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Specialty: Orthopaedics

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Total 95 results found since Jan 2013.

Expression of Caveolin-1 in Periodontal Tissue and Its Role in Osteoblastic and Cementoblastic Differentiation In Vitro
This study demonstrates, for the first time, that Cav-1 is expressed in developing periodontal tissue and in vitro in periodontal-related cells. Cav-1 inhibition positively regulates osteoblastic differentiation in hPDLCs, cementoblasts, and osteoblasts via BMP, AMPK, MAPK, and NF-κB pathway. Thus, Cav-1 inhibition may be a novel molecular target for therapeutic approaches in periodontitis or osteolytic disease.
Source: Calcified Tissue International - December 19, 2015 Category: Orthopaedics Source Type: research

Clinical and biological significance of PIM1 kinase in osteosarcoma
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - December 19, 2015 Category: Orthopaedics Authors: Yunfei Liao, Yong Feng, Jacson Shen, Yan Gao, Gregory Cote, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek, Zhenfeng Duan Tags: Research Article Source Type: research

Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid methylprednisolone (MPS). At 2, 4, 6weeks after induction, Src siRNA, control siRNA and saline were intramedullary injected into proximal femur, respectively.
Source: Bone - November 17, 2015 Category: Orthopaedics Authors: Li-Zhen Zheng, Xin-Luan Wang, Hui-Juan Cao, Shi-Hui Chen, Le Huang, Ling Qin Tags: Original Full Length Article Source Type: research

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - November 17, 2015 Category: Orthopaedics Authors: Xianyi Cai, Yunlu Liu, Wen Yang, Yun Xia, Cao Yang, Shuhua Yang, Xianzhe Liu Tags: Research Article Source Type: research

CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function
The CCN family of proteins plays important roles in development and homeostasis of bone and cartilage. To understand the role of CCN4 in chondrogenesis, human bone marrow stromal cells (hBMSCs) were transduced with CCN4 adenovirus (adCCN4) or siRNA to CCN4 (siCCN4) in the presence or absence of transforming growth factor-β3 (TGF-β3). Overexpression of CCN4 enhanced TGF-β3-induced SMAD2/3 phosphorylation and chondrogenesis of hBMSCs in an in vitro assay using a micromass culture model. On the other hand, knockdown of CCN4 inhibited the TGF-β3-induced SMAD2/3 phosphorylation and synthesis of cartilage matrix in micromass cultures of hBMSCs.
Source: Bone - November 7, 2015 Category: Orthopaedics Authors: Yuya Yoshioka, Mitsuaki Ono, Azusa Maeda, Tina M. Kilts, Emilio Satoshi Hara, Hany Khattab, Junji Ueda, Eriko Aoyama, Toshitaka Oohashi, Masaharu Takigawa, Marian F. Young, Takuo Kuboki Tags: Original Full Length Article Source Type: research

Expression of XBP1s in fibroblasts is critical for TiAl6V4 particle‐induced RANKL expression and osteolysis
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - September 25, 2015 Category: Orthopaedics Authors: Zhenheng Wang, Naicheng Liu, Gang Zhou, Tongguo Shi, Zhenzhen Wang, Jingjing Gan, Rui Wang, Hongbo Qian, Nirong Bao, Ting Guo, Jianning Zhao Tags: Research Article Source Type: research

Expression of XBP1s in fibroblasts is critical for TiAl6V4 particle ‐induced RANKL expression and osteolysis
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - September 24, 2015 Category: Orthopaedics Authors: Zhenheng Wang, Naicheng Liu, Gang Zhou, Tongguo Shi, Zhenzhen Wang, Jingjing Gan, Rui Wang, Hongbo Qian, Nirong Bao, Ting Guo, Jianning Zhao Tags: Research Article Source Type: research

Transmission of ER stress response by ATF6 promotes endochondral bone growth
Conclusions: Our observations demonstrate that ATF6 positively regulates chondrocyte hypertrophy and endochondral bone formation through activating Runx2-mediated hypertrophic chondrocyte differentiation.
Source: Journal of Orthopaedic Surgery and Research - September 15, 2015 Category: Orthopaedics Authors: Zhangyuan XiongRong JiangPeng ZhangXiaofeng HanFeng-Jin Guo Source Type: research

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Conclusions GPRC6A, the likely receptor of osteocalcin (OC), is expressed in mouse muscle. ucOC treatment augments insulin-stimulated skeletal muscle glucose uptake in C2C12 myotubes and following ex vivo muscle contraction. ucOC may partly account for the insulin sensitizing effect of exercise.
Source: Osteoporosis International - August 10, 2015 Category: Orthopaedics Source Type: research

Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid‐Associated Osteonecrosis in Rabbits
This study was designed to prove our hypothesis that blocking VEGF‐Src signaling pathway by specific Src siRNA was able to prevent destructive repair in a SAON rabbit model. Destructive repair in SAON was induced in rabbits. At 2, 4, 6 weeks after SAON induction, VEGF, anti‐VEGF, Src siRNA, Src siRNA + VEGF, control siRNA and saline were intramedullary injected into proximal femora for each group, respectively. Vascularization and permeability were quantified by dynamic contrast‐enhanced (DCE) MRI. At week 6 after SAON induction, proximal femora were dissected for micro‐CT‐based trabecular architecture with f...
Source: Journal of Bone and Mineral Research - April 27, 2015 Category: Orthopaedics Authors: Li‐zhen Zheng, Hui‐juan Cao, Shi‐hui Chen, Tao Tang, Wei‐min Fu, Le Huang, Dick Ho Kiu Chow, Yi‐xiang Wang, James Francis Griffith, Wei He, Hong Zhou, De‐wei Zhao, Ge Zhang, Xin‐luan Wang, Ling Qin Tags: Original Article Source Type: research

Caspase-2 Modulates Osteoclastogenesis through Down-Regulating Oxidative Stress
In this study, we show that Casp-2 is involved in osteoclastogenesis. Protein levels of Casp-2 decrease during the differentiation of macrophages to osteoclasts. Furthermore, siRNA-mediated Casp-2 knockdown in osteoclast precursors or differentiation of bone marrow macrophage (BMM) precursors from Casp2-/- mice result in increased osteoclast numbers and tartrate-resistant acid phosphatase (TRAP) activity.
Source: Bone - March 19, 2015 Category: Orthopaedics Authors: Danielle A. Callaway, Manuel A. Riquelme, Ramaswamy Sharma, Marisa Lopez-Cruzan, Brian A. Herman, Jean X. Jiang Tags: Original Full Length Article Source Type: research

Connexin 43 and ERK Regulate Tension‐Induced Signal Transduction in Human Periodontal Ligament Fibroblasts
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - March 2, 2015 Category: Orthopaedics Authors: Shengnan Li, Huajing Zhang, Shuna Li, Yanqi Yang, Bo Huo, Ding Zhang Tags: Research Article Source Type: research

Anabolic Bone Formation Via a Site‐Specific Bone‐Targeting Delivery System by Interfering With Semaphorin 4d Expression
ABSTRACT Semaphorins have been recently targeted as new molecules directly implicated in the cell‐cell communication that occurs between osteoclasts and osteoblasts. Overexpression of certain semaphorins, such as semaphorin4D (sema4D), is found in an osteoporotic phenotype and plays a key role in osteoclast activity by suppressing osteoblast maturation, thus significantly altering the bone modeling cycle. In the present study, we fabricate a site‐specific bone‐targeting drug‐delivery system from polymeric nanoparticles with the incorporation of siRNA interference molecule for sema4D and demonstrate their cellular u...
Source: Journal of Bone and Mineral Research - January 22, 2015 Category: Orthopaedics Authors: Yufeng Zhang, Lingfei Wei, Richard J Miron, Bin Shi, Zhuan Bian Tags: Original Article Source Type: research

Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity – an mechanism study for preventing destructive repair of osteonecrosis
Destructive repair is the pathological feature of ONFH characterized with the elevated vascular permeability and persistent bone resorption, which is associated with higher VEGF expression, activated c-Src, and vascular leakage. Activated c-Src also participates in mediating endothelial permeability and osteoclasts activity. However, the molecular mechanism of the VEGF and c-Src contributing to the destructive repair process remains unknown. The purpose of this study is to delineate the role of VEGF and c-Src in triggering destructive repair of osteonecrosis in vitro, as well as to elucidate if VEGF mediating vascular perm...
Source: Bone - December 29, 2014 Category: Orthopaedics Authors: Hui-Juan Cao, Li-Zhen Zheng, Nan Wang, Lin-Ying Wang, Ye Li, Dan Li, Yu-Xiao Lai, Xin-Luan Wang, Ling Qin Tags: Original Full Length Article Source Type: research

Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity– an mechanism study for preventing destructive repair of osteonecrosis
Destructive repair is the pathological feature of ONFH characterized with the elevated vascular permeability and persistent bone resorption, which is associated with higher VEGF expression, activated c-Src, and vascular leakage. Activated c-Src also participates in mediating endothelial permeability and osteoclasts activity. However, the molecular mechanism of the VEGF and c-Src contributing to the destructive repair process remains unknown. The purpose of this study is to delineate the role of VEGF and c-Src in triggering destructive repair of osteonecrosis in vitro, as well as to elucidate if VEGF mediating vascular perm...
Source: Bone - December 29, 2014 Category: Orthopaedics Authors: Hui-Juan Cao, Li-Zhen Zheng, Nan Wang, Lin-Ying Wang, Ye Li, Dan Li, Yu-Xiao Lai, Xin-Luan Wang, Ling Qin Source Type: research