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Volatolome of the Female Genitourinary Area: Toward the Metabolome of Cervical Cancer
Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 19, 2018 Category: Research Authors: Miriam Rodr íguez-Esquivel, Juan Rosales, Rafael Castro, Teresa Apresa-García, Ónix Garay, Pablo Romero-Morelos, Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Ricardo López-Romero, Héctor Guerrero-Flores, Betsabé Morales, Mónica Mendoza-Rodr Tags: Original Article Source Type: research

10  years Analysis of Diabetes-related Major Lower Extremity Amputations in Mexico
Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in M éxico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Iv án de Jesús Ascencio-Montiel Tags: Original Article Source Type: research

Prognostic Value of Cd95, Active Caspase-3, and Bcl-2 Expression in Adult Patients With De Novo Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is an aggressive malignant disease with high mortality rates in adults. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jaime Garcia-Chavez, Alvaro Hernandez-Caballero, Rubiraida Molina-Aguilar, Miriam America Garcia-Ruiz Esparza, Jorge Vela-Ojeda Tags: Original Article Source Type: research

Differential Impact of Sleep Duration on Fasting Plasma Glucose Level  According to Work Timing
To quantify the differential contribution of sleep duration on fasting plasma glucose level by traditional regular daytime work and shift work in subjects without diabetes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Chan-hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-yeon Kim, Chul-hee Kim, Sung-koo Kang, Ji-oh Mok Tags: Original Article Source Type: research

Clinical and Inflammatory Phenotyping: Can Electronic Nose and NMR-based  Metabolomics Work at the Bedside?
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Mauro Maniscalco, Andrea Motta Tags: Opinion Source Type: research

Copeptin Plasma Levels are Associated With Decline of Renal Function in Patients With Type 2 Diabetes Mellitus
Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 14, 2018 Category: Research Authors: Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel G ómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F. Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar Tags: Original Article Source Type: research

Intranasal Administration of a Naked Plasmid Reached Brain Cells and Expressed Green Fluorescent Protein, a Candidate for Future Gene Therapy Studies
Intranasal administration (Int adm) has been well-studied and offers the possibility to deliver larger molecular weight biologics, such as proteins, viral vectors, nanoparticles, and naked plasmids to the brain and treat a variety of diseases in the central nervous system. The predominant challenge in this field is finding efficient vectors that are capable of crossing the blood-brain barrier (BBB). (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 16, 2018 Category: Research Authors: Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Su árez, Teresa Juárez-Cedillo, Vilma Carolina Bekker Méndez, Emiliano Tesoro-Cruz Tags: Original Article Source Type: research

Hyperbaric-Oxygen Therapy Improves Survival and Functional Outcome of Acute Severe Intracerebral Hemorrhage-Prospective, Randomized Controlled Trial
Prognosis of spontaneous intracerebral hemorrhage (ICH) remains poor worldwide. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 13, 2018 Category: Research Authors: Xiaowei Li, Jingze Li, Xuehui Yang, Zhaosheng Sun, Jinrong Zhang, Wangmiao Zhao, Shuzhi Dong, Cong Li, Yanqiao Ye, Jianchao Chen, Yongqian Li, Yi Xiang, Jianhui Mao, Guangjie Li, Hong Guo, Wenchao Zhang, Hao Guo, Yazhao Zhang, Mingzhe Zhang, Wanzeng Zhang Tags: Original Article Source Type: research

Inhibitory Effect of Artesunate on Growth and Apoptosis of Gastric Cancer Cells
The present study aimed to explore the inhibitory effect of artesunate on the growth and apoptosis of gastric cancer cells, in order to search for high effective and low toxic anti-gastric cancer drugs. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 12, 2018 Category: Research Authors: Lei Wang, Liang Liu, Jing Wang, YueTong Chen Tags: Original Article Source Type: research

Spinogenesis and Plastic Changes in the Dendritic Spines of Spinal Cord Motoneurons After Traumatic Injury in Rats
Spinal cord injury (SCI) is highly incapacitating, and the neurobiological factors involved in an eventual functional recovery remain uncertain. Plastic changes to dendritic spines are closely related with the functional modifications of behavior. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 10, 2018 Category: Research Authors: Eliseo Portilla-de Buen, Hermelinda Salgado-Ceballos, David Gonz ález-Tapia, Caridad Leal-Cortés, Rodrigo Mondragón-Lozano, Stephanie Sánchez-Torres, Laura Álvarez-Mejía, Omar Fabela-Sánchez, Néstor I. Martínez-Torres, Myrna M. González-Ramírez Tags: Original Article Source Type: research

Koch Postulate: Why Should we Grow Bacteria?
Understanding infectious diseases has long relied on the Koch postulate, which consists of the pure culture of microorganisms. The advent of molecular methods in clinical microbiology has led the phasing out of culture as a diagnostic tool and metagenomics has become the technique most commonly used to assess the impact of commensal microbes on human health. However, culturing microbes has led to substantial advances, even recently, in infectious diseases involving fastidious microorganisms, as evidenced by the Tropheryma whipplei or Bartonella species. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 6, 2018 Category: Research Authors: Jean-Christophe Lagier, Gr égory Dubourg, Sophie Amrane, Didier Raoult Tags: Review Article Source Type: research

Koch Postulate: Why do we Should Grow Bacteria?
Understanding infectious diseases has long relied on the Koch postulate, which consists of the pure culture of microorganisms. The advent of molecular methods in clinical microbiology has led the phasing out of culture as a diagnostic tool and metagenomics has become the technique most commonly used to assess the impact of commensal microbes on human health. However, culturing microbes has led to substantial advances, even recently, in infectious diseases involving fastidious microorganisms, as evidenced by the Tropheryma whipplei or Bartonella species. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 6, 2018 Category: Research Authors: Jean-Christophe Lagier, Gr égory Dubourg, Sophie Amrane, Didier Raoult Tags: Review Article Source Type: research

Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population
The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) single nucleotide polymorphism has been associated with BMI and obesity in distinct populations, both adult and pediatric, with contradictory results involving either Val or Met as the risk variant. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 2, 2018 Category: Research Authors: Jos é Darío Martínez-Ezquerro, Mario Enrique Rendón-Macías, Gerardo Zamora-Mendoza, Jacobo Serrano-Meneses, Beatriz Rosales-Rodríguez, Deyanira Escalante-Bautista, Maricela Rodríguez-Cruz, Raúl Sánchez-González, Yessica Arellano-Pineda, Mardia L Tags: Original Article Source Type: research

Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex Picture
Depression plays an important role in the pathogenesis and treatment of obesity and type 2 diabetes (T2D). However, its relevance is frequently unrecognized by clinicians and researchers. The purpose of this review is to present a critical analysis of the evidence linking depression and metabolic disorders and to highlight the practical implications of this complex relationship. Evidence obtained from epidemiological, basic, clinical and controlled studies demonstrate that the association goes beyond a random phenomenon. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 22, 2018 Category: Research Authors: Magdalena del Roc ío Sevilla-González, Brenda Macale Quintana-Mendoza, Carlos Alberto Aguilar-Salinas Tags: Review Article Source Type: research

Hypolipidemic Components from Medicine Food Homology Species Used in China: Pharmacological and Health Effects
Hyperlipidemia is a systemic disease caused by abnormal human lipid metabolism. Dietary control and treatment on hyperlipidemia is now a popular therapy pathway. This paper focuses on the medicine food homology (MFH) species used in China with hypolipidemic function, and emphasizes on the active ingredients and their pharmacological effect. The single herbal and its hypolipidemic active ingredients are summarized through reviewing the relevant literatures published in the past twenty years. The ingredients are divided into polysaccharides, flavonoids, steroidal saponins, quinones, alkaloids and others, of which the related...
Source: Archives of Medical Research - February 13, 2018 Category: Research Authors: De-xing Song, Jian-guo Jiang Tags: Review Article Source Type: research

Hearing Loss in Type 2 Diabetes in Association with Diabetic Neuropathy
Reports assessing hearing abnormalities in diabetes are debated. We aimed to evaluated auditory alterations and their possible associations with vascular and neurological dysfunction in 160 Type 2 diabetes mellitus individuals and 100 age and sex-matched healthy controls. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 9, 2018 Category: Research Authors: Huihui Ren, Zhenggang Wang, Zhongyao Mao, Ping Zhang, Chunfang Wang, Aiguo Liu, Gang Yuan Tags: Original Article Source Type: research

Expanding our Understanding of the Role of the Microbiome in Health and Disease
Our understanding of the microbial side of ourselves, and its implications in health and disease, has been completely transformed in the past decade. Advances in DNA sequencing, and in the computational techniques required to understand this wealth of DNA sequences, allow us to read out the complex microbial communities that inhabit our bodies and our world at unprecedented rates. However, relating this information to function, and learning how to  modify our microbiomes to improve health, remain important challenges in the field. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 8, 2018 Category: Research Authors: Rob Knight Tags: Preface Source Type: research

Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNF α, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia
Preeclampsia (PE) is known as a major cause of maternal and neonatal morbidity and mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of angiogenic factors can be observed in PE (1). The reduction in uteroplacental perfusion can cause ischemia and the ischemic placenta releases soluble factors causing maternal endothelial dysfunction and hypertension (2). These alterations also lead to an increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF- α) and IL-6 from the placenta (3). (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 4, 2018 Category: Research Authors: Metehan Uzun, Meryem Gencer, Hakan Turkon, Rahime Ozlem Oztopuz, Ufuk Demir, Mehmet Akif Ovali Tags: Original Article Source Type: research

20 Years Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever  in Mexico
Dengue Fever (DF) is a human vector-borne disease and a major public health problem worldwide. In Mexico, DF and Dengue Hemorrhagic Fever (DHF) cases have increased in recent years. The aim of this study was to identify variations in the spatial distribution of DF and DHF cases over time using space-time statistical analysis and geographic information systems. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 2, 2018 Category: Research Authors: Sendy Isarel Hern ández-Gaytán, Francisco Javier Díaz-Vásquez, Luis Gerardo Duran-Arenas, Malaquías López Cervantes, Stephen J. Rothenberg Tags: Original Article Source Type: research

Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever in Mexico from 1995 –2015
Dengue Fever (DF) is a human vector-borne disease and a major public health problem worldwide. In Mexico, DF and Dengue Hemorrhagic Fever (DHF) cases have increased in recent years. The aim of this study was to identify variations in the spatial distribution of DF and DHF cases over time using space-time statistical analysis and geographic information systems. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 2, 2018 Category: Research Authors: Sendy Isarel Hern ández-Gaytán, Francisco Javier Díaz-Vásquez, Luis Gerardo Duran-Arenas, Malaquías López Cervantes, Stephen J. Rothenberg Tags: Original Article Source Type: research

Human Virome
The human virome is composed by the set of all viruses, eukaryotic and prokaryotic, present in the human body; as each body compartment constitutes a different microenvironment, the virome varies with the body part. Additionally, other factors influence the virome composition, such as age, diet, and the presence of other components of the microbiome. The study of the virome takes advantage of the development of next generation sequencing, and has allowed the discovery of novel viruses, and the characterization of the virome in healthy and diseased individuals, allowing the association of viruses with specific diseases. (So...
Source: Archives of Medical Research - February 1, 2018 Category: Research Authors: Selene Z árate, Blanca Taboada, Martha Yocupicio-Monroy, Carlos F. Arias Tags: Review Article Source Type: research

The Human Virome
The human virome is composed by the set of all viruses, eukaryotic and prokaryotic, present in the human body; as each body compartment constitutes a different microenvironment, the virome varies with the body part. Additionally, other factors influence the virome composition, such as age, diet, and the presence of other components of the microbiome. The study of the virome takes advantage of the development of next generation sequencing, and has allowed the discovery of novel viruses, and the characterization of the virome in healthy and diseased individuals, allowing the association of viruses with specific diseases. (So...
Source: Archives of Medical Research - February 1, 2018 Category: Research Authors: Selene Z árate, Blanca Taboada, Martha Yocupicio-Monroy, Carlos F. Arias Tags: Review Article Source Type: research

Evolving Ecosystems: Inheritance and Selection in the Light of the Microbiome
The importance of microorganisms in human biology is undeniable. The amount of research that supports that microbes have a fundamental role in animal and plant physiology is substantial and increasing every year. Even though we are only beginning to comprehend the broadness and complexity of microbial communities, evolutionary theories need to be recast in the light of such discoveries to fully understand and incorporate the role of microbes in our evolution. Fundamental evolutionary concepts such as diversity, heredity, selection, speciation, etc., which constitute the modern synthesis, are now being challenged, or at lea...
Source: Archives of Medical Research - January 22, 2018 Category: Research Authors: Santiago Sandoval-Motta, Maximino Aldana, Alejandro Frank Tags: Review Article Source Type: research

Gut Microbiota in Obesity and Metabolic Abnormalities: A Matter of Composition or Functionality?
The obesity pandemic and the metabolic complications derived from it represent a major public health challenge worldwide. Although obesity is a multifactorial disease, research from the past decade suggests that the gut microbiota interacts with host genetics and diet, as well as with other environmental factors, and thus contributes to the development of obesity and related complications. Despite abundant research on animal models, substantial evidence from humans has only started to accumulate over the past few years. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 29, 2017 Category: Research Authors: Sofia Moran-Ramos, Blanca E. L ópez-Contreras, Samuel Canizales-Quinteros Tags: Review Article Source Type: research

Human Intestinal Microbiota: Interaction Between Parasites and the Host Immune Response
The human gut is a highly complex ecosystem with an extensive microbial community, and the influence of the intestinal microbiota reaches the entire host organism. For example, the microbiome regulates fat storage, stimulates or renews epithelial cells, and influences the development and maturation of the brain and the immune system. Intestinal microbes can protect against infection by pathogenic bacteria, viruses, fungi and parasites. Hence, the maintenance of homeostasis between the gut microbiota and the rest of the body is crucial for health, with dysbiosis affecting disease. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 28, 2017 Category: Research Authors: Oswaldo Partida-Rodr íguez, Angélica Serrano-Vázquez, Miriam E. Nieves-Ramírez, Patricia Moran, Liliana Rojas, Tobias Portillo, Enrique González, Eric Hernández, B. Brett Finlay, Cecilia Ximenez Tags: Review Article Source Type: research

Conditional Inference Tree for Multiple Gene-Environment Interactions on Myocardial Infarction
Identifying gene-environment interaction in the context of multiple environmental factors has been a challenging task. We aimed to use conditional inference tree (CTREE) to strata myocardial infarction (MI) risk synthesizing information from both genetic and environmental factors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 16, 2017 Category: Research Authors: Zhijun Wu, Xiuxiu Su, Haihui Sheng, Yanjia Chen, Xiang Gao, Le Bao, Wei Jin Tags: Original Article Source Type: research

Conditional Inference Tree for Multiple Gene-Environment Interactions on Myocardial Infarction Among Chinese Men
Identifying gene-environment interaction in the context of multiple environmental factors has been a challenging task. We aimed to use conditional inference tree (CTREE) to strata myocardial infarction (MI) risk synthesizing information from both genetic and environmental factors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 16, 2017 Category: Research Authors: Zhijun Wu, Xiuxiu Su, Haihui Sheng, Yanjia Chen, Xiang Gao, Le Bao, Wei Jin Tags: Original Article Source Type: research

Correlations of Serum Cyclophilin A and Melatonin Concentrations with Hypertension-induced Left Ventricular Hypertrophy
Cyclophilin A (CyPA) is an abundantly expressed pro-inflammatory cytokine and a major secreted oxidative stress-induced factor (SOXF). Melatonin is an important chronobiological regulatory molecule that is mainly released from the pineal gland and exerts antioxidant effects by acting as a radical scavenger. Based on accumulating evidence, both CyPA and melatonin play important roles in cardiovascular diseases. However, further investigations are required to determine whether CyPA and melatonin are associated with hypertension-induced left ventricular hypertrophy (LVH). (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 14, 2017 Category: Research Authors: Hongyan Su, Tongshuai Chen, Jingyuan Li, Jie Xiao, Shujian Wang, Xiaobin Guo, Peili Bu Tags: Original Article Source Type: research

Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins
In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 13, 2017 Category: Research Authors: B ünyamin Özgeriş, Yusuf Akbaba, Özlem Özdemir, Hasan Türkez, Süleyman Göksu Tags: Original Article Source Type: research

Microbiota and Aging. A Review and Commentary
Although there is a consensus that the dominant species that make up the adult microbiota remains unchanged in elderly people, it has been reported that there are significant alterations in the proportion and composition of the different taxa, leading to reduced microbiota diversity, as well as an increase of enteropathogens that may lead to chronic inflammation. The ageing of mucosal immune and motor systems also contributes to these changes. As the individual ages, there is a loss in the number of Peyer's patches, an altered local capacity of T and B cell functions as well as chronic macrophage activation. (Source: Archi...
Source: Archives of Medical Research - December 8, 2017 Category: Research Authors: Carmen Garc ía-Peña, Teresa Álvarez-Cisneros, Ricardo Quiroz-Baez, Robert P. Friedland Tags: Review Article Source Type: research

Combined Raloxifene and Letrozole for Breast Cancer Patients
Raloxifene, an anti-osteoporotic drug, is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole, another anticancer drug. However, the cytotoxic effect of their combination on human breast cancer (MCF-7) and human embryonic kidney (HEK) cell lines is not known. MCF-7 and HEK cell lines were treated with different graded doses of letrozole, raloxifene and their combination, then incubated for 24 –48 h. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 8, 2017 Category: Research Authors: Divya Vohora, Abul Kalam, Ankita Leekha, Sushama Talegaonkar, Anita Kamra Verma Tags: Preliminary Report Source Type: research

Hygiene Hypothesis in Asthma Development: Is Hygiene to Blame?
Industrialized countries have registered epidemic rates on allergic diseases, such as hay fever, asthma, eczema, and food allergies. The Hygiene Hypothesis was born from work made by Dr. David Strachan, who observed that younger siblings were less susceptible to eczema and asthma, and proposed that this was a result of increased transmission of infectious agents via unhygienic practices within a household. This initial hypothesis was then reframed as the old friends/microbiota hypothesis, implicating non-pathogenic commensal microorganisms as the source of immunomodulatory signals necessary to prevent immune-mediated chron...
Source: Archives of Medical Research - December 7, 2017 Category: Research Authors: Erik van Tilburg Bernardes, Marie-Claire Arrieta Tags: Review Article Source Type: research

Regulation of SIRT3/FOXO1 Signaling Pathway in Rats with Non-alcoholic Steatohepatitis by Salvianolic Acid B
To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 7, 2017 Category: Research Authors: Yingchun Wang, Juan Chen, Weizong Kong, Ruiping Zhu, Kai Liang, Quanxiang Kan, Yanhong Lou, Xiangyu Liu Tags: Original Article Source Type: research

Gut Microbiome and Antibiotics
Despite that the human gastrointestinal tract is the most populated ecological niche by bacteria in the human body, much is still unknown about its characteristics. This site is highly susceptible to the effects of many external factors that may affect in the quality and the quantity of the microbiome. Specific factors such as diet, personal hygiene, pharmacological drugs and the use of antibiotics can produce a significant impact on the gut microbiota. The effect of these factors is more relevant early in life, when the gut microbiota has not yet fully established. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 5, 2017 Category: Research Authors: Tadasu Iizumi, Thomas Battaglia, Victoria Ruiz, Guillermo I. Perez Perez Tags: Review Article Source Type: research

Inflammation in the Prediction of Type 2 Diabetes and Hypertension in Healthy Adults
While inflammation is associated with obesity and insulin resistance, their inter-relationships in the development of type 2 diabetes or hypertension are not clear. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 5, 2017 Category: Research Authors: Ki-chul Sung, Seungho Ryu, Joo-wook Sung, Yong Bum Kim, Yu Sam Won, Dong Sik Cho, Sun H. Kim, Alice Liu Tags: Original Article Source Type: research

Donor Polymorphisms of Toll-like Receptor 4 rs1927914 Associated with the Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation
Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) severely restricts the long-term survival of patients. Toll-like receptor 4 (TLR4) has been considered to be involved in hepatocarcinogenesis and metastasis. Additionally, there is a study demonstrating the significant association between TLR4 gene rs1927914 polymorphism and HCC, but no study investigated the association of the TLR4 rs1927914 polymorphism with the risk of HCC recurrence following LT. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 5, 2017 Category: Research Authors: Guangjun Shi, Chuanxu Wang, Ping Zhang, Lisha Ji, Shifeng Xu, Xueying Tan, Hao Li Tags: Preliminary Report Source Type: research

Optimizing Non-Pharmacologic Management of Hypertriglyceridemia
The cornerstone of initial management for hypertriglyceridemia (HTG) is lifestyle modification. The combination of weight loss through caloric restriction, alteration in macronutrient composition and increased energy expenditure reduces TG levels by approximately 50%. The addition of cinnamon, cacao products and isocaloric substitution of 1 serving of nuts may contribute another 5 –15% lowering of TG. This can be particularly beneficial in patients with HTG who are at increased risk of cardiovascular disease. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 5, 2017 Category: Research Authors: Alexandra Byrne, Sunal Makadia, Aimee Sutherland, Michael Miller Tags: Review Article Source Type: research

On the Search to Elucidate the Role of Microbiota in the Genesis of Cancer: The Cases of Gastrointestinal and Cervical Cancer
The microbiota that inhabits the human body plays an important role in health and disease, by their fundamental role in food digestion, training of the immune system or protection against pathogen colonization. However, when the equilibrium with its host is altered, some diseases like cancer might be promoted. In this review we describe the information collected in recent studies between the microbiota and its association with cancer. We conducted the review of the relation of microbiome and cancer etiology focusing on the gastrointestinal and cervical cancer. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 1, 2017 Category: Research Authors: Francisco Avil és-Jiménez, Yu Guoqin, Kirvis Torres-Poveda, Vicente Madrid-Marina, Javier Torres Tags: Review Article Source Type: research

On the Search to Elucidate the Role of the Microbiota in the Genesis of Cancer: The Cases of Gastrointestinal and Cervical Cancer
The microbiota that inhabits the human body plays an important role in health and disease, by their fundamental role in food digestion, training of the immune system or protection against pathogen colonization. However, when the equilibrium with its host is altered, some diseases like cancer might be promoted. In this review we describe the information collected in recent studies between the microbiota and its association with cancer. We conducted the review of the relation of microbiome and cancer etiology focusing on the gastrointestinal and cervical cancer. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 1, 2017 Category: Research Authors: Francisco Avil és-Jiménez, Yu Guogin, Kirvis Torres-Poveda, Vicente Madrid-Marina, Javier Torres Tags: Review Article Source Type: research

Insulin-like Growth Factor 1 Mediates Adrenal Development Dysfunction in Offspring Rats Induced by Prenatal Food Restriction
Our previous study demonstrated that prenatal food restriction (PFR) could induce the dysfunction of the hypothalamic –pituitary–adrenal axis and glucocorticoid-related glucose and lipid metabolic alterations in adult offspring rats. (Source: Archives of Medical Research)
Source: Archives of Medical Research - December 1, 2017 Category: Research Authors: Zheng He, Feng Lv, Yufeng Ding, Chunyan Zhu, Hegui Huang, Li Zhang, Yu Guo, Hui Wang Tags: Original Article Source Type: research

Development of Microbiota in Infants and its Role in Maturation of Gut Mucosa and Immune System
Dysbiosis of the gut microbiota has been associated with increasing numbers of diseases, including obesity, diabetes, inflammatory bowel disease, asthma, allergy, cancer and even neurologic or behavioral disorders. The other side of the coin is that a healthy microbiota leads to a healthy human development, to a mature and well trained immune system and to an efficient metabolic machinery. What we have learned in adults is in the end the result of a good start, a programmed, healthy development of the microbiota that must occur in the early years of life, probably even starting during the fetal stage. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 30, 2017 Category: Research Authors: Cecilia Ximenez, Javier Torres Tags: Review Article Source Type: research

Development of the Microbiota in Infants and its Role in Maturation of the Gut Mucosa and the Immune System
Dysbiosis of the gut microbiota has been associated with increasing numbers of diseases, including obesity, diabetes, inflammatory bowel disease, asthma, allergy, cancer and even neurologic or behavioral disorders. The other side of the coin is that a healthy microbiota leads to a healthy human development, to a mature and well trained immune system and to an efficient metabolic machinery. What we have learned in adults is in the end the result of a good start, a programmed, healthy development of the microbiota that must occur in the early years of life, probably even starting during the fetal stage. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 30, 2017 Category: Research Authors: Cecilia Ximenez, Javier Torres Tags: Reviewer Article Source Type: research

Lipoamide Inhibits NF1 Deficiency-induced Epithelial-Mesenchymal Transition in Murine Schwann Cells
This study was designed to investigate whether excessive ROS conferred to Nf1 deficiency-induced EMT in Schwann cells. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 29, 2017 Category: Research Authors: Yuchen Zhang, Rongsheng Zhou, Yiping Qu, Maoguo Shu, Shuzhong Guo, Zhuanli Bai Tags: Original Article Source Type: research

Contemporary Applications of Fecal Microbiota Transplantation to Treat Intestinal Diseases in Humans
The intestinal microbiota comprise an important organ that plays a vital role in host digestion, development, energy maintenance, hemostasis, and immunity. Disruption of the gut microbial community due to diet, lifestyle, or antibiotic exposure increases susceptibility to chronic infection and disease. Fecal microbiota transplantation (FMT) involves the transfer of gut microbiota from a healthy donor to a patient in order to restore normal diversity and function of the microbial community. This method has become a well established alternative therapy for the treatment of recurrent Clostridium difficile infection. (Source: ...
Source: Archives of Medical Research - November 25, 2017 Category: Research Authors: Christopher Staley, Alexander Khoruts, Michael J. Sadowsky Tags: Review Article Source Type: research

Maternal Micronutrients, Omega-3 Fatty Acids and Gene Expression of Angiogenic and Inflammatory Markers in Pregnancy Induced Hypertension Rats
Preeclampsia is a disorder of pregnancy and is associated with inflammation and altered angiogenesis. The present study examines the effect of micronutrient and omega-3 fatty acid supplementation (individual, as well as combined) on genes involved in inflammation and angiogenesis, as well as global DNA methylation levels in a pregnancy induced hypertension (PIH) rat model. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 10, 2017 Category: Research Authors: Nisha Kemse, Deepali Sundrani, Anvita Kale, Sadhana Joshi Tags: Original Article Source Type: research

Effect of Native and Minimally Modified Low-density Lipoprotein on the Activation of Monocyte Subsets
The objective of this research was to determine the number of monocyte subsets positives to cytokines in response to native (nLDL) and minimally modified LDL (mmLDL). (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 10, 2017 Category: Research Authors: Francisco Blanco-Favela, Jos é Esteban Espinosa-Luna, Adriana Karina Chávez-Rueda, Alejandra Madrid-Miller, Luis Chávez-Sánchez Tags: Original Article Source Type: research

Prognostic Value of microRNA-224 in Various Cancers: A Meta-analysis
During previous studies, microRNA-224 (miR-224) was frequently investigated and discovered to be of vital significance to prognosis of patients with various cancers. However, its accurate prognostic value has not been estimated worldwide. Herein, we performed meta-analysis to assess its potential predictive value in a variety of human tumors. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 10, 2017 Category: Research Authors: Yue Zhang, Cong-Cong Guo, Dong-Hui Guan, Chuan-Hua Yang, Yue-Hua Jiang Tags: Original Article Source Type: research

Comparative Assessment of Serum Adipokines Zinc- α2-glycoprotein and Adipose Triglyceride Lipase, and Cardiovascular Risk Factors Between Normal Weight and Obese Patients with Hemodialysis
Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc- α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and glucose metabolism. The aim of this study was to investigate serum concentrations of ZAG and ATGL, and the relationship of these adipokines with cardiovas cular risk factors in normal weight (NW) and obese (OB) patients undergoing hemodialysis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 8, 2017 Category: Research Authors: Mohammad Javad Hosseinzadeh-Attar, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Elham Alipoor Tags: Original Article Source Type: research

Comparative Assessment of Serum Adipokines Zinc- α2-glycoprotein and Adipose Triglyceride Lipase and Cardiovascular Risk Factors Between Normal Weight and Obese Patients with Hemodialysis
Little is known about the potential relationship of obesity, adipose tissue and novel adipokines with cardiometabolic risk factors in end-stage renal disease. Zinc- α2-glycoprotein (ZAG) and adipose triglyceride lipase (ATGL) are novel adipokines with proposed desirable effects on inflammation, and lipid and glucose metabolism. The aim of this study was to investigate serum concentrations of ZAG and ATGL, and the relationship of these adipokines with cardiovas cular risk factors in normal weight (NW) and obese (OB) patients undergoing hemodialysis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 8, 2017 Category: Research Authors: Mohammad Javad Hosseinzadeh-Attar, Mitra Mahdavi-Mazdeh, Mehdi Yaseri, Narges Sadat Zahed, Elham Alipoor Tags: Original Article Source Type: research

Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch –Schönlein Purpura Nephritis
Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-Sch önlein purpura (HSP) patients. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 6, 2017 Category: Research Authors: Yuanyuan Zhang, Aiju Li, Jiliang Wen, Junhui Zhen, Qiufa Hao, Yidan Zhang, Zhao Hu, Xiaoyan Xiao Tags: Original Article Source Type: research