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Procedure: Transplants

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Total 526 results found since Jan 2013.

Bone marrow-mesenchymal stem cells alleviate microglial Pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3
CONCLUSION: BMSCs can inhibit neuroinflammation by inhibiting microglial pyroptosis, thus alleviate ICH symptoms, likely by suppressing the Syk signaling pathway while promoting the PI3K/AKT signaling pathway activation through producing CTRP3.PMID:36958593 | DOI:10.1016/j.expneurol.2023.114387
Source: Experimental Neurology - March 23, 2023 Category: Neurology Authors: Qinghua Wang Jifeng Piao Yulong Li Huiru Tu Dingyi Lv Libin Hu Run Zhang Zhenzhong Zhong Source Type: research

Transplantation of endothelial progenitor cells improves myocardial hypertrophy in spontaneously hypertensive rats through HO-1/CREB3/AKT axis
Arch Biochem Biophys. 2023 Sep 5:109739. doi: 10.1016/j.abb.2023.109739. Online ahead of print.ABSTRACTHypertensive myocardial hypertrophy produces a hostile microenvironment characterized by cardiomyocyte hypertrophy, inflammation and oxidative stress, which also leads to endothelial progenitor cells (EPCs) dysfunction, preventing EPC migration, adhesion and angiogenesis. Heme oxygenase-1 (HO-1) is an intracellular protein that plays an important role in angiogenesis and cell survival. The upregulation of cAMP response element-binding protein 3 (CREB3) is closely related to the formation of endothelial cells. The purpose ...
Source: Archives of Biochemistry and Biophysics - September 7, 2023 Category: Biochemistry Authors: Hui Liu Jing Liu Cong Liu Xiaolin Niu Jun Liu Source Type: research

Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model.
Conclusions: PGI(2) may induce persistent angiogenic effects in HLI through adhesion of EPCs to perivascular sites of neovessels via integrins in addition to paracrine effects. PMID: 23257313 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 20, 2012 Category: Cardiology Authors: Aburakawa Y, Kawabe JI, Okada M, Yamauchi A, Asanome A, Kabara M, Matsuki M, Takehara N, Nakagawa N, Okumura S, Minami Y, Mizukami Y, Yuhki KI, Ushikubi F, Hasebe N Tags: Circ J Source Type: research

Bcl3 in Mammary Tumors
Bcl3 is a putative proto-oncogene deregulated in hematopoietic and solid tumors. Studies in cell lines suggest that its oncogenic effects are mediated through the induction of proliferation and inhibition of cell death, yet its role in endogenous solid tumors has not been established. Here, we address the oncogenic effect of Bcl3 in vivo and describe how this Stat3-responsive oncogene promotes metastasis of ErbB2-positive mammary tumors without affecting primary tumor growth or normal mammary function. Deletion of the Bcl3 gene in ErbB2-positive (MMTV-Neu) mice resulted in a 75% reduction in metastatic tumor burden in the ...
Source: Cancer Research - January 16, 2013 Category: Cancer & Oncology Authors: Wakefield, A., Soukupova, J., Montagne, A., Ranger, J., French, R., Muller, W. J., Clarkson, R. W. E. Tags: Molecular and Cellular Pathobiology Source Type: research

Safety of xenotransplantation: screening the donor pig and the recipient
Conclusion:  Investigations of the last years resulted in highly sensitive and specific methods to study PERV and other microorganisms in donor pigs and human recipients of xenotransplants. These methods showed absence of PERV transmission in all investigated cases, both in more than 200 human xenotransplant recipients, mostly recipients of cellular xenotransplants, as well as in non‐human primates and small animals. New technologies under development may further decrease the probability of transmission. References:  1. Denner J. Recombinant porcine endogenous retroviruses (PERV‐A/C): A new risk for xenotransplanta...
Source: Xenotransplantation - February 5, 2013 Category: Transplant Surgery Authors: Joachim Denner Source Type: research

Active proteases in nephrotic plasma lead to a podocin‐dependent phosphorylation of VASP in podocytes via protease activated receptor‐1
Abstract Focal segmental glomerulosclerosis (FSGS) is associated with glomerular podocyte injury. Podocytes undergo dramatic changes in their actin structure, with little mechanistic insight to date into the human disease. Post‐transplantation recurrence of FSGS is the archetypal form of the disease caused by unknown circulating plasma ‘factors’. There is increasing indication that plasma protease activity could be central to this disease. Using clinical plasma exchange material, collected from patients in relapse and remission stages of disease, the effects of FSGS plasma on human conditionally immortalized podocyte...
Source: The Journal of Pathology - February 22, 2013 Category: Pathology Authors: Jessica J Harris, Hugh J McCarthy, Lan Ni, Matthew Wherlock, HeeGyung Kang, Jack F Wetzels, Gavin I Welsh, Moin A Saleem Tags: Original Paper Source Type: research

HIF-1α Confers Resistance to Induced Stress in Bone Marrow-derived Mesenchymal Stem Cells
Conclusions: Our study is the first to demonstrate how human MSCs can be manipulated to gain protection against stresses that potentially limit their clinical application.
Source: Archives of Medical Research - March 25, 2013 Category: Research Authors: Ali Asghar Kiani, Ahmad Kazemi, Rahele Halabian, Mahshid Mohammadipour, Ali Jahanian-Najafabadi, Mehryar Habibi Roudkenar Tags: Biomedical Source Type: research

Tubular ischemia and toxicity
Conclusions: EPC-derived EVs protect the kidney from ischemic AKI by delivering mRNAs coding for factor H, DAF and CD59 to injured tubular epithelial and endothelial cells. These results confirmed previous data on the relevance of complement inhibition after kidney IRI and suggest the potential use of EPC-derived EVs as therapeutic option to avoid delayed graft function after kidney transplantation.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Cantaluppi, V., Medica, D., Figliolini, F., Gatti, S., Bruno, S., Quercia, A. D., Dellepiane, S., Biancone, L., Tetta, C., Camussi, G., Zhou, L., Dai, X., Feng, M., Huang, X., Fu, P., Lan, H. Y., de Ramon, L., Ripoll, E., Luzardo, L., Merino, A., Bolanos, Tags: Abstracts Source Type: research

Repression of the Equilibrative Nucleoside Transporters Dampens Inflammatory Lung Injury.
Conclusions: Our findings reveal transcriptional repression of ENTs as innate protective response during acute pulmonary inflammation. The inhibition of ENTs could be pursued as therapeutic option to ameliorate inflammatory lung injury. PMID: 23590299 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - April 3, 2013 Category: Molecular Biology Authors: Morote-Garcia JC, Köhler D, Roth JM, Mirakaj V, Eldh T, Eltzschig HK, Rosenberger P Tags: Am J Respir Cell Mol Biol Source Type: research

Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats
Abstract Prolonged hypothermic storage causes ischemia‐reperfusion injury (IRI) in the renal graft, which is considered to contribute to the occurrence of the delayed graft function (DGF) and chronic graft failure. Strategies are required to protect the graft and to prolong renal graft survival. We demonstrated that xenon exposure to human proximal tubular cells (HK‐2) led to activation of range of protective proteins. Xenon treatment prior to or after hypothermia–hypoxia challenge stabilized the HK‐2 cellular structure, diminished cytoplasmic translocation of high‐mobility group box (HMGB) 1 and suppressed NF‐...
Source: American Journal of Transplantation - May 24, 2013 Category: Transplant Surgery Authors: H. Zhao, H. R. Watts, M. Chong, H. Huang, C. Tralau‐Stewart, P. H. Maxwell, M. Maze, A. J. T. George, D. Ma Tags: Original Article Source Type: research