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Procedure: Transplants

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Total 526 results found since Jan 2013.

Prof. Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3
CONCLUSIONS: Antitumor effects caused by TRPV4 inhibition in NSCLC might be attributed to the suppression of Foxp3 which induced subsequent cell apoptosis. Thus, pharmacological inhibition of TRPV4 may be a promising option for NSCLC treatment.PMID:34995050 | DOI:10.18388/abp.2020_5614
Source: Acta Biochim Pol - January 7, 2022 Category: Biochemistry Authors: Jiang-Tao Pu Tao Zhang Kai-Ming He Deng-Guo Zhang Zhang-Yu Teng Yun-Fei Wu Source Type: research

Testis ‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization
hnRNP G-T promoted cancer cell growth and mediated the stabilization ofZDHHC11 mRNA in colorectal cancer cells. A growth inhibition effect induced by the reduction of hnRNP G-T was detected in cancer cells, but not non-cancerous cells. Thus, hnRNP G-T is an attractive therapeutic target for colorectal cancer. AbstractVarious heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be associated with cancer cell growth. However, it remains unclear whether hnRNP G-T, which is specifically expressed in the testis, is expressed in tumor cells, and whether hnRNP G-T expressed in colorectal cancer (CRC) cells is a...
Source: Cancer Medicine - April 5, 2022 Category: Cancer & Oncology Authors: Yuki Murakami, Hiroaki Konishi, Mikihiro Fujiya, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura Tags: RESEARCH ARTICLE Source Type: research

Knockdown of Porcine Endogenous Retroviruses by RNA Interference in Chinese Experimental Miniature Pig Fibroblasts
Conclusions: Engineered CEMPF, which possess no risk of PERV-A/C infection, can serve as a nuclear donor to generate xenograft donor pigs.
Source: Transplantation Proceedings - March 1, 2013 Category: Transplant Surgery Authors: Z.-G. Li, G.-B. Liu, M.-X. Pan, Q.-S. Wu, M. Ge, J. Du, Y. Wang, Y. Gao Tags: Experimental Investigations and Innovations in Transplantation Source Type: research

Cell signalling
Conclusions: Taken together, it is likely that klotho protects against renal fibrotic process accompanied by down-regulation of fibrotic markers, counteracting to TGF-β, and one of possible mechanism mediating translocation of Na/K ATPase, resulting in Ca+ channel stabilization/alternation of Ca+ ion concentration. Klotho should be involved in the accentuation of the progression of renal fibrosis in CKD.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Tsuchiya, K., Shiohira, S., Sugiura, H., Suzuki, M., Okano, K., Nitta, K., Kaesler, N., Immendorf, S., Ouyang, C., Carmeliet, P., Floege, J., Kruger, T., Schlieper, G., Georgescu, A., Kalucka, J., Olbrich, S., Baumgartl, J., Hackenbeck, T., Eckardt, K.-U. Tags: Abstracts Source Type: research

Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes.
Abstract Deregulated expression of high-risk human papillomavirus oncogenes (E6 and E7) is a pivotal event for pathogenesis and progression in cervical cancer. Both viral oncogenes are therefore regarded as ideal therapeutic targets. Small interfering RNAs (siRNA) or double-stranded RNAs can knock down target genes effectively through siRNA-induced transcriptional gene silencing (TGS). Here, we established lentiviral-vector mediated shRNA (LV-shRNA) targeting common promoter of HPV16 E6/E7 and targeting E6 transcript, transduced the lentiviral construct into cervical HPV16-positive cell lines Siha and Caski, then ...
Source: Antiviral Research - May 1, 2013 Category: Virology Authors: Zhou J, Li B, Peng C, Wang F, Fu Z, Zhou C, Hong D, Ye F, Lü W, Xie X Tags: Antiviral Res Source Type: research

Hypoxia Inhibits Cellular Senescence to Restore the Therapeutic Potential of Old Human Endothelial Progenitor Cells via the Hypoxia-Inducible Factor-1α-TWIST-p21 Axis.
CONCLUSIONS: This study introduces ex vivo expansion protocols involving hypoxic preconditioning that are suitable for efficiently expanding old EPCs without senescence through modulation of the hypoxia-induced hypoxia-inducible factor-1α-TWIST-p21 axis. In addition, the expanded cells are shown to be useful for therapeutic vasculogenesis. PMID: 23928864 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 8, 2013 Category: Cardiology Authors: Lee SH, Lee JH, Yoo SY, Hur J, Kim HS, Kwon SM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Inhibition of porcine endogenous retroviruses (PERVs) in PK15 cell line by efficient multi‐targeting RNA interference
This article is protected by copyright. All rights reserved.
Source: Transplant International - October 21, 2013 Category: Transplant Surgery Authors: Hee Chun Chung, VanGiap Nguyen, Hyoung Joon Moon, Hye Kwon Kim, Seong Jun Park, Ji Hoon Lee, Min Kyung Choi, A Reum Kim, Bong Kyun Park Tags: Original Article Source Type: research

Abstract 601: Bcl10 Deficiency of Both Cardiac Cells and Bone Marrow Derived Cells Attenuates Angiotensin (Ang) II-induced Target Organ Damage Poster Session II
Conclusion Our results demonstrate that cardiac fibrosis in Bcl10 KO mice depends on both immune/BM-derived cells and resident cardiac cells.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Marko, L., Henke, N., Park, J.-K., Spallek, B., Qadri, F., Apel, I. J., Oravecz-Wilson, K., Przybyl, L., Luft, F. C., Dechend, R., Ruland, J., Lucas, P. C., McAllister-Lucas, L. M., Mueller, D. N. Tags: Poster Session II Source Type: research

SMYD3 as an Oncogenic Driver in Prostate Cancer by Stimulation of Androgen Receptor Transcription
Conclusions SMYD3 promotes prostate tumorigenesis and mediates epigenetic upregulation of AR expression.
Source: JNCI - November 19, 2013 Category: Cancer & Oncology Authors: Liu, C., Wang, C., Wang, K., Liu, L., Shen, Q., Yan, K., Sun, X., Chen, J., Liu, J., Ren, H., Liu, H., Xu, Z., Hu, S., Xu, D., Fan, Y. Tags: Article Source Type: research