Vanderbilt-led team discovers new genetic disease and defines underlying mechanism
(Vanderbilt University Medical Center) An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms: cleft palate, cataracts, tooth abnormality, intellectual disability, facial dysmorphism and ADHD. The investigators report in Nature Medicine that the new disease is caused by a defect in collagen secretion. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 13, 2020 Category: International Medicine & Public Health Source Type: news

Early Signs Types and Stages of Cleft Palate
Cleft Palate: Early Signs, Types, and Stages (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 16, 2019 Category: General Medicine Source Type: news

Poor asthma control in pregnancy linked to serious adverse outcomes
Maternal asthma exacerbation linked to increased risk of pre-eclampsia, low birth weight, preterm birth, heart defect and cleft lip Related items fromOnMedica Tool helps GPs predict risk of epilepsy seizures in pregnancy Parental confidence in immunisation programme ‘very high’ NHS staff, patients and parents urged to get flu vaccine SSRIs raise risk of rare neonatal hypertension Caffeine in pregnancy linked to risk of child overweight (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 27, 2019 Category: UK Health Source Type: news

What is the Lifespan for a Child with Holoprosencephaly?
Discussion Holoprosencephaly (HPE) is a clefting problem of the brain. “[HPE] the result of incomplete or absent midline division of the embryonic forebrain into distinct cerebral hemispheres (prosencephalon) between the 18th and 28th day after conception.” There are four distinct subtypes: Alobar – both hemispheres are completely fused and are not separated into the left and right hemispheres. There is agenesis of the corpus callosum, arrhinencephaly and a single ventricle with fused thalami. Facial features are almost always affected. Semilobar – the cerebral hemispheres are fused anteriorly bu...
Source: PediatricEducation.org - November 18, 2019 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Nasoalveolar Molding Corrects Cleft Lip and Palate with Fewer Surgeries
Treatment TermsPediatric Plastic and Reconstructive SurgeryCleft Lip and Cleft Palate Repair Author Bryan Roth Overview If your child is born with a cleft lip or cleft palate, a customized orthodontic device called nasoalveolar molding (NAM) can help correct your child ’s cleft. It allows for fewer surgeries to achieve a symmetrical appearance. According to Pedro Santiago, DMD, a craniofacial orthodontist with the Duke Cleft and Craniofacial team who helped develop the NAM technique,"No other techniques can make the adjustments in the nose like the NAM molding does, and that's the most important structu...
Source: dukehealth.org: Duke Health News - October 24, 2019 Category: Consumer Health News Authors: br44 at duke.edu Source Type: news

Baby born with webbed fingers and toes will have life-changing surgery
Amaya John, five months, from Barry in Wales, has Apert syndrome. This has also left her with a protruding forehead and cleft lip. The five-month-old has to breathe via a machine. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2019 Category: Consumer Health News Source Type: news

Kenya: Nairobi Hospital Inspires Hope for Cleft Lip and Palate Cases
[Capital FM] Nairobi -It is 5 o'clock on a chilly Friday morning, and Mzee Taiko and his wife Melicile have embarked on a long journey to Nairobi for a free screening and reconstructive surgery on cleft lip and cleft palate at the Nairobi Hospital. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 21, 2019 Category: African Health Source Type: news

IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion
Cleft palate is a common craniofacial defect caused by a failure in palate fusion. The palatal shelves migrate toward one another and meet at the embryonic midline, creating a seam. Transforming growth factor–β3 (TGF-β3)–induced apoptosis of the medial edge epithelium (MEE), the cells located along the seam, is required for completion of palate fusion. The transcription factor interferon regulatory factor 6 (IRF6) promotes TGF-β3–induced MEE cell apoptosis by stimulating the degradation of the transcription factor Np63 and promoting the expression of the gene encoding the cyclin-dependent k...
Source: Signal Transduction Knowledge Environment - August 6, 2019 Category: Science Authors: Ke, C.-Y., Mei, H.-H., Wong, F.-H., Lo, L.-J. Tags: STKE Research Articles Source Type: news

Repairing Cleft Lip and Cleft Palate with Fewer Surgeries
Treatment TermsCleft Lip and Cleft Palate RepairPediatric Plastic and Reconstructive Surgery Overview When Jack Stroud was born with a cleft lip and cleft palate, his parents were prepared. Their son ’s birth defect was detected during a pregnancy ultrasound, which gave the couple time to research where he would receive his care. Jack began seeing specialists at Duke during his first week of life. Just four years later, it’s nearly impossible to tell he was born with a cleft lip and palate. Hero Image2019_cleft_jack_02.jpg Preview Image Content Blocks CTA Header Learn More CTA ButtonCleft Lip and Palate...
Source: dukehealth.org: Duke Health News - July 12, 2019 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news

Hollywood To Boston Children ’ s Hospital: Simulations Engineer Helps Surgeons Practice
BOSTON (CBS) — Bringing Hollywood to the hospital: A Lexington man is putting his special effects skills to work to help improve the care of children in the Boston area. It may look like the newest Hollywood project, but Ridley is actually a neurological teaching robot and the brainchild of Greg Loan, the senior simulation engineer at Boston Children’s Hospital. “I was obsessed with Hollywood movies and I thought I’d be working with George Lucas or something like that,” said Loan. Greg Loan, senior simulation engineer at Boston Children’s Hospital (WBZ-TV) Loan began his career in specia...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - July 4, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall Health News Source Type: news

Costs, Complications Up for Minorities in Cleft Palate Repair
TUESDAY, June 4, 2019 -- Racial-minority populations incur higher costs and experience higher rates of complications in cleft palate repair, according to a study published in the June issue of Plastic and Reconstructive Surgery. Robin T. Wu, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 4, 2019 Category: Pharmaceuticals Source Type: news

Tanzania: GGM Sends More Children for Cleft Lip Surgeries
[Daily News] OVER 1,700 children with cleft lip and palate from different villages in Geita Region have received surgical treatment for the last 17 years, yet survey indicates that the problem is far from being solved. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - April 1, 2019 Category: African Health Source Type: news

Cleft lip and palate: Mayo Clinic Radio Health Minute
In this Mayo Clinic Radio Health Minute,? Dr. John Volz, an orthodontist at Mayo Clinic, explains treatment for cleft lip and cleft palate. To listen, click the link below. Cleft lip and palate (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 20, 2019 Category: Databases & Libraries Source Type: news

3D models could help reduce radiotherapy's side effects
3D models could help decrease radiotherapy side effects, according to a study...Read more on AuntMinnie.comRelated Reading: 3D printing transitions from laboratory to bedside New 3D printer materializes entire 3D model at once 3D printing enhances training for cleft lip repair 3D-printed head phantom helps calibrate 7T MRI 3D-printed aortas could work well for TAVR (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 14, 2019 Category: Radiology Source Type: news

Shriners Hospital adds telehealth location in Kansas
St. Louis' Shriners Hospital for Children has partnered with Newton Medical Center in Newton, Kansas to create the organization ’s first telehealth location in Kansas.  The two entities say in a press release that the partnership will allow patients in Kansas and beyond to utilize equipment that will be housed at Newton Medical Center to connect with physicians and caregivers at the St. Louis hospital. Shriners Hospital is known for its care in orthopedics, cleft lip and palate, spinal-cord injury… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 25, 2019 Category: Biotechnology Authors: Daniel McCoy Source Type: news

Shriners Hospital adds telehealth location in Kansas
St. Louis' Shriners Hospital for Children has partnered with Newton Medical Center in Newton, Kansas to create the organization ’s first telehealth location in Kansas.  The two entities say in a press release that the partnership will allow patients in Kansas and beyond to utilize equipment that will be housed at Newton Medical Center to connect with physicians and caregivers at the St. Louis hospital. Shriners Hospital is known for its care in orthopedics, cleft lip and palate, spinal-cord injury… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - February 25, 2019 Category: American Health Authors: Daniel McCoy Source Type: news

Newton Medical Center partners with Shriners to add telehealth location
Newton Medical Center has partnered with St. Louis ’ Shriners Hospital for Children to create that organization’s first telehealth location in Kansas.  The two entities say in a press release that the partnership will allow patients in Kansas and beyond to utilize equipment that will be housed at Newton Medical Center to connect with physician s and caregivers at the St. Louis hospital. The Shriners Hospital is known for its care in orthopedics, cleft lip and palate, spinal-cord injury rehabilitation,… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - February 25, 2019 Category: Health Management Authors: Daniel McCoy Source Type: news

3D printing unites radiology, otolaryngology
3D printing is emerging as a key technology in the management of ear, nose,...Read more on AuntMinnie.comRelated Reading: 3D printing helps separate rare case of conjoined twins 3D printing offers alternative to CT-guided lung surgery 3D printing gives pediatric heart surgery a boost 3D-printed lungs improve patient understanding of surgery 3D printing enhances training for cleft lip repair (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 13, 2019 Category: Radiology Source Type: news

Mutations in One Gene Linked to Two Separate Birth Defects
The same network of transcription factors may be responsible for both cleft palate and neural tube defects, according to a new study connecting mouse and human data. (Source: The Scientist)
Source: The Scientist - February 1, 2019 Category: Science Tags: News & Opinion Source Type: news

3D printing helps separate rare case of conjoined twins
Researchers from Pennsylvania used 3D printing and computer-aided intraoperative...Read more on AuntMinnie.comRelated Reading: 3D printing gives pediatric heart surgery a boost 3D-printed lungs improve patient understanding of surgery 3D printing enhances training for cleft lip repair 3D printing boosts efficiency of rib fracture repair 3D-printed device aids knee replacement surgery (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 29, 2019 Category: Radiology Source Type: news

Call the Midwife praised for cleft lip storyline
Sunday's episode featuring a baby born with a cleft lip and palate is praised for its handling of the topic. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 28, 2019 Category: Consumer Health News Source Type: news

Interferon regulatory factor 6 mutations implicated in neural tube defects, including spina bifida
(Children's National Health System) Mutations in a gene known as interferon regulatory factor 6 that cause cleft lip and palate also are implicated in neural tube defects such as spina bifida, suggests research by an international study team published online Jan. 25, 2019, in Human Molecular Genetics. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 25, 2019 Category: Biology Source Type: news

Morning sickness pill study finds small link to increased risk of clefts but 'not a cause for alarm'
A new study finds no association between ondansetron and an increased risk of heart-related malformations or other malformations in newborns overall. It found a small increased risk of oral clefts, including cleft lip and cleft palate, in babies born to women who used ondansetron. (Source: CNN.com - Health)
Source: CNN.com - Health - December 18, 2018 Category: Consumer Health News Source Type: news

Life-size 3D-printed 'human' primed for radiation therapy
Researchers from Louisiana have created a 3D-printed full-body phantom that...Read more on AuntMinnie.comRelated Reading: 3D printing technique improves heart valve sizing 3D printing gives pediatric heart surgery a boost 3D-printed lungs improve patient understanding of surgery 3D head models reduce workload for brain radiotherapy 3D printing enhances training for cleft lip repair (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 18, 2018 Category: Radiology Source Type: news

3D printing gives pediatric heart surgery a boost
Researchers in the U.S. have created hundreds of individually tailored 3D-printed...Read more on AuntMinnie.comRelated Reading: 3D-printed lungs improve patient understanding of surgery 3D printing enhances training for cleft lip repair 3D printing boosts efficiency of rib fracture repair 3D printing bolsters care for congenital heart disease Flexible 3D-printed heart replicates size, texture (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 21, 2018 Category: Radiology Source Type: news

3D-printed lungs improve patient understanding of surgery
Using transparent, flexible 3D-printed models of the lung helped physicians...Read more on AuntMinnie.comRelated Reading: 3D head models reduce workload for brain radiotherapy 3D printing enhances training for cleft lip repair 3D printing boosts efficiency of rib fracture repair Virtual reality, 3D printing resolve obscure lung cancer 3D-printed device aids knee replacement surgery (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 15, 2018 Category: Radiology Source Type: news

3D head models reduce workload for brain radiotherapy
3D-printed models of human heads may remove the need for brain cancer patients...Read more on AuntMinnie.comRelated Reading: 3D printing enhances training for cleft lip repair 3D printing boosts efficiency of rib fracture repair Virtual reality, 3D printing resolve obscure lung cancer 3D-printed device aids knee replacement surgery 3D-printed hips may improve complex fracture diagnosis (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 8, 2018 Category: Radiology Source Type: news

3D printing enhances training for cleft lip repair
A 3D-printed skull base provided surgical residents with the opportunity to...Read more on AuntMinnie.comRelated Reading: 3D printing boosts efficiency of rib fracture repair Virtual reality, 3D printing resolve obscure lung cancer 3D-printed device aids knee replacement surgery 3D-printed hips may improve complex fracture diagnosis SIR: 3D printing aids US-guided procedure simulation (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 2, 2018 Category: Radiology Source Type: news

Incredible transformation of a woman, 21, who underwent four surgeries for her cleft lip
Lauren Cross, 21, from Pontefract, West Yorkshire, was born with a cleft lip and palate, and underwent her first operation at just three months old. Bullies called her 'scar face'. (Source: the Mail online | Health)
Source: the Mail online | Health - October 26, 2018 Category: Consumer Health News Source Type: news

Nigeria:Rotary Club, Lasuth Begin Cleft Lip Palate Surgical Mission
[Guardian] A group in the United States, the Alliance for Smile alongside Rotary International in partnership with the Lagos State University Teaching Hospital (LASUTH) on Tuesday kicked off a free five-day surgery procedure and care for indigent patients with cleft lip and palate medical conditions. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 19, 2018 Category: African Health Source Type: news

Cross Arch stabilization for Adult Cleft Palate patient?
I have a 72 year old male patient with a failing full arch fixed partial denture as a result of extensive caries of natural tooth abutments. Patient was edentulated and six implants placed with a treatment plan for a maxillary bar overdenture.The postCross Arch stabilization for Adult Cleft Palate patient? appeared first onOsseoNews Dental Implants. (Source: Dental Implants Discussed by Experts)
Source: Dental Implants Discussed by Experts - August 22, 2018 Category: Dentistry Authors: osseonews Tags: Clinical Cases Restorative Surgical Source Type: news

#MayoClinicRadio podcast: 7/28/18
Listen: Mayo Clinic Radio 7/28/18 On the Mayo Clinic Radio podcast, Dr. Pritish Tosh, an infectious diseases specialist at Mayo Clinic, discusses shingles and who should get vaccinated. Also on the podcast, Dr. John Volz, an orthodontist at Mayo Clinic, explains treatment for cleft lip and cleft palate. And?Dr. Scott Litin, an internal medicine specialist [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 30, 2018 Category: Databases & Libraries Source Type: news

Unilateral Cleft Lip Repair With an Asymmetric Z-plasty Unilateral Cleft Lip Repair With an Asymmetric Z-plasty
A unique modification of the classic Z-plasty for cleft lip repair is described here.ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2018 Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news

Venezuela toddler with 'crown on her head' reaches third birthday
Helianny, from San Cristobal, Venezuela, was born with a brain, eyes and nose that failed to form properly in the womb, as well as her suffering a cleft lip, clubbed foot and fused fingers. (Source: the Mail online | Health)
Source: the Mail online | Health - June 11, 2018 Category: Consumer Health News Source Type: news

Toddler whose parents were advised to terminate the pregnancy is approaching her third birthday
Helianny, from San Cristobal, Venezuela, was born with a brain, eyes and nose that failed to form properly in the womb, as well as her suffering a cleft lip, clubbed foot and fused fingers. (Source: the Mail online | Health)
Source: the Mail online | Health - June 11, 2018 Category: Consumer Health News Source Type: news

What is the Developmental Outcomes of Patients with 22q11 Deletion Sequence?
Discussion 22q11.2 deletion sequence (22q11) is the most common micro-deletion syndrome. Most deletions are de novo. It affects ~1 in 2000-4000 live births. As it is autosomal, it affects males and females equally. Childhood mortality is low and often associated with congenital heart defects. Its phenotypic expression is highly variable. Some of the most common medical problems are: Congenital heart defects especially conotruncal abnormalities Palatal problems especially velopharyngeal incompetence and/or cleft lip/palate Immunodeficiency especially T-cell lymphopenia, but also abnormalities of IgG production, autoimmu...
Source: PediatricEducation.org - June 11, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Sheffield student with cleft lip bullied for the way he looked
A 13-year-old boy bullied because of his cleft lip is working with a charity to help others like him. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 25, 2018 Category: Consumer Health News Source Type: news

Woman born with a cleft palate reveals stunning transformation
Laura Hawkes, 25, from West Sussex, was days old when she had her first surgery. After being bullied at school about her 'squashed' nose, Laura's face has been transformed via operations. (Source: the Mail online | Health)
Source: the Mail online | Health - May 16, 2018 Category: Consumer Health News Source Type: news

Christian Buchanan was born with no eyes
WARNING: GRAPHIC CONTENT Christian Buchanan, six, from Woodbury, Tennessee, suffers from Tessier cleft lip and palate, which has just 60 known cases in medical history. (Source: the Mail online | Health)
Source: the Mail online | Health - March 8, 2018 Category: Consumer Health News Source Type: news

Six-year-old boy was born with no eyes
WARNING: GRAPHIC CONTENT Christian Buchanan, six, from Woodbury, Tennessee, suffers from Tessier cleft lip and palate, which has just 60 known cases in medical history. (Source: the Mail online | Health)
Source: the Mail online | Health - March 8, 2018 Category: Consumer Health News Source Type: news

Kenya:How Partnerships Are Helping Cleft Lip and Palate Surgeries in Kenya
[The Conversation Africa] About 6% of all children worldwide are born with a birth defect. More than 300 000 babies with birth defects die annually within a month of being born. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 15, 2018 Category: African Health Source Type: news

More proof prescriptions and pregnancy don’t mix: Epilepsy drug found to affect fetal development, causing cleft palate
(Natural News) In the last 10 years, topiramate, an anti-epileptic drug, has been increasingly prescribed to prevent seizures. It is also used to treat bipolar disorder and migraine headaches. Topiramate is also an ingredient for a weight-loss drug that was recently approved by the Food and Drug Administration (FDA). Earlier studies have determined that women who took topiramate... (Source: NaturalNews.com)
Source: NaturalNews.com - January 4, 2018 Category: Consumer Health News Source Type: news

Topiramate in early pregnancy increases risk of oral clefts
Risk of cleft lip or cleft palate is greater if mother takes a higher dose of the drug Related items fromOnMedica Adverse pregnancy outcomes far more likely in epilepsy Study reveals mental cost of epilepsy in pregnancy Cannabis derivative cannabidiol reduces seizures in severe epilepsy disorder New guidelines on epilepsy in pregnancy Epilepsy drug linked to 4,000 birth defects in France (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 2, 2018 Category: UK Health Source Type: news

Risk of Oral Clefts with Topiramate May Be Dose-Dependent (CME/CE)
(MedPage Today) -- Higher doses tied to higher risk of cleft lip, palate (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - December 30, 2017 Category: Neurology Source Type: news

Epilepsy Drug Could Raise Birth Defect Risks
Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester  may boost the risk that their child will be born with a cleft lip or cleft palate. (Source: WebMD Health)
Source: WebMD Health - December 27, 2017 Category: Consumer Health News Source Type: news

Does dosing of drug for mom make a difference for baby's risk of cleft lip, palate?
(American Academy of Neurology) Taking a higher dose of topiramate during the first three months of pregnancy may increase a baby's risk of cleft lip or cleft palate more than when taking a lower dose, according to a study published in the Dec. 27, 2017, online issue of Neurology ® , the medical journal of the American Academy of Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 27, 2017 Category: International Medicine & Public Health Source Type: news

Topiramate in Early Pregnancy Increases Risk of Oral Clefts
Study finds that taking a higher dose of the drug in the first trimester increases risk of cleft lip or cleft palate more than taking a lower dose. (Source: BWH for Journalists)
Source: BWH for Journalists - December 27, 2017 Category: Research Source Type: news

Bryan Aves obituary
My father, Bryan Aves, who has died aged 92, established a successful career as a radiographer and radiotherapist despite having left school at 14 without qualifications. At one point he worked as an assistant for the physicistsOtto Frisch andJoseph Rotblat in the secret “tube alloys” experiments that led to the creation of the atom bomb, apparently without knowing what the project was about.Born in Brixton, south London, to Arthur, an accounts clerk for a dog biscuit factory, and Ellen (nee Stallard), a cleaner, Bryan had a cleft palate at birth; reconstructive surgery was not undertaken until he was 13. Becau...
Source: Guardian Unlimited Science - December 21, 2017 Category: Science Authors: Simon Aves Tags: Physics Cancer research Medicine Source Type: news

Exposure to air pollution just before or after conception raises risk of birth defects
(Cincinnati Children's Hospital Medical Center) Women exposed to air pollution just prior to conception or during the first month of pregnancy face an increased risk of their children being born with birth defects, such as cleft lip or palate or abnormal hearts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2017 Category: International Medicine & Public Health Source Type: news