Ablation of shank1 protects against 6-OHDA-induced cytotoxicity via PRDX3-mediated inhibition of ER stress in SN4741 cells

CONCLUSION: In summary, the present study has provided the first evidence that the knockdown of shank1 protects against 6-OHDA-induced ER stress and mitochondrial dysfunction through activating the PRDX3 pathway.PMID:36797610 | DOI:10.2174/1871527322666230216124156
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research