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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
siRNA-Based Novel Therapeutic Strategies to Improve Effectiveness of Antivirals: An Insight
AAPS PharmSciTech. 2023 Aug 11;24(6):170. doi: 10.1208/s12249-023-02629-1.ABSTRACTSince the ground-breaking discovery of RNA interference (RNAi), scientists have made significant progress in the field of small interfering RNA (siRNA) treatments. Due to severe barriers to the therapeutic application of siRNA, nanoparticle technologies for siRNA delivery have been designed. For pathological circumstances such as viral infection, toxic RNA abnormalities, malignancies, and hereditary diseases, siRNAs are potential therapeutic agents. However, systemic administration of siRNAs in vivo remains a substantial issue due to a lack o...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Krittika Chatterjee Sagheerah Lakdawala Sheikh Shahnawaz Quadir Dinesh Puri Dinesh Kumar Mishra Garima Joshi Sanjay Sharma Deepak Choudhary Source Type: research
Paeoniflorin alleviates AngII-induced cardiac hypertrophy in H9c2 cells by regulating oxidative stress and Nrf2 signaling pathway
In conclusion, Our data confirm that paeoniflorin alleviates cardiac hypertrophy through modulating oxidative stress and Nrf2 signaling pathway in vitro.PMID:37542855 | DOI:10.1016/j.biopha.2023.115253
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 5, 2023 Category: Drugs & Pharmacology Authors: Shan Ren Yuge Wang Yanyan Zhang Peimei Yan Dan Xiao Yu Zhao Weiwei Jia Lin Ding Haiying Dong Can Wei Song Lin Yan Lin Source Type: research
Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells
This study improves our understanding of a molecular target of escin that mediates its effect on chronic vascular inflammation.PMID:37541373 | DOI:10.1016/j.ejphar.2023.175951
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Yuman Wang Tianjiao Chu Xianmei Pan Yifei Bian Jing Li Source Type: research
Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies
Biomed Pharmacother. 2023 Jul 31;165:115242. doi: 10.1016/j.biopha.2023.115242. Online ahead of print.ABSTRACTBladder cancer (BC) is a common and serious type of cancer that ranks among the top ten most prevalent malignancies worldwide. Due to the high occurrence rate of BC, the aggressive nature of cancer cells, and their resistance to medication, managing this disease has become a growing challenge in clinical care. Long noncoding RNAs (lncRNAs) are a group of RNA transcripts that do not code for proteins and are more than 200 nucleotides in length. They play a significant role in controlling cellular pathways and molecu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 2, 2023 Category: Drugs & Pharmacology Authors: Amirreza Mehmandar-Oskuie Kasra Jahankhani Arman Rostamlou Sepideh Arabi Zahra Sadat Razavi Amirhossein Mardi Source Type: research
The Promise of PCSK9 and Lipoprotein(a) as Targets for Gene Silencing Therapies
Clin Ther. 2023 Jul 29:S0149-2918(23)00258-8. doi: 10.1016/j.clinthera.2023.07.008. Online ahead of print.ABSTRACTPURPOSE: High plasma concentrations of LDL and lipoprotein(a) (Lp[a]) are independent and causal risk factors for atherosclerotic cardiovascular disease (ASCVD). There is an unmet therapeutic need for high-risk patients with elevated levels of LDL-C and/or Lp(a). Recent advances in the development of nucleic acids for gene silencing (ie, triantennary N-acetylgalactosamine conjugated antisense-oligonucleotides [ASOs] and small interfering RNA [siRNA]) targeting proprotein convertase subtilisin/kexin type 9 (PCSK...
Source: Clinical Therapeutics - July 31, 2023 Category: Drugs & Pharmacology Authors: Dick C Chan Gerald F Watts Source Type: research
Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury
In this study, VILI was generated in mice with high tidal volume mechanical ventilation (20 ml/kg). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 concentrations in serum and gut measured by ELISA showed significant elevation in the VILI mice. Significant increases in gut injury and PANoptosis were observed in the VILI mice, which were positively correlated with the serum levels of TNF-α, IL-1β, and IL-6. The VILI mice displayed intestinal barrier defects, decreased expressions of occludin and zonula occludin-1 (ZO-1), and increased expression of claudin-2 and the activation of myosin light chain (...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 29, 2023 Category: Drugs & Pharmacology Authors: Ning Ding Hui Xiao Lixiao Zhen Huiqing Li Zengzhen Zhang Junke Ge Haiyan Jia Source Type: research
Biophysical characterization of siRNA-loaded Lipid Nanoparticles with different PEG content in an aqueous system
This study evaluated the influence of PEGylation and stress conditions on the stability of siRNA-loaded LNPs with different concentrations of PEG (0.5 mol%; 0.5% PEG-LNP and 1.0 mol%; 1.0% PEG-LNP) anchored to their surface. We applied end-over-end agitation, elevated temperature, and repeated freeze and thaw (F/T) cycles as physicochemical stressors of pH and ionic strength. Dynamic light scattering (DLS), flow imaging microscopy (FIM), and ionic-exchange chromatography (IEX) were to determine the degree of aggregation and change in siRNA content. The results indicate that 0.5% PEG-LNP resisted aggregation only at low pH ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 29, 2023 Category: Drugs & Pharmacology Authors: Ki Hyun Kim Ripesh Bhujel Ravi Maharjan Jae Chul Lee Hun Soon Jung Hye Jeong Kim Nam Ah Kim Seong Hoon Jeong Source Type: research
Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury
In this study, VILI was generated in mice with high tidal volume mechanical ventilation (20 ml/kg). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 concentrations in serum and gut measured by ELISA showed significant elevation in the VILI mice. Significant increases in gut injury and PANoptosis were observed in the VILI mice, which were positively correlated with the serum levels of TNF-α, IL-1β, and IL-6. The VILI mice displayed intestinal barrier defects, decreased expressions of occludin and zonula occludin-1 (ZO-1), and increased expression of claudin-2 and the activation of myosin light chain (...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 29, 2023 Category: Drugs & Pharmacology Authors: Ning Ding Hui Xiao Lixiao Zhen Huiqing Li Zengzhen Zhang Junke Ge Haiyan Jia Source Type: research
Biophysical characterization of siRNA-loaded Lipid Nanoparticles with different PEG content in an aqueous system
This study evaluated the influence of PEGylation and stress conditions on the stability of siRNA-loaded LNPs with different concentrations of PEG (0.5 mol%; 0.5% PEG-LNP and 1.0 mol%; 1.0% PEG-LNP) anchored to their surface. We applied end-over-end agitation, elevated temperature, and repeated freeze and thaw (F/T) cycles as physicochemical stressors of pH and ionic strength. Dynamic light scattering (DLS), flow imaging microscopy (FIM), and ionic-exchange chromatography (IEX) were to determine the degree of aggregation and change in siRNA content. The results indicate that 0.5% PEG-LNP resisted aggregation only at low pH ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 29, 2023 Category: Drugs & Pharmacology Authors: Ki Hyun Kim Ripesh Bhujel Ravi Maharjan Jae Chul Lee Hun Soon Jung Hye Jeong Kim Nam Ah Kim Seong Hoon Jeong Source Type: research
Ultrasound-Mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment via Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes
CONCLUSION: UMND enhanced PLGA-PEI NBs-STAT6 siRNA to repolarize TAMs from the M2 to the M1 phenotype, thus treating NSCLC. These findings provide a promising therapeutic approach for enhancing NSCLC immunotherapy.PMID:37491853 | DOI:10.2174/1567201820666230724151545
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hong Shu Wenhao Lv Zhi-Jian Ren Hui Li Tiantian Dong Yao Zhang Fang Nie Source Type: research
