Serum Amyloid A, Paraoxonase-1 Activity, and Apolipoprotein Concentrations as Biomarkers of Subclinical Atherosclerosis Risk in Adrenal Incidentaloma Patients
Adrenal incidentalomas (AIs), particularly subclinical hypercortisolism (SH), are related to an increased risk of atherosclerosis. The anti-oxidative enzyme paraoxonase-1 (PON1) and the acute phase reactant serum amyloid A (SAA) are transported by highdensity lipoprotein and reciprocally regulated in acute inflammatory response. Our aim was to investigate serum SAA, PON1, and apolipoprotein levels as indicators of subclinical atherosclerosis in patients with nonfunctioning AI (NFAI) and SH. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 18, 2018 Category: Research Authors: Narin Nasiroglu Imga, Canan Topcuoglu, Dilek Berker, Turan Turhan Tags: Original Article Source Type: research

Human CATSPER1 Promoter Is Regulated by CREB1 and CREM τ Transcriptional Factors In Vitro
The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca2+ ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0 –2, in which CRE0 is located near the transcription start site. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Norma Oviedo, Lizdy Ortiz-Borrayo, Javier Hern ández-Sánchez, Salma Elizabeth Jiménez-Badillo, Tesoro Cruz Emiliano, Esperanza Moreno-Navor, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Méndez Tags: Original Article Source Type: research

Effect of Endoplasmic Reticulum Stress and Autophagy in the Regulation of  Post-infarct Cardiac Repair
Acute myocardial infarction (AMI) is reported to be accompanied by endoplasmic reticulum (ER) stress and autophagy induction. Nevertheless, the roles of ER stress and autophagy in post-infarct reparative fibrosis remain to be elucidated. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Rongjie Lin, Zizhuo Su, Xiaohui Tan, Yinqing Su, Yuyang Chen, Xiaorong Shu, Shumin Liang, Jingfeng Wang, Shuanglun Xie Tags: Preliminary Report Source Type: research

Mannose Binding Lectin and Pentraxin 3 in Patients with Diabetic Retinopathy
Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 28, 2018 Category: Research Authors: Kenzo Hokazono, Fernando Sakata Beliz ário, Vanessa Portugal, Iara Messias-Reason, Renato Nisihara Tags: Preliminary Report Source Type: research

Health Systems in Latin America: The Search for Universal Health Coverage
This paper discusses the health challenges faced by countries in Latin America. These challenges have two dimensions: those related to the health needs of populations and those related to the way in which health systems are responding to these needs. The main conclusion is that in order to improve health conditions and move towards universal health coverage, Latin American countries need to design a new generation of policy innovations based on the separation of the three main functions of health systems: financing, delivery and stewardship. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 27, 2018 Category: Research Authors: Julio Frenk, Octavio G ómez-Dantés Source Type: research

Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 12, 2018 Category: Research Authors: Evelyn G. Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Kl ünder-Klünder, Begoña Segura-Stanford, Julio R. Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T. Granados Riverón, Leonardo J. Mejía-Marín, Norma Source Type: research

Pathway to Tau Modifications and the Origins of Alzheimer's Disease
Several studies have pointed to the mechanisms on how the microtubule-associated protein tau, once modified, triggers a cascade of molecular events that are the main culprit of Alzheimer's disease and tauopathies. These discoveries have been considered as one of the main breakthroughs in science during this first part of this century. The critical reaction is the anomalous phosphorylation of tau by the complex kinase systems CDK5/p35 and GSK3 β (1). There is cumulative evidence that once tau protein is hyperphosphorylated, it turns into a neurotoxic agent that promotes neuronal degeneration and also neuronal death. (S...
Source: Archives of Medical Research - May 31, 2018 Category: Research Authors: Ricardo B. Maccioni, Jos é Pablo Tapia, Leonardo Guzman-Martinez Source Type: research

Seasonal Variations in Cerebral Palsy Births
Previous studies of cerebral palsy (CP) suggest that it seasonal variations in the incidence of CP. The purpose of this paper was to compare seasonal variations in the incidence of cerebral palsy (CP) in Podlaskie Province, Poland, between 1990 –1999 (study 2005) and 2000–2014 (study 2017) in a retrospective case-controlled study. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 23, 2018 Category: Research Authors: Dorota Sienkiewicz, Gra żyna Paszko-Patej, Bożena Okurowska-Zawada, Wojciech Kułak Source Type: research

Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma
In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 17, 2018 Category: Research Authors: Jeny Salazar-Anguiano, Mar ía de Guadalupe Chávez-López, Violeta Zúñiga-García, Javier Camacho, David Elías-Viñas Tags: Original Article Source Type: research

rs3212227 SNP in the IL12B Gene Prevents Delayed Graft Function after Kidney Transplantation
Transplantation is the best treatment option for end stage kidney disease. The most common early complications in post-transplant period are acute rejection (AR) of the graft and delayed graft function (DGF). The underlying mechanisms in these events are heterogeneous and at least in part involve cytokine genes which regulate immune response to allograft. We have investigated whether functional single nucleotide polymorphisms (SNP) in the genes encoding IFN- γ (IFNG), TNF (TNFA), IL-10 (IL10) and p40 subunit of IL-12/IL-23 (IL12B) could predict risk of AR and DGF in kidney allograft recipients. (Source: Archives of Medical Research)
Source: Archives of Medical Research - May 10, 2018 Category: Research Authors: Vladimir Perovic, Milos Markovic, Milica Kravljaca, Emina Milosevic, Milica Djoric, Vera Pravica, Radomir Naumovic Tags: Original Article Source Type: research

FOXO3a Reverses the Cisplatin Resistance in Ovarian Cancer
Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the relief ovarian cancer. Our previous study found that decreased FOXO3a might be a poor prognosis in human ovarian cancer. In this research, we study whether FOXO3a was involved in the mechanism of platinum drug resistance. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 28, 2018 Category: Research Authors: Mudan Lu, Xuan Chen, Jianping Xiao, Jingying Xiang, Lan Yang, Daozhen Chen Tags: Original Article Source Type: research

ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients
Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation. The aim of this study was to assess the effect ofACE-rs4646994, APOA5-rs662799, and MTP-rs1800591 gene polymorphisms on clinical and b...
Source: Archives of Medical Research - April 25, 2018 Category: Research Authors: Lilia Carranza-Gonz ález, Rafael B.R. León-Cachón, María Antonia González-Zavala, Clara Ríos-Ibarra, Jesús Morlett-Chávez, Celia Sánchez-Domínguez, Ana Cepeda-Nieto, Mauricio Salinas-Santander Tags: Original Article Source Type: research

Persistent Arthralgia and Related Risks Factors: A Cohort Study at 12  Months from Laboratory-Confirmed Chikungunya Infection
To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12  months from acute chikungunya virus (CHIKV) infection. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 24, 2018 Category: Research Authors: Efr én Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Enrique Higareda-Almaraz, Martha Alicia Higareda-Almaraz, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo Tags: Original Article Source Type: research

Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis
The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 24, 2018 Category: Research Authors: Emiy Yokoyama, Margarita Ch ávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero Tags: Original Article Source Type: research

Persistent Arthralgia and Related Risks Factors: A Cohort Study at 12  Months from Laboratory-Confirmed Chikungunya Infection
To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12  months from acute chikungunya virus (CHIKV) infection. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 24, 2018 Category: Research Authors: Efr én Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, José Guzmán-Esquivel, Enrique Higareda-Almaraz, Martha Alicia Higareda-Almaraz, Ramón Alberto Sánchez-Piña, Agustin Lugo-Radillo Tags: Original Article Source Type: research

Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis
The variation in cystic fibrosis (CF) lung disease not always is explained by the CFTR genotype, so it has become apparent that modifier genes must play a considerable role in the phenotypic heterogeneity of CF, so we investigated the association of allelic variants in modifier genes that modulate the severity of lung function in a group of Mexican patients diagnosed with CF. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 24, 2018 Category: Research Authors: Emiy Yokoyama, Margarita Ch ávez-Saldaña, Lorena Orozco, Francisco Cuevas, José Luis Lezana, Rosa María Vigueras-Villaseñor, Julio Cesar Rojas-Castañeda, Daniel Adrian Landero Tags: Original Article Source Type: research

Vitamin A and Retinoic Acid Exhibit Protective Effects on Necrotizing Enterocolitis by Regulating Intestinal Flora and Enhancing the Intestinal  Epithelial Barrier
Exaggerated inflammation that characterizes necrotizing enterocolitis (NEC) is caused by the invasion of pathogens through an immature intestinal barrier. Vitamin A (VA) and retinoic acid (RA) play important roles in the growth of epithelial tissue and in modulating immune function. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Sa Xiao, Qiuping Li, Kun Hu, Yu He, Qing Ai, Liuhong Hu, Jialin Yu Tags: Original Article Source Type: research

Characterization of Folic Acid Surface-Coated Selenium Nanoparticles and Corresponding In  Vitro and In Vivo Effects Against Breast Cancer
Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in  vitro and in vivo effects of SeNPs and folic acid surface–coated selenium nanoparticles (FA@SeNPs) on breast cancer. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini Tags: Original Article Source Type: research

Serum Paraoxonase-1 Concentration as a Potential Predictor of Urinary Bladder Cancer Recurrence. A Five Year Follow-Up Study
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer. (Source: Ar...
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Simona Iftimie, Anabel Garc ía-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven Tags: Preliminary Report Source Type: research

Vitamin A and Retinoic Acid Exhibit Protective Effects on Necrotizing Enterocolitis by Regulating Intestinal Flora and Enhancing the Intestinal  Epithelial Barrier
Exaggerated inflammation that characterizes necrotizing enterocolitis (NEC) is caused by the invasion of pathogens through an immature intestinal barrier. Vitamin A (VA) and retinoic acid (RA) play important roles in the growth of epithelial tissue and in modulating immune function. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Sa Xiao, Qiuping Li, Kun Hu, Yu He, Qing Ai, Liuhong Hu, Jialin Yu Tags: Original Article Source Type: research

Characterization of Folic Acid Surface-Coated Selenium Nanoparticles and Corresponding In  Vitro and In Vivo Effects Against Breast Cancer
Selenium nanoparticles (SeNPs) have been reported to exhibit an inhibitory effect on cancer cells. In the present study, we aimed to compare the in  vitro and in vivo effects of SeNPs and folic acid surface–coated selenium nanoparticles (FA@SeNPs) on breast cancer. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Ahmad Reza Shahverdi, Faranak Shahverdi, Elnaz Faghfuri, Mohammad Reza khoshayand, Faranak Mavandadnejad, Mohammad Hossein Yazdi, Mohsen Amini Tags: Original Article Source Type: research

Serum Paraoxonase-1 Concentration as a Potential Predictor of Urinary Bladder Cancer Recurrence. A Five Year Follow-Up Study
This study provides preliminary information on the usefulness of measuring serum paraoxonase-1 (PON1) concentration and activity (and other inflammatory markers) to predict tumor recurrence in patients with urinary bladder cancer. We studied a total of 39 hospitalized patients in whom the diagnosis of urinary bladder cancer was confirmed by transurethral resection. After five years of follow-up, 29 patients presented with tumor recurrence. As control subjects, we also studied 61 healthy subjects and a further 132 hospitalized patients who had a urinary catheter-related infection due to causes other than cancer. (Source: Ar...
Source: Archives of Medical Research - April 23, 2018 Category: Research Authors: Simona Iftimie, Anabel Garc ía-Heredia, Francesc Pujol-Bosch, Antoni Pont-Salvadó, Ana Felisa López-Azcona, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Isabel Fort-Gallifa, Antoni Castro, Jordi Camps, Jorge Joven Tags: Preliminary Report Source Type: research

Volatolome of the Female Genitourinary Area: Toward the Metabolome of Cervical Cancer
Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 19, 2018 Category: Research Authors: Miriam Rodr íguez-Esquivel, Juan Rosales, Rafael Castro, Teresa Apresa-García, Ónix Garay, Pablo Romero-Morelos, Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Ricardo López-Romero, Héctor Guerrero-Flores, Betsabé Morales, Mónica Mendoza-Rodr Tags: Original Article Source Type: research

10  years Analysis of Diabetes-related Major Lower Extremity Amputations in Mexico
Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in M éxico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Iv án de Jesús Ascencio-Montiel Tags: Original Article Source Type: research

Prognostic Value of Cd95, Active Caspase-3, and Bcl-2 Expression in Adult Patients With De Novo Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is an aggressive malignant disease with high mortality rates in adults. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jaime Garcia-Chavez, Alvaro Hernandez-Caballero, Rubiraida Molina-Aguilar, Miriam America Garcia-Ruiz Esparza, Jorge Vela-Ojeda Tags: Original Article Source Type: research

10  years Analysis of Diabetes-related Major Lower Extremity Amputations in Mexico
Little is known about diabetes-related major lower extremity amputations (DMLEA) burden in M éxico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Iv án de Jesús Ascencio-Montiel Tags: Original Article Source Type: research

Prognostic Value of Cd95, Active Caspase-3, and Bcl-2 Expression in Adult Patients With De Novo Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is an aggressive malignant disease with high mortality rates in adults. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 18, 2018 Category: Research Authors: Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jaime Garcia-Chavez, Alvaro Hernandez-Caballero, Rubiraida Molina-Aguilar, Miriam America Garcia-Ruiz Esparza, Jorge Vela-Ojeda Tags: Original Article Source Type: research

Differential Impact of Sleep Duration on Fasting Plasma Glucose Level  According to Work Timing
To quantify the differential contribution of sleep duration on fasting plasma glucose level by traditional regular daytime work and shift work in subjects without diabetes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Chan-hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-yeon Kim, Chul-hee Kim, Sung-koo Kang, Ji-oh Mok Tags: Original Article Source Type: research

Clinical and Inflammatory Phenotyping: Can Electronic Nose and NMR-based  Metabolomics Work at the Bedside?
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Mauro Maniscalco, Andrea Motta Tags: Opinion Source Type: research

Differential Impact of Sleep Duration on Fasting Plasma Glucose Level  According to Work Timing
To quantify the differential contribution of sleep duration on fasting plasma glucose level by traditional regular daytime work and shift work in subjects without diabetes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Chan-hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-yeon Kim, Chul-hee Kim, Sung-koo Kang, Ji-oh Mok Tags: Original Article Source Type: research

Clinical and Inflammatory Phenotyping: Can Electronic Nose and NMR-based  Metabolomics Work at the Bedside?
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 17, 2018 Category: Research Authors: Mauro Maniscalco, Andrea Motta Tags: Opinion Source Type: research

Copeptin Plasma Levels are Associated With Decline of Renal Function in Patients With Type 2 Diabetes Mellitus
Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. (Source: Archives of Medical Research)
Source: Archives of Medical Research - April 14, 2018 Category: Research Authors: Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel G ómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F. Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar Tags: Original Article Source Type: research

Intranasal Administration of a Naked Plasmid Reached Brain Cells and Expressed Green Fluorescent Protein, a Candidate for Future Gene Therapy Studies
Intranasal administration (Int adm) has been well-studied and offers the possibility to deliver larger molecular weight biologics, such as proteins, viral vectors, nanoparticles, and naked plasmids to the brain and treat a variety of diseases in the central nervous system. The predominant challenge in this field is finding efficient vectors that are capable of crossing the blood-brain barrier (BBB). (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 16, 2018 Category: Research Authors: Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Su árez, Teresa Juárez-Cedillo, Vilma Carolina Bekker Méndez, Emiliano Tesoro-Cruz Tags: Original Article Source Type: research

Hyperbaric-Oxygen Therapy Improves Survival and Functional Outcome of Acute Severe Intracerebral Hemorrhage-Prospective, Randomized Controlled Trial
Prognosis of spontaneous intracerebral hemorrhage (ICH) remains poor worldwide. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 13, 2018 Category: Research Authors: Xiaowei Li, Jingze Li, Xuehui Yang, Zhaosheng Sun, Jinrong Zhang, Wangmiao Zhao, Shuzhi Dong, Cong Li, Yanqiao Ye, Jianchao Chen, Yongqian Li, Yi Xiang, Jianhui Mao, Guangjie Li, Hong Guo, Wenchao Zhang, Hao Guo, Yazhao Zhang, Mingzhe Zhang, Wanzeng Zhang Tags: Original Article Source Type: research

Inhibitory Effect of Artesunate on Growth and Apoptosis of Gastric Cancer Cells
The present study aimed to explore the inhibitory effect of artesunate on the growth and apoptosis of gastric cancer cells, in order to search for high effective and low toxic anti-gastric cancer drugs. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 12, 2018 Category: Research Authors: Lei Wang, Liang Liu, Jing Wang, YueTong Chen Tags: Original Article Source Type: research

Spinogenesis and Plastic Changes in the Dendritic Spines of Spinal Cord Motoneurons After Traumatic Injury in Rats
Spinal cord injury (SCI) is highly incapacitating, and the neurobiological factors involved in an eventual functional recovery remain uncertain. Plastic changes to dendritic spines are closely related with the functional modifications of behavior. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 10, 2018 Category: Research Authors: Eliseo Portilla-de Buen, Hermelinda Salgado-Ceballos, David Gonz ález-Tapia, Caridad Leal-Cortés, Rodrigo Mondragón-Lozano, Stephanie Sánchez-Torres, Laura Álvarez-Mejía, Omar Fabela-Sánchez, Néstor I. Martínez-Torres, Myrna M. González-Ramírez Tags: Original Article Source Type: research

Koch Postulate: Why Should we Grow Bacteria?
Understanding infectious diseases has long relied on the Koch postulate, which consists of the pure culture of microorganisms. The advent of molecular methods in clinical microbiology has led the phasing out of culture as a diagnostic tool and metagenomics has become the technique most commonly used to assess the impact of commensal microbes on human health. However, culturing microbes has led to substantial advances, even recently, in infectious diseases involving fastidious microorganisms, as evidenced by the Tropheryma whipplei or Bartonella species. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 6, 2018 Category: Research Authors: Jean-Christophe Lagier, Gr égory Dubourg, Sophie Amrane, Didier Raoult Tags: Review Article Source Type: research

Koch Postulate: Why do we Should Grow Bacteria?
Understanding infectious diseases has long relied on the Koch postulate, which consists of the pure culture of microorganisms. The advent of molecular methods in clinical microbiology has led the phasing out of culture as a diagnostic tool and metagenomics has become the technique most commonly used to assess the impact of commensal microbes on human health. However, culturing microbes has led to substantial advances, even recently, in infectious diseases involving fastidious microorganisms, as evidenced by the Tropheryma whipplei or Bartonella species. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 6, 2018 Category: Research Authors: Jean-Christophe Lagier, Gr égory Dubourg, Sophie Amrane, Didier Raoult Tags: Review Article Source Type: research

Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population
The brain-derived neurotrophic factor (BDNF) rs6265 (G196A; Val66Met) single nucleotide polymorphism has been associated with BMI and obesity in distinct populations, both adult and pediatric, with contradictory results involving either Val or Met as the risk variant. (Source: Archives of Medical Research)
Source: Archives of Medical Research - March 2, 2018 Category: Research Authors: Jos é Darío Martínez-Ezquerro, Mario Enrique Rendón-Macías, Gerardo Zamora-Mendoza, Jacobo Serrano-Meneses, Beatriz Rosales-Rodríguez, Deyanira Escalante-Bautista, Maricela Rodríguez-Cruz, Raúl Sánchez-González, Yessica Arellano-Pineda, Mardia L Tags: Original Article Source Type: research

Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex Picture
Depression plays an important role in the pathogenesis and treatment of obesity and type 2 diabetes (T2D). However, its relevance is frequently unrecognized by clinicians and researchers. The purpose of this review is to present a critical analysis of the evidence linking depression and metabolic disorders and to highlight the practical implications of this complex relationship. Evidence obtained from epidemiological, basic, clinical and controlled studies demonstrate that the association goes beyond a random phenomenon. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 22, 2018 Category: Research Authors: Magdalena del Roc ío Sevilla-González, Brenda Macale Quintana-Mendoza, Carlos Alberto Aguilar-Salinas Tags: Review Article Source Type: research

Hypolipidemic Components from Medicine Food Homology Species Used in China: Pharmacological and Health Effects
Hyperlipidemia is a systemic disease caused by abnormal human lipid metabolism. Dietary control and treatment on hyperlipidemia is now a popular therapy pathway. This paper focuses on the medicine food homology (MFH) species used in China with hypolipidemic function, and emphasizes on the active ingredients and their pharmacological effect. The single herbal and its hypolipidemic active ingredients are summarized through reviewing the relevant literatures published in the past twenty years. The ingredients are divided into polysaccharides, flavonoids, steroidal saponins, quinones, alkaloids and others, of which the related...
Source: Archives of Medical Research - February 13, 2018 Category: Research Authors: De-xing Song, Jian-guo Jiang Tags: Review Article Source Type: research

Hearing Loss in Type 2 Diabetes in Association with Diabetic Neuropathy
Reports assessing hearing abnormalities in diabetes are debated. We aimed to evaluated auditory alterations and their possible associations with vascular and neurological dysfunction in 160 Type 2 diabetes mellitus individuals and 100 age and sex-matched healthy controls. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 9, 2018 Category: Research Authors: Huihui Ren, Zhenggang Wang, Zhongyao Mao, Ping Zhang, Chunfang Wang, Aiguo Liu, Gang Yuan Tags: Original Article Source Type: research

Expanding our Understanding of the Role of the Microbiome in Health and Disease
Our understanding of the microbial side of ourselves, and its implications in health and disease, has been completely transformed in the past decade. Advances in DNA sequencing, and in the computational techniques required to understand this wealth of DNA sequences, allow us to read out the complex microbial communities that inhabit our bodies and our world at unprecedented rates. However, relating this information to function, and learning how to  modify our microbiomes to improve health, remain important challenges in the field. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 8, 2018 Category: Research Authors: Rob Knight Tags: Preface Source Type: research

Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNF α, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia
Preeclampsia (PE) is known as a major cause of maternal and neonatal morbidity and mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of angiogenic factors can be observed in PE (1). The reduction in uteroplacental perfusion can cause ischemia and the ischemic placenta releases soluble factors causing maternal endothelial dysfunction and hypertension (2). These alterations also lead to an increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF- α) and IL-6 from the placenta (3). (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 4, 2018 Category: Research Authors: Metehan Uzun, Meryem Gencer, Hakan Turkon, Rahime Ozlem Oztopuz, Ufuk Demir, Mehmet Akif Ovali Tags: Original Article Source Type: research

20 Years Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever  in Mexico
Dengue Fever (DF) is a human vector-borne disease and a major public health problem worldwide. In Mexico, DF and Dengue Hemorrhagic Fever (DHF) cases have increased in recent years. The aim of this study was to identify variations in the spatial distribution of DF and DHF cases over time using space-time statistical analysis and geographic information systems. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 2, 2018 Category: Research Authors: Sendy Isarel Hern ández-Gaytán, Francisco Javier Díaz-Vásquez, Luis Gerardo Duran-Arenas, Malaquías López Cervantes, Stephen J. Rothenberg Tags: Original Article Source Type: research

Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever in Mexico from 1995 –2015
Dengue Fever (DF) is a human vector-borne disease and a major public health problem worldwide. In Mexico, DF and Dengue Hemorrhagic Fever (DHF) cases have increased in recent years. The aim of this study was to identify variations in the spatial distribution of DF and DHF cases over time using space-time statistical analysis and geographic information systems. (Source: Archives of Medical Research)
Source: Archives of Medical Research - February 2, 2018 Category: Research Authors: Sendy Isarel Hern ández-Gaytán, Francisco Javier Díaz-Vásquez, Luis Gerardo Duran-Arenas, Malaquías López Cervantes, Stephen J. Rothenberg Tags: Original Article Source Type: research