Filtered By:
Specialty: ENT & OMF

This page shows you your search results in order of relevance. This is page number 2.

Order by Relevance | Date

Total 59 results found since Jan 2013.

Enhanced expression of SAM‐pointed domain–containing Ets‐like factor in Chronic rhinosinusitis with nasal polyps
ConclusionsOur findings suggested that SPDEF may be regarded as a promising therapeutic target for modulating mucus hypersecretion in CRSwNP. Level of EvidenceN/A. Laryngoscope, 2014
Source: The Laryngoscope - November 6, 2014 Category: ENT & OMF Authors: Jing Bai, Beiping Miao, Xingmei Wu, Xi Luo, Renqiang Ma, Jia Zhang, Lei Li, Jianbo Shi, Huabin Li Tags: Allergy/Rhinology Source Type: research

Corticosteroid Regulates Epithelial Occludin Expression in Nasal Polyps through a MKP-1-Dependent Pathway
Objective: To evaluate the regulatory effect of corticosteroid on occludin expression in polyp tissues of chronic rhinosinusitis with nasal polyps (CRSwNP) patients and in vitro. Methods: Twenty CRSwNP patients were enrolled and subjected to prednisone (30 mg/day for 14 days). The expression of occludin in polyp tissues was examined before and after treatment using immunohistochemical staining and quantitative reverse transcription polymerase chain reaction. Moreover, the expression of occludin in polyp-derived epithelial cells (PECs) and human bronchial epithelial cells (BECs) was examined using Western blot analysis in t...
Source: ORL - November 19, 2014 Category: ENT & OMF Source Type: research

Osteopontin Promotes EZH2 Expression and Tumor Progression in Nasopharyngeal Carcinoma
Objective: To evaluate the possible mechanism of osteopontin (OPN) in the tumor progression of nasopharyngeal carcinoma (NPC). Methods: Twenty NPC specimens and 10 normal biopsy specimens were analyzed, and the expression of OPN and enhancer of zeste homolog 2 (EZH2) was examined by immunohistochemical staining. Moreover, the expression of EZH2 in NPC cell lines was examined using quantitative reverse transcription polymerase chain reaction and Western blot analysis in the presence of recombinant human (rh) OPN and specific inhibitors. NPC cell migration and invasion were evaluated using a transwell chamber in the presence...
Source: ORL - November 27, 2014 Category: ENT & OMF Source Type: research

Delphinidin Inhibits LPS-Induced MUC8 and MUC5B Expression Through Toll-like Receptor 4-Mediated ERK1/2 and p38 MAPK in Human Airway Epithelial Cells.
CONCLUSION: These results suggest that delphinidin attenuates LPS-induced MUC8 and MUC5B expression through the TLR4-mediated ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells. These findings indicated that delphinidin may be a therapeutic agent for control of inflammatory airway diseases. PMID: 25177436 [PubMed]
Source: Clinical and Experimental Otorhinolaryngology - December 2, 2014 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Plasminogen activator inhibitor‐1 regulates tumor initiating cell properties in head and neck cancers
Conclusion The inhibition of PAI‐1 by PAI‐039 or siRNA could suppress HNC‐TICs within HNC cell lines through the down‐regulation of Sox2. This article is protected by copyright. All rights reserved.
Source: Head and Neck - May 1, 2015 Category: ENT & OMF Authors: Yueh‐Chun Lee, Cheng‐Chia Yu, Chih Lan, Che‐Hsin Lee, Hsueh‐Te Lee, Yu‐Liang Kuo, Po‐Hui Wang, Wen‐Wei Chang Tags: Original Article Source Type: research

Plasminogen activator inhibitor‐1 as regulator of tumor‐initiating cell properties in head and neck cancers
ConclusionThe inhibition of PAI‐1 by PAI‐039 or siRNA could suppress head and neck cancer‐TICs within head and neck cancer cell lines through the downregulation of Sox2. © 2015 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - July 16, 2015 Category: ENT & OMF Authors: Yueh‐Chun Lee, Cheng‐Chia Yu, Chih Lan, Che‐Hsin Lee, Hsueh‐Te Lee, Yu‐Liang Kuo, Po‐Hui Wang, Wen‐Wei Chang Tags: Original Article Source Type: research

The role of Smad3 in the fibrotic phenotype in human vocal fold fibroblasts
ConclusionTransforming growth factor‐β1 stimulated profibrotic cell activities in our cell line and these actions were largely reduced with Smad3 knockdown. These data provide continued support for therapeutic targeting of Smad3 for vocal fold fibrosis because it appears to regulate the fibrotic phenotype. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - September 30, 2015 Category: ENT & OMF Authors: Ryan C. Branski, Renjie Bing, Iv Kraja, Milan R. Amin Tags: Laryngology Source Type: research

Increased Expression of FGF19 Contributes to Tumor Progression and Cell Motility of Human Thyroid Cancer
Conclusion Our data revealed that the increased expression of FGF19 might be involved in the malignant behaviors of thyroid cancer, highlighting its potential as a molecular marker for early diagnosis and as a possible target for therapeutic intervention of this disease.
Source: Otolaryngology - Head and Neck Surgery - January 6, 2016 Category: ENT & OMF Authors: Zhang, X., Wang, Z., Tian, L., Xie, J., Zou, G., Jiang, F. Tags: Endocrine Surgery Source Type: research

Spleen tyrosine kinase induces MUC5AC expression in human airway epithelial cell.
CONCLUSION: These results indicated that SYK increased MUC5AC expression via ERK2 and p38 MAPK signaling pathways in human airway epithelial cells. PMID: 26980390 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2016 Category: ENT & OMF Authors: Na HG, Bae CH, Choi YS, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Interleukin (IL) 36 gamma induces mucin 5AC, oligomeric mucus/gel-forming expression via IL-36 receptor-extracellular signal regulated kinase 1 and 2, and p38-nuclear factor kappa-light-chain-enhancer of activated B cells in human airway epithelial cells.
CONCLUSION: These results indicated that IL-36 gamma induced MUC5AC expression via the IL-36 receptor-mediated ERK1/2 and p38/NF-kappa B pathway in human airway epithelial cells. PMID: 29644902 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2018 Category: ENT & OMF Authors: Bae CH, Choi YS, Na HG, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells.
Conclusion: These results demonstrate that ER stress plays an important role in the regulation of MUC5AC and MUC5B via the activations of XBP-1, CHOP, and ATF6 in human nasal airway epithelial cells. PMID: 30336657 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - October 20, 2018 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Impacts of CD40- and CD86-Silenced Antigen-Specific B Cells on the Control of Allergies.
CONCLUSION: This study showed, for the first time, that siRNA-induced CD86-silenced B cells significantly inhibited allergic responses and symptoms antigen-specifically, and that siRNA-induced CD40-/CD86-silenced antigen-specific B cells are a more useful antigen-specific therapy than CD40- or CD86-silenced B cells alone for the control of allergies. Furthermore, it was shown that CD40-/CD86-silenced B cells have stronger inhibition of IgE production and allergic symptoms than CD40-/CD86-silenced DCs. PMID: 31064207 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - May 7, 2019 Category: ENT & OMF Authors: Suzuki M, Matsumoto T, Toyoda K, Nakamura Y, Murakami S Tags: Am J Rhinol Allergy Source Type: research

BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate
CONCLUSIONS: BMP4 enhances cell migration and promotes cell EMT through Smad1 signaling pathway. Abnormal BMP4 mediates migration and EMT through other relevant signaling pathways resulting in NSCL/P. The study provides new insight into the mechanisms of NSCL/P associated with BMP4.n.PMID:35702016 | DOI:10.1177/10556656221105762
Source: The Cleft Palate-Craniofacial Journal - June 15, 2022 Category: ENT & OMF Authors: Jia-Wei Hong Yue Yu Lu-Shan Wang Zheng Li Rui Zhang Qi Wang Zhen Ding Jin-Peng Zhang Mei-Rong Zhang Li-Chun Xu Source Type: research

Stable gene-silence of Kif2a synergistic with 5-fluorouracil suppresses oral tongue squamous cell carcinoma growth in vitro and in vivo
Conclusions: Our data support that Kif2a is a potential molecular target for the therapeutics of recurrent and metastatic SCCOT.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 8, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Yu-Jun Li, Zhi-Min Wei, Chang-Jun Zhu, Xun Qu, Feng-Cai Wei, Xiao-Ming Xing, Wen-Juan Yu Tags: Oral Medicine Source Type: research