2ME2 increase radiation ‐induced apoptosis of keloid fibroblasts by targeting HIF‐1α in vitro

ConclusionsThe present study indicates that HIF‐1α might serve as a therapeutic target for keloids. Furthermore, suppression of HIF‐1α by 2ME2 may be a promising therapeutic adjuvant in radiation therapy for keloids.

Source: Australasian Journal of Dermatology - April 14, 2015 Category: Dermatology Authors: Fei Long, Loubin Si, Xiao Long, Bob Yang, Xiaojun Wang, Fuquan Zhang Tags: Original Research Source Type: research