Percutaneous short-segment pedicle instrumentation assisted with O-arm navigation in the treatment of thoracolumbar burst fractures
Publication date: Available online 5 December 2019Source: Journal of Orthopaedic TranslationAuthor(s): Peng Yang, Kangwu Chen, Kai Zhang, Jiajia Sun, Huilin Yang, Haiqing Mao (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 6, 2019 Category: Orthopaedics Source Type: research

PEG-sheddable reduction-sensitive polyurethane micelles for triggered intracellular drug delivery for osteosarcoma treatment
In this study, PEG-sheddable reduction-sensitive polyurethane (SS-PU-SS-PEG) micelles were prepared for triggered intracellular drug delivery to improve the therapy efficacy of osteosarcoma. The SS-PU-SS-PEG micelles were about 80~90 ​nm in diameter and exhibited good biocompatibility and decent stability in PBS. In vitro drug release studies revealed that drug-loaded SS-PU-SS-PEG micelles released doxorubicin (DOX), a model drug used in this study, in a well-controlled fashion under a reductive environment. Nearly, 80% of the drug was released within 5 ​h. Intracellular release of DOX from the SS-PU-SS-PEG...
Source: Journal of Orthopaedic Translation - December 6, 2019 Category: Orthopaedics Source Type: research

Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
This article reviews the potential role of exosomes in OA regenerative medicine. Special attention is given to mesenchymal stem cells-derived exosomes due to the extensive research on their cartilage repair property and their function as miRNA cargo. More investigations are needed for the effects of exosomes from synovial fluid and chondrocytes in joints. A better understanding of the mechanisms will contribute to a novel and promising therapy for OA patients. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - December 6, 2019 Category: Orthopaedics Source Type: research

Different subchondral trabecular bone microstructure and biomechanical properties between developmental dysplasia of the hip and primary osteoarthritis
Publication date: Available online 27 September 2019Source: Journal of Orthopaedic TranslationAuthor(s): Linyang Chu, Zihao He, Xinhua Qu, Xuqiang Liu, Weituo Zhang, Shuo Zhang, Xuequan Han, Mengning Yan, Qi Xu, Shuhong Zhang, Xifu Shang, Zhifeng YuAbstractObjectiveDevelopmental dysplasia of the hip (DDH) is recognized as a frequent cause of secondary osteoarthritis (OA). The purpose in this study was to compare structural and biomechanical properties of subchondral trabecular bone ​and its relationship with cartilage damage between patients with DDH and patients with primary hip OA.MethodsForty-three femoral head s...
Source: Journal of Orthopaedic Translation - December 3, 2019 Category: Orthopaedics Source Type: research

A preliminary study of a novel robotic system for pedicle screw fixation: A randomised controlled trial
ConclusionThe outcome of screw accuracy of this robotic system was comparable with that of experienced surgeons, and no screw-related complication was found in the RA group during hospitalisation. In addition, radiation time per screw in the robotic group was significantly lower than that in the conventional group, which shows the potential to reduce radiation exposure of pedicle screw fixation assisted by this robotic system.Translational potentialOur study shows that pedicle screw fixation assisted by “Orthbot” system is accurate and safe. It is concluded that this novel robotic system offers a new option for...
Source: Journal of Orthopaedic Translation - November 26, 2019 Category: Orthopaedics Source Type: research

Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone
Publication date: Available online 21 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yong Dai, Han Guo, Linyang Chu, Zihao He, Minqi Wang, Shuhong Zhang, Xifu ShangAbstractPolyetheretherketone (PEEK) as an implanted biomaterial for bone substitute has become increasingly popular in orthopaedic and dental applications. However, PEEK is a bioinert material which displays no osteoconductivity. In this work, a bioactive coating of nanosilicon nitride (Si3N4, SN) with micro/nano structures on PEEK (CSNPK) was created by a method of suspension coating and melt bonding. The results revealed that surface roughne...
Source: Journal of Orthopaedic Translation - November 22, 2019 Category: Orthopaedics Source Type: research

Subchondral bone deterioration in femoral heads in patients with osteoarthritis secondary to hip dysplasia: A case–control study
ConclusionsOsteoarthritic deteriorations of subchondral bone induced by hip dysplasia spread throughout the whole joint, but exhibit region-dependent variations, with the weight-bearing region more seriously affected. Biomechanical stress might exert a pivotal impact on subchondral bone homeostasis in hip dysplasia.The translational potential of this articleThe histomorphometric findings in the project indicate an early intervention for the development of hip dysplasia in clinic. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 22, 2019 Category: Orthopaedics Source Type: research

Diffusion of neutral solutes within human osteoarthritic cartilage: Effect of loading patterns
ConclusionsTo our knowledge, this is the first study to combine the cyclic compression and CEμCT scanning in the diffusion testing of human OA cartilage. This loading pattern could simulate the physiological conditions and reduce the time to reach solute equilibrium within cartilage. The diffusion data may contribute to joint drug-injection therapies for early OA.The translational potential of this articleThe combination of cyclic loading and CEμCT scanning enabled diffusion analysis of osteoarthritic cartilage under different compressions. A comprehensive evaluation of OA cartilage and subchondral bone may benefit f...
Source: Journal of Orthopaedic Translation - November 22, 2019 Category: Orthopaedics Source Type: research

Lubricin expression in the lumbar endplate and its association with Modic changes
ConclusionLubricin is present in the lumbar endplate where it may have an anti-inflammatory role. P. acnes infection inhibits lubricin expression by cartilage endplate cells and this may facilitate the progression of MCs and endplate degeneration.The translational potential of this articleLubricin may have an anti-inflammatory role. P. acnes infection inhibits lubricin expression by cartilage endplate cells and this may facilitate the progression of MCs and endplate degeneration. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 16, 2019 Category: Orthopaedics Source Type: research

The influence of sample size and gender composition on the metaanalysis conclusion of platelet-rich plasma treatment for osteoarthritis
ConclusionsAccording to the currently available data, PRP injections are beneficial for pain relief and function improvement in patients with OA. This metaanalysis, however, demonstrated that the efficacy of PRP is related to sample size and gender composition. Thus, more randomised controlled trials of high quality and larger patient size, also including gender aspects, are required to understand this phenomenon. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 16, 2019 Category: Orthopaedics Source Type: research

Three-dimensional distribution of cystic lesions in osteonecrosis of the femoral head
ConclusionsCystic lesions most often occur at the junction of the necrotic ​and normal areas and are most commonly located in the anterolateral femoral head, which is similar to the distribution of the stress concentration region. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 14, 2019 Category: Orthopaedics Source Type: research

Comparing clinical outcomes of using 3 versus 5 titanium miniplates in laminoplasty for multilevel cervical myelopathy: A prospective cohort study
Publication date: Available online 13 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Wei Ji, Yi-Jian Zhang, Feng Zhou, Hai-qing Mao, Hui-lin Yang, Tao LiuAbstractStudy designProspective cohort study.ObjectiveThe aim of this study was to compare clinical outcomes, radiographic changes, and complications of cervical expansive open-door laminoplasty(EOLP)for cervical multilevel myelopathy, using either 3 or 5 titanium miniplates.Summary of background dataCervical EOLP is a common and effective operation for cervical myelopathy. Standard procedures utilize either 3 or 5 titanium miniplates; however, no d...
Source: Journal of Orthopaedic Translation - November 14, 2019 Category: Orthopaedics Source Type: research

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)
Publication date: Available online 11 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Wise Young, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari Shanker Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, Shiqing Feng, International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, &...
Source: Journal of Orthopaedic Translation - November 12, 2019 Category: Orthopaedics Source Type: research

Underreporting characteristics of osteoporotic vertebral fracture in back pain clinic patients of a tertiary hospital in China
ConclusionAmong the patients with VCD/VCF, the false negative rate among was 23.9% (17/71), but the missed cases were all minimal or mild grades. One or more VCFs were missed in 32.4% (23/71) of the cases with multiple VCFs. Appropriate severity grading was not reported for most cases. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 10, 2019 Category: Orthopaedics Source Type: research

Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats
ConclusionsSpinal instability induced by CMS increases bone mass and biomechanical loading of the ventral side of vertebrae in the early stage, which might initiate VEP damage and cause intervertebral disc degeneration.The translational potential of this articleOur study indicates that vertebral trabecular changes may involve in intervertebral disc degeneration induced by spinal instability. This may help to elucidate the mechanisms by which disc degeneration occur. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 7, 2019 Category: Orthopaedics Source Type: research

Development of generic Asian pelvic bone models using CT-based 3D statistical modelling
Publication date: Available online 4 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Marc-Daniel Ahrend, Hansrudi Noser, Rukmanikanthan Shanmugam, Felix Burr, Lukas Kamer, Tunku Kamarul Zaman, Heinz Hügli, Andreas Nagy, Robert Geoff Richards, Boyko Gueorguiev-RüeggAbstractBackground/ObjectiveArtificial bone models (ABMs) are used in orthopaedics for research of biomechanics, development of implants and educational purposes. Most of the commercially available ABMs approximate the morphology of Europeans, but they may not depict the Asian anatomy. Therefore, our aim was to develop the first Asian ...
Source: Journal of Orthopaedic Translation - November 5, 2019 Category: Orthopaedics Source Type: research

Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model
ConclusionsQuadriceps muscle atrophy triggered the subchondral bone abnormal change and cartilage degeneration, which would be a risk factor for development of osteoarthritis. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 2, 2019 Category: Orthopaedics Source Type: research

Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon
ConclusionTaken together, this study showed that TSPCs are capable of differentiating towards fibrocartilage-like cells, and the fibrochondrogenic characteristics were conserved even in vivo, and thus might have the potential application for fibrocartilage regeneration in BTJ repair.The translational potential of this articleTSPCs are able to differentiate into fibrocartilage-like cells and thus might well be one potential cell source for fibrocartilage regeneration in a damaged BTJ repair. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - November 2, 2019 Category: Orthopaedics Source Type: research

Comparison of O-arm navigation and microscope-assisted minimally invasive transforaminal lumbar interbody fusion and conventional transforaminal lumbar interbody fusion for the treatment of lumbar isthmic spondylolisthesis
The objective of this study is to compare the clinical efficacy of O-arm navigation and microscope-assisted minimally invasive transforaminal lumbar interbody fusion (modified MIS-TLIF) versus conventional TLIF in the lumbar isthmic spondylolisthesis.Materials and methodsForty patients with 1-level lumbar isthmic spondylolisthesis were enrolled in the study. Perioperative indexes including operation time, intraoperative bleeding, bed rest time, time of hospitalisation stay and the accuracy rate of screw placement were analysed. Preoperative and postoperative visual analogue scale (VAS) and Oswestry disability index (ODI) w...
Source: Journal of Orthopaedic Translation - November 1, 2019 Category: Orthopaedics Source Type: research

Stearic acid methyl ester ​promotes migration of mesenchymal stem cells and accelerates cartilage defect repair
Publication date: Available online 23 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yamei Liu, Liangliang Xu, Liuchao Hu, Dongfeng Chen, Lijuan Yu, Xican Li, Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo, Bin Wang, Gang LiAbstractMesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homin...
Source: Journal of Orthopaedic Translation - October 24, 2019 Category: Orthopaedics Source Type: research

A novel percutaneous crossed screws fixation in treatment of Day type II crescent fracture–dislocation: A finite element analysis
ConclusionsWith sufficient biomechanical stability and minimally invasive advantage, percutaneous crossed screw fixation is a recommended treatment for Day Type-II Crescent Fracture–dislocation. It is recommended to fix crescent fracture fragment and sacroiliac joint simultaneously during the operation. If it is difficult to fix the both position, the sacroiliac joint is preferentially fixed.The translational potential of this articleThere is a controversy on the operative approach and fixation technique of Day type-II crescent fracture–dislocation. This article proves that percutaneous crossed screw fixation i...
Source: Journal of Orthopaedic Translation - October 23, 2019 Category: Orthopaedics Source Type: research

Systematic effects of femoral component rotation and tibial slope on the medial and lateral tibiofemoral flexion gaps in total knee endoprostheses
Publication date: Available online 22 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Claudio Stöbe, Sebastian Hoechel, Magdalena Müller-Gerbl, Andrej M. NowakowskiAbstractPurposeTo quantify the effects of the systematic internal and external femoral component rotations and tibial slope on the medial and lateral tibiofemoral gaps in total knee endoprostheses.MethodsNineteen knee cadaver specimens with an intact ligament apparatus were fixed in a custom frame, facilitating physiological flexion motion. Virtual total knee arthroplasty was performed on three-dimensional models obtained from computed...
Source: Journal of Orthopaedic Translation - October 23, 2019 Category: Orthopaedics Source Type: research

Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants
In this study, a facile method was applied to fabricate a zoledronate-loaded coating on AZ31 Mg alloy in comparison with the previous construction strategies, such as Ca–P chelation with BPs. The results showed that the fluoride-pretreated coating could provide better corrosion resistance. Zoledronic acid was successfully loaded on the surface of Mg alloy, detected by X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analysis, and the release profile was quantified by UV detection. It is considered that this construction of zoledronate-coated Mg-based orthopaedic implants could be easily an...
Source: Journal of Orthopaedic Translation - October 20, 2019 Category: Orthopaedics Source Type: research

State-of-the-art research in robotic hip exoskeletons: A general review
Publication date: Available online 14 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Bing Chen, Bin Zi, Ling Qin, Qiaosheng PanAbstractAgeing population is now a global challenge, where physical deterioration is the common feature in elderly people. In addition, the diseases, such as spinal cord injury, stroke, and injury, could cause a partial or total loss of the ability of human locomotion. Thus, assistance is necessary for them to perform safe activities of daily living. Robotic hip exoskeletons are able to support ambulatory functions in elderly people and provide rehabilitation for the patients with...
Source: Journal of Orthopaedic Translation - October 15, 2019 Category: Orthopaedics Source Type: research

Design of a new magnesium-based anterior cruciate ligament interference screw using finite element analysis
ConclusionIt was concluded that improving the design of a Mg-based screw may increase surgical success rates, by decreasing device failure at insertion.The translational potential of this articleThe results of this work have the potential to improve designs of degradable IFSs, allowing for greater torque to be applied and thus greater screw fixation between host bone and the graft. Such a fixation will allow greater integration, better patient healing, and ultimately improved patient outcomes. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - October 15, 2019 Category: Orthopaedics Source Type: research

Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview
Publication date: Available online 8 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Meng Zhang, Jukka P. Matinlinna, James K.H. Tsoi, Wenlong Liu, Xu Cui, William W. Lu, Haobo PanAbstractReconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone...
Source: Journal of Orthopaedic Translation - October 9, 2019 Category: Orthopaedics Source Type: research

Different subchondral trabecular bone microstructures and biomechanical properties between developmental dysplasia of the hip and primary osteoarthritis
Publication date: Available online 27 September 2019Source: Journal of Orthopaedic TranslationAuthor(s): Linyang Chu, Zihao He, Xinhua Qu, Xuqiang Liu, Weituo Zhang, Shuo Zhang, Xuequan Han, Mengning Yan, Qi Xu, Shuhong Zhang, Xifu Shang, Zhifeng YuAbstractObjectiveDevelopmental dysplasia of the hip (DDH) is recognized as a frequent cause of secondary osteoarthritis (OA). The purpose in this study was to compare structural and biomechanical properties of subchondral trabecular bone ​and its relationship with cartilage damage between patients with DDH and patients with primary hip OA.MethodsForty-three femoral head s...
Source: Journal of Orthopaedic Translation - September 28, 2019 Category: Orthopaedics Source Type: research

Reduced expression of carbonic anhydrase III in skeletal muscles could be linked to muscle fatigue: A rat muscle fatigue model
Publication date: Available online 23 September 2019Source: Journal of Orthopaedic TranslationAuthor(s): Atik B. Shaikh, Hongwei Fang, Min Li, Shiyi Chen, Peng Shang, Xiliang ShangAbstractBackgroundCarbonic anhydrase III (CAIII) is expressed abundantly in slow skeletal muscles, adipocytes, and the liver. It plays a critical role in maintaining intracellular pH, antioxidation, and energy metabolism, which are further involved in fatigue. However, its function and mechanism in maintaining the physiological function of muscles or antifatigue are still ambiguous. We hypothesized that changes of CAIII in skeletal muscles might ...
Source: Journal of Orthopaedic Translation - September 24, 2019 Category: Orthopaedics Source Type: research

Long-term outcome after revision of hip arthroplasty with the BioBall® adapter system in multimorbid patients
ConclusionsIn multimorbid patients, using the BioBall® adapter system for total hip arthroplasty, revision due to dislocation results in good long-term outcome without impairment of quality of life. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 21, 2019 Category: Orthopaedics Source Type: research

A preliminary study of a novel robotic system for pedicle screw fixation: A randomized controlled trial
ConclusionThe outcome of screw accuracy of this robotic system was comparable with that of experienced surgeons, and no screw-related complication was found in the RA group during hospitalization. In addition, radiation time per screw in the robotic group was significantly lower than that in the conventional group, which shows the potential to reduce radiation exposure of pedicle screw fixation assisted by this robotic system. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 18, 2019 Category: Orthopaedics Source Type: research

Does mobile-bearing have better flexion and axial rotation than fixed-bearing in total knee arthroplasty? A randomised controlled study based on gait
Publication date: Available online 9 September 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yi-Ming Zeng, Meng-Ning Yan, Hui-Wu Li, Jun Zhang, You WangAbstractObjectiveTo analyse the 6 degrees of freedom of the knee and gait data of patients with medial knee osteoarthritis before and after fixed-bearing (FB) and mobile-bearing (MB) total knee arthroplasty (TKA) ​and examine the influence of TKA on gait characteristics and the difference between FB and MB prosthesis. We also sought to explore the prosthesis options available for TKA in these patients.MethodsThirty patients who underwent TKA at the Departm...
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research

Evaluation of hollow mesh augmentation on the biomechanical properties of the flexor tendon repaired with modified Kessler technique
ConclusionOur data have demonstrated that MK repair augmented with the centre hollow mesh suture increased failure strength without inducing increased friction.The translational potential of this articleOur study elucidates that a Tri-C augmentation designed in this study can achieve mechanical enhancements without increasing the repaired tendon friction. Hence, this novel technique has potential biological validity and clinical application. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research

The efficacy and safety of denosumab in postmenopausal women with osteoporosis previously treated with bisphosphonates: A review
ConclusionThe outcomes and treatment compliance were improved in postmenopausal osteoporotic women who shifted to denosumab from bisphosphonates.The translational potential of this articleThe replacement of bisphosphonates with denosumab may lead to better therapeutic efficacy and fewer adherence barriers ​than those with continued usage of bisphosphonates, which in the future may guide the choice of drug therapy in clinics. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 11, 2019 Category: Orthopaedics Source Type: research

Association between the ABO blood group and primary knee osteoarthritis: A case–control study
ConclusionsThis study suggested that the blood group AB was associated with primary knee osteoarthritis, as well as its radiological severity. Further study indicated that LeY antigen, which was related to the blood group, was associated with primary knee osteoarthritis. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 6, 2019 Category: Orthopaedics Source Type: research

A novel percutaneous crossed screws fixation in treatment of Day type II crescent fFracture–dislocation: A finite element analysis
ConclusionsWith sufficient biomechanical stability and minimally invasive advantage, percutaneous crossed screw fixation is a recommended treatment for Day Type-II Crescent Fracture–dislocation. It is recommended to fix crescent fracture fragment and sacroiliac joint simultaneously during the operation. If it is difficult to fix the both position, the sacroiliac joint is preferentially fixed. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 5, 2019 Category: Orthopaedics Source Type: research

A novel calcium phosphate–based nanocomposite for the augmentation of cement-injectable cannulated pedicle screws fixation: A cadaver and biomechanical study
Publication date: Available online 5 September 2019Source: Journal of Orthopaedic TranslationAuthor(s): Haolin Sun, Chun Liu, Xuwen Li, Huiling Liu, Weiguang Zhang, Huilin Yang, Chunde Li, Lei YangAbstractBackground/objectiveBoth polymethylmethacrylate (PMMA) and traditional calcium phosphate–based cements have some deficiencies as augmentation materials for pedicle screw fixation. Here, a novel calcium phosphate–based nanocomposite (CPN) for the augmentation of pedicle screw fixation was developed based on previous study, and the handling properties, biomechanical performance, and biodegradation behaviour of C...
Source: Journal of Orthopaedic Translation - September 5, 2019 Category: Orthopaedics Source Type: research

Development of bone seeker–functionalised microspheres as a targeted local antibiotic delivery system for bone infections
ConclusionWe report the development and characterisation of a DDS which can release antibiotics in a sustained manner. Surface-grafted alendronate groups enhanced bone affinity of the microsphere construct, resulting in a bone targeting DDS.The Translational Potential of this ArticleThe DDS presented can be loaded with hydrophobic antibiotics, representing a potential, versatile and biodegradable candidate to locally treat bone infection. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - September 1, 2019 Category: Orthopaedics Source Type: research

Letter to the editor concerning “Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis” by Chen et al., Journal of Orthopaedic Translation, 2019, https://doi.org/10.1016/j.jot.2018.12.001
Publication date: Available online 27 August 2019Source: Journal of Orthopaedic TranslationAuthor(s): Rob C. Brink, René M. Castelein (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 29, 2019 Category: Orthopaedics Source Type: research

Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
ConclusionGEN inhibits IL-6–induced VEGF expression and angiogenesis partially through the JAK2/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA.The translational potential of this articleOur study provides scientific guidance for the clinical translational research of GEN in the RA treatment. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 23, 2019 Category: Orthopaedics Source Type: research

Current surgical options and innovation for repairing articular cartilage defects in the femoral head
Publication date: Available online 10 August 2019Source: Journal of Orthopaedic TranslationAuthor(s): Dajiang Du, Peichun Hsu, Zhenzhong Zhu, Changqing ZhangAbstractTotal hip arthroplasty is a common surgical technique, yet it has severe complications, such as loosening and repeated revision. Thus, hip-preserving surgical options should be considered first to treat cartilage defects in the femoral head, especially for younger patients. Current surgical options for chondral repair of the femoral head include microfracture, trapdoor procedure, transplantation of osteochondral allografts and autografts, and autologous chondro...
Source: Journal of Orthopaedic Translation - August 10, 2019 Category: Orthopaedics Source Type: research

How much do we know about the role of osteocytes in different phases of fracture healing? A systematic review
ConclusionTo further illustrate the function of osteocytes, additional longitudinal studies with appropriate clinically relevant model to study osteoporotic fractures are crucial. Future investigations on the morphological changes of osteocyte lacuno-canalicular network during healing, osteocyte-mediated signalling molecules in the transforming growth factor-beta-Smad3 pathway, perilacunar remodelling, type of fixation and putative biomarkers to monitor fracture healing are highly desirable to bridge the current gaps of knowledge.The translational potential of this article: This systematic review provides an up-to-date chr...
Source: Journal of Orthopaedic Translation - August 10, 2019 Category: Orthopaedics Source Type: research

Early degeneration of the meniscus revealed by microbiomechanical alteration in a rabbit anterior cruciate ligament transection model
ConclusionThe microbiomechanical properties in the meniscus changed significantly after ACLT and were site dependent. Their alterations occurred before the histological changes of degeneration were observed.The Translational Potential of this ArticleThe results of our study indicated that degeneration promoted meniscus stiffening. Thus, they provide a better understanding of the disease process affecting the meniscus. Our results might be beneficial to understand how mechanical forces distribute throughout the healthy and pathologic joint. They indicate the possibility of early diagnosis using a minimally invasive arthrosc...
Source: Journal of Orthopaedic Translation - August 10, 2019 Category: Orthopaedics Source Type: research

Basic fibroblast growth factor and agarose gel promote ​the ability of immune privilege of allogeneic cartilage transplantation in rats
ConclusionsAllogeneic cartilage transplantation induces acute immune rejection, which compromises the validity of the implant. The combination of basic fibroblast growth factor and agarose gel facilitates the goal of immune privilege and promotes the success of the allograft tissues. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 10, 2019 Category: Orthopaedics Source Type: research

Prevalence of patellofemoral joint osteoarthritis after anterior cruciate ligament injury and associated risk factors: A systematic review
ConclusionsLarge variations of PFJ OA after ACL injury are associated with different follow-up period and surgical techniques. ACL reconstructed population with bone-patellar tendon-bone graft, single-bundle reconstruction, and delayed operation time has a high prevalence of PFJ OA. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Percutaneous vertebral augmentation in special Genant IV osteoporotic vertebral compression fractures
ConclusionDespite a great challenge, vertebral augmentation can be considered as a safe and effective option for treating special the Genant IV OVCF, showing significant restoration of vertebral body height, local kyphotic angle, and daily life function. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signaling
ConclusionThese results suggested that AP significantly abolished the DOX-induced stemness phenotype and metastasis capacity in osteosarcoma cells by inhibiting Sox2 via STAT3 signalling. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Three-dimensional finite-element analysis of aggravating medial meniscus tears on knee osteoarthritis
This study does favour to obtain a better understanding on the symptoms and pathological changes of OA. It also may provide some potential directions for the prophylaxis and treatment of OA. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Benefits of opposite screw insertion technique in medial open-wedge high tibial osteotomy: A virtual biomechanical study
ConclusionThe present study revealed that pretensioned opposite lag screw insertion is a simple and effective technique to improve the structural stability in medial open-wedge HTO. Further biomechanical and clinical verification will be required to enhance user confidence in this technique. (Source: Journal of Orthopaedic Translation)
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Prediction on the plantar fascia strain offload upon Fascia taping and Low-Dye taping during running
ConclusionFrom a mechanical point of view, our study provided quantitative evidence to support the application of taping treatments for overstrained plantar fascia. The untensed fascia band by Fascia taping could be a potential indicator of pain relief for the runners. However, a prospective study targeting the patient population would be needed to address the point.The Translational Potential of this ArticleThe study quantified the loading status of the plantar fascia during running and provided mechanical evidence to support the usage of taping as a mean to reduce fascial strain, thus possibly controlling injury risks fo...
Source: Journal of Orthopaedic Translation - August 7, 2019 Category: Orthopaedics Source Type: research

Clinical neurorestorative therapeutic guidelines for spinal cord injury (International Association of Neurorestoratology/Chinese Association of Neurorestoratology version 2019)
Publication date: Available online 9 July 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Shiqing Feng, Milan Dimitrijevic, Yaping Feng, Wise Young, Tiansheng Sun, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari S. Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, The International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration following spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the...
Source: Journal of Orthopaedic Translation - July 10, 2019 Category: Orthopaedics Source Type: research