Reduction of No Reflow with a Loading Dose of Atorvastatin before Primary Angioplasty in Patients with Acute ST Myocardial Infarction
No reflow defined as an altered myocardial reperfusion and failure at microvascular level is a frequent complication in acute myocardial infarction that attenuates beneficial effect of reperfusion therapy leading to poor outcomes. There is not enough evidence to support that previous use of statins improves coronary flow in patients undergoing primary percutaneous coronary intervention (PCI). (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 13, 2018 Category: Research Authors: Rosalba C. Garc ía-Méndez, Eduardo Almeida-Gutierrez, Leonor Serrano-Cuevas, Jesús Salvador Sánchez-Díaz, Martín Rosas-Peralta, Jose Alberto Ortega-Ramirez, Jose Antonio Palomo-Villada, Irma Isordia-Salas, Rosa Marisol Alonso-Bravo, Gabriela Borrayo Tags: Preliminary Report Source Type: research

Clinical Interests of Circulating Tumor DNA in Oncology
Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heterogeneity. In various body fluids like plasma, somatic mutations have been identified. Circulating tumor DNA (ctDNA) holds promises in tumor burden monitoring or malignancies early detection. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 7, 2018 Category: Research Authors: Claire Franczak, Pierre Filhine-Tressarieu, Julien Bros éus, Pauline Gilson, Jean-Louis Merlin, Alexandre Harlé Tags: Review Article Source Type: research

Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway
Hepatic gluconeogenesis plays an important role in regulating fasting plasma glucose levels and is a target of anti-diabetic drugs. Several kinds of iridoid glucosides exhibit hypoglycemic effect, whereas the mechanism was not clear. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 5, 2018 Category: Research Authors: Shao-Qing Yang, Ye-Dan Chen, Heng Li, Xian Hui, Wen-Yun Gao Tags: Original Article Source Type: research

Predicting Human miRNA-like Sequences within Human Papillomavirus Genomes
This study presents a prediction of putative miRNA within several Human Papillomavirus (HPV) types by using bioinformatics tools and a strategy based on sequence and structure alignment. Currently, little is known about HPV miRNAs. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 3, 2018 Category: Research Authors: Denisse A. Guti érrez, Armando Varela-Ramírez, Miriam Rodríguez-Esquivel, Mónica G. Mendoza-Rodríguez, Jorge T. Ayala-Sumuano, David Pineda, Efraín Garrido-Guerrero, Florinda Jiménez-Vega, Saúl Aguilar, Miguel Quiñones, María J. Nambo, Pedro Ch Tags: Original Article Source Type: research

Metabolic Syndrome and Cardiovascular Disease: A Health Challenge in Mexico
Metabolic Syndrome (MetS) is a cluster of risk factors that, taken alone or synergically, are independent predictors of type 2 diabetes and cardiovascular disease (CVD), which are both major public health problems that requires urgent containment actions. Current controversies regarding MetS are focused on ascertain the unifying explanation of molecular and pathophysiological mechanisms originating the syndrome, involving insulin resistance and low-grade chronic inflammation. This review aims to present the clinical relevance of MetS and its complications, as well as the hypotheses addressing its etiopathogenic relation wi...
Source: Archives of Medical Research - October 24, 2018 Category: Research Authors: Antonio Gonzalez-Ch ávez, José Alejandro Chávez-Fernández, Sandra Elizondo-Argueta, Alonso González-Tapia, José Israel León-Pedroza, Cesar Ochoa Tags: Review Article Source Type: research

Diagnosis of Transient/Latent HPV Infections - A Point of View!
Diagnosis of transient/latent HPV infections requires a rethinking of ideas concerning the host virus relationship. With this in mind, we address several concepts, such as mutualism and commensalism, to understand better the different stages of development, in addition to briefly covering current methods of detection. We suggest analyzing molecules related to the innate immune response for earlier diagnosis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 24, 2018 Category: Research Authors: Eduardo Perez-Campos Mayoral, Gabriel Mayoral-Andrade, Laura P érez-Campos Mayoral, Socorro Pina Canseco, Ruth Martínez Cruz, María Teresa Hernández-Huerta, Adriana Moreno Rodriguez, Hector A. Cabrera-Fuentes, Eduardo Pérez-Campos Tags: Review Article Source Type: research

Association Studies of HSPA1A and HSPA1L Gene Polymorphisms With Schizophrenia in the Polish Population
Schizophrenia is a severe psychiatric disorder with a strong genetic component. The HSP70 chaperones are particularly interesting in terms of schizophrenia, especially with regard to neurodevelopmental hypothesis, because they are critical regulators in normal neural physiological function as well as in cell stress responses. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 17, 2018 Category: Research Authors: Malgorzata Kowalczyk, Krzysztof Kucia, Aleksander Owczarek, Renata Suchanek-Raif, Wojciech Merk, Monika Paul-Samojedny, Jan Kowalski Tags: Original Article Source Type: research

Antioxidant Activity and Protective Effect of Carob Honey in CCl4-induced Kidney and Liver Injury
Various honey samples exhibited protective effect against drug and chemical induced toxicity. The study was designed to determine the antioxidant content and activity of carob honey and to investigate its hepato-renal protective effect in carbon tetrachloride (CCl4) induced kidney and liver injury in rats. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 17, 2018 Category: Research Authors: Redouan El-haskoury, Noori Al-Waili, Zineb Kamoun, Mohamed Makni, Hamza Al-Waili, Badiaa Lyoussi Tags: Original Article Source Type: research

Varicella-Zoster Virus in Cerebrospinal Fluid at Relapses of Multiple Sclerosis is Infective in  Vitro
We have reported the presence of varicella-zoster virus (VZV) DNA and viral particles in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients during exacerbation. It is not known whether these viruses are infective. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 17, 2018 Category: Research Authors: Olivia Hern ández-González, Adolfo Martínez-Palomo, Julio Sotelo, Bibiana Chávez-Munguía, Graciela Ordoñez, Daniel Talamás-Lara, Benjamin Pineda, José de Jesús Flores-Rivera, Martha Espinosa-Cantellano Tags: Preliminary Report Source Type: research

Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer  Cell Line
Rutin and Silibinin are active flavonoid compounds, well-known for possessing multiple biological activities. We have studied how Rutin and Silibinin in combination modulate wide range intracellular signaling cascades as evidenced by in-vitro research. Data obtained from preclinical studies provide evidence to be supportive to bridge basic and translational studies. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 9, 2018 Category: Research Authors: Sana Nafees, Syed Hassan Mehdi, Mohammad Zafaryab, Bushra Zeya, Tarique Sarwar, Moshahid Alam Rizvi Tags: Original Article Source Type: research

Response to: Chikungunya in Bolivia: Still a Neglected Disease?
We greatly appreciate the thoughtful comments from the authors (1). We agree with them about the importance of timely and accurate diagnosis and treatment of chikungunya infection. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 8, 2018 Category: Research Authors: Efr én Murillo-Zamora, Oliver Mendoza-Cano Tags: Letter to the Editor Source Type: research

Vaccination Status and Another Preventive Measures in Medical Schools. Big Needs and Opportunities
Vaccination Status and other Preventive Measures in Medical School. Big Needs and Opportunities, Diana Vilar-Compte, et  al. (1), is a public health priority and one of the many challenges medical schools in Mexico and worldwide face. Our country has a longstanding tradition of highly effective immunization coverage in infancy dating to the nineteen fifties that led to a significant decrease of under five mortality rates. Over the following years, intensive annual vaccination campaigns targeted hard to reach populations in urban and rural areas and the National Immunization Council was created in 1991 (2). (Source: Ar...
Source: Archives of Medical Research - October 6, 2018 Category: Research Authors: Germ án Fajardo Dolci Tags: Opinion Source Type: research

Vaccination Status and Another Preventive Measures in Medical School. Big Needs and Opportunities
Vaccination Status and other Preventive Measures in Medical School. Big Needs and Opportunities, Diana Vilar-Compte, et  al. (1), is a public health priority and one of the many challenges medical schools in Mexico and worldwide face. Our country has a longstanding tradition of highly effective immunization coverage in infancy dating to the nineteen fifties that led to a significant decrease of under five mortality rates. Over the following years, intensive annual vaccination campaigns targeted hard to reach populations in urban and rural areas and the National Immunization Council was created in 1991 (2). (Source: Ar...
Source: Archives of Medical Research - October 6, 2018 Category: Research Authors: Germ án Fajardo Dolci Tags: Opinion Source Type: research

Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder
The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 3, 2018 Category: Research Authors: Huan Rui, Hongjia Qian, Muhua Shi, Guorui Zhang, Liqun Wang Tags: Original Article Source Type: research

Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder. A Meta-analysis
The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings. (Source: Archives of Medical Research)
Source: Archives of Medical Research - October 3, 2018 Category: Research Authors: Huan Rui, Hongjia Qian, Muhua Shi, Guorui Zhang, Liqun Wang Tags: Original Article Source Type: research

Association Between miR-149 Gene rs2292832 Polymorphism and Risk of Gastric Cancer
Accumulating evidence suggested that microRNA (miRNA) genes take part in different processes associated with gastric cancer (GC). The single nucleotide polymorphisms (SNPs) located on miRNA sequences may affect the interaction with their target mRNAs and consequently the genetic susceptibility to GC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 28, 2018 Category: Research Authors: Lili Zhang, Qingna Liu, Fan Wang Tags: Original Article Source Type: research

Effect of Fat Graft ıng on Postoperatıve Intraabdomınal Adhesions on a Rat Model
We aimed to evaluate the effect of fat grafting on postoperative intraabdominal adhesions by promoting mesothelial healing on a rat model. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 28, 2018 Category: Research Authors: Asudan Tugce Bozkurter Cil, Ilhami Oguzhan Aydogdu Tags: Original Article Source Type: research

Association Between miR-149 Gene rs2292832 Polymorphism and Risk of Gastric Cancer: A Case-control Study
Accumulating evidence suggested that microRNA (miRNA) genes take part in different processes associated with gastric cancer (GC). The single nucleotide polymorphisms (SNPs) located on miRNA sequences may affect the interaction with their target mRNAs and consequently the genetic susceptibility to GC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 28, 2018 Category: Research Authors: Lili Zhang, Qingna Liu, Fan Wang Tags: Original Article Source Type: research

Role of Reduced Nitric Oxide in Liver Cell Apoptosis Inhibition During Liver Damage
Hepatic injury is a major event in liver surgery and may lead to liver cell apoptosis. Nitric oxide (NO) is an unstable, carbon-centered radical with a short half-time and a key role in molecular signaling. Increasing evidence demonstrates that NO plays an important role in the liver cell apoptosis caused by hepatic ischemia reperfusion (IR) injury and other liver damage. Our recent article summarized the association between elevated nitric oxide levels and hepatic cell apoptosis during liver injury. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 27, 2018 Category: Research Authors: Ying-yi Wang, Meng-ting Chen, Hui-min Hong, Ying Wang, Qian Li, Hui Liu, Mei-wen Yang, Fen-fang Hong, Shu-long Yang Tags: Review Article Source Type: research

Chikungunya in Bolivia: Still a Neglected Disease?
We read with great interest the article by Murillo-Zamora et  al about chikungunya (CHIKV) (1), an emerging condition in the Americas, but still neglected in some countries. Then, we would like to take the opportunity to highlight the current situation of this disease in Bolivia, as well as difficulties and gaps of knowledge for its diagnosis, treatment and control. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 27, 2018 Category: Research Authors: Juan Pablo Escalera-Antezana, David R. Murillo-Garc ía, Alfonso J. Rodriguez-Morales Tags: Letter to the Editor Source Type: research

Roles of Reduced Nitric Oxide in Liver Cell Apoptosis Inhibition During Liver Damage
Hepatic injury is a major event in liver surgery and may lead to liver cell apoptosis. Nitric oxide (NO) is an unstable, carbon-centered radical with a short half-time and a key role in molecular signaling. Increasing evidence demonstrates that NO plays an important role in the liver cell apoptosis caused by hepatic ischemia reperfusion (IR) injury and other liver damage. Our recent article summarized the association between elevated nitric oxide levels and hepatic cell apoptosis during liver injury. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 27, 2018 Category: Research Authors: Ying-yi Wang, Meng-ting Chen, Hui-min Hong, Ying Wang, Qian Li, Hui Liu, Mei-wen Yang, Fen-fang Hong, Shu-long Yang Tags: Review Article Source Type: research

Promoter Polymorphisms of TNF- α Gene as a Risk Factor for Schizophrenia
The latest data showed a link between mental disorders and altered immune function. Schizophrenia is a multifactorial disease with numerous changes in the immunological system. The TNF- α gene is a strong candidate for schizophrenia susceptibility. The focus of this paper were the −1031 T/C, −863 C/A, −857 C/T, −308 G/A single nucleotide polymorphisms (SNPs) of the TNF-α gene. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 26, 2018 Category: Research Authors: Renata Suchanek-Raif, Pawe ł Raif, Małgorzata Kowalczyk, Monika Paul-Samojedny, Krzysztof Kucia, Wojciech Merk, Jan Kowalski Tags: Original Article Source Type: research

Decompensated Chronic Heart Failure Reduces Plasma L-carnitine
The heart has an intense aerobic metabolism and is among the most metabolically active organs in the body. Its tissue stores fatty acid, the main energetic substrate, and requires high concentrations of plasma L-carnitine. This nutrient is essential in the transport of fatty acids to the mitochondria to generate energy and maintain the proper concentration of coenzyme A free. In decompensated chronic heart failure metabolic changes, associated with inflammation, alter the metabolism of L-carnitine and compromise cardiac energy metabolism. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 26, 2018 Category: Research Authors: Sheila Moreira da Silva Guimar ães, Wanise Maria de Souza Cruz, Guilherme de Souza Weigert, Fernanda Bertão Scalco, Alexandre Siciliano Colafranceschi, Marcia Gonçalves Ribeiro, Gilson Teles Boaventura Tags: Preliminary Report Source Type: research

A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease
Early diagnosis of Alzheimer's disease (AD) remains challenging even with the assistance of imaging. Radiation exposure limits the application of positron emission tomography (PET) for amyloid imaging. Magnetic resonance imaging (MRI) offers superior spatial resolution without the disadvantage of radiation exposure. We developed Mn0.6Zn0.4Fe2O4 (MZF) modified by Pittsburgh compound B (PiB) to specifically bind to amyloid plaques. Coated with amphiphilic nanopolymer 6sPCL-b-P(MEO2MA-co-OEGMA), PiB-MZF was stable, biocompatible, and approximately 100  nm in size. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 26, 2018 Category: Research Authors: Jiaqi Zeng, Jiaqi Wu, Minghua Li, Peijun Wang Tags: Preliminary Report Source Type: research

Promoter Polymorphisms of TNF- α Gene (−1031 T/C, −863 C/A, −857 C/T, −308 G/A) as a Risk Factor for Schizophrenia
The latest data showed a link between mental disorders and altered immune function. Schizophrenia is a multifactorial disease with numerous changes in the immunological system. The TNF- α gene is a strong candidate for schizophrenia susceptibility. The focus of this paper were the −1031 T/C, −863 C/A, −857 C/T, −308 G/A single nucleotide polymorphisms (SNPs) of the TNF-α gene. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 26, 2018 Category: Research Authors: Renata Suchanek-Raif, Pawe ł Raif, Małgorzata Kowalczyk, Monika Paul-Samojedny, Krzysztof Kucia, Wojciech Merk, Jan Kowalski Tags: Original Article Source Type: research

Discriminatory Accuracy of Preeclampsia Risk Factors in Primary Care
Although it is common to use risk factors in the screening for preeclampsia, they do not always accurately identify patients who truly have this condition. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 25, 2018 Category: Research Authors: Hid Felizardo Cordero-Franco, Ana Mar ía Salinas-Martínez, Tania Abigail García-Alvarez, Eloísa Verónica Maldonado-Sánchez, Francisco Javier Guzmán-de la Garza, Alvaro Mathiew-Quirós Tags: Original Article Source Type: research

Discriminatory Accuracy of Preeclampsia Risk Factors in a Primary Care
Although it is common to use risk factors in the screening for preeclampsia, they do not always accurately identify patients who truly have this condition. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 25, 2018 Category: Research Authors: Hid Felizardo Cordero-Franco, Ana Mar ía Salinas-Martínez, Tania Abigail García-Alvarez, Eloísa Verónica Maldonado-Sánchez, Francisco Javier Guzmán-de la Garza, Alvaro Mathiew-Quirós Tags: Original Article Source Type: research

Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an  Old-fashioned Enigma
The presence of different APOE isoforms represents a well-known risk factor for cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart and neurological diseases, this review summarizes the less-known functions of APOE and the possible implications for cardiovascular disorders. Beyond the role as lipid transporting protein, its involvement in lipid membrane homeostasis and signaling, as well as its nuclear transcriptional effects suggests a more complex role of APOE, receiving great interest from researchers and physicians from all medical fields. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 10, 2018 Category: Research Authors: Elisa A. Liehn, Victor Ponomariov, Rodica Diaconu, Ioana Streata, Mihai Ioana, Gustavo E. Crespo-Avilan, Sauri Hern ández-Reséndiz, Hector A. Cabrera-Fuentes Tags: Review Article Source Type: research

Vaccination Status and Other Preventive Measures in Medical Schools. Big  Needs and Opportunities
Proper immunization and knowledge in infection prevention are key factors in protecting medical students. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 5, 2018 Category: Research Authors: Diana Vilar-Compte, Daniel de-la-Rosa-Martinez, Samuel Ponce de Le ón Tags: Original Article Source Type: research

Vaccination Status and Other Preventive Measures in Medical School. Big  Needs and Opportunities
Proper immunization and knowledge in infection prevention are key factors in protecting medical students. (Source: Archives of Medical Research)
Source: Archives of Medical Research - September 5, 2018 Category: Research Authors: Diana Vilar-Compte, Daniel de-la-Rosa-Martinez, Samuel Ponce de Le ón Tags: Original Article Source Type: research

Selective Screening of Fatty Acids Oxidation Defects and Organic Acidemias by Liquid Chromatography/tandem Mass Spectrometry Acylcarnitine Analysis in Brazilian Patients
Inborn errors of metabolism (IEM) are diseases which can lead to accumulation of toxic metabolites in the organism. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Carmen Regla Vargas, Graziela Schmitt Ribas, Janine Machado da Silva, Angela Sitta, Marion Deon, Daniella de Moura Coelho, Moacir Wajner Tags: Original Article Source Type: research

Data Mining and Endocrine Diseases: A New Way to Classify?
Data mining consists of using large database analysis to detect patterns, relationships and models in order to describe (or even predict) the appearance of a future event; to accomplish this, it uses classification methods, rules of association, regression patterns, link and cluster analyses. Recently this approach has been used to propose a new diabetes mellitus classification, using information analysis techniques through which the selection bias minimally influences categorization, this new focus that includes data mining previously implemented to predict, identify biomarkers, complications, therapies, health policies, ...
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Juan Salazar, Cristobal Espinoza, Andres Mindiola, Valmore Bermudez Tags: Opinion Source Type: research

Impact of miR-302b on Calcium-phosphorus Metabolism and Vascular Calcification of Rats with Chronic Renal Failure by Regulating BMP-2/Runx2/Osterix Signaling Pathway
To investigate how miR-302b affect the calcium-phosphorus metabolism and vascular calcification (VC) of rats with chronic renal failure (CRF) via the regulation of bone morphogentic proteins 2/Runt-related transcription factor 3/Osterix (BMP-2/Runx2/Osterix) signaling pathway. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Wen-li Sun, Nan Wang, Yan Xu Tags: Original Article Source Type: research

Cardiometabolic Risk Indicators for Kidney Disease in Mexican Patients with Type 2 Diabetes
The objective of this study was to identify the primary risk factors associated with kidney disease in Mexican patients with type 2 diabetes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Lubia Vel ázquez-López, Rubí Hernández-Sánchez, Ivonne Roy García, Abril Violeta Muñoz-Torres, Patricia Medina-Bravo, Jorge Escobedo-de la Peña Tags: Original Article Source Type: research

Endothelial Colony-forming Cells Attenuate Ventilator-induced Lung Injury in Rats with Acute Respiratory Distress Syndrome
Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Ying-nan Ju, Jing Gong, Xue-ting Wang, Jing-li Zhu, Wei Gao Tags: Original Article Source Type: research

Role of Response-to-Diuretic in Predicting Prognosis in Discharged Heart Failure Patients After an Acute Decompensation
The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharged determination of galectin-3 and BNP in predicting mid-term clinical outcome. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Mauro Feola, Marzia Testa, Cinzia Ferreri, Marco Cardone, Mario Sola, Sara Ariotti, Gian Luca Rosso Tags: Original Article Source Type: research

Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats
Insulin sensitizers like metformin and pioglitazone are clinically used since last decades for the treatment of PCOS, but their efficacy and possible role in PCOS patients remains questionable. Also, the mechanism by which these insulin sensitizers show effect is not clear. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 10, 2018 Category: Research Authors: Roshni Patel, Gaurang Shah Tags: Original Article Source Type: research

Improvement in the Diagnosis of Tuberculosis Combining Mycobacterium Tuberculosis Immunodominant Peptides and Serum Host Biomarkers
Pulmonary tuberculosis (PTB) is a public health problem with 10.4 million new cases reported in 2017 (1). According to the World Health Organization (WHO), accurate diagnostic tests based in serum biomarkers to detect new cases of tuberculosis are necessary. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 20, 2018 Category: Research Authors: Juan E. L ópez-Ramos, Noe Macías-Segura, Betzaida Cuevas-Cordoba, Zaida Araujo-Garcia, Yadira Bastián, Julio E. Castañeda-Delgado, Edgar E. Lara-Ramirez, Benjamin Gándara-Jasso, Carmen J. Serrano, Eva Salinas, Jose A. Enciso-Moreno Tags: Original Article Source Type: research

Serum Amyloid A, Paraoxonase-1 Activity, and Apolipoprotein Concentrations as Biomarkers of Subclinical Atherosclerosis Risk in Adrenal Incidentaloma Patients
Adrenal incidentalomas (AIs), particularly subclinical hypercortisolism (SH), are related to an increased risk of atherosclerosis. The anti-oxidative enzyme paraoxonase-1 (PON1) and the acute phase reactant serum amyloid A (SAA) are transported by highdensity lipoprotein and reciprocally regulated in acute inflammatory response. Our aim was to investigate serum SAA, PON1, and apolipoprotein levels as indicators of subclinical atherosclerosis in patients with nonfunctioning AI (NFAI) and SH. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 18, 2018 Category: Research Authors: Narin Nasiroglu Imga, Canan Topcuoglu, Dilek Berker, Turan Turhan Tags: Original Article Source Type: research

Human CATSPER1 Promoter Is Regulated by CREB1 and CREM τ Transcriptional Factors In Vitro
The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca2+ ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0 –2, in which CRE0 is located near the transcription start site. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Norma Oviedo, Lizdy Ortiz-Borrayo, Javier Hern ández-Sánchez, Salma Elizabeth Jiménez-Badillo, Tesoro Cruz Emiliano, Esperanza Moreno-Navor, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Méndez Tags: Original Article Source Type: research

Effect of Endoplasmic Reticulum Stress and Autophagy in the Regulation of  Post-infarct Cardiac Repair
Acute myocardial infarction (AMI) is reported to be accompanied by endoplasmic reticulum (ER) stress and autophagy induction. Nevertheless, the roles of ER stress and autophagy in post-infarct reparative fibrosis remain to be elucidated. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Rongjie Lin, Zizhuo Su, Xiaohui Tan, Yinqing Su, Yuyang Chen, Xiaorong Shu, Shumin Liang, Jingfeng Wang, Shuanglun Xie Tags: Preliminary Report Source Type: research

Mannose Binding Lectin and Pentraxin 3 in Patients with Diabetic Retinopathy
Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 28, 2018 Category: Research Authors: Kenzo Hokazono, Fernando Sakata Beliz ário, Vanessa Portugal, Iara Messias-Reason, Renato Nisihara Tags: Preliminary Report Source Type: research

Health Systems in Latin America: The Search for Universal Health Coverage
This paper discusses the health challenges faced by countries in Latin America. These challenges have two dimensions: those related to the health needs of populations and those related to the way in which health systems are responding to these needs. The main conclusion is that in order to improve health conditions and move towards universal health coverage, Latin American countries need to design a new generation of policy innovations based on the separation of the three main functions of health systems: financing, delivery and stewardship. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 27, 2018 Category: Research Authors: Julio Frenk, Octavio G ómez-Dantés Source Type: research

Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 12, 2018 Category: Research Authors: Evelyn G. Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Kl ünder-Klünder, Begoña Segura-Stanford, Julio R. Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T. Granados Riverón, Leonardo J. Mejía-Marín, Norma Source Type: research

Pathway to Tau Modifications and the Origins of Alzheimer's Disease
Several studies have pointed to the mechanisms on how the microtubule-associated protein tau, once modified, triggers a cascade of molecular events that are the main culprit of Alzheimer's disease and tauopathies. These discoveries have been considered as one of the main breakthroughs in science during this first part of this century. The critical reaction is the anomalous phosphorylation of tau by the complex kinase systems CDK5/p35 and GSK3 β (1). There is cumulative evidence that once tau protein is hyperphosphorylated, it turns into a neurotoxic agent that promotes neuronal degeneration and also neuronal death. (S...
Source: Archives of Medical Research - May 31, 2018 Category: Research Authors: Ricardo B. Maccioni, Jos é Pablo Tapia, Leonardo Guzman-Martinez Source Type: research

Seasonal Variations in Cerebral Palsy Births
Previous studies of cerebral palsy (CP) suggest that it seasonal variations in the incidence of CP. The purpose of this paper was to compare seasonal variations in the incidence of cerebral palsy (CP) in Podlaskie Province, Poland, between 1990 –1999 (study 2005) and 2000–2014 (study 2017) in a retrospective case-controlled study. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 23, 2018 Category: Research Authors: Dorota Sienkiewicz, Gra żyna Paszko-Patej, Bożena Okurowska-Zawada, Wojciech Kułak Source Type: research

Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma
In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 17, 2018 Category: Research Authors: Jeny Salazar-Anguiano, Mar ía de Guadalupe Chávez-López, Violeta Zúñiga-García, Javier Camacho, David Elías-Viñas Tags: Original Article Source Type: research

rs3212227 SNP in the IL12B Gene Prevents Delayed Graft Function after Kidney Transplantation
Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. We have investigated whether functional single nucleotide polymorphisms (SNP) in the genes encoding IFN- γ (IFNG), TNF (TNFA), IL-10 (IL10) and p40 subunit of IL-12/IL-23 (IL12B) could predict risk of AR and DGF in kidney allograft recipients. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 10, 2018 Category: Research Authors: Vladimir Perovic, Milos Markovic, Milica Kravljaca, Emina Milosevic, Milica Djoric, Vera Pravica, Radomir Naumovic Tags: Original Article Source Type: research

Editorial Board
(Source: Archives of Medical Research)
Source: Archives of Medical Research - May 1, 2018 Category: Research Source Type: research

Table of Contents
(Source: Archives of Medical Research)
Source: Archives of Medical Research - May 1, 2018 Category: Research Source Type: research