512 ATM significantly protects against oxidative injury in human melanocyte associated with activation of Nrf2 pathway

Vitiligo is a common depigmentation disorder characterized by a loss of functional melanocytes from human epidermis, our previous study showed the increased sensitivity to H2O2-induced oxidative insults of vitiligo melanocytes is due to the dysfunction inNrf2-ARE signaling pathway. Here, we sought to determine the underlying mechanism for the aberrant expression of Nrf2-ARE signaling pathway. We found that transfection with ATM-siRNA leads to a significantly increased cell deathcaused by H2O2 and higher intracellular ROS and MDA levels in melanocytes, but have no effect on melanin synthesis and tyrosinase activity.

Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: Z. Jian, Q. Zhang Tags: Photobiology and Pigmentation Source Type: research