells and gastric cancer xenograftsin nude mice.
CONCLUSION: Gastric cancer xenografts were established in nude mice with human gastric cancer BGC823 cells. The volume and weight of tumor were decreased after inhibition of Annexin A7 expression in BGC823 cells. Tumor cells were arranged sparsely after inhibition of Annexin A7 expression in BGC823 cells. The siRNA-Annexin A7 inhibits Annexin A7 expression in transplanted gastric cancer of nude mice, and influences the growth, migration, and invasion of tumors by down-regulating the expression of PCNA and MMP-2, as well as up-regulating the expression of p27. PMID: 32211092 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - March 28, 2020 Category: Pathology Authors: Yuan HF, Li Y, Tan BB, Zhao Q, Fan LQ, An ZJ Tags: Int J Clin Exp Pathol Source Type: research

Effect of STAT5 silenced by siRNA on proliferation apoptosis and invasion of esophageal carcinoma cell line Eca-109
Background: STAT is the backward position of cytokine and growth factor receptors in the nucleus, STAT dimers could bind to DNA and induce transcription of specific target genes. Several lines ofevidence support the important roles of STAT, especially STAT5, in carcinogenesis. The overexpression of STAT 5 is related to the differentiation and apoptosis of tumor cells. However, the role of STAT5 in esophageal squamous cell carcinoma remains unclear. Methods: The siRNA vectors aiming to STAT5 gene were constructed. STAT5 siRNA was transfected into Eca-109 cells by LipofectamineTM2000. Expression of STAT5Bcl-2 and Cyclin D1 w...
Source: Diagnostic Pathology - August 5, 2013 Category: Pathology Authors: Qian YangMin LiTao WangHong XuWenqiao ZangGuoqiang Zhao Source Type: research

Amelioration of Colorectal Cancer Using Negative Lipidoid Nanoparticles to Encapsulate siRNA Against APRIL by Enema Delivery Mode.
This study reveals APRIL to be a potential anti-CRC target by in vivo experiments, and suggests that the application of similar modes of siRNA delivery may be feasible in other therapeutic settings. PMID: 24771268 [PubMed - as supplied by publisher]
Source: Pathology Oncology Research - April 26, 2014 Category: Pathology Authors: Ding W, Wang G, Shao K, Wang F, Huang H, Ju S, Cong H, Wang H Tags: Pathol Oncol Res Source Type: research

Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy.
We describe the safety and toxicity studies with siG12D-LODER in 192 Hsd:Sprague Dawley rats, after repeated subcutaneous administrations (days 1, 14, and 28). Animals were sacrificed on days 29 and 42 (recovery phase). In all groups, no adverse effects were noted, and all animals showed favorable local and systemic tolerability. Histopathologically, LODER implantation resulted in the expected capsule formation, composed of a thin fibrotic tissue. On the interface between the cavity and the capsule, a single layer composed of macrophages and multinucleated giant cells was observed. No difference was noted between the place...
Source: Toxicologic Pathology - May 3, 2016 Category: Pathology Authors: Ramot Y, Rotkopf S, Gabai RM, Khvalevsky EZ, Muravnik S, Marzoli GA, Domb AJ, Shemi A, Nyska A Tags: Toxicol Pathol Source Type: research

VE-statin/Egfl7 siRNA inhibits angiogenesis in malignant glioma in vitro.
This study investigated the role of VE-statin/Egfl7 and its mechanism in angiogenesis in malignant glioma. Transwell culture plates were used to establish an U251-HUVEC co-culture system, which was used to mimic the interaction between malignant glioma and endothelial cells. Lentiviral vectors expressing VE-statin/Egfl7 siRNA were constructed, and U251 cells and HUVECs were transfected to inhibit VE-statin/Egfl7 expression. The proliferation, adherence, migration, and lumen formation of endothelial cells were assayed to investigate the influence of VE-statin/Egfl7 on angiogenesis in malignant glioma in vitro. Data showed t...
Source: International Journal of Clinical and Experimental Pathology - April 7, 2014 Category: Pathology Authors: Huang C, Yuan X, Li Z, Tian Z, Zhan X, Zhang J, Li X Tags: Int J Clin Exp Pathol Source Type: research

Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation
This study aimed to determine the transcript level of PCa-related genes, HPN and IMPDH2, in archived tissues. Their functional roles were further determined using an in vitro model of PCa. Total RNA extraction was done from formalin-fixed paraffin-embedded PCa tissues, and benign prostatic hyperplasia (BPH) tissues acted as the control. Quantitative real-time polymerase chain reaction (qPCR) was performed to measure HPN and IMPDH2 expression. The functional assay was performed in a prostate cancer cell line (DU145) on these two genes by silencing their RNA. We discovered a significantly higher expression of IMPDH2 in PCa s...
Source: Malaysian Journal of Pathology - April 29, 2022 Category: Pathology Authors: N A Wahab H D Dardar R Yunus Z M Zainudin N M Mokhtar Source Type: research