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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research
Significance of Oct-4 transcription factor as a pivotal therapeutic target for CD44 < sup > + < /sup > /24 < sup > - < /sup > mammary tumor initiating cells: Aiming at the root of the recurrence
In this study, we have attempted to identify previously unrecognized CSC survival factors that can be used as druggable targets for bCSCs apoptosis regulators isolated from the TNBC line, MDA MB 468. After a thorough literature review, Oct-4 was identified as the most promising marker for its unique abundance in cancer and absence in normal cells and the contribution of Oct-4 to the sustenance of cancer cells. We then validated a very high expression of Oct-4 in the MDA MB 468 bCSCs population using flow-cytometry. The loss of Oct-4 was carried out using small interfering RNA (siRNA)-mediated knockdown in the bCSCs, follow...
Source: Cell Biology International - December 27, 2022 Category: Cytology Authors: Utsav Sen Shanooja Shanavas Apoorva H Nagendra Muhammad Nihad Debajit Chaudhury Hari K Rachamalla Rajkumar Banerjee Sudheer Shenoy P Bipasha Bose Source Type: research
Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway
ConclusionThese findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 21, 2023 Category: Research Source Type: research
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in an...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
Regulation of XPC Binding Dynamics and Global Nucleotide Excision Repair by p63 and Vitamin D Receptor
J Phys Chem B. 2023 Mar 6. doi: 10.1021/acs.jpcb.2c07257. Online ahead of print.ABSTRACTp63 and the vitamin D receptor (VDR) play important roles in epidermal development and differentiation, but their roles and relationship in the response to ultraviolet (UV) radiation are less clear. Using TERT-immortalized human keratinocytes expressing shRNA targeting p63 in concert with exogenously applied siRNA targeting VDR, we assessed p63 and VDR's separate and combined effect on nucleotide excision repair (NER) of UV-induced 6-4 photoproducts (6-4PP). Knockdown of p63 reduced VDR and XPC expression relative to nontargeting contro...
Source: Health Physics - March 6, 2023 Category: Physics Authors: Christian T Wong Katherine Ona Dennis H Oh Source Type: research
SMO-CRISPR-mediated apoptosis in CD133-targeted cancer stem cells and tumor growth inhibition
J Control Release. 2023 Mar 15:S0168-3659(23)00190-6. doi: 10.1016/j.jconrel.2023.03.023. Online ahead of print.ABSTRACTCancer stem cells (CSCs) possess the ability to indefinitely proliferate and resist therapy, leading to cancer relapse and metastasis. To address this, we aimed to develop a CSC-inclusive therapy that targets both CSCs and non-CSC glioblastoma (GBM) cells. We accomplished this by using a smoothened (SMO) CRISPR/Cas9 plasmid to suppress the hedgehog pathway in CSCs, in combination with inhibiting the serine hydroxymethyl transferase 1 (SHMT1)-driven thymidylate biosynthesis pathway in non-CSC GBM cells usi...
Source: Cancer Control - March 17, 2023 Category: Cancer & Oncology Authors: Shambhavi Pandey Myungchul Lee Jaewoon Lim Sangbae Park Yun-Hoon Choung Jae Eun Kim Pankaj Garg Jong Hoon Chung Source Type: research
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
ConclusionThese findings demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in PDA and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Source: Digestive Diseases and Sciences - April 18, 2023 Category: Gastroenterology Source Type: research
Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition
In this study, we assessed the impact of vitamin D and its receptor (VDR) on NMD-ROS-EMT signaling in in vitro and in vivo osteosarcoma animal models. Initiation of VDR signaling facilitated the enrichment of EMT pathway genes, after which 1,25(OH)2D, the active vitamin D derivative, inhibited the EMT pathway in osteosarcoma subtypes. The ligand-bound VDR directly downregulated the EMT inducer SNAI2, differentiating highly metastatic from low metastatic subtypes and 1,25(OH)2D sensitivity. Moreover, epigenome-wide motif and putative target gene analysis revealed the VDR’s integration with NMD tumorigenic and immunogenic ...
Source: Frontiers in Oncology - May 9, 2023 Category: Cancer & Oncology Source Type: research
ATRA ameliorates fibrosis by suppressing the pro-fibrotic molecule Fra2/AP-1 in systemic sclerosis
In this study, the pro-fibrotic effect of Fra2 in SSc is confirmed. SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc animals exhibit increased levels of Fra2. Inhibition of Fra2 expression in SSc dermal fibroblasts with Fra2 siRNA markedly decreased collagen I expression. ATRA reduced the expressions of Fra2, collagen I, and α-smooth muscle actin(α-SMA) in SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc mice. In addition, chromatin immunoprecipitation and dual-luciferase assays demonstrated that retinoic acid receptor RARα binds to the FRA2 promoter and modulates its transcriptio...
Source: International Immunopharmacology - June 18, 2023 Category: Allergy & Immunology Authors: Zixin Pi Jiani Liu Yangfan Xiao Xinglan He Ruixuan Zhu Rui Tang Xiangning Qiu Yi Zhan Zhuotong Zeng Yaqian Shi Rong Xiao Source Type: research
Cancers, Vol. 15, Pages 3432: Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1
In this study, using chromatin immunoprecipitation (ChIP) assay and siRNA, we demonstrate that vitamin D/VDR regulates PD-L1 expression in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells. We have examined whether a VDR antagonist, MeTC7, can inhibit PD-L1. To ensure that MeTC7 inhibits VDR/PD-L1 without off-target effects, we examined competitive inhibition of VDR by MeTC7, utilizing ligand-dependent dimerization of VDR-RXR, RXR-RXR, and VDR-coactivators in a mammalian 2-hybrid (M2H) assay. MeTC7 inhibits VDR selectively, suppresses PD-L1 expression sparing PD-L2, and inhibits the cell viability, clon...
Source: Cancers - June 30, 2023 Category: Cancer & Oncology Authors: Negar Khazan Emily R. Quarato Niloy A. Singh Cameron W. A. Snyder Taylor Moore John P. Miller Masato Yasui Yuki Teramoto Takuro Goto Sabeeha Reshi Jennifer Hong Naixin Zhang Diya Pandey Priyanka Srivastava Alexandra Morell Hiroki Kawano Yuko Kawano Thomas Tags: Article Source Type: research
