The role of Smad3 in the fibrotic phenotype in human vocal fold fibroblasts

ConclusionTransforming growth factor‐β1 stimulated profibrotic cell activities in our cell line and these actions were largely reduced with Smad3 knockdown. These data provide continued support for therapeutic targeting of Smad3 for vocal fold fibrosis because it appears to regulate the fibrotic phenotype. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Laryngology Source Type: research