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Specialty: Dermatology

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Total 964 results found since Jan 2013.

2ME2 increase radiation ‐induced apoptosis of keloid fibroblasts by targeting HIF‐1α in vitro
ConclusionsThe present study indicates that HIF‐1α might serve as a therapeutic target for keloids. Furthermore, suppression of HIF‐1α by 2ME2 may be a promising therapeutic adjuvant in radiation therapy for keloids.
Source: Australasian Journal of Dermatology - April 14, 2015 Category: Dermatology Authors: Fei Long, Loubin Si, Xiao Long, Bob Yang, Xiaojun Wang, Fuquan Zhang Tags: Original Research Source Type: research

USP2 as a potential link between miR ‐125b and psoriasis
ConclusionsShedding further light on the multi‐factorial causes of psoriasis is essential, if the goal is to progress towards finer control of therapeutic tools in disease management. Findings, such as the ones presented herein, are therefore necessary in order to achieve the future of personalized medicine.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - July 31, 2016 Category: Dermatology Authors: T. Wei, L. Folkersen, E. Biskup, N. Xu, V. Manfe, O. Niazi, R. Gniadecki Tags: Original Article Source Type: research

USP2 as a potential link between miR-125b and psoriasis.
CONCLUSIONS: Shedding further light on the multi-factorial causes of psoriasis is essential, if the goal is to progress towards finer control of therapeutic tools in disease management. Findings, such as the ones presented herein, are therefore necessary in order to achieve the future of personalized medicine. This article is protected by copyright. All rights reserved. PMID: 27479112 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - July 31, 2016 Category: Dermatology Authors: Wei T, Folkersen L, Biskup E, Xu N, Manfe V, Niazi O, Gniadecki R Tags: Br J Dermatol Source Type: research

Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR ‐2 protein half‐life in part via a VE‐cadherin dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - July 31, 2016 Category: Dermatology Authors: Igor Hrgovic, Monika Doll, Andreas Pinter, Roland Kaufmann, Stefan Kippenberger, Markus Meissner Tags: Regular Article Source Type: research

512 ATM significantly protects against oxidative injury in human melanocyte associated with activation of Nrf2 pathway
Vitiligo is a common depigmentation disorder characterized by a loss of functional melanocytes from human epidermis, our previous study showed the increased sensitivity to H2O2-induced oxidative insults of vitiligo melanocytes is due to the dysfunction inNrf2-ARE signaling pathway. Here, we sought to determine the underlying mechanism for the aberrant expression of Nrf2-ARE signaling pathway. We found that transfection with ATM-siRNA leads to a significantly increased cell deathcaused by H2O2 and higher intracellular ROS and MDA levels in melanocytes, but have no effect on melanin synthesis and tyrosinase activity.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: Z. Jian, Q. Zhang Tags: Photobiology and Pigmentation Source Type: research

133 Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis
ATP-binding cassette transporter A12 (ABCA12), a lipid transporter, is known to be critical for skin barrier integrity. Mutations in this gene cause the most severe form of Autosomal Recessive Congenital Ichthyosis (ARCI): Harlequin Ichthyosis (HI). HI patients have marked hyperkeratosis at birth with fissuring, leading to life-threatening complications due to increased risk of infection, trans-epidermal water and heat loss. To understand the pathomechanisms of HI, we used siRNA knockdown of ABCA12 in primary keratinocytes with subsequent calcium-induced differentiation to model HI as well as a HPV- immortalised HI patient-derived cell line.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: F. Enjalbert, P. Dewan, M. Caley, B. Fell, M. Donaldson, D.P. Kelsell, E.A. O ’Toole Tags: Epidermal Structure and Function Source Type: research

132 Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis
Recessive X-Linked Ichthyosis (RXLI) results from a deficiency of steroid sulfatase (STS) and is characterized by an accumulation of cholesterol sulfate in the upper layers of the epidermis, resulting in a scaling phenotype and barrier dysfunction. To further understand the pathomechanisms of RXLI, we have generated an RNA-Seq data set of the transcriptome of keratinocytes with siRNA-induced loss of STS. To validate these data, we generated a 3D XLRI model using 2 telomerase-immortalized keratinocyte cell lines with stable knockdown of STS using different lentiviral shRNA clones.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: F. McGeoghan, M. Menon, P. Dewan, M. Caley, M. Donaldson, E.A. O ’Toole Tags: Epidermal Structure and Function Source Type: research

076 Investigating miRNA maturation machinery through the study of two cellular models involved in skin aging
Discovered this last decade, miRNAs play a fundamental role in post-transcriptional inhibition of gene expression, constituting an essential part of epigenetics. During skin aging, the dysregulation of some miRNAs is well known, inducing the perturbation of collagen and hyaluronic acid homeostasis. Interestingly, miRNA-19b expression was shown to decrease as skin ages, except for centenarians, who keep a high level of this miRNA (suggesting its association with longevity). First, to study the implication of miRNA maturation machinery in cellular senescence, in vitro skin fibroblasts were transfected with DICER-siRNA.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: L. Mur, A. Lebleu, C. Gondran, L. Bergeron, E. Oger, F. Portolan, J. Botto, K Cucumel, N. Domloge Tags: Epidermal Structure and Function Source Type: research

IL ‐17F regulates psoriasis‐associated genes through IκBζ
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 29, 2016 Category: Dermatology Authors: Trine Bertelsen, Christine Ljungberg, Rasmus Boye Kjellerup, Lars Iversen, Claus Johansen Tags: Regular Article Source Type: research

UV irradiation-induced production of monoglycosylated biglycan through downregulation of xylosyltransferase 1 in human dermal fibroblasts
In this study, we investigated the acute UV irradiation-induced changes of BGN protein and its GAG chain synthesis in cultured human dermal fibroblasts. After UV irradiation, intact BGN protein (I-BGN) and core protein form were reduced, but other smaller-sized bands were increased unexpectedly. Because these smaller-sized ones were reduced by transfection of BGN siRNA, and shifted to the core protein size by treatment with chondroitinase ABC, they are defectively- glycosylated BGN (D-BGN) protein.
Source: Journal of Dermatological Science - September 29, 2016 Category: Dermatology Authors: Jang-Hee Oh, Cheng Long Jin, Mira Han, Min Kyeong Shin, Cheng Yao, Chi-Hyun Park, Hanon Lee, Mira Choi, Yeon Kyung Kim, Se-Rah Lee, Xinghua Yuan, Zhe Hu Jin, Jin Ho Chung Tags: P12-08[O3-15] Source Type: research

TRIF and MAVS pathway is essential to induce Rab27A and melanosome transportation by TLR3 agonist Poly(I:C) in human epidermal melanocytes
Innate immune stimuli such as microbe molecules restlessly influence epidermis where human melanocytes reside. We have examined how innate immunity affects pigmentation and observed that TLR3 agonist poly(I:C) increased melanin release from melanocytes. Poly(I:C) increased Rab27A expression and accumulation, which facilitate melanosome transportation to cell membrane. SiRNA for Rab27A abrogated melanosome transfer to keratinocytes by poly(I:C). Thus we revealed functions of TLR3 to Rab27A pathway in melanin transfer.
Source: Journal of Dermatological Science - September 29, 2016 Category: Dermatology Authors: Saaya Koike Tags: P13-06[C09-04] Source Type: research

The IKK α-dependent non-canonical pathway of NF-κB activation is constitutively active and modulates progression-related functions in a subset of human melanomas
AbstractOwing to activation of several resistance-mediating pathways including NF- κB signaling, metastasized melanoma is almost universally resistant against chemotherapy. Given that blocking of NF-κB either by proteasome-, pan-IKK- or selective IKKβ-inhibitors may increase the susceptibility of melanoma cells to chemotherapy, we have assessed the role of the second kinase wit hin the IKK complex, IKKα. While expression of IKKα and overall activation of NF-κB were heterogeneous, the IKKα-specific p100/p52 processing was detected in a small subset of melanomas (1/9 primary and 1/12 metastatic melanomas) as well as i...
Source: Archives of Dermatological Research - October 14, 2016 Category: Dermatology Source Type: research

A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling.
Abstract Keloid disease is a fibroproliferative tumour characterised by aggressive local invasion, evident from a clinically and histologically active migrating margin. During combined laser capture microdissection and microarray analysis-based in situ gene expression profiling, we identified upregulation of the polypeptide growth factor neuregulin-1 (NRG1) and ErbB2 oncogene in keloid margin dermis, leading to the hypothesis that NRG1 contributed to keloid margin migration through ErbB2-mediated signalling. The aim of this study was to probe this hypothesis through functional in vitro studies. Exogenous NRG1 addi...
Source: Acta Dermato-Venereologica - November 23, 2016 Category: Dermatology Authors: Jumper N, Hodgkinson T, Paus R, Bayat A Tags: Acta Derm Venereol Source Type: research

Transforming growth factor-beta inducible early gene-1 (TIEG1) represses Smad7-mediated activation of TGF- β1/Smad signaling in keloid pathogenesis
Transforming growth factor β (TGF-β)/Smad signaling plays a key role in excessive fibrosis and keloid formations. Smad7 is a negative feedback regulator that prevents activation of TGF-β/Smad signaling. However, the regulatory mechanism for Smad7 in the keloid pathogenic process remains elusive. Here, we show that expressi on of TGF-β inducible early gene-1 (TIEG1) is markedly higher in keloid fibroblasts (KFs), while protein, mRNA, and promoter activity levels of Smad7 are decreased. When TIEG1 was knocked down with small interfering RNA (siRNA), both the promoter activity and protein expression of Smad7 were increa s...
Source: Journal of Investigative Dermatology - January 16, 2017 Category: Dermatology Authors: Zhi-Cheng Hu, Fen Shi, Peng Liu, Jian Zhang, Dong Guo, Xiao-ling Cao, Chu-Fen Chen, Shanqiang Qu, Jia-Yuan Zhu, Bing Tang Tags: Original Article Source Type: research

Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL) ‐1β and IL‐18 release
In conclusion, the NLRP3 inflammasome can act as a sensor of dsRNA in epidermal keratinocytes, which may be important in both skin innate immune defense against viral infection and skin inflammation. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 6, 2017 Category: Dermatology Authors: Xiuju Dai, Mikiko Tohyama, Masamoto Murakami, Koji Sayama Tags: Regular Article Source Type: research