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Total 681 results found since Jan 2013.

Long non-coding RNA MALAT1 aggravates human retinoblastoma by sponging miR-20b-5p to upregulate STAT3.
CONCLUSION: MALAT1 could increase proliferation and reduce apoptosis by sponging miR-20b-5p to upregulate STAT3 in RB cells. Therefore, MALAT1 might be a latent target in the RB treatment. PMID: 32336590 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - April 17, 2020 Category: Pathology Authors: Wang L, Zhang Y, Xin X Tags: Pathol Res Pract Source Type: research

Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB.
Abstract The transcription factor EB (TFEB) is known for its role in lysosomal biogenesis, and it coordinates this process by driving autophagy and lysosomal gene expression during ischemia. In the present study, we aimed to explore the role of the TFEB-regulated autophagolysosome pathway (ALP) in rats with chronic cerebral ischemia (CCI) that were treated with remote ischemic postconditioning (RIPC). A modified 2-vessel occlusion (2-VO) method was utilized to establish the CCI rat model, and the CCI rats were identified by the Morris water maze test and histological staining. After the CCI rats were treated with ...
Source: Experimental and Molecular Pathology - May 26, 2020 Category: Pathology Authors: Li Z, Cui X, Lv H, Liu J, Di W, Jiang F, Liu Y, Cheng X Tags: Exp Mol Pathol Source Type: research

Nanog suppression enhanced the chemosensitivity of human non-small-cell lung cancer cells to Cisplatin and inhibited cell migration
In conclusion, the findings of the current study demonstrated that silencing Nanog combined with Cisplatin could be a potent treatment approach for lung cancer patients.PMID:35398618 | DOI:10.1016/j.prp.2022.153869
Source: Pathology, Research and Practice - April 10, 2022 Category: Pathology Authors: Basira Najafzadeh Rouhollah Motafakkerazad Souzan Najafi Mohammad Amini Hajar Alemohammad Parisa Vasefifar Behzad Baradaran Source Type: research

Activated PAR-2 Regulates Pancreatic Cancer Progression through ILK/HIF-α-Induced TGF-α Expression and MEK/VEGF-A-Mediated Angiogenesis.
In conclusion, the activation of PAR-2 signaling induced human pancreatic cancer progression through the induction of TGF-α expression by ILK/HIFs-α, as well as through MEK/VEGF-A-mediated angiogenesis, and it plays a role in the interaction between cancer progression and cancer-related thrombosis. PMID: 23764046 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - June 10, 2013 Category: Pathology Authors: Chang LH, Pan SL, Lai CY, Tsai AC, Teng CM Tags: Am J Pathol Source Type: research

Altered Unfolded Protein Response Is Implicated in the Age-Related Exacerbation of Proteinuria-Induced Proximal Tubular Cell Damage.
Abstract Aging is a dominant risk factor for end-stage renal disease. We analyzed the mechanism involved in age-related exacerbation of proteinuria-induced proximal tubular cell (PTC) damage by focusing on endoplasmic reticulum-related unfolded protein response (UPR). After equal-degree induction of proteinuria in 24-month-old (aged) and 3-month-old (young) mice by intraperitoneal free fatty acid-bound albumin overload, tubulointerstitial lesions were more severe in aged than in young mice. In aged PTCs, proteinuria-induced cell-adaptive UPR resulting from induction of the molecular chaperone BiP was significantly...
Source: The American Journal of Pathology - July 16, 2013 Category: Pathology Authors: Takeda N, Kume S, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki SI, Haneda M, Koya D, Kashiwagi A, Maegawa H, Uzu T Tags: Am J Pathol Source Type: research

Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model: Role of S1P Signaling and Nox Proteins.
Abstract Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tissues; however, the role of increased S1P in the pathobiological characteristics of bronchopulmonary dysplasia has not been investigated. We hypothesized that an altered S1P signaling axis, in part, is responsible for neonatal lung injury leading to bronchopulmonary dysplasia. To validate this hypothesis, newborn wild-type, sphingosine kinase1(-/-) (Sphk1(-/-))...
Source: The American Journal of Pathology - August 7, 2013 Category: Pathology Authors: Harijith A, Pendyala S, Reddy NM, Bai T, Usatyuk PV, Berdyshev E, Gorshkova I, Shuang Huang L, Mohan V, Garzon S, Kanteti P, Reddy SP, Raj U, Natarajan V Tags: Am J Pathol Source Type: research

Upregulation of ATF-3 is correlated with prognosis and proliferation of laryngeal cancer by regulating Cyclin D1 expression.
CONCLUSION: ATF-3 is involved in the progress of LSCC, and may provide clinical information for evaluation of prognosis of LSCC. The oncologic role of ATF-3 may be correlated with Cyclin D1 regulation. PMID: 24133584 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - October 19, 2013 Category: Pathology Authors: Feng J, Sun Q, Wu T, Lu J, Qu L, Sun Y, Tian L, Zhang B, Li D, Liu M Tags: Int J Clin Exp Pathol Source Type: research

Hypoxia-Inducible Factor-1α and its Role in the Proliferation of Retinoblastoma Cells.
Abstract In order to better understand the role of HIF-1α in the proliferation of the retinoblastoma cells, a siRNA knockdown of HIF-1α followed by a proliferation assay was performed. Further sequencing was then carried out in order to assess knockdown efficiency and expression of HIF-1α. Upregulation of HIF-1α gene expression in CoCl2-treated retinoblastoma cells was demonstrated via melting curve analysis from PCR tests and was further analyzed using western blot and densitometry analysis. Reduction of HIF-1α expression in retinoblastoma, post HIF-1α knockdown, was observed after siRNA transfection into Y...
Source: Pathology Oncology Research - December 14, 2013 Category: Pathology Authors: Fernandes BF, Coates J, Odashiro AN, Quezada C, Huynh A, Odashiro PR, Odashiro M, Burnier MN Tags: Pathol Oncol Res Source Type: research

Protection from renal fibrosis, Putative role of TRIB3 gene silencing.
CONCLUSIONS: TRIB3 gene silencing can attenuate renal fibrosis for beneficial effect on the development of renal fibrosis in chronic kidney disease in rat. PMID: 24368111 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - December 21, 2013 Category: Pathology Authors: Ding WY, Li WB, Ti Y, Bi XP, Sun H, Wang ZH, Zhang Y, Zhang W, Zhong M Tags: Exp Mol Pathol Source Type: research

Recombinant adenovirus encoding FAT10 small interfering RNA inhibits HCC growth in vitro and in vivo.
Abstract Hepatocellular carcinoma is an aggressive and rapidly fatal malignancy representing the common cancer worldwide. The specific cellular gene involved in carcinogenesis has nor been full charactered. The ubiquitin-like modifier FAT10, a recently reported to be overexpressed in 90% of hepatocellular carcinoma carcinomas, was attributed to transcriptional upregulation upon the loss of p53 and induced chromosome instability in long-term in vitro culture. However, the exact function of FAT10 in Hepatocellular carcinoma is not clear. In the present study, we utilized adenovirus-mediated RNA interference to knock...
Source: Experimental and Molecular Pathology - January 14, 2014 Category: Pathology Authors: Chen J, Zi W, Yang Z Tags: Exp Mol Pathol Source Type: research

Depleting ABCE1 expression induces apoptosis and inhibits the ability of proliferation and migration of human esophageal carcinoma cells.
CONCLUSION: ABCE1 is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of 2-5A/RNase L. PMID: 24551278 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Huang B, Gong X, Zhou H, Xiong F, Wang S Tags: Int J Clin Exp Pathol Source Type: research

MicroRNA -21 is a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs.
CONCLUSIONS: MiR-21 might be a biomarker for plaque unstability by suppressing target gene RECK to promote the expression and secretion of MMP-9 in macrophages. PMID: 24594117 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - March 1, 2014 Category: Pathology Authors: Fan X, Wang E, Wang X, Cong X, Chen X Tags: Exp Mol Pathol Source Type: research

Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes.
Abstract Diabetic nephropathy is a complication of diabetes and a major cause of end-stage renal disease. To characterize the early pathophysiological mechanisms leading to glomerular podocyte injury in diabetic nephropathy, we performed quantitative proteomic profiling of glomeruli isolated from rats with streptozotocin-induced diabetes and controls. Fluorescence-based two-dimensional difference gel electrophoresis, coupled with mass spectrometry, identified 29 differentially expressed spots, including actin-binding protein ezrin and its interaction partner, NHERF2, which were down-regulated in the streptozotocin...
Source: The American Journal of Pathology - April 8, 2014 Category: Pathology Authors: Wasik AA, Koskelainen S, Hyvönen ME, Musante L, Lehtonen E, Koskenniemi K, Tienari J, Vaheri A, Kerjaschki D, Szalay C, Révész C, Varmanen P, Nyman TA, Hamar P, Holthöfer H, Lehtonen S Tags: Am J Pathol Source Type: research

Modulation of insulin /IGFs pathways by sirtuin-7 inhibition in drug- induced chemoreistance
Conclusion: Our data demonstrate that stress-induced Sirt7 inhibition significantly increases stress resistance and modulates insulin/IGF-1 signaling pathways. More importantly, this study links Sir2 family proteins to insulin/IGF signaling in drug-induced stress resistance in neoplasia.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1135426681234493
Source: Diagnostic Pathology - May 22, 2014 Category: Pathology Authors: Ahmad AljadaAyman SalehSalem Al Suwaidan Source Type: research