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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly- γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC
Drug Dev Ind Pharm. 2023 Feb 24:1-13. doi: 10.1080/03639045.2023.2182125. Online ahead of print.ABSTRACTDue to the complexity of the pathophysiology of non-small cell lung cancer (NSCLC) and the susceptibility of single chemotherapy to drug resistance, the combination of drugs and small interfering RNA (siRNA) may produce a desired therapeutic effect on NSCLC through the action of multiple pathways. We designed to develop poly-γ-glutamic acid-modified cationic liposomes (γ-PGA-CL) to co-deliver pemetrexed disodium (PMX) and siRNA to treat NSCLC. Firstly, γ-PGA was modified on the surface of PMX and siRNA co-loaded catio...
Source: Drug Development and Industrial Pharmacy - February 21, 2023 Category: Drugs & Pharmacology Authors: Xiaoyu Huang Ruonan Song Xiao Wang Kongfang He Rumeng Shan Fei Xie Guihua Huang Source Type: research
Ablation of shank1 protects against 6-OHDA-induced cytotoxicity via PRDX3-mediated inhibition of ER stress in SN4741 cells
CONCLUSION: In summary, the present study has provided the first evidence that the knockdown of shank1 protects against 6-OHDA-induced ER stress and mitochondrial dysfunction through activating the PRDX3 pathway.PMID:36797610 | DOI:10.2174/1871527322666230216124156
Source: CNS and Neurological Disorders Drug Targets - February 16, 2023 Category: Drugs & Pharmacology Authors: Ye-Ping Xu Jing Zhang Xue Mei Yan Wu Wei Jiao Yu-Hai Wang Ai-Qin Zhang Source Type: research
RNA Targeting and Gene Editing Strategies for Transthyretin Amyloidosis
AbstractTransthyretin (TTR) is a tetrameric protein synthesized primarily by the liver. TTR can misfold into pathogenic ATTR amyloid fibrils that deposit in the nerves and heart, causing a progressive and debilitating polyneuropathy (PN) and life-threatening cardiomyopathy (CM). Therapeutic strategies, which are aimed at reducing ongoing ATTR amyloid fibrillogenesis, include stabilization of the circulating TTR tetramer or reduction of TTR synthesis. Small interfering RNA (siRNA) or antisense oligonucleotide (ASO) drugs are highly effective at disrupting the complementary mRNA and inhibiting TTR synthesis. Since their deve...
Source: BioDrugs - February 16, 2023 Category: Drugs & Pharmacology Source Type: research
Tetramethylpyrazine Attenuates Oxygen-glucose Deprivation-induced Neuronal Damage through Inhibition of the HIF-1 α/BNIP3 Pathway: From Network Pharmacological Finding to Experimental Validation
CONCLUSION: Our study shows that TMP protects OGD-damaged PC12 cells by inhibiting the HIF-1α/BNIP3 pathway, which provides new insights into the mechanism of TMP and its neuroprotective potential.PMID:36790003 | DOI:10.2174/1381612829666230215100507
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: Shixin Xu Nannan Zhang Lanlan Cao Lu Liu Hao Deng Shengyu Hua Yunsha Zhang Source Type: research
Self-Assembly of Peptide: Structure, Function, and Advanced Application in Biomedicine
Curr Pharm Des. 2023 Feb 13. doi: 10.2174/1381612829666230213152259. Online ahead of print.ABSTRACTThe self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly were described. And the advances of pep...
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: He Diao Yunhua Lu Yun Ling Yingjie Shen Jingmou Yu Kun Ma Source Type: research
Tetramethylpyrazine Attenuates Oxygen-glucose Deprivation-induced Neuronal Damage through Inhibition of the HIF-1 α/BNIP3 Pathway: From Network Pharmacological Finding to Experimental Validation
CONCLUSION: Our study shows that TMP protects OGD-damaged PC12 cells by inhibiting the HIF-1α/BNIP3 pathway, which provides new insights into the mechanism of TMP and its neuroprotective potential.PMID:36790003 | DOI:10.2174/1381612829666230215100507
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: Shixin Xu Nannan Zhang Lanlan Cao Lu Liu Hao Deng Shengyu Hua Yunsha Zhang Source Type: research
Self-Assembly of Peptide: Structure, Function, and Advanced Application in Biomedicine
Curr Pharm Des. 2023 Feb 13. doi: 10.2174/1381612829666230213152259. Online ahead of print.ABSTRACTThe self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly were described. And the advances of pep...
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: He Diao Yunhua Lu Yun Ling Yingjie Shen Jingmou Yu Kun Ma Source Type: research
Pharmacokinetics of Jnj-73763989 And Jnj-56136379 (Bersacapavir) In Participants With Moderate Hepatic Impairment
This article is protected by copyright. All rights reserved.PMID:36786053 | DOI:10.1002/jcph.2214
Source: The Journal of Clinical Pharmacology - February 14, 2023 Category: Drugs & Pharmacology Authors: Thomas N Kakuda Atef Halabi Gernot Klein Madhu Sanga Carine Guinard-Azadian Monika Kowalik Katja Nedoschinsky Julius Nangosyah Emmanuel Njumbe Ediage Vera Hillewaert Peter Verboven Ivo Goris Jan Snoeys Martyn Palmer Michael Biermer Source Type: research
