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Total 59 results found since Jan 2013.

HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells
Conclusion: Activating HRAS mutations can confer erlotinib resistance in an HRAS mutant HNSCC cell line. Head Neck, 2013.
Source: Head and Neck - September 30, 2013 Category: ENT & OMF Authors: J. Hun Hah, Mei Zhao, Curtis R. Pickering, Mitchell J. Frederick, Genevieve A. Andrews, Samar A. Jasser, David R. Fooshee, Zvonimir L. Milas, Chad Galer, Daisuke Sano, William N. William, Edward Kim, John Heymach, Lauren A. Byers, Vali Papadimitrakopoulou Tags: Research Article Source Type: research

NFκB Silencing Induces Chromatin Acetylation and Ablates Resistance to Cisplatin in Head and Neck Cancer
Conclusion: Our results suggest that HDAC inhibitors and NFκB targeted therapies may represent viable adjuvant chemotherapy to revert HNSCC resistant to platinum-based therapies.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 21, 2014 Category: ENT & OMF Authors: ALINE CORREA ABRAHAO, LUCIANA O. ALMEIDA, LUCIANA K. ROSSELLI-MURAI, FERNANDA S. GIUDICE, ANDREIA M. LEOPOLDINO, CRISTIANE H. SQUARIZE, ROGERIO M. CASTILHO Tags: Online Only Articles Source Type: research

Relation between the expression of mitotic centromere–associated kinesin and the progression of squamous cell carcinoma of the tongue
Objective: Mitotic centromere–associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).Study Design: Immunohistochemistry was used in 47 cases of SCCOT. Determination of proliferation and migratory capabilities was performed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Transwell chamber assay, respectively, on cells from the human tongue squamous cell carcinoma cell line Tca8113 that were ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 22, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Feng-Gang Xiang, Yu-Jun Li, Xiao-Ming Xing, Ning Wang, Jing-Hua Chi, Wen-Juan Yu Tags: Oral and Maxillofacial Pathology Source Type: research

In vitro study of normoxic epidermal growth factor (EGF)‐induced HIF‐1α, VEGF and BNIP3 expression in head and neck squamous cell carcinoma cell lines: implications for anti‐EGFR therapy
Conclusions The search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, pAkt, pMAPK, and HIF‐1α. Head Neck, 2014
Source: Head and Neck - May 2, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz de Santamaría, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

In vitro study of normoxic epidermal growth factor receptor–induced hypoxia‐inducible factor‐1‐alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti–epidermal growth factor receptor therapy
ConclusionThe search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, phosphorylated protein kinase B, pMAPK, and HIF‐1α. © 2014 Wiley Periodicals, Inc. Head Neck, 2014
Source: Head and Neck - July 7, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz Santa‐María, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

Inhibition of myeloid cell leukemia‐1: Association with sorafenib‐induced apoptosis in human mucoepidermoid carcinoma cells and tumor xenograft
ConclusionTaken together, these findings suggest that sorafenib can be a good anticancer drug candidate for the treatment of MEC. © 2014 Wiley Periodicals, Inc. Head Neck, 2014
Source: Head and Neck - July 19, 2014 Category: ENT & OMF Authors: Hyun‐Ju Yu, Ji‐Ae Shin, Ji‐Youn Jung, Jeong‐Seok Nam, In‐Sun Hong, Nam‐Pyo Cho, Sung‐Dae Cho Tags: Original Article Source Type: research

EGFR inhibition by anti‐CD147 therapy in Cutaneous Squamous cell Carcinoma
Conclusions: Inhibition and down‐regulation of CD147 in cSCC resulted in suppression of the malignant phenotype in vitro and in vivo which may be mediated in part by an alteration in EGFR expression. As a result, CD147 may serve as a potential therapeutic target for advanced cSCC. Head Neck, 2014
Source: Head and Neck - October 1, 2014 Category: ENT & OMF Authors: John W. Frederick, Larissa Sweeny, Yolanda Hartman, Tong Zhou, Eben L. Rosenthal Tags: Original Article Source Type: research

Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling
In conclusion, this study suggests that endogenous PI3K/Akt signaling is an intrinsic protective mechanism of the inner ear. Blockade of PI3K/Akt signaling pathways increases sensitivity to TTS noise-induced hearing loss.
Source: JARO - Journal of the Association for Research in Otolaryngology - March 20, 2015 Category: ENT & OMF Source Type: research

Epidermal growth factor receptor inhibition by anti‐CD147 therapy in cutaneous squamous cell carcinoma
ConclusionInhibition and downregulation of CD147 in cutaneous SCC resulted in suppression of the malignant phenotype in vitro and in vivo, which may be mediated in part by an alteration in EGFR expression. As a result, CD147 may serve as a potential therapeutic target for advanced cutaneous SCC. © 2014 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - June 16, 2015 Category: ENT & OMF Authors: John W. Frederick, Larissa Sweeny, Yolanda Hartman, Tong Zhou, Eben L. Rosenthal Tags: Original Article Source Type: research

Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss
In this study, we investigated the effect of noise exposure on histone H3 lysine 9 acetylation (H3K9ac) in the inner ear of adult CBA/J mice and determined if inhibition of histone deacetylases by systemic administration of suberoylanilide hydroxamic acid (SAHA) could attenuate NIHL. Our results showed that H3K9ac was decreased in the nuclei of outer hair cells (OHCs) and marginal cells of the stria vascularis in the basal region after exposure to a traumatic noise paradigm known to induce permanent threshold shifts (PTS). Consistent with these results, levels of histone deacetylases 1, 2, and 3 (HDAC1, HDAC2 and HDAC3) we...
Source: JARO - Journal of the Association for Research in Otolaryngology - April 18, 2016 Category: ENT & OMF Source Type: research

Effect of High Glucose on MUC5B Expression in Human Airway Epithelial Cells.
Conclusion: These findings suggest that HG induces MUC5B expression via the sequential activations of the EGFR/p38 MAPK signaling pathway in human airway epithelial cells. PMID: 27384035 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - July 9, 2016 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Experimental Study on 1,25(OH)2D3 Amelioration of Oral Lichen Planus through Regulating NF ‐κB Signaling Pathway
ConclusionThese results suggest that 1,25(OH)2D3 plays an anti‐inflammatory role in OLP by mediating NF‐κB signaling pathway but not AP‐1 signaling pathway with a VDR‐dependent manner, predicting vitamin D supplement may be a potential strategy for the OLP management.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - February 22, 2017 Category: ENT & OMF Authors: Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang Tags: Original Article Source Type: research

SMAD3 expression and regulation of fibroplasia in vocal fold injury
ConclusionCumulatively, these data support SMAD3 as a potential master regulator of TGF‐β‐mediated fibrosis. SMAD3 transcription peaked 7 days following injury. Multi‐gene analysis indicated that the therapeutic effectiveness of SMAD3 knockdown may be related to regulation of downstream mediators of fibroplasia and altered TGF‐β signaling. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - May 21, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Iv Kraja, Milan R. Amin, Ryan C. Branski Tags: Laryngology Source Type: research

Clusterin Induces MUC5AC Expression via Activation of NF- κB in Human Airway Epithelial Cells.
Conclusion: These results suggest that nCLU induces MUC5AC expression via the activation of NF-κB signaling pathway in human airway epithelial cells. PMID: 29316784 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - January 12, 2018 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss
In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the humanEHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice. The conditions of noise exposure used in this study led to losses of cochlear synapses and outer hair cells (OHCs) and permanent auditory threshold shifts. Inhibition of G9a with its specific inhibitor BIX 01294 or with siRNA significantly attenuated these pathological features. Treatment with BIX 01294 also prevented the noise-induced decrease of KCNQ4 immun...
Source: JARO - Journal of the Association for Research in Otolaryngology - February 1, 2019 Category: ENT & OMF Source Type: research