Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression

CONCLUSIONS: Baicalein preserved the BLM-induced downregulation of lung Sirt3 expression, and thus the suppression of TGF-β1/Smad signalling pathway and lung fibrosis, which might provide an experimental basis for treatment of IPF.PMID:36815239 | DOI:10.1080/13880209.2022.2160767

Source: Pharmaceutical Biology - February 23, 2023 Category: Drugs & Pharmacology Authors: Yuan Ji-Hong Ma Yu Yuan Ling-Hong Gong Jing-Jing Xu Ling-Li Wang Lv Jin Yong-Mei Source Type: research