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Specialty: Orthopaedics

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Total 95 results found since Jan 2013.

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
ConclusionOur results suggested that low expression of HDAC2 under SeD condition increased ROS content by decreasing FOXO3A in chondrocytes, which led to the activation of NF- κB pathway and ECM homeostasis imbalance.
Source: Journal of Bone and Mineral Metabolism - September 26, 2022 Category: Orthopaedics Source Type: research

Metabolic Switch Under Glucose Deprivation Leading to Discovery of NR2F1 as a Stimulus of Osteoblast Differentiation
In conclusion, the results of this study provide an understanding of the metabolic profile of implanted cells in an ischemic microenvironment and demonstrate that NR2F1 treatment may overcome this deprivation by enhancing AKT and ERK regulation. These findings can be utilized in regenerative medicine for bone regeneration. © 2022 American Society for Bone and Mineral Research (ASBMR).
Source: Journal of Bone and Mineral Research - May 23, 2022 Category: Orthopaedics Authors: Eugene Lee, Seo ‐Young Park, Jae‐Yeon Moon, Ji‐Yun Ko, Tae Kyung Kim, Gun‐Il Im Tags: Original Article Source Type: research

Metabolic switch under glucose deprivation leading to discovery of NR2F1 as a stimulus of osteoblast differentiation
In conclusion, the results of this study provide an understanding of the metabolic profile of implanted cells in an ischemic microenvironment and demonstrate that NR2F1 treatment may overcome this deprivation by enhancing AKT and ERK regulation. These findings can be utilized in regenerative medicine for bone regeneration.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - April 24, 2022 Category: Orthopaedics Authors: Eugene Lee, Seo ‐Young Park, Jae‐Yeon Moon, Ji‐Yun Ko, Tae Kyung Kim, Gun‐Il Im Tags: Original Article Source Type: research

Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction
Study Design. In vitro experimental study. Objective. To establish an axial impact injury model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate structural disruption could initiate intervertebral disc degeneration (IDD), and what is the roles of Piezo1 in this process. Summary of Background Data. Although IDD process has been confirmed to be associated with structural failures such as endplate fractures, whether a single impact injury of the endplates without structural disruption could initiate IDD remains controversial. Previous studies reported that Piezo1 med...
Source: Spine - February 8, 2022 Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research

The construction of a novel xenograft bovine bone scaffold, (DSS)6-liposome/CKIP-1 siRNA/calcine bone and its osteogenesis evaluation on skull defect in rats
Publication date: May 2021Source: Journal of Orthopaedic Translation, Volume 28Author(s): Gang Xu, Xiantong Hu, Liwei Han, Yantao Zhao, Zhonghai Li
Source: Journal of Orthopaedic Translation - March 3, 2021 Category: Orthopaedics Source Type: research

LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF- β/SMAD4 signaling
ConclusionsOur results demonstrate LncRNA PVT1 is involved in cartilage degradation in diabetic OA and correlated with disease severity. Efficiency of ad-siRNA-PVT1 in controlling joint inflammation in diabetic OA mice is associated with the suppression of the expression of miR-146a, pro-inflammatory cytokines and activation of TGF- β/SMAD4 pathway.
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Delta-like Factor 1 as a Possible Therapeutic Target for Sarcomas.
Conclusions: Our study showed that the DLK1 gene induces tumorigenesis in various sarcomas and is associated with invasive mechanism in sarcoma. These results suggest DLK1 could serve as a possible therapeutic target in a variety of sarcomas. PMID: 32904069 [PubMed - in process]
Source: Clinics in Orthopedic Surgery - September 11, 2020 Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Long non-coding RNA PCAT-1 regulates apoptosis of chondrocytes in osteoarthritis by sponging miR-27b-3p
ConclusionsBased on the comparisons and analysis, we could conclude that lncRNA PCAT-1 regulated the apoptosis of chondrocytes through sponging miR-27b-3p in OA. PCAT-1 has potential values to act as a new therapeutic target for OA patients.
Source: Journal of Bone and Mineral Metabolism - August 7, 2020 Category: Orthopaedics Source Type: research

Cyclin-dependent kinase 12 (CDK12) in chordoma: prognostic and therapeutic value
ConclusionHigh expression of CDK12 is an independent predictor of poor prognosis in chordoma. Inhibition of CDK12 significantly decreased chordoma cell proliferation and induced apoptosis. Our results support CDK12 as a novel prognostic biomarker and therapeutic target in chordoma.
Source: European Spine Journal - July 19, 2020 Category: Orthopaedics Source Type: research

Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain.
Conclusions: The results revealed that activation of mGluR8 in PAG is not capable of improving the thermal hyperalgesia threshold. Based on the decreased expression of mGluR8 after SCI induced by clip compression injury and its significant increase after treatment of siRNA against mGluR8, this method might still hold promise as an effective treatment of neuropathic pain. It can be concluded that increased expression of mGluR8 is due to the fact that DCPG prevents the death of neurons that express these receptors. PMID: 32460469 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - May 29, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway
In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was examined by CCK8 assay and Edu staining. Cell apoptosis was detected by Annexin V assay under H2O2 treatment. The differentiation of osteoblast was determined by Alizarin red S staining. We also tested the expression of osteoblast phenotype related protein by real-time PCR and Western blot. The interaction between Circ_0001843 and miR-214, miR-214 and TAFA5 was examined by luciferase report assay. Circ_000...
Source: Calcified Tissue International - March 17, 2020 Category: Orthopaedics Source Type: research

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 12, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - February 27, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research