BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate

CONCLUSIONS: BMP4 enhances cell migration and promotes cell EMT through Smad1 signaling pathway. Abnormal BMP4 mediates migration and EMT through other relevant signaling pathways resulting in NSCL/P. The study provides new insight into the mechanisms of NSCL/P associated with BMP4.n.PMID:35702016 | DOI:10.1177/10556656221105762

Source: The Cleft Palate-Craniofacial Journal - June 15, 2022 Category: ENT & OMF Authors: Jia-Wei Hong Yue Yu Lu-Shan Wang Zheng Li Rui Zhang Qi Wang Zhen Ding Jin-Peng Zhang Mei-Rong Zhang Li-Chun Xu Source Type: research