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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery
Chem Pharm Bull (Tokyo). 2023;71(3):250-256. doi: 10.1248/cpb.c22-00852.ABSTRACTAmphipathic peptides composed of cationic amino acids and hydrophobic amino acids have cell-penetrating ability and are often used as a delivery tool for membrane-impermeable compounds. Small interfering RNA (siRNAs) are one of the delivery targets for such cell-penetrating peptides (CPPs). Cationic CPPs can associate with anionic siRNAs by electrostatic interactions resulting in the formation of nano-sized complexes, which can deliver siRNAs intracellularly. CPPs containing unnatural amino acids offer promising tools to siRNA delivery. However...
Source: Chemical and Pharmaceutical Bulletin - March 1, 2023 Category: Drugs & Pharmacology Authors: Makoto Oba Mika Shibuya Yuto Yamaberi Hidetomo Yokoo Satoshi Uchida Atsushi Ueda Masakazu Tanaka Source Type: research
ASAP Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV ‑1 Latent Reservoir Cell Types
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.2c01030
Source: Molecular Pharmaceutics - February 27, 2023 Category: Drugs & Pharmacology Authors: Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D. Kelleher, and Chantelle L. Ahlenstiel Source Type: research
Cell surface GRP78 regulates TGF β1-mediated profibrotic responses via TSP1 in diabetic kidney disease
Discussion: These data support an important role for csGRP78 in regulating HG-induced TSP1 transcriptional induction via PI3K/Akt signaling. Functionally, this enables TGFβ1 activation in response to HG, with consequent increase in ECM proteins. Means of inhibiting csGRP78 signaling represent a novel approach to preventing fibrosis in DKD.
Source: Frontiers in Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression
CONCLUSIONS: Baicalein preserved the BLM-induced downregulation of lung Sirt3 expression, and thus the suppression of TGF-β1/Smad signalling pathway and lung fibrosis, which might provide an experimental basis for treatment of IPF.PMID:36815239 | DOI:10.1080/13880209.2022.2160767
Source: Pharmaceutical Biology - February 23, 2023 Category: Drugs & Pharmacology Authors: Yuan Ji-Hong Ma Yu Yuan Ling-Hong Gong Jing-Jing Xu Ling-Li Wang Lv Jin Yong-Mei Source Type: research
COMMD5 is involved in the mechanisms of hypotension after parathyroidectomy in patients receiving hemodialysis
CONCLUSIONS: Serum COMMD5 levels were increased after PTx in SHPT patients. COMMD5 promoted high expression of ANP and eNOS in endothelial cells, leading to vasodilation and resulting in hypotension.PMID:36804542 | DOI:10.1016/j.ejphar.2023.175596
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Bohou Li Xueqin Chen Juan Hu Guibao Ke Nan Jiang Fengxia Zhang Zhiwen Lian Sichun Wen Qiong Wu Yubin Xia Hong Zhang Sujuan Kuang Lixia Xu Chunyu Deng Shuangxin Liu Source Type: research
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly- γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC
Drug Dev Ind Pharm. 2023 Feb 20:1-18. doi: 10.1080/03639045.2023.2182125. Online ahead of print.ABSTRACTDue to the complexity of pathophysiology of non-small cell lung cancer (NSCLC) and susceptibility of single chemotherapy to drug resistance, the combination of drugs and small interfering RNA (siRNA) may produce desired therapeutic effect on NSCLC through action of multiple pathways. We designed to develop poly-γ-glutamic acid-modified cationic liposomes (γ-PGA-CL) to co-deliver pemetrexed disodium (PMX) and siRNA to treat NSCLC. Firstly, γ-PGA was modified on surface of PMX and siRNA co-loaded cationic liposomes by e...
Source: Drug Development and Industrial Pharmacy - February 21, 2023 Category: Drugs & Pharmacology Authors: Huang Xiaoyu Song Ruonan Wang Xiao Kongfang He Rumeng Shan Xie Fei Guihua Huang Source Type: research
