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Specialty: Orthopaedics
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Total 95 results found since Jan 2013.
Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts
In conclusion, Fam210a might enhance myoblast differentiation and proteolysis. Moreover, insulin and 1,25(OH)2D may induce myoblast differentiation and degradation by enhancing the expression of Fam210a.
Source: Calcified Tissue International - January 23, 2020 Category: Orthopaedics Source Type: research
MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes
ConclusionsMiR-203 is critical in the onset and progression of OA, at least in part, caused by estrogen deficiency and ER α instability in OA patients, providing a novel therapeutic target for the treatment of OA.
Source: Journal of Bone and Mineral Metabolism - December 31, 2019 Category: Orthopaedics Source Type: research
Stearic acid methyl ester promotes migration of mesenchymal stem cells and accelerates cartilage defect repair
Publication date: Available online 23 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yamei Liu, Liangliang Xu, Liuchao Hu, Dongfeng Chen, Lijuan Yu, Xican Li, Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo, Bin Wang, Gang LiAbstractMesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homin...
Source: Journal of Orthopaedic Translation - October 24, 2019 Category: Orthopaedics Source Type: research
Long Non-coding RNA XIST May Influence Cervical Ossification of the Posterior Longitudinal Ligament Through Regulation of miR-17-5P/AHNAK/BMP2 Signaling Pathway
This study was conducted to investigate the role and mechanism of lncRNA X inactive specific transcript (XIST) in the occurrence of cervical ossification of the posterior longitudinal ligament (OPLL). Here, primary human ligament fibroblasts cells (LFCs) were isolated from 30 cases of OPLL and 30 normal cervical posterior longitudinal ligament (non-OPLL) tissues to perform the qPCR and Western blot assay. We found that the mRNA level of lncRNA XIST was significantly increased in OPLL LFCs compared to non-OPLL LFCs. By bioinformatics analysis, we found that lncRNA XIST has four binding sites for miR-17-5p and found that the...
Source: Calcified Tissue International - September 10, 2019 Category: Orthopaedics Source Type: research
Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs
AbstractGlucocorticoid (GC)-induced osteonecrosis has been considered as the most serious side effect in long-term or over-dose steroid therapy. The decreased bone mass and increased marrow fat tissue demonstrated that GC can destroy the normal differentiation of bone marrow mesenchymal stem cells (BMSCs), which accelerates adipogenesis but not osteogenesis. However, the underlying mechanisms are still unclear. Ski, an evolutionary conserved protein, is a multifunctional transcriptional regulator that involved in regulating signaling pathways associated with adipogenesis differentiation, but the concrete function remains u...
Source: Calcified Tissue International - July 29, 2019 Category: Orthopaedics Source Type: research
Cyclic Dinucleotides Inhibit Osteoclast Differentiation Through STING ‐Mediated Interferon‐β Signaling
In this study, we investigated the effect of CDNs on the differentiation and function of osteoclasts and osteoblasts. When bone marrow‐derived macrophages (BMMs) were differentiated into osteoclasts with macrophage colony‐stimulating factor (M‐CSF) and receptor activator of NF‐κB ligand (RANKL) in the presence of CDNs, the differentiation was inhibited by CDNs in a dose‐d ependent manner. In contrast, CDNs did not influence the differentiation of committed osteoclasts or osteoblast precursors. STING signaling pathway appeared to be critical for CDNs‐mediated inhibition of osteoclast differentiation since CDNs ...
Source: Journal of Bone and Mineral Research - July 14, 2019 Category: Orthopaedics Authors: Yeongkag Kwon,
Ok ‐Jin Park,
Jiseon Kim,
Jae‐Ho Cho,
Cheol‐Heui Yun,
Seung Hyun Han Tags: Original Article Source Type: research
Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/ β‐Catenin in Primary Cilia of Osteoblasts
ABSTRACTExtremely low ‐frequency electromagnetic fields have been considered a potential candidate for the prevention and treatment of osteoporosis; however, their action mechanism and optimal magnetic flux density (intensity) parameter are still elusive. The present study found that 50‐Hz sinusoidal electromagnetic fields (SEMFs) at 1.8 mT increased the peak bone mass of young rats by increasing bone formation. Gene array expression studies with femoral bone samples showed that SEMFs increased the expression levels of collagen‐1α1 and Wnt10b, a critical ligand of the osteogenic Wnt/β‐catenin pathway. Con sistent...
Source: Journal of Bone and Mineral Research - July 14, 2019 Category: Orthopaedics Authors: Jian Zhou,
Yu ‐Hai Gao,
Bao‐Ying Zhu,
Jia‐Le Shao,
Hui‐Ping Ma,
Cory J Xian,
Ke‐Ming Chen Tags: Original Article Source Type: research
Chondrocytes Promote Vascularization in Fracture Healing Through a FOXO1 ‐Dependent Mechanism
We examined the role of chondrocytes in angiogenesis during fracture healing and the role of the transcription factor forkhead box ‐O 1 (FOXO1), which upregulates wound healing in soft tissue. Closed fractures were induced in experimental mice with lineage‐specific FOXO1 deletion by Cre recombinase under the control of a collagen‐2α1 promoter element (Col2α1Cre+FOXO1L/L) and Cre recombinase negative control littermates containing flankingloxP sites (Col2 α1Cre–FOXO1L/L). Experimental mice had significantly reduced CD31+ new vessel formation. Deletion of FOXO1 in chondrocytes in vivo suppressed the expression of ...
Source: Journal of Bone and Mineral Research - March 11, 2019 Category: Orthopaedics Authors: Citong Zhang,
Daniel Feinberg,
Mohammed Alharbi,
Zhenjiang Ding,
Chanyi Lu,
J Patrick O'Connor,
Dana T Graves Tags: Original Article Source Type: research
Cyclic Dinucleotides Inhibit Osteoclast Differentiation Through STING ‐Mediated Interferon‐β Signaling
In this study, we investigated the effect of CDNs on the differentiation and function of osteoclasts and osteoblasts. When bone marrow‐derived macrophages (BMMs) were differentiated into osteoclasts with macrophage colony‐stimulating factor (M‐CSF) and receptor activator of NF‐κB ligand (RANKL) in the presence of CDNs, the differentiation was inhibited by CDNs in a dose‐d ependent manner. In contrast, CDNs did not influence the differentiation of committed osteoclasts or osteoblast precursors. STING signaling pathway appeared to be critical for CDNs‐mediated inhibition of osteoclast differentiation since CDNs ...
Source: Journal of Bone and Mineral Research - March 5, 2019 Category: Orthopaedics Authors: Yeongkag Kwon,
Ok ‐Jin Park,
Jiseon Kim,
Jae‐Ho Cho,
Cheol‐Heui Yun,
Seung Hyun Han Tags: Original Article Source Type: research
Cyclic Dinucleotides Inhibit Osteoclast Differentiation Through STING ‐mediated Interferon‐β Signaling
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - February 19, 2019 Category: Orthopaedics Authors: Yeongkag Kwon,
Ok ‐Jin Park,
Jiseon Kim,
Jae Ho Cho,
Cheol‐Heui Yun,
Seung Hyun Han Tags: Original Article Source Type: research
Sinusoidal electromagnetic fields increase peak bone mass in rats by activating Wnt10b/ β‐catenin in primary cilia of osteoblasts
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - February 19, 2019 Category: Orthopaedics Authors: Jian Zhou,
Yu ‐Hai Gao,
Bao‐Ying Zhu,
Jia‐Le Shao,
Hui‐Ping Ma,
Cory J Xian,
Ke‐Ming Chen Tags: Original Article Source Type: research
Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
In this study, we aimed to explore the functions of Ras-related protein Rab-31 (RAB31) in OS-cell proliferation, migration, and invasion as well as its roles in the Hedgehog signaling pathway for better understanding of the mechanism. To assess the detailed regulatory mechanism of RAB31 silencing on OS, both RT-qPCR and Western blot analysis were employed to evaluate the expressions of RAB31 as well as the Hedgehog signaling pathway-related genes. Besides, we also investigated the effects of silenced RAB31 both in vitro and in vivo. First, we found that in OS tissues, both mRNA and protein expressions of RAB31 and PCNA had...
Source: Journal of Bone and Mineral Metabolism - November 23, 2018 Category: Orthopaedics Source Type: research
