Filtered By:
Specialty: Drugs & Pharmacology

This page shows you your search results in order of date. This is page number 17.

Order by Relevance | Date

Total 3220 results found since Jan 2013.

Protective role of cytochrome c oxidase 5A (COX5A) against mitochondrial disorder and oxidative stress in VSMC phenotypic modulation and neointima formation
CONCLUSION: The present study demonstrated that COX5A protects VSMCs against phenotypic modulation by improving mitochondrial respiratory function and attenuating mitochondrial damage, as well as reducing oxidative stress, thereby preventing neointima formation.PMID:36924093 | DOI:10.2174/1570161121666230315142507
Source: Current Vascular Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Haijing Guan Jingwen Sun Xiuying Liang Wenjuan Yao Source Type: research

Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Eur J Pharmacol. 2023 Mar 13:175649. doi: 10.1016/j.ejphar.2023.175649. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is the most prevalent chronic inflammatory skin condition and significantly reduces quality of life. Tight junction (TJ), which is located directly beneath the stratum corneum, maintains skin barrier function and aids in the identification of the cell's "territory". We evaluated seventeen TJ related genes to explore AD related alterations of TJ. Remarkably, we found that the expression of ZO-3, a gene that had not been linked to the development of TJ in AD, was significantly down-regulated in the ski...
Source: European Journal of Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Xueqin Hu Yuan Zhou Jianxin Shi Mingxin Qi Xue Li Yan Yang Chan Zhu Changming Wang Zongxiang Tang Yuxiang Ma Guang Yu Source Type: research

Targeting the chemokine ligand 2-chemokine receptor 2 axis provides the possibility of immunotherapy in chronic pain
Eur J Pharmacol. 2023 Mar 10:175646. doi: 10.1016/j.ejphar.2023.175646. Online ahead of print.ABSTRACTChronic pain affects patients' physical and psychological health and quality of life, entailing a tremendous public health challenge. Currently, drugs for chronic pain are usually associated with a large number of side effects and poor efficacy. Chemokines in the neuroimmune interface combine with their receptors to regulate inflammation or mediate neuroinflammation in the peripheral and central nervous system. Targeting chemokines and their receptor-mediated neuroinflammation is an effective means to treat chronic pain. I...
Source: European Journal of Pharmacology - March 12, 2023 Category: Drugs & Pharmacology Authors: Shan Liu Xiao-Bing Lan Miao-Miao Tian Chun-Hao Zhu Lin Ma Jia-Mei Yang Juan Du Ping Zheng Jian-Qiang Yu Ning Liu Source Type: research

Pharmacokinetic ‐Pharmacodynamic Model of Urinary δ‐Aminolevulinic Acid Reduction After Givosiran Treatment in Patients with Acute Hepatic Porphyria
AbstractGivosiran, an RNA interference-based therapeutic, is a recent addition to the limited treatment armamentarium for acute hepatic porphyria (AHP). As a small interfering RNA (siRNA) that is selectively taken up in the liver, both the mechanism and targeted delivery create a complex relationship between givosiran pharmacokinetics (PK) and the pharmacodynamic (PD) response. Using pooled data from phase 1-3 clinical trials of givosiran, we developed a semi-mechanistic PK/PD model to describe the relationship between predicted liver and RNA induced silencing complex (RISC) concentrations of givosiran and the associated r...
Source: CPT: Pharmacometrics and Systems Pharmacology - March 8, 2023 Category: Drugs & Pharmacology Authors: Jongtae Lee, Megan Melch, Gabriel J. Robbie Tags: ARTICLE Source Type: research

CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF- β/Smad signaling
Biochem Pharmacol. 2023 Mar 2:115475. doi: 10.1016/j.bcp.2023.115475. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a type of fatal respiratory diseases with limited therapeutic options and poor prognosis. The chemokine CCL17 plays crucial roles in the pathogenesis of immune diseases. Bronchoalveolar lavage fluid (BALF) CCL17 levels are significantly higher in patients with idiopathic PF (IPF) than in healthy volunteers. However, the source and function of CCL17 in PF remain unclear. Here, we demonstrated that the levels of CCL17 were increased in the lungs of IPF patients and mice with bleomycin (BLM)-induced P...
Source: Biochemical Pharmacology - March 4, 2023 Category: Drugs & Pharmacology Authors: Qian-Rong Wang Suo-Si Liu Jia-Li Min Min Yin Yan Zhang Yu Zhang Xiang-Ning Tang Xia Li Shan-Shan Liu Source Type: research