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Specialty: Drugs & Pharmacology
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Total 3220 results found since Jan 2013.
(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1
CONCLUSION: Our findings indicate that EGCG promotes intestinal epithelial cell proliferation and barrier function after I/R injury in vitro and in vivo via activation of Nurr1.PMID:37621064 | PMC:PMC10461505 | DOI:10.1080/13880209.2023.2245445
Source: Pharmaceutical Biology - August 25, 2023 Category: Drugs & Pharmacology Authors: Jiacheng Gao Yuhang Wang Zirui Jia Jiaming Xue Tingting Zhou Guo Zu Source Type: research
Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs
This article is protected by copyright. All rights reserved.PMID:37589246 | DOI:10.1002/jcph.2337
Source: The Journal of Clinical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Guohua An Source Type: research
Hydrogen sulfide promoted retinoic acid-related orphan receptor α transcription to alleviate diabetic cardiomyopathy
Biochem Pharmacol. 2023 Aug 15:115748. doi: 10.1016/j.bcp.2023.115748. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is one serious and common complication in diabetes without effective treatments. Hydrogen sulfide (H2S) fights against a variety of cardiovascular diseases including DCM. Retinoic acid-related orphan receptor α (RORα) has protective effects on cardiovascular system. However, whether RORα mediates the protective effect of H2S against DCM remains unknown. The present research was to explore the roles and mechanisms of RORα in H2S against DCM. The study demonstrated that H2S donor sodium hydro...
Source: Biochemical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Shuping Zhang Jieru Shen Yu Zhu Yangyang Zheng Wenqin San Danyi Cao Yun Chen Guoliang Meng Source Type: research
Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution
Eur J Pharm Biopharm. 2023 Aug 12:S0939-6411(23)00205-9. doi: 10.1016/j.ejpb.2023.08.002. Online ahead of print.ABSTRACTRNA therapeutics represents a powerful strategy for diseases where other approaches have failed, especially given the recent successes of mRNA vaccines against the coronavirus disease 2019 (COVID-19) and small interfering (siRNA) therapeutics. However, further developments are still required to reduce toxicity, improve stability and biodistribution of mRNA-LNPs (lipid nanoparticles). Here, we show a rational combinatorial approach to select the best formulation based on a new cationic lipid molecule (IM21...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Claire Gu éguen Thibaut Ben Chimol Margaux Briand Kassandra Renaud M élodie Seiler Morgane Ziesel Patrick Erbacher Malik Hellal Source Type: research
A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics
Adv Drug Deliv Rev. 2023 Aug 9:115052. doi: 10.1016/j.addr.2023.115052. Online ahead of print.ABSTRACTSmall interfering RNAs (siRNAs) are among the most promising therapeutic platforms in many life-threatening diseases. Owing to the significant advances in siRNA design, many challenges in the stability, specificity and delivery of siRNA have been addressed. However, safety concerns and dose-limiting toxicities still stand among the reasons for the failure of clinical trials of potent siRNA therapies, calling for a need of more comprehensive understanding of their potential mechanisms of toxicity. This review delves into th...
Source: Advanced Drug Delivery Reviews - August 11, 2023 Category: Drugs & Pharmacology Authors: Sheyda Ranjbar Xiao-Bo Zhong Jos é Manautou Xiuling Lu Source Type: research
siRNA-Based Novel Therapeutic Strategies to Improve Effectiveness of Antivirals: An Insight
AAPS PharmSciTech. 2023 Aug 11;24(6):170. doi: 10.1208/s12249-023-02629-1.ABSTRACTSince the ground-breaking discovery of RNA interference (RNAi), scientists have made significant progress in the field of small interfering RNA (siRNA) treatments. Due to severe barriers to the therapeutic application of siRNA, nanoparticle technologies for siRNA delivery have been designed. For pathological circumstances such as viral infection, toxic RNA abnormalities, malignancies, and hereditary diseases, siRNAs are potential therapeutic agents. However, systemic administration of siRNAs in vivo remains a substantial issue due to a lack o...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Krittika Chatterjee Sagheerah Lakdawala Sheikh Shahnawaz Quadir Dinesh Puri Dinesh Kumar Mishra Garima Joshi Sanjay Sharma Deepak Choudhary Source Type: research
