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Nutrition: Sodium

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Total 222 results found since Jan 2013.

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.
CONCLUSIONS: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. PMID: 29178675 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Rapamycin enhances lytic replication of Epstein-Barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters.
In this study, we assessed the effects of rapamycin on EBV reactivation in gastric carcinoma cells. We found that rapamycin upregulated expression of EBV lytic proteins and increased the viral proliferation triggered by the EBV lytic inducer sodium butyrate. Reverse transcription-qPCR, luciferase activity assays, chromatin immunoprecipitation and western blotting were employed to explore the mechanism by which rapamycin promotes EBV reactivation. Our results showed that rapamycin treatment resulted in increased mRNA levels of EBV immediate-early genes. Rapamycin also enhanced the transcriptional activities of the EBV immed...
Source: Virus Research - November 20, 2017 Category: Virology Authors: Wang M, Wu W, Zhang Y, Yao G, Gu B Tags: Virus Res Source Type: research

Sulphonated Formononetin Induces Angiogenesis through Vascular Endothelial Growth Factor/cAMP Response Element-Binding Protein/Early Growth Response 3/Vascular Cell Adhesion Molecule 1 and Wnt/ β-Catenin Signaling Pathway
Conclusions: These results may suggest that Sul-F induces angiogenesis in vitro via a programed Wnt/ β-catenin pathway and VEGF/CREB/Egr-3/VCAM-1 signaling axis.Pharmacology 2018;101:76 –85
Source: Pharmacology - October 31, 2017 Category: Drugs & Pharmacology Source Type: research

NF- κB-Dependent Upregulation of (Pro)Renin Receptor Mediates High NaCl-Induced Apoptosis in Mouse Inner Medullary Collecting Duct Cells.
In conclusion, PRR expression is induced by high NaCl through NF-κB and contributes to cell apoptosis under this circumstance. PMID: 29021196 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - October 11, 2017 Category: Cytology Authors: Su J, Liu X, Xu C, Lu X, Wang F, Fang H, Lu A, Qiu Q, Li C, Yang T Tags: Am J Physiol Cell Physiol Source Type: research

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells
Conclusions: We propose that the inhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the environmental and occupational chemical carcinogen FA. https://doi.org/10.1289/EHP1275 Received: 25 October 2016 Revised: 19 May 2017 Accepted: 23 May 2017 Published: 21 September 2017 Address correspondence to C. Jin, Dept. of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo Park, NY 10987 USA. Telephone: (845) 731-3602. Email: Chunyuan.jin@nyumc.org *Current affiliation: Medical School of Nanjing University, Nanjing, China. †Current affiliatio...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Abstract P218: Role of UCP2 on Mitochondrial Dysfunction and Blood Pressure Regulation in the Renal Oxidative Stress-mediated Hypertension Associated With Dj-1 Depletion Session Title: Onsite Poster Competition I With Reception
In conclusion, deletion of DJ-1 leads to oxidative stress-induced hypertension associated with down-regulation of NO synthesis. UCP2 has protective properties against the development of MT dysfunction in MT oxidative stress conditions. However, excessive and chronic over expression of UCP2 could have deleterious consequences on BP regulation.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Carmen De Miguel, William C Hamrick, Sudhar Jagarlamudi, Xiaobo Ma, Laureano Asico, Pedro Jose, Santiago Cuevas Tags: Poster Abstract Presentations Source Type: research

GSE77621 Multiplex bisulfite sequencing identifies differentially methylated regions in target genes in embryonic cardiomyocytes following knockdown of DNMT3a or DNMT3b expression
This study aims to identify the differentially methylated regions in target genes in embryonic cardiomyocytes following the knockdown of DNMT3a or DNMT3b expression. Methods: Primary cardiomyocytes were isolated from mouse embryonic day (E) 13.5 ventricles, and cultured for 48 h at 37 °C to reach 70-80% confluency. Cells were transfected with either Qiagen FlexiTube GeneSolution (with 4 siRNAs) DNMT3a siRNA (#GS13435), DNMT3b siRNAs (#GS13436), or AllStars negative control siRNA (#1027281) at 0.012 pmol using lipofectamine RNAiMAX (n=3 per treatment). At 72 h after transfection, cells were released with Accutase (Innovati...
Source: GEO: Gene Expression Omnibus - September 8, 2017 Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research

Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling.
Abstract Mounting evidence demonstrated deficient cystathionine-γ-lyase (CSE)/H2S implicated the development of cardiovascular disease. The present study aimed to evaluating the favorable action of CSE derived H2S on endothelial function in CSE(-/-) mice. CSE(-/-) mice exhibited attenuated endothelium-dependent relaxations, coupled with reduction of endothelial nitric oxide synthase (eNOS) phosphorylation at site of Ser1177, increase of thioredoxin interacting protein (TXNIP) level and MAPK phosphorylation, which were corrected by sodium hydrosulfide chronic treatment for 8 weeks. Impaired relaxations to ACh and ...
Source: Free Radical Biology and Medicine - June 29, 2017 Category: Biology Authors: Tian D, Dong J, Jin S, Teng X, Wu Y Tags: Free Radic Biol Med Source Type: research

Sodium influx through cerebral sodium-glucose transporter type 1 exacerbates the development of cerebral ischemic neuronal damage.
Abstract We recently reported that cerebral sodium-glucose transporter type 1 (SGLT-1) plays a role in exacerbation of cerebral ischemia. However, the mechanism by which cerebral SGLT-1 acts remains unclear. Here we demonstrated that sodium influx through cerebral SGLT-1 exacerbates cerebral ischemic neuronal damage. SGLT-specific sodium ion influx was induced using α-methyl-D-glucopyranoside (α-MG). Intracellular sodium concentrations in primary cortical neurons were estimated using sodium-binding benzofuran isophthalate fluorescence. SGLT-1 knockdown in primary cortical neurons and mice was achieved using SGLT...
Source: European Journal of Pharmacology - February 3, 2017 Category: Drugs & Pharmacology Authors: Yamazaki Y, Harada S, Wada T, Hagiwara T, Yoshida S, Tokuyama S Tags: Eur J Pharmacol Source Type: research

Sodium butyrate down-regulates Tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies.
Abstract Butyrate regulates multiple host cellular events including the cell cycle; however, little is known about the molecular mechanism by which butyrate induces a global down-regulation of the expression of genes associated with the cell cycle. Here, we demonstrate that treating HEK293T cells and the non-small-cell lung cancer cell line A549 with a high concentration of sodium butyrate reduces cyclin B1 expression. The underlying mechanism is related to the destabilization of its mRNA by tristetraprolin, which is up-regulated in response to sodium butyrate. Specifically, the sodium butyrate stimulation reduces...
Source: The International Journal of Biochemistry and Cell Biology - November 6, 2015 Category: Biochemistry Authors: Zheng XT, Xiao XQ Tags: Int J Biochem Cell Biol Source Type: research

Abstract 116: Characterization of a Sodium Responsive Human Sodium Bicarbonate Transporter NBCe2 in Human Proximal Tubule Session Title: Concurrent XVIII B: Kidney and Hypertension II
The electrogenic sodium bicarbonate cotransporter (NBCe2) is encoded by SLC4A5, variants of which have been associated with salt sensitivity of blood pressure (BP), which affects 25% of the adult population. NBCe2 is thought to mediate sodium bicarbonate cotransport primarily in the renal collecting duct, but NBCe2 mRNA is also found in the rodent renal proximal tubule (RPT), another site of bicarbonate transport. The protein expression or function of NBCe2 has not been demonstrated in the human RPT. We validated an NBCe2 antibody by siRNA and Western blot, as well as overexpression of an epitope-tagged NBCe2 construct in ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Gildea, J. J., Xu, P., Carlson, M., Gaglione, R. T., Bigler Wang, D., Kemp, B. A., Reyes, C. M., McGrath, H. E., Carey, R. M., Jose, P. A., Felder, R. A. Tags: Session Title: Concurrent XVIII B: Kidney and Hypertension II Source Type: research

Rubbing salt into wounded endothelium: Sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress.
In conclusion, elevated sodium has a direct effect on endothelial activation under atherogenic shear-stress in vitro and in vivo, and promotes the endothelial-leukocyte interactions even in the absence of increased lipid concentrations. PMID: 24573382 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 27, 2014 Category: Hematology Authors: Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I Tags: Thromb Haemost Source Type: research