Self-Assembly of Peptide: Structure, Function, and Advanced Application in Biomedicine

Curr Pharm Des. 2023 Feb 13. doi: 10.2174/1381612829666230213152259. Online ahead of print.ABSTRACTThe self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly were described. And the advances of peptide-based self-assembly were highlighted in biomedical applications, such as drug packaging and delivery, tissue engineering, antibacterial agents, siRNA targeted delivery and vaccines. Moreover, the challenges and future perspectives of the self-assembly of polypeptides are discussed.PMID:36788692 | DOI:10.2174/1381612829666230213152259
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research