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Specialty: Dermatology

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Total 964 results found since Jan 2013.

Chloroform upregulates early growth response‐1‐dependent thymic stromal lymphopoietin expression via the JNK and ERK pathways in human keratinocytes
ConclusionsTaken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr‐1‐dependent mechanism that requires the c‐JNK and ERK pathways. Our results suggest that exposure to chloroform may aggravate allergic skin diseases such as AD through Egr‐1‐dependent TSLP regulation.
Source: International Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: Hana Lee, Hyun Cheol Bae, Jinhee Kim, Sang Hoon Jeong, Woo‐In Ryu, Sang Wook Son Tags: Report Source Type: research

miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1
In conclusion, our findings suggest that miR-196a-2 polymorphisms can regulate the Tyr levels, which influences the susceptibility of vitiligo.
Source: Archives of Dermatological Research - October 1, 2015 Category: Dermatology Source Type: research

The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense
In this study, we investigated DJ-1 function in keratinocytes. DJ-1 was induced by H2O2 exposure and UV irradiation in keratinocytes. DJ-1 knockdown with small interfering RNA (siRNA) increased reactive oxygen species (ROS) and lactate dehydrogenase (LDH) release after UVB irradiation, suggesting that DJ-1 reduces ROS and might protect skin cells from UV damage in vitro. To investigate the in vivo role of DJ-1 in the skin, we determined DJ-1 levels in human stratum corneum samples obtained by the tape-stripping method. DJ-1 levels in the stratum corneum (scDJ-1) correlated with total antioxidant capacity. We also examined ...
Source: Archives of Dermatological Research - October 26, 2015 Category: Dermatology Source Type: research

CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities
ConclusionBasal keratinocytes may divide frequently during skin lifespan, and signs of deterioration could appear such as loss of protein factors required for correct mitosis. Our findings suggest that mitotic abnormalities can be prevented by the modulation of CRM1 and survivin. We demonstrated the ability of compound “IV08.009” to efficiently protect cultured keratinocytes from mitotic abnormalities.This article is protected by copyright. All rights reserved.
Source: International Journal of Cosmetic Science - February 1, 2016 Category: Dermatology Authors: Florian Labarrade, Jean‐Marie Botto, Nouha Domloge Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the anti‐psoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits anti‐psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF‐κB pathway.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the anti-psoriatic effect of calcipotriol.
CONCLUSIONS: Calcipotriol exhibits anti-psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF-κB pathway. This article is protected by copyright. All rights reserved. PMID: 26875609 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: Liu X, Liu Y, Xu M, Li J, Teng X, Cheng H, Xia Y Tags: Br J Dermatol Source Type: research

724 Inhibition of SHIP2 or cofilin inhibits human keratinocyte migration in vitro
Both cofilin, an actin-binding protein, and SH2-containing phosphoinositide 5’-phosphatase 2 (SHIP2) have been implicated in cell migration and concomitant effects on wound healing. However, there are conflicting reports in the literature as to their direct role. In these studies, we sought to compare the role of SHIP2 and cofilin in keratinocyte migration through both pharmacologic and sh/siRNA treatments. Cofilin was inhibited in human keratinocytes [HaCaT cell line] by transfection with a plasmid containing cofilin shRNA; the conversion of cofilin to its active form p-cofilin was inhibited with damnacanthal, a LIM kinase inhibitor.
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: D. Felsen, B. Roth, L.J. Kim, J. Chen, D.P. Poppas, J. Carucci Tags: Tissue Regeneration & Wound Healing Source Type: research

705 Ablation of alkaline phosphatase in human dermal papilla spheroid impairs hair follicle induction
We have recently shown that sphere formation increases the ability of cultured human dermal papilla (DP) cells to induce hair follicles from mouse epidermal cells in a hair reconstitution assay. Since alkaline phosphatase (ALP) activity, which is reported to be correlated with the hair-inducing capacity of murine DP cells, was significantly restored in human DP spheres, we investigated the effect of ALP knockdown on hair-inducing capacity (trichogenicity) of the DP spheres. We adopted a small interfering RNA (siRNA)-mediated gene knockdown and a ‘patch assay’ to elucidate the role of ALP for the maintenance of trichogenicity.
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: M. Kwack, M. Kim, J. Kim, Y. Sung Tags: Skin & Hair Developmental Biology Source Type: research

405 Hydrophobically modified siRNAs (hsiRNAs) provide a platform to silence gene expression in inflammatory skin diseases
RNA interference (RNAi) is a highly conserved biological process in which small RNA molecules inhibit gene expression. It has great potential to treat different human diseases, including inflammatory skin disorders. Despite promising results in vitro, therapeutic application of RNAi has been limited mainly due to difficulties in efficient delivery of the therapeutic oligonucleotides to target cells. Here we describe that direct conjugation of fully stabilized siRNA (hsiRNAs) to cholesterol (Chol) or biologically occurring lipids results in widespread distribution in the skin following local administration.
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: M. Rashighi, M. Nikan, A.H. Coles, A. Khvorova, J.E. Harris Tags: Genetic Disease, Gene Regulation & Gene Therapy Source Type: research

375 Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro
X-Linked Recessive Ichthyosis (XLRI) results from a deficiency of steroid sulfatase (STS) and is characterized by an accumulation of cholesterol sulfate in the upper layers of the epidermis, resulting in a scaling phenotype and barrier dysfunction. We have generated an RNA-Seq data set of the transcriptome of keratinocytes with siRNA-induced loss of the enzyme steroid sulfatase (STS) to further understand the pathomechanisms of XLRI. To validate these data, we generated a 3D XLRI model using 2 telomerase-immortalized keratinocyte cell lines with stable knockdown of STS using different lentiviral shRNA clones.
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: F.T. McGeoghan, E. O’Toole, M. Caley, M. Menon, P. Dewan, M. Donaldson Tags: Genetic Disease, Gene Regulation & Gene Therapy Source Type: research

310 Sphingosine-1-phosphate stimulates CAMP expression through a novel stress specific signaling complex formation
We recently discovered a novel sphingosine-1-phosphate (S1P)-induced signaling mechanism of cathelicidin antimicrobial peptide (CAMP) production in response to external perturbant-mediated endoplasmic reticulum (ER) stress. Activation occurs by an S1P receptor (S1PR)–independent activation of NF-κB, followed by C/EBPα transactivation (rather than through the well-established vitamin D receptor-mediated mechanism). Yet, how S1P activates NF-κB remains unresolved. In addition to using both specific activators and inhibitors of each S1PR isomers, we have employed a gene silencing approach and showed that ER stress-induce...
Source: Journal of Investigative Dermatology - April 20, 2016 Category: Dermatology Authors: K. Park, H. Ikushiro, H. Seo, K. Shin, T. Yano, W.M. Holleran, P.M. Elias, Y. Uchida Tags: Epidermal Structure & Barrier Function Source Type: research

Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits its antipsoriatic function through suppressing A20 expression and stabilizing negative regulators of the NF‐κB pathway.
Source: British Journal of Dermatology - May 13, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Translational Research Source Type: research

Cell division cycle‐associated protein 1 as a new melanoma‐associated antigen
Abstract Immune checkpoint inhibitors have increased the median survival of melanoma patients. To improve their effects, antigen‐specific therapies utilizing melanoma‐associated antigens should be developed. Cell division cycle‐associated protein 1 (CDCA1), which has a specific function at the kinetochores for stabilizing microtubule attachment, is overexpressed in various cancers. CDCA1, which is a member of cancer–testis antigens, does not show detectable expression levels in normal tissues. Quantitative reverse transcription polymerase chain reaction and immunoblotting analyses revealed that CDCA1 was expressed ...
Source: The Journal of Dermatology - May 29, 2016 Category: Dermatology Authors: Aki Tokuzumi, Satoshi Fukushima, Azusa Miyashita, Satoshi Nakahara, Yosuke Kubo, Junji Yamashita, Miho Harada, Kayo Nakamura, Ikko Kajihara, Masatoshi Jinnin, Hironobu Ihn Tags: Original Article Source Type: research

Down-regulation of peroxin synthesis by silencing RNA (siRNA): A novel hypothesis for treatment of leishmaniasis
Masoud Keighobadi, Saeed Emami, Abbas Khonakdar Tarsi, Mahdi FakharIndian Journal of Dermatology, Venereology, and Leprology 2016 82(4):436-437
Source: Indian Journal of Dermatology, Venereology and Leprology - June 5, 2016 Category: Dermatology Authors: Masoud KeighobadiSaeed EmamiAbbas Khonakdar TarsiMahdi Fakhar Source Type: research

Cell division cycle ‐associated protein 1 as a new melanoma‐associated antigen
Abstract Immune checkpoint inhibitors have increased the median survival of melanoma patients. To improve their effects, antigen‐specific therapies utilizing melanoma‐associated antigens should be developed. Cell division cycle‐associated protein 1 (CDCA1), which has a specific function at the kinetochores for stabilizing microtubule attachment, is overexpressed in various cancers. CDCA1, which is a member of cancer–testis antigens, does not show detectable expression levels in normal tissues. Quantitative reverse transcription polymerase chain reaction and immunoblotting analyses revealed that CDCA1 was expressed ...
Source: The Journal of Dermatology - May 29, 2016 Category: Dermatology Authors: Aki Tokuzumi, Satoshi Fukushima, Azusa Miyashita, Satoshi Nakahara, Yosuke Kubo, Junji Yamashita, Miho Harada, Kayo Nakamura, Ikko Kajihara, Masatoshi Jinnin, Hironobu Ihn Tags: Original Article Source Type: research