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Specialty: Dermatology

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Total 964 results found since Jan 2013.

Wnt5a attenuates Wnt/β‐catenin signaling in human dermal papilla cells
Abstract Findings of recent studies have demonstrated modulation of Wnt/β‐catenin signaling by Wnt5a, which is highly expressed in hair follicular dermal papilla (DP) in vivo. Here we investigated the question of whether Wnt5a can affect canonical Wnt/β‐catenin signaling in DP cells. Treatment with Wnt5a resulted in attenuation of Wnt3a‐mediated elevation of β‐catenin signaling, which was increased by Wnt5a siRNA transfection in cultured DP cells, as examined by reporter assay. In addition, treatment with Wnt5a resulted in repressed Wnt3a‐mediated expression of Axin2, EP2, and LEF1 in cultured DP cells whereas...
Source: Experimental Dermatology - January 1, 2013 Category: Dermatology Authors: Mi Hee Kwack, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung Tags: Letter to the Editors Source Type: research

Thy-1 knockdown retards wound repair in mouse skin
Conclusion: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.
Source: Journal of Dermatological Science - January 11, 2013 Category: Dermatology Authors: Min-Jung Lee, Jeong-Oh Shin, Han-Sung Jung Tags: Regular articles Source Type: research

Up-regulation of miR-18a contributes to the epidermal necrolysis in severe drug eruptions
Conclusion: Considering that BCL2L10 is an anti-apoptotic member of the BCL2 family, our results indicate that down-regulated BCL2L10 caused by miR-18a overexpression induce keratinocyte apoptosis in TEN. Investigation of the regulatory mechanisms of keratinocyte apoptosis by microRNA may lead to develop new treatments and new disease marker.
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Asako Ichihara, Masatoshi Jinnin, Keisuke Sakai, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Depressed PPARα accelerates a vicious cycle between allergic inflammation and barrier dysfunction
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and are of three subtypes: PPARα, PPARβ/δ and PPARγ. Activation of PPARs not only has positive effects on permeability barrier homeostasis but also has anti-inflammatory effects. Reduced expression of PPARα in lesional skin in atopic dermatitis (AD) and the preventive and therapeutic effects of a synthetic ligand for PPARα on AD-like dermatitis in a hapten-induced model of AD in mice have been demonstrated. Epidermal levels of expression of PPARα but of neither PPARβ/δ nor PPARγ were reduced in mice with hapten-induced AD. Expressio...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation
Conclusion: BANF1 is translocated onto the nuclear envelope in the psoriatic epidermal keratinocytes, suggesting that BANF1 is associated with upregulated proliferation of keratinocytes in psoriatic lesions. Activation of BANF1 possibly suppresses S100A9 expression and inactivates c-Jun, resulting in suppression of cutaneous inflammation.
Source: Journal of Dermatological Science - May 10, 2013 Category: Dermatology Authors: Hiroyuki Takama, Kazumitsu Sugiura, Yasushi Ogawa, Yoshinao Muro, Masashi Akiyama Tags: Regular Articles Source Type: research

Reduction of CC-chemokine ligand 5 by aryl hydrocarbon receptor ligands
Conclusion: Our findings indicate that CCL5 is a target gene for AhR, and might be associated with the pathology of dioxin exposure.
Source: Journal of Dermatological Science - July 1, 2013 Category: Dermatology Authors: Saori Morino-Koga, Hiroshi Uchi, Gaku Tsuji, Masakazu Takahara, Junboku Kajiwara, Teruaki Hirata, Masutaka Furue Tags: Regular Articles Source Type: research

Activation of transient receptor potential melastatin 8 reduces ultraviolet B‐induced prostaglandin E2 production in keratinocytes
In conclusion, the activation of TRPM8 inhibits UV‐B‐induced PGE2 production in keratinocytes, and the activation of TRPM8 may reduce inflammatory responses in skin.
Source: The Journal of Dermatology - September 23, 2013 Category: Dermatology Authors: Nok‐Hyun Park, Yong‐Joo Na, Hyang‐Tae Choi, Jun‐Cheol Cho, Hae‐Kwang Lee Tags: Concise Communication Source Type: research

Notch‐1 mediates endothelial cell activation and invasion in Psoriasis
ConclusionNotch‐receptor‐ligand interactions mediate vascular dysfunction in Psoriasis and may represent a potential therapeutic target.This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - December 1, 2013 Category: Dermatology Authors: Peadar Rooney, Mary Connolly, Wei Gao, Jennifer McCormick, Monika Biniecka, Owen Sullivan, Brian Kirby, Cheryl Sweeney, Eamonn Molloy, Trevor Markham, Ursula Fearon, Douglas J Veale Tags: Regular Article Source Type: research

Protease-activated receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytes
Conclusion: Collectively, PAR-2 activation enhanced nuclear Nrf2 translocation, and PAR-2-mediated Nrf2 activation was attributable to existing Nrf2 stabilization rather than de novo production. Our findings suggest that in addition to induction of inflammation, PAR-2 can play a chemopreventative role via Nrf2 stabilization in keratinocytes.
Source: Journal of Dermatological Science - December 9, 2013 Category: Dermatology Authors: Ji Young Kim, Do Young Kim, Hyojung Son, Yoon Jee Kim, Sang Ho Oh Tags: Regular Articles Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
Abstract Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair, glycolysis and inflammation. However, the role of sirtuin 6 (SIRT6), a NAD+‐dependent nuclear deacetylase, in wound healing specifically under diabetic condition remains unclear. To analyse the role of SIRT6 in cutaneous wound healing, paired 6‐mm stented wound was created in diabetic db/db mice...
Source: Experimental Dermatology - August 18, 2015 Category: Dermatology Authors: Rajarajan A. Thandavarayan, Venkata Naga Srikanth Garikipati, Darukeshwara Joladarashi, Sahana Suresh Babu, Prince Jeyabal, Suresh K. Verma, Alexander R. Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Original Article Source Type: research

Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through Notch and PI3K-AKT signaling pathways.
CONCLUSIONS: Deficiency of nicastrin gene in familial acne inversa may regulate proliferation and differentiation of keratinocytes mainly through Notch and PI3K-AKT signaling pathways. This article is protected by copyright. All rights reserved. PMID: 26473517 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: Xiao X, He Y, Li C, Zhang X, Xu H, Wang B Tags: Br J Dermatol Source Type: research

Psoriasin (S100A7) promotes stress‐induced angiogenesis
ConclusionThese findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS‐induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features of the angiogenic process.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - May 6, 2016 Category: Dermatology Authors: J. Vegfors, A.‐K. Ekman, S.W. Stoll, C. Bivik Eding, C. Enerbäck Tags: Original Article Source Type: research

Psoriasin (S100A7) promotes stress-induced angiogenesis.
CONCLUSION: These findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS-induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features of the angiogenic process. This article is protected by copyright. All rights reserved. PMID: 27155199 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - May 6, 2016 Category: Dermatology Authors: Vegfors J, Ekman AK, Stoll SW, Bivik Eding C, Enerbäck C Tags: Br J Dermatol Source Type: research

043 Mechanism of action of propranolol in Infantile Hemangioma: New insights from a xenograft model
8 years after propranolol was found efficacious in infantile hemangioma (IH), therapeutic mechanisms remain elusive. It has been shown, in an ovarian cancer model, that ADRB2 signaling is key for chronic stress induced tumor growth. In this model, tumor promotion is abolished by propranolol or ADRB2 siRNA but not by ADRB1 siRNA. In IH patients, after oral administration of 3 mg/kg/day of propranolol, plasma Cmax is below 1 μM, whereas propranolol has been used in vitro at 100 μM and up to 50 mg/kg in mouse models.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: F. Moisan, J. Nissen, P. Kaulanjan-Checkmodine, S. Prey, P. Dufourcq, T. Couffinhal, H. Rezvani, A. Taieb Tags: Clinical Outcomes Source Type: research