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Total 353 results found since Jan 2013.

Identification, expression profiling and localization of thoc in common carp ovary: Influence of thoc3-siRNA transient silencing.
Abstract The THO complex is a multisubunit complex with a function in transcription and mRNA export. In the present study, THO complex transcripts (thoc) were identified in developing ovary of common carp and their role during ovarian development and growth has been characterized for the first time in a teleost using expression profiling and transient siRNA silencing. Thoc expression revealed a spatiotemporal pattern in the gonads with high levels at 120 days post-hatch, with moderately high levels thereafter. In situ hybridization and immunohistochemical localization revealed the presence of thoc3 in follicular l...
Source: Gene - January 10, 2020 Category: Genetics & Stem Cells Authors: Gupta YR, Senthilkumaran B Tags: Gene Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Improved islet transplantation outcome by the co-delivery of siRNAs for iNOS and 17β-estradiol using an R3V6 peptide carrier.
Abstract Silencing target genes such as inducible nitric oxide synthase (iNOS) using small interfering double-stranded RNA (siRNA) in islet cells has been attempted to enhance the survival of transplanted islets. However, the efficient and safe delivery of siRNA into intact islets is challenging. Here, we prepared R3V6 peptides containing a three-arginine stretch and a six-valine stretch, which form micelles with hydrophobic valine cores and cationic arginine surfaces in aqueous solution, to co-deliver siRNA and cytoprotective hydrophobic drugs to islet cells. The cationic surfaces bound to the negatively charged ...
Source: Biomaterials - December 6, 2014 Category: Materials Science Authors: Hwang HJ, Lee M, Park JH, Jung HS, Kang JG, Kim CS, Lee SJ, Ihm SH Tags: Biomaterials Source Type: research

The involvement of osteopontin and matrix metalloproteinase- 9 in the migration of endometrial epithelial cells in patients with endometriosis
Conclusions: The present study suggests that the up-regulation of MMP-9 via activation of OPN induced by estrogen may correlate with the migration of endometrial epithelial cells in patients with endometriosis.
Source: Reproductive Biology and Endocrinology - August 20, 2015 Category: Endocrinology Authors: Mei YangChunfan JiangHua ChenYan NianZhimiao BaiChunfang Ha Source Type: research

Abstract 2435: FGFR1 is associated with resistance to interaction with estrogen receptor (ER) {alpha} endocrine therapy in ER+/FGFR1-amplified breast cancer
Conclusions: These data suggest FGFR1 binds ER and regulates ligand-independent ER transcriptional activity. This role depends on the FGFR1 kinase activity and may involve its association with cyclin D1. These interactions may explain the endocrine resistance reported in ER+/FGFR1 amplified breast cancers and suggest these tumors should be treated with a combination of antiestrogen and FGFR inhibitors.Citation Format: Luigi Formisano, Christian D. Young, Neil Bhola, Jennifer M. Giltnane, Monica V. Estrada, Carlos L. Arteaga. FGFR1 is associated with resistance to interaction with estrogen receptor (ER) α endocrine therapy...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Formisano, L., Young, C. D., Bhola, N., Giltnane, J. M., Estrada, M. V., Arteaga, C. L. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

SUMO-1 Promotes Ishikawa Cell Proliferation and Apoptosis in Endometrial Cancer by Increasing Sumoylation of Histone H4
Conclusion: SUMO-1 regulates the Ishikawa cell proliferation and apoptosis by the sumoylation of histone H4.
Source: International Journal of Gynecological Cancer - September 24, 2015 Category: Cancer & Oncology Tags: Basic Sciences Source Type: research

ID: 82: DISTINCT ACTIONS OF ER{alpha} AND ER{beta} IN HUMAN PROSTATE STEM AND PROGENITOR CELL SELF-RENEWAL AND DIFFERENTIATION
Estrogens are implicated in prostate development and cancer, while stem cells are essential in tissue homeostasis and carcinogenesis. We have previously demonstrated that estradiol-17β (E2) treatment augments prostaspheres (PS) number and size, implicating them as direct estrogen targets. The present studies sought to elucidate specific roles for ERα and ERβ in prostate stem and progenitor cells. Prostate stem-progenitor cells were identified and isolated from normal primary prostate epithelial cells (PrEC) using long term BrdU retention in 3-D PS culture. FACS analyses (BrdU/ERα or ERβ) showed p...
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Hu, D., Hu, W., Majumdar, S., Gauntner, T., Li, Y., Shi, G., Kasper, S., Prins, G. Tags: Endocrinology/Metabolism Source Type: research

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells
Conclusions: This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Anissa BelkaidSabrina DuguayRodney OuelletteMarc Surette Source Type: research

Multiple Sites of Type II Site Ligand (Luteolin and BMHPC) Regulation of Gene Expression in PC-3 Cells.
Authors: Markaverich BM, Vijjeswarapu M Abstract Type II [(3)H]estradiol binding site ligands including luteolin (a naturally occurring bioflavonoid) and synthetic compounds such as 2,6-bis((3-methoxy-4-hydroxyphenyl)methylene)cyclohexanone (BMHPC) inhibit normal and malignant prostate cell (PC-3, LNCaP, DU-145) proliferation in vitro and in vivo. Type II sites represent a binding domain on histone H4 possibly involved in an epigenetic mechanism for controlling gene transcription. Treatment of PC-3 human prostate cancer cells with luteolin or BMHPC modulated the expression of a number of genes in the epidermal grow...
Source: International Journal of Biomedical Science - December 12, 2015 Category: Biomedical Science Tags: Int J Biomed Sci Source Type: research

Oestrogen exerts anti-inflammation via p38 MAPK/NF-κB cascade in adipocytes
Conclusions E2 inhibits LPS-stimulated MCP-1 in adipocytes. This effect is related to the inhibition of p38 MAPK/NF-κB cascade, and ERα appears to be the dominant ER subtype in these events.
Source: Obesity Research and Clinical Practice - March 21, 2016 Category: Eating Disorders and Weight Management Source Type: research

Inhibition of TrkB limits development of the zebra finch song system.
Abstract Large sexual dimorphisms exist in the zebra finch song system. Masculinization may be mediated by both estradiol and expression of one or more Z-genes (males: ZZ; females: ZW). Roles of the Z-gene tyrosine kinase B (TrkB) in HVC in masculinizing both it and its target the robust nucleus of the arcopallium (RA) were tested using siRNA administration in juvenile males at two ages (post-hatching days 15-17 or 25-27). Birds were euthanized 10 days later. Potential interactions or additive effects with estradiol were evaluated by treating males with the estrogen synthesis inhibitor fadrozole. Females treated w...
Source: Brain Research - April 14, 2016 Category: Neurology Authors: Beach LQ, Tang YP, Kerver H, Wade J Tags: Brain Res Source Type: research

Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor α
Publication date: Available online 9 September 2016 Source:Journal of Pharmacological Sciences Author(s): Sun Ae Kim, Kyung Young Lee, Jae-Ryong Kim, Hyoung Chul Choi The prevalence rate of cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC. We identified the estrogenic properties of nordihydrogaiaretic acid (NDGA, a lignan phytoestrogen) that inhibit VSMC proliferation and explored the underlying mechanisms. Both the phosphorylation and expression of LKB1 were increased by NDGA. In addition, N...
Source: Journal of Pharmacological Sciences - September 8, 2016 Category: Drugs & Pharmacology Source Type: research

Oestrogen exerts anti-inflammation via p38 MAPK/NF- κB cascade in adipocytes
Conclusions E2 inhibits LPS-stimulated MCP-1 in adipocytes. This effect is related to the inhibition of p38 MAPK/NF-κB cascade, and ERα appears to be the dominant ER subtype in these events.
Source: Obesity Research and Clinical Practice - November 10, 2016 Category: Eating Disorders and Weight Management Source Type: research

RCC2 Expression Stimulates ER-Positive Breast Tumorigenesis.
Conclusions: Our results suggest that estrogen-induced RCC2 expression prompts IGF1, TWIST1, and IL-6 expression, stimulates cell migration, and inhibits apoptosis to contribute to ER + breast tumorigenesis. PMID: 32565805 [PubMed]
Source: Journal of Oncology - June 24, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research