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Condition: Mitochondrial Disease
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Total 454 results found since Jan 2013.
Estrogen signaling increases nuclear receptor subfamily 4 group A member 1 expression and energy production in skeletal muscle cells.
Authors: Nagai S, Ikeda K, Horie-Inoue K, Takeda S, Inoue S
Abstract
Estrogen deficiency has been known to associate with musculoskeletal diseases in women, based on the clinical observations of frequent susceptibility to osteoporosis and sarcopenia among postmenopausal women. In skeletal muscles, estrogen has been assumed to play physiological roles in maintaining muscle mass and strength, although its precise molecular mechanism remains to be elucidated. We have previously shown that estrogen regulates energy metabolism through the downregulation of mitochondrial uncoupling protein 3 (UCP3) in skeletal muscles, w...
Source: Endocrine Journal - October 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research
Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor- α.
Resveratrol attenuates high fat diet-induced mouse cardiomyopathy through upregulation of estrogen related receptor-α.
Eur J Pharmacol. 2018 Oct 17;:
Authors: Lu Y, Lu X, Wang L, Yang W
Abstract
Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti-oxidative property, anti-apoptosis and anti-inflammation. However, the molecular mediators of resveratrol-induced cardiac benefits are still not fully disclosed. Present study aims to investigate whether estrogen-related receptor (...
Source: European Journal of Pharmacology - October 17, 2018 Category: Drugs & Pharmacology Authors: Lu Y, Lu X, Wang L, Yang W Tags: Eur J Pharmacol Source Type: research
Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line
In conclusion, farrerol attenuated Aβ-induced oxidative stress and inflammation in BV-2 cells through enhancing the activation of Nrf2/Keap1 pathway. The findings indicated that farrerol could be considered as a therapeutic approach for the treatment of Alzheimer’s disease (AD).
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research
FOXRED1 silencing in mice: a possible animal model for Leigh syndrome
AbstractLeigh syndrome (LS) is one of the most puzzling mitochondrial disorders, which is also known as subacute necrotizing encephalopathy. It has an incidence of 1 in 77,000 live births worldwide with poor prognosis. Currently, there is a poor understanding of the underlying pathophysiological mechanisms of the disease without any available effective treatment. Hence, the inevitability for developing suitable animal and cellular models needed for the development of successful new therapeutic modalities. In this short report, we blocked FOXRED1 gene with small interfering RNA (siRNA) using C57bl/6 mice. Results showed neu...
Source: Metabolic Brain Disease - November 3, 2018 Category: Neurology Source Type: research
Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.
In conclusion, farrerol attenuated Aβ-induced oxidative stress and inflammation in BV-2 cells through enhancing the activation of Nrf2/Keap1 pathway. The findings indicated that farrerol could be considered as a therapeutic approach for the treatment of Alzheimer's disease (AD).
PMID: 30396067 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 2, 2018 Category: Drugs & Pharmacology Authors: Cui B, Zhang S, Wang Y, Guo Y Tags: Biomed Pharmacother Source Type: research
Cigarette smoke induces mitochondrial dysfunction via PKCd-p66Shc signaling pathway in human bronchial epithelial cells
Conclusions: These data suggest that PKC-p66Shc pathway may be involved in the pathogenesis of COPD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zhang, M., Li, Y., Tang, J., Zhang, J., Yang, X., Shan, H., Zhang, Q. Tags: Airway Cell Biology and Immunopathology Source Type: research
Complement 1q-like-3 protein inhibits insulin secretion from pancreatic {beta}-cells via the cell adhesion G protein-coupled receptor BAI3 Cell Biology
Secreted proteins are important metabolic regulators in both healthy and disease states. Here, we sought to investigate the mechanism by which the secreted protein complement 1q-like-3 (C1ql3) regulates insulin secretion from pancreatic β-cells, a key process affecting whole-body glucose metabolism. We found that C1ql3 predominantly inhibits exendin-4– and cAMP-stimulated insulin secretion from mouse and human islets. However, to a lesser extent, C1ql3 also reduced insulin secretion in response to KCl, the potassium channel blocker tolbutamide, and high glucose. Strikingly, C1ql3 did not affect insulin secretion stimula...
Source: Journal of Biological Chemistry - November 23, 2018 Category: Chemistry Authors: Rajesh Gupta, Dan C. Nguyen, Michael D. Schaid, Xia Lei, Appakalai N. Balamurugan, G. William Wong, Jeong-a Kim, James E. Koltes, Michelle E. Kimple, Sushant Bhatnagar Tags: Metabolism Source Type: research
Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation
Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Chu-Tian Mai, Mei-Mei Wu, Chun-Li Wang, Zi-Ren Su, Yuan-Yuan Cheng, Xiao-Jun ZhangAbstractActivation of NLRP3 inflammasomes is crucial in the pathological process of Ulcerative colitis (UC), which could be negatively regulated by PINK1/Parkin-driven mitophagy. Palmatine is a herb derived isoquinoline alkaloid with potent anti-inflammatory and anti-bacteria activities. In present study, we evaluated the effect of palmatine on dextran sulfate sodium (DSS)-induced mice colitis and examined whether its effect is exerted by promoting mitophagy-medi...
Source: Molecular Immunology - November 28, 2018 Category: Allergy & Immunology Source Type: research
Increased Dynamin ‐Related Protein 1‐Dependent Mitochondrial Fission Contributes to High‐Fat Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn high ‐fat diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signalling pathway and alleviates insulin resistance.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 10, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
Increased Dynamin ‐Related Protein 1–Dependent Mitochondrial Fission Contributes to High‐Fat‐Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn HF ‐diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signaling pathway and alleviates insulin resistance.
Source: Molecular Nutrition and Food Research - January 18, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 21, 2019 Category: Neuroscience Authors: Robert J. Andrew,
Kate Fisher,
Kate J. Heesom,
Katherine A. B. Kellett,
Nigel M. Hooper Tags: Original Article Source Type: research
Increased Dynamin ‐Related Protein 1–Dependent Mitochondrial Fission Contributes to High‐Fat‐Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn HF ‐diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signaling pathway and alleviates insulin resistance.
Source: Molecular Nutrition and Food Research - January 18, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
Protective effects of ethyl gallate on H 2 O 2 -induced mitochondrial dysfunction in PC12 cells
AbstractOxidative stress has been suggested to play an important role in neuronal injury. Ethyl gallate (EG) is the ethyl ester of gallic acid which has been acknowledged as an antioxidant. We previously demonstrated that EG effectively inhibited H2O2-induced cytotoxicity and decreased the ROS levels in PC12 cells, while the relevant mechanisms of action of this compound remain largely uncharacterized. The present study was carried out in an attempt to clarify the underlying mechanisms of EG against H2O2-induced neurotoxicity in PC12 cells. EG pretreatment attenuated H2O2-induced mitochondrial dysfunction as indicated by t...
Source: Metabolic Brain Disease - February 12, 2019 Category: Neurology Source Type: research
Mitochondrial fusion and maintenance of mitochondrial homeostasis in diabetic retinopathy
This study aims to investigate the role of mitochondrial fusion in the development of diabetic retinopathy, and illustrate the molecular mechanism responsible for Mfn2 suppression. Using human retinal endothelial cells, manipulated for Mfn2, we investigated the role of fusion in mitochondrial structural and functional damage in diabetes. The molecular mechanism of its suppression in diabetic milieu was determined by investigating Mfn2 promoter DNA methylation, and confirmed using molecular and pharmacological inhibitors of DNA methylation. Similar studies were performed in the retinal microvasculature (prepared by hypotoni...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - March 27, 2019 Category: Molecular Biology Source Type: research
Mammalian STE20-like Kinase 1 Knockdown Attenuates TNF α-Mediated Neurodegenerative Disease by Repressing the JNK Pathway and Mitochondrial Stress.
Mammalian STE20-like Kinase 1 Knockdown Attenuates TNFα-Mediated Neurodegenerative Disease by Repressing the JNK Pathway and Mitochondrial Stress.
Neurochem Res. 2019 Apr 04;:
Authors: Geng C, Wei J, Wu C
Abstract
Neuroinflammation has been acknowledged as a primary factor contributing to the pathogenesis of neurodegenerative disease. However, the molecular mechanism underlying inflammation stress-mediated neuronal dysfunction is not fully understood. The aim of our study was to explore the influence of mammalian STE20-like kinase 1 (Mst1) in neuroinflammation using TNFα and CATH.a cells in vitro. T...
Source: Neurochemical Research - April 3, 2019 Category: Neuroscience Authors: Geng C, Wei J, Wu C Tags: Neurochem Res Source Type: research
