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Nutrition: Vitamins

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Total 289 results found since Jan 2013.

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/ β-catenin signaling pathway
CONCLUSIONS: TSIIA was able to attenuate high glucose-induced EMT in HK2 cells by up-regulating VDR levels, which might be related to the inhibitory effect of VDR on the Wnt pathway.PMID:34852178 | DOI:10.5603/FHC.a2021.0025
Source: Folia Histochemica et Cytobiologica - December 1, 2021 Category: Cytology Authors: Jingyi Zeng Xiaorong Bao Source Type: research

CK2 Inhibitor Enhances Vitamin D-Mediated Antitumor Effects
Vitamin D has broad range of physiological functions and antitumor effects. 24-Hydroxylase, encoded by the CYP24A1 gene, is the key enzyme for degrading many forms of vitamin D including the most active form, 1,25D3. Inhibition of CYP24A1 enhances 1,25D3 antitumor activity. To isolate regulators of CYP24A1 expression in prostate cancer cells, we established a stable prostate cancer cell line PC3 with CYP24A1 promoter driving luciferase expression to screen a small molecular library for compounds that inhibit CYP24A1 promoter activity. From this screening, we identified, 4,5,6,7-tetrabromobenzimidazole (TBBz), a protein kin...
Source: Cancer Research - April 2, 2013 Category: Cancer & Oncology Authors: Luo, W., Yu, W.-D., Ma, Y., Chernov, M., Trump, D. L., Johnson, C. S. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Effects of 25-hydroxyvitamin D3 on cathelicidin production and antibacterial function of human oral keratinocytes.
In this study, we investigated the regulation of antibacterial functions of oral keratinocyte cells by 25-hydroxyvitamin D3 (25VD3). OKF6/TERT2 cells, an immortalized human oral keratinocyte cell line, were transfected with or without 24-hydroxylase small interfering RNA (siRNA) and incubated with different amounts of 25VD3. These epithelial cells expressed high levels of inactivating 24-hydroxylase (CYP24A1) and relatively low levels of activating 1α-hydroxylase (CYP27B1) in the presence of 25VD3. 25VD3 influenced the expression of vitamin D-driven genes and cathelicidin in a dose-related manner. SiRNA specific to 24-hyd...
Source: Cellular Immunology - June 19, 2013 Category: Allergy & Immunology Authors: Wang Q, Zhang W, Li H, Aprecio R, Wu W, Lin Y, Li Y Tags: Cell Immunol Source Type: research

Helicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses
ConclusionsThe expression of VDR and CAMP in the gastric epithelium is up‐regulated in the case of H. pylori infection; thus, VDR plays an important role in gastric mucosa homeostasis and host protection from H. pylori infection.
Source: Helicobacter - November 5, 2013 Category: Gastroenterology Authors: Lihua Guo, Wenguo Chen, Huatuo Zhu, Yu Chen, Xingyong Wan, Ningmin Yang, Shuhua Xu, Chaohui Yu, Lihua Chen Tags: Original Article Source Type: research

Competitive regulation of human intestinal β-Carotene 15,15’-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1α and HNF-4α
Publication date: Available online 30 October 2014 Source:Life Sciences Author(s): Noriaki Yamaguchi , Akiko Sunto , Toshinao Goda , Kazuhito Suruga Aim Among the pro-vitamin A carotenoids, β-carotene is an excellent source of vitamin A. β-Carotene 15,15’-monooxygenase 1 (BCMO1) is a critical enzyme involved in the conversion of β-carotene into vitamin A (retinal) in the small intestine of many vertebrates. In the present study, we investigated the regulation of human BCMO1 gene expression using human intestinal Caco-2 BBe cells. Main methods We performed electrophoretic mobility shift assays and chromatin immunopr...
Source: Life Sciences - November 4, 2014 Category: Biology Source Type: research

Competitive regulation of human intestinal β-carotene 15,15′-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1α and HNF-4α
Publication date: Available online 30 October 2014 Source:Life Sciences Author(s): Noriaki Yamaguchi , Akiko Sunto , Toshinao Goda , Kazuhito Suruga Aim Among the pro-vitamin A carotenoids, β-carotene is an excellent source of vitamin A. β-Carotene 15,15′-monooxygenase 1 (BCMO1) is a critical enzyme involved in the conversion of β-carotene into vitamin A (retinal) in the small intestine of many vertebrates. In the present study, we investigated the regulation of human BCMO1 gene expression using human intestinal Caco-2 BBe cells. Main methods We performed electrophoretic mobility shift assays and chromatin immunopr...
Source: Life Sciences - November 5, 2014 Category: Biology Source Type: research

Calcitriol prevents in vitro vascular smooth muscle cell mineralization by regulating Calcium-Sensing Receptor expression.
In conclusion, these findings suggest that nanomolar concentrations of 1,25(OH)2D3 induce a CaSR-dependent protection against VC. Both lower and higher concentrations are either ineffective or may even promote VC. Whether this also holds true in the clinical setting requires further study. PMID: 25763635 [PubMed - as supplied by publisher]
Source: Endocrinology - March 12, 2015 Category: Endocrinology Authors: Mary A, Hénaut L, Boudot C, Six I, Brazier M, Massy ZA, Drüeke TB, Kamel S, Mentaverri R Tags: Endocrinology Source Type: research

The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction
This study examines the effect of maternal diabetes on fetal endothelial function and gene expression under physiological glucose conditions (5mM). Human umbilical vein endothelial cell (HUVEC) isolated from diabetic mothers (d.HUVEC) grew more slowly than HUVEC isolated from healthy mothers (c.HUVEC) and had delayed doubling time despite increased levels of total vascular endothelial growth factor (VEGF) expression and protein production as determined by real time PCR and ELISA respectively. Using western blot, the levels of antiproliferative VEGF165b isoform were increased in d.HUVEC relative to c.HUVEC. Successful VEGF1...
Source: Journal of Cellular Physiology - March 24, 2015 Category: Cytology Authors: Samar A Sultan, Wanting Liu, Yonghong Peng, W. Roberts, Donald Whitelaw, Anne M Graham Tags: Original Research Article Source Type: research

Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.
Abstract Folate is an essential B vitamin required for de novo purine and thymidylate synthesis, and for the remethylation of homocysteine to form methionine. Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). We aimed to determine the effect of altered folate metabolism on placental cell proliferation, viability and invasive capacity and on progesterone and human chorionic gonadotropin (hCG) secretion. Human placental choriocarcinoma (JEG-3) cell...
Source: The British Journal of Nutrition - August 24, 2015 Category: Nutrition Authors: Moussa C, Ross N, Jolette P, MacFarlane AJ Tags: Br J Nutr Source Type: research

Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells
Planta MedDOI: 10.1055/s-0035-1557898To examine whether quercetin interacts with vitamin D receptor, we investigated the effects of quercetin on vitamin D receptor activity in human intestinal Caco-2 cells. The effects of quercetin on the expression of the vitamin D receptor target genes, vitamin D3 24-hydroxylase, cytochrome P450 3A4, multidrug resistance protein 1, and transient receptor potential vanilloid type 6 were measured using quantitative polymerase chain reaction. The vitamin D receptor siRNA was used to assess the involvement of the vitamin D receptor. Vitamin D receptor activation using a vitamin D responsive ...
Source: Planta Medica - September 14, 2015 Category: Drugs & Pharmacology Authors: Chae, Yoon-JeeCho, Kwan HyungYoon, In-SooNoh, Chi-KyoungLee, Hyo-JongPark, YohanJi, EunheeSeo, Min-DukMaeng, Han-Joo Tags: Original Papers Source Type: research