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Total 59 results found since Jan 2013.

Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines.
Conclusion: Our results indicate that siRNA E6 and/or E7 may have potential as a gene-specific therapy for human papillomavirus (HPV) type 16 (HPV16)-related squamous cell carcinoma of the head and neck (HNSCC). Objectives: To evaluate the effectiveness of siRNA targeting E6 and/or E7 on the in vitro and in vivo growth suppression of HPV16-related HNSCC. Methods: HPV16-related HNSCC (UM-SCC47) cell lines were used for the present study. Expression of HPV viral oncogenes E6 and/or E7 and their cellular targets, p53 and pRb, was evaluated by real-time PCR, Western blotting, and immunofluorescence staining. To study the effec...
Source: Acta Oto-Laryngologica - May 3, 2013 Category: ENT & OMF Authors: Adhim Z, Otsuki N, Kitamoto J, Morishita N, Kawabata M, Shirakawa T, Nibu KI Tags: Acta Otolaryngol Source Type: research

Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts
ConclusionLipitoid effectively knocked down Smad3 expression across multiple transfection conditions. These preliminary data are encouraging, and lipitoid warrants further investigation with the goal of clinical utility. Level of EvidenceNA. Laryngoscope, 2016
Source: The Laryngoscope - November 30, 2016 Category: ENT & OMF Authors: Iv Kraja, Renjie Bing, Nao Hiwatashi, Bernard Rousseau, Danielle Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

Smad3: An emerging target for vocal fold fibrosis
Conclusion. These data provide a foundation for further investigation regarding the development of novel RNA‐based therapeutics for the VF, specifically locally‐delivered siRNA for challenging fibrotic conditions of the VF.
Source: The Laryngoscope - April 16, 2014 Category: ENT & OMF Authors: Benjamin C. Paul, Benjamin Y. Rafii, Sonate Gandonu, Renjie Bing, Hayley Born, Milan R. Amin, Ryan C. Branski Tags: Original Report Source Type: research

Staphylococcus enterotoxin A induces MUC5B expression via Toll-like receptor 2, extracellular signal-regulated kinase 1/2, and p38 mitogen-activated protein kinase in human airway epithelial cells.
CONCLUSION: These results show for the first time that SEA induces MUC5B expression via TLR2, ERK1/2, and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 24717875 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Song SY, Chi DH, Bae CH, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Asian sand dust increases MUC8 and MUC5B expressions via TLR4-dependent ERK2 and p38 MAPK in human airway epithelial cells.
CONCLUSIONS: These results show that ASD induces MUC8 and MUC5B expressions via TLR4-dependent ERK2 and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 25975246 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - May 1, 2015 Category: ENT & OMF Authors: Choi YS, Bae CH, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Sprouty2 Inhibition Promotes Proliferation and Migration of Periodontal Ligament Cells
ConclusionSpry2 combined with bFGF and EGF stimulation reduced PDL cell migration and proliferation with inducing osteoblastic differentiation. These in vitro findings may provide a molecular basis for novel therapeutic approaches for establishing periodontal tissue regeneration.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - September 1, 2015 Category: ENT & OMF Authors: Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Takaharu Taketomi, Ryo Atomura, Kensuke Yamamichi, Hidefumi Maeda, Fusanori Nishimura Tags: Original Article Source Type: research

Nanoparticle delivery of RNA ‐based therapeutics to alter the vocal fold tissue response to injury
ConclusionsThe current study is the first to demonstrate targeted gene manipulation in the VFs as well as the potential utility of lipitoid for localized delivery of genetic material in vivo. Ideally, these data will serve as a platform for future investigation regarding the functional implications of therapeutic gene manipulation in the VFs. Level of EvidenceNA Laryngoscope, 2017
Source: The Laryngoscope - December 14, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Iv Kraja, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Bernard Rousseau, Milan R. Amin, Danielle M. Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

Effect of Neurokinin-1 Receptor Knockdown on the Expression of RANTES in Allergic Rhinitis
Am J Rhinol Allergy. 2023 Jul 31:19458924231191012. doi: 10.1177/19458924231191012. Online ahead of print.ABSTRACTBACKGROUND: Neurokinin-1 receptor (NK-1R) and normal T cell expressed and secreted (RANTES) have been shown to play important roles in allergic rhinitis (AR). However, whether the regulating effect of NK-1R in AR is achieved via RANTES remains unknown.METHODS: In the present study, Sprague-Dawley rats were sensitized and challenged with ovalbumin to make AR models. During the challenge period, the rats were treated intranasally with NK-1R-specific small interfering RNA (siRNA) for NKR group, negative siRNA for ...
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Hong Wang Jing Wu Ruxin Zhang Source Type: research

Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax
ConclusionThese findings suggest that DBA may be a potential anticancer drug candidate to induce apoptosis through down‐regulation of Sp1 in human oral cancer.
Source: Oral Diseases - January 11, 2013 Category: ENT & OMF Authors: H‐J Yu, J‐A Shin, J‐S Nam, B S Kang, S‐D Cho Tags: Original Article Source Type: research

Effect of Onchocerca volvulus chitinase on MUC5B expression in human airway epithelial cells.
CONCLUSION: These results suggest that chitinase induces MUC5B expression by activation of the p38 MAPK signaling pathway in human airway epithelial cells. PMID: 23406586 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2013 Category: ENT & OMF Authors: Song SY, Seo YJ, Kim YW, Park SY, Bae CH, Kim YD Tags: Am J Rhinol Allergy Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic HDAC inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - July 1, 2013 Category: ENT & OMF Authors: Ji‐Ae Shin, Gyoonhee Han, Song‐Kyu Park, Kiho Lee, Hyun‐Jung Kim, Sung‐Dae Cho, Hwan Mook Kim Tags: Original Article Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors, may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.
Source: Oral Diseases - July 14, 2013 Category: ENT & OMF Authors: J‐A Shin, G Han, S‐K Park, K Lee, H‐J Kim, S‐D Cho, HM Kim Tags: Original Article Source Type: research

IL‐1β‐induced matrix metalloproteinase‐3 regulates cell proliferation in rat dental pulp cells
ConclusionsInterleukin‐1β induces matrix metalloproteinase‐3–regulated cell proliferation and suppresses apoptosis in dental pulp cells.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - December 12, 2013 Category: ENT & OMF Authors: Nobuaki Ozeki, Hideyuki Yamaguchi, Taiki Hiyama, Rie Kawai, Kazuhiko Nakata, Makio Mogi, Hiroshi Nakamura Tags: Original Article Source Type: research