Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL) ‐1β and IL‐18 release

In conclusion, the NLRP3 inflammasome can act as a sensor of dsRNA in epidermal keratinocytes, which may be important in both skin innate immune defense against viral infection and skin inflammation.
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Source: Experimental Dermatology - March 6, 2017 Category: Dermatology Authors: Xiuju Dai, Mikiko Tohyama, Masamoto Murakami, Koji Sayama Tags: Regular Article Source Type: research