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Total 3220 results found since Jan 2013.

Highlights on Cell-Penetrating Peptides and Polymer-Lipid Hybrid Nanoparticle: Overview and Therapeutic Applications for Targeted Anticancer Therapy
AAPS PharmSciTech. 2023 May 24;24(5):124. doi: 10.1208/s12249-023-02576-x.ABSTRACTPolymer-lipid hybrid nanoparticles (PLHNs) have been widely used as a vehicle for carrying anticancer owing to its unique framework of polymer and lipid combining and giving the maximum advantages over the lipid and polymer nanoparticle drug delivery system. Surface modification of PLHNs aids in improved targeting and active delivery of the encapsulated drug. Therefore, surface modification of the PLHNs with the cell-penetrating peptide is explored by many researchers and is explained in this review. Cell-penetrating peptides (CPPs) are made ...
Source: AAPS PharmSciTech - May 24, 2023 Category: Drugs & Pharmacology Authors: Pragathi Devanand Bangera Divya Dhatri Kara Katikala Tanvi Vamshi Krishna Tippavajhala Mahalaxmi Rathnanand Source Type: research

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1
Biomed Pharmacother. 2023 May 20;164:114920. doi: 10.1016/j.biopha.2023.114920. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a chronic obstructive disease characterized by vascular remodeling. Studies have confirmed that ginsenoside Rg1 can improve pulmonary hypertension to a certain extent, but the potential mechanism by which it improves hypoxia-induced PAH remains unclear. The aim of this study was to investigate the therapeutic effect of ginsenoside Rg1 on hypoxia-induced PAH. The results showed that hypoxia promoted inflammation, EndMT, and vascular remodeling, which were accompanied by decre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 22, 2023 Category: Drugs & Pharmacology Authors: Bai-Lin Tang Yu Liu Jing-Liang Zhang Mei-Li Lu Hong-Xin Wang Source Type: research

Differential regulation of histamine H 1 receptor-mediated ERK phosphorylation by G q proteins and arrestins
Biochem Pharmacol. 2023 May 16:115595. doi: 10.1016/j.bcp.2023.115595. Online ahead of print.ABSTRACTGq protein-coupled histamine H1 receptors play crucial roles in allergic and inflammatory reactions, in which the phosphorylation of extracellular signal-regulated kinase (ERK) appears to mediate the production of inflammatory cytokines. ERK phosphorylation is regulated by G protein- and arrestin-mediated signal transduction pathways. Here, we aimed to explore how H1 receptor-mediated processes of ERK phosphorylation might be differentially regulated by Gq proteins and arrestins. For this purpose, we evaluated the regulator...
Source: Biochemical Pharmacology - May 18, 2023 Category: Drugs & Pharmacology Authors: Shotaro Michinaga Ayaka Nagata Ryosuke Ogami Yasuhiro Ogawa Shigeru Hishinuma Source Type: research

Targeted and Functional Genomics Approaches to the Mechanism of Action of Lagunamide D, a Mitochondrial Cytotoxin from Marine Cyanobacteria
Biochem Pharmacol. 2023 May 16:115608. doi: 10.1016/j.bcp.2023.115608. Online ahead of print.ABSTRACTLagunamide D, a cyanobacterial cyclodepsipeptide, exhibits potent antiproliferative activity against HCT116 colorectal cancer cells (IC50 5.1 nM), used as a model system to probe the mechanism of action. Measurements of metabolic activity, mitochondrial membrane potential, caspase 3/7 activity and cell viability indicate the rapid action of lagunamide D on mitochondrial function and downstream cytotoxic effects in HCT116 cells. Lagunamide D preferentially targets the G1 cell cycle population and arrests cells in G2/M phase ...
Source: Biochemical Pharmacology - May 18, 2023 Category: Drugs & Pharmacology Authors: Danmeng Luo Ranjala Ratnayake Kalina R Atanasova Valerie J Paul Hendrik Luesch Source Type: research

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha
In conclusion, we confirmed that NCTS improves myocardial energy metabolism, including fatty acid oxidation and mitochondrial biogenesis, by regulating the RXRα/PPARα pathway in mice with HF post-AMI.PMID:37201263 | DOI:10.1016/j.biopha.2023.114868
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 18, 2023 Category: Drugs & Pharmacology Authors: Lin Ma Mingyan Shao Wenkun Cheng Jinchi Jiang Xu Chen Nannan Tan Guanjing Ling Ye Yang Qian Wang Ran Yang Chun Li Yong Wang Source Type: research

Differential regulation of histamine H 1 receptor-mediated ERK phosphorylation by G q proteins and arrestins
Biochem Pharmacol. 2023 May 16;213:115595. doi: 10.1016/j.bcp.2023.115595. Online ahead of print.ABSTRACTGq protein-coupled histamine H1 receptors play crucial roles in allergic and inflammatory reactions, in which the phosphorylation of extracellular signal-regulated kinase (ERK) appears to mediate the production of inflammatory cytokines. ERK phosphorylation is regulated by G protein- and arrestin-mediated signal transduction pathways. Here, we aimed to explore how H1 receptor-mediated processes of ERK phosphorylation might be differentially regulated by Gq proteins and arrestins. For this purpose, we evaluated the regul...
Source: Biochemical Pharmacology - May 18, 2023 Category: Drugs & Pharmacology Authors: Shotaro Michinaga Ayaka Nagata Ryosuke Ogami Yasuhiro Ogawa Shigeru Hishinuma Source Type: research

Microfluidic mixing as platform technology for production of chitosan nanoparticles loaded with different macromolecules
Eur J Pharm Biopharm. 2023 May 15:S0939-6411(23)00124-8. doi: 10.1016/j.ejpb.2023.05.010. Online ahead of print.ABSTRACTIn recent decades, biotechnological drugs have emerged as relevant therapeutic tools. However, therapeutic molecules can exert their activity only if properly formulated and delivered into the body. In this regard, nano-sized drug delivery systems have been shown to provide protection, stability, and controlled release of payloads, increasing their therapeutic efficacy. In this work, a microfluidic mixing technique for the preparation of chitosan-based nanoparticles was established with the capability of ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 17, 2023 Category: Drugs & Pharmacology Authors: Antonietta Greco Bettina Gabold Siyu Chen Xiaoxuan Wang Zehua Xu Achim Hartschuh Enrica Chiesa Ida Genta Christian L Ried Thomas Merdan Olivia M Merkel Source Type: research

TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I
In this study we explored the downstream signal of activated PARP1 to induce nuclear translocation of AIF in DPT-triggered glioma cell parthanatos. We showed that treatment with DPT (450 nM) induced PARP1 over-activation and Tax1 binding protein 1 (TAX1BP1) distribution to mitochondria in human U87, U251 and U118 glioma cells. PARP1 activation promoted TAX1BP1 distribution to mitochondria by depleting nicotinamide adenine dinucleotide (NAD+). Knockdown of TAX1BP1 with siRNA not only inhibited TAX1BP1 accumulation in mitochondria, but also alleviated nuclear translocation of AIF and glioma cell death. We demonstrated that T...
Source: Acta Pharmacologica Sinica - May 15, 2023 Category: Drugs & Pharmacology Authors: Xuan-Zhong Wang Shi-Peng Liang Xi Chen Zhen-Chuan Wang Chen Li Chun-Sheng Feng Shan Lu Chuan He Yu-Bo Wang Guang-Fan Chi Peng-Fei Ge Source Type: research

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