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Nutrition: Sodium

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Total 222 results found since Jan 2013.

Hydrogen sulfide alleviates beryllium sulfate ‐induced ferroptosis and ferritinophagy in 16HBE cells
This study aimed to investigate the effect of H2S on BeSO4-induced ferroptosis and ferritinophagy in 16HBE cells and the underlying mechanism. In this study, BeSO4-induced 16HBE cell injury model was established based on cellular level and pretreated with deferoxamine (DFO, a ferroptosis inhibitor), sodium hydrosulfide (NaHS, a H2S donor), or NCOA4 siRNA and, subsequently, performed to detect the levels of lipid peroxidation and Fe2+ and the biomarkers of ferroptosis and ferritinophagy. More importantly, our research found that DFO, NaHS, or NCOA4 siRNA alleviated BeSO4-induced ferroptosis and ferritinophagy by decreasing ...
Source: Journal of Applied Toxicology - March 22, 2023 Category: Toxicology Authors: Xiuli Liu, Guilan Li, Shaoxiong Chen, Huiyun Jin, Xiaodong Liu, Linfang Zhang, Zhaohui Zhang Tags: RESEARCH ARTICLE Source Type: research

Nrf2/PINK1-mediated mitophagy induction alleviates sodium fluoride-induced hepatic injury by improving mitochondrial function, oxidative stress, and inflammation
Ecotoxicol Environ Saf. 2023 Feb 13;252:114646. doi: 10.1016/j.ecoenv.2023.114646. Online ahead of print.ABSTRACTMitophagy has distinct functions, which can lead to either protection or damage of tissues. Though current evidence indicated that NaF triggers mitophagy, the role and regulation of mitophagy in sodium fluoride (NaF)-induced liver injury still remain unclear. Therefore, we exployed the cell and mouse models and confirmed that NaF treatment activates mitophagy. Knocking down PTEN-induced putative kinase protein 1 (PINK1) expression attenuated mitophagy and increased the degree of mitochondrial impairment, oxidati...
Source: Ecotoxicology and Environmental Safety - February 15, 2023 Category: Environmental Health Authors: Chao Song Aiguo Zhang Man Zhang Yuzhen Song Heping Huangfu Shuangxing Jin Yanting Sun Chunhui Zhang Dongmei Shi Jundong Wang Wei Peng Qin Luo Source Type: research

Cancers, Vol. 15, Pages 217: Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR- & gamma; Signaling
Cancers, Vol. 15, Pages 217: Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling Cancers doi: 10.3390/cancers15010217 Authors: Alessia Filippone Giovanna Casili Sarah Adriana Scuderi Deborah Mannino Marika Lanza Michela Campolo Irene Paterniti Anna Paola Capra Cristina Colarossi Annalisa Bonasera Sofia Paola Lombardo Salvatore Cuzzocrea Emanuela Esposito New therapeutic approaches are needed to improve the outcome of patients with glioblastoma (GBM). Propionate, a short-chain fatty acid (SCFA), has a potent antiproliferative effect on various tumo...
Source: Cancers - December 29, 2022 Category: Cancer & Oncology Authors: Alessia Filippone Giovanna Casili Sarah Adriana Scuderi Deborah Mannino Marika Lanza Michela Campolo Irene Paterniti Anna Paola Capra Cristina Colarossi Annalisa Bonasera Sofia Paola Lombardo Salvatore Cuzzocrea Emanuela Esposito Tags: Article Source Type: research

Sodium butyrate protects against rotavirus-induced intestinal epithelial barrier damage by activating AMPK-Nrf2 signaling pathway in IPEC-J2 cells
Int J Biol Macromol. 2022 Dec 21:S0141-8130(22)03130-0. doi: 10.1016/j.ijbiomac.2022.12.219. Online ahead of print.ABSTRACTRotavirus (RV) mainly infects intestinal epithelial cells, which leads to diarrhea in newborn piglets with dysfunction in the intestinal mucosal mechanical barrier. Sodium butyrate (SB) is one of the metabolites excreted by gut microbes. However, the protective effect of SB on RV infection induced intestinal mucosal mechanical barrier injury and its potential mechanism has not been well elucidated. In the present study, IPEC-J2 cells with RV infection was a model of intestinal mucosal mechanical barrie...
Source: International Journal of Biological Macromolecules - December 24, 2022 Category: Biochemistry Authors: Xia Dong Yi Wang Xiaoxiao Zhu Linyuan Shen Lei Chen Lili Niu Mailin Gan Shunhua Zhang Ming Zhang Jun Jiang Daiwen Chen Li Zhu Ye Zhao Source Type: research

Smooth muscle cell FTO regulates contractile function
Am J Physiol Heart Circ Physiol. 2022 Oct 28. doi: 10.1152/ajpheart.00427.2022. Online ahead of print.ABSTRACTThe Fat mass and obesity gene (FTO) is a N6-methyladenosine RNA demethylase that was initially linked by GWAS studies to increased rates of obesity. Subsequent studies have revealed multiple mass-independent effects of the gene, including cardiac myocyte contractility. We created a mouse with a conditional and inducible smooth muscle cell deletion of Fto (Myh11 Cre + Ftofl/fl) and did not observe any changes in mouse body mass or mitochondrial metabolism. However, the mice had significantly decreased blood pressure...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Melissa A Luse Nenja Kr üger Miranda E Good Lauren A Biwer Vlad Serbulea Anita Salamon Rebecca A Deaton Norbert Leitinger Axel G ödecke Brant E Isakson Source Type: research

Enhanced sucrose-mediated cryoprotection of siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles
Colloids Surf B Biointerfaces. 2022 Sep 28;220:112880. doi: 10.1016/j.colsurfb.2022.112880. Online ahead of print.ABSTRACTThe present study aimed to determine the effects of sucrose on the physical stability, cellular entry pathways and functional efficacy of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs). PLGA-NPs were synthesized in the absence or presence of 10 % sucrose, using HEI-101, an unmodified small interfering RNA (siRNA), as a drug model. The newly synthesized HEI-101-loaded PLGA-NPs (HEI-101-NPs) were exposed to repeated freeze-thaw cycles and iteratively tested over a six-month evaluation period. The ...
Source: Colloids and Surfaces - October 14, 2022 Category: Biotechnology Authors: Ibrahima Youm Matthew B West Xiangping Huang Wei Li Richard D Kopke Source Type: research