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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice by improving the TFEB-mediated autophagy-lysosome pathway
Biomed Pharmacother. 2023 Jul 4;165:115122. doi: 10.1016/j.biopha.2023.115122. Online ahead of print.ABSTRACTNephrotoxicity is a major side effect of cisplatin treatment of solid tumors in the clinical setting. Long-term low-dose cisplatin administration causes renal fibrosis and inflammation. However, few specific medicines with clinical application value have been developed to reduce or treat the nephrotoxic side effects of cisplatin without affecting its tumor-killing effect. The present study analyzed the potential reno-protective effect and mechanism of asiatic acid (AA) in long-term cisplatin-treated nude mice suffer...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2023 Category: Drugs & Pharmacology Authors: Xiao-Cui Chen Li-Feng Huang Ji-Xin Tang Dan Wu Ning An Zhen-Nan Ye Hui-Yao Lan Hua-Feng Liu Chen Yang Source Type: research
Effect of SH2B1 on glucose metabolism during pressure overload-induced cardiac hypertrophy and cardiac dysfunction
This study mainly explored the effect and mechanism of Src homology 2 (SH2) B adaptor protein 1 (SH2B1) on cardiac glucose metabolism during pressure overload-induced cardiac hypertrophy and dysfunction. A pressure-overloaded cardiac hypertrophy model was constructed, and SH2B1-siRNA was injected through the tail vein. Haematoxylin and eosin (H&E) staining was used to detect myocardial morphology. ANP, BNP, β-MHC and the diameter of myocardial fibres were quantitatively measured to evaluate the degree of cardiac hypertrophy, respectively. GLUT1, GLUT4, and IR were detected to assess cardiac glucose metabolism. Cardiac...
Source: Clinical and Experimental Pharmacology and Physiology - July 4, 2023 Category: Drugs & Pharmacology Authors: Beilei Liu Xuguang Liu Shan Hu Shuai Mao Manqi Yang Bin Wu Gang Wu Source Type: research
A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy
Biomed Pharmacother. 2023 Jun 29;165:115087. doi: 10.1016/j.biopha.2023.115087. Online ahead of print.ABSTRACTAll forms of life produce nanosized extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and participate in a variety of physiological and pathological processes. Exosomes function via their bioactive components, which are delivered to target cells in the form of proteins, nucleic acids, and lipids. Exosomes function as drug delivery vehicles due to their unique properties of innate stability, low immunogenicity, biocompatibility, biodi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Jian Li Ye Zhang Pei-Yu Dong Guo-Ming Yang Sangiliyandi Gurunathan Source Type: research
The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging therapeutic targets
Biomed Pharmacother. 2023 Jun 29;165:115067. doi: 10.1016/j.biopha.2023.115067. Online ahead of print.ABSTRACTNoncoding ribonucleic acids (ncRNAs) are a class of ribonucleic acids (RNAs) that carry cellular information and perform essential functions. This class encompasses various RNAs, such as small nuclear ribonucleic acids (snRNA), small interfering ribonucleic acids (siRNA) and many other kinds of RNA. Of these, circular ribonucleic acids (circRNAs) and long noncoding ribonucleic acids (lncRNAs) are two types of ncRNAs that regulate crucial physiological and pathological processes, including binding, in several organs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Huilei Zhao Ziqi Tan Jin Zhou Yifan Wu Qingwen Hu Qing Ling Jitao Ling Menglu Liu Jianyong Ma Deju Zhang Yue Wang Jing Zhang Peng Yu Yuan Jiang Xiao Liu Source Type: research
A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy
Biomed Pharmacother. 2023 Jun 29;165:115087. doi: 10.1016/j.biopha.2023.115087. Online ahead of print.ABSTRACTAll forms of life produce nanosized extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and participate in a variety of physiological and pathological processes. Exosomes function via their bioactive components, which are delivered to target cells in the form of proteins, nucleic acids, and lipids. Exosomes function as drug delivery vehicles due to their unique properties of innate stability, low immunogenicity, biocompatibility, biodi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Jian Li Ye Zhang Pei-Yu Dong Guo-Ming Yang Sangiliyandi Gurunathan Source Type: research
The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging therapeutic targets
Biomed Pharmacother. 2023 Jun 29;165:115067. doi: 10.1016/j.biopha.2023.115067. Online ahead of print.ABSTRACTNoncoding ribonucleic acids (ncRNAs) are a class of ribonucleic acids (RNAs) that carry cellular information and perform essential functions. This class encompasses various RNAs, such as small nuclear ribonucleic acids (snRNA), small interfering ribonucleic acids (siRNA) and many other kinds of RNA. Of these, circular ribonucleic acids (circRNAs) and long noncoding ribonucleic acids (lncRNAs) are two types of ncRNAs that regulate crucial physiological and pathological processes, including binding, in several organs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Huilei Zhao Ziqi Tan Jin Zhou Yifan Wu Qingwen Hu Qing Ling Jitao Ling Menglu Liu Jianyong Ma Deju Zhang Yue Wang Jing Zhang Peng Yu Yuan Jiang Xiao Liu Source Type: research
Targeted Delivery Methods for RNA Interference Are Necessary to Obtain a Potential Functional Cure for HIV/AIDS
Adv Drug Deliv Rev. 2023 Jun 27:114970. doi: 10.1016/j.addr.2023.114970. Online ahead of print.ABSTRACTRibonucleic acid (RNA) is of great interest in many different therapeutic areas including infectious diseases such as immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Thanks to current, advanced treatments for HIV, the diagnosis is no longer a death sentence. However, even with these treatments, latency is suggested to persist in T-lymphocyte-rich tissues including gut-associated lymphatic tissue (GALT), spleen, and bone marrow making HIV an incurable disease. Therefore, it is important to design syst...
Source: Advanced Drug Delivery Reviews - June 29, 2023 Category: Drugs & Pharmacology Authors: Ethan Cisneros Najia Sherwani Olivia L Lanier Nicholas A Peppas Source Type: research
Polyplex Designs for Improving the Stability and Safety of RNA Therapeutics
Adv Drug Deliv Rev. 2023 Jun 24:114972. doi: 10.1016/j.addr.2023.114972. Online ahead of print.ABSTRACTNanoparticle-based delivery systems have contributed to the recent clinical success of RNA therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct properties, such as enabling RNA delivery into extra-hepatic organs, modulation of immune responses to RNA, and regulation of intracellular RNA release. However, delivery systems should overcome safety and stability issues to achieve widespread therapeutic applications. Safety concerns include direct damage to cellular components, innate and ada...
Source: Advanced Drug Delivery Reviews - June 26, 2023 Category: Drugs & Pharmacology Authors: Satoshi Uchida Chun Yin Jerry Lau Makoto Oba Kanjiro Miyata Source Type: research
siRNA drug delivery across the blood-brain barrier in Alzheimer's Disease
Adv Drug Deliv Rev. 2023 Jun 21:114968. doi: 10.1016/j.addr.2023.114968. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-approved drugs that provide modest symptomatic benefits and only two FDA-approved disease-modifying treatments for AD. The advancements in understanding the causative genes and non-coding sequences at the molecular level of the pathophysiology of AD have resulted in several exciting research papers that employed small interfering RNA (siRNA)-based therapy. Although siRNA is being sought by academia and biopharma industries, several challeng...
Source: Advanced Drug Delivery Reviews - June 23, 2023 Category: Drugs & Pharmacology Authors: Muhammad Imran Sajid Fahad Sultan Sheikh Faiza Anis Nourina Nasim Rachita K Sumbria Surya M Nauli Rakesh Kumar Tiwari Source Type: research
Magnetosomes as Potential Nanocarriers for Cancer Treatment
Curr Drug Deliv. 2023 Jun 19. doi: 10.2174/1567201820666230619155528. Online ahead of print.ABSTRACTMagnetotactic bacteria (MTBs) and their organelles, magnetosomes, are intriguing options that might fulfill the criteria of using bacterial magnetosomes (BMs). The ferromagnetic crystals contained in BMs can condition the magnetotaxis of MTBs, which is common in water storage facilities. This review provides an overview of the feasibility of using MTBs and BMs as nanocarriers in cancer treatment. More evidence suggests that MTBs and BMs can be used as natural nanocarriers for conventional anticancer medicines, antibodies, va...
Source: Current Drug Delivery - June 21, 2023 Category: Drugs & Pharmacology Authors: Rawan Alsharedeh Nid'a Alshraiedeh Alaa A Aljabali Murtaza M Tambuwala Source Type: research
Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells
This study is the first to demonstrate that curcumin can prevent oxidative stress-induced auditory hair cell degeneration through Nrf2 activation, highlighting its potential therapeutic value in preventing ARHL.PMID:37334787 | DOI:10.1016/j.bcp.2023.115575
Source: Biochemical Pharmacology - June 19, 2023 Category: Drugs & Pharmacology Authors: Ning Li Xirui Yan Weiling Huang Min Chu Yang Dong Haiyan Song Yinting Peng Jianrong Shi Qing Liu Source Type: research
